Review
Critical Care Medicine
Yuting Li, Jianxing Guo, Hongmei Yang, Hongxiang Li, Yangyang Shen, Dong Zhang
Summary: This systematic review and meta-analysis found that culture positivity or negativity is not associated with mortality in patients with sepsis or septic shock. Additionally, culture-positive patients had longer hospital stays and mechanical ventilation durations compared to culture-negative patients. Further large-scale studies are needed to confirm these findings.
Review
Orthopedics
Feng Li, Yongjie Qiao, Haoqiang Zhang, Guoding Cao, Shenghu Zhou
Summary: This study compared the clinical outcomes of culture-negative periprosthetic joint infection (CN PJI) with those of culture-positive periprosthetic joint infection (CP PJI). The results showed that patients who underwent DAIR, one-stage or two-stage revision had similar or better survival rates in the CN PJI group, indicating that negative culture was not a worse prognostic factor for PJI.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Microbiology
Elora G. Demers, Jason E. Stajich, Alix Ashare, Patricia Occhipinti, Deborah A. Hogan
Summary: The evolution of pathogens under selective pressures in chronic infections can impact their persistence, virulence, and response to antimicrobial therapy. Genetic analysis of isolates from single infections reveals dynamic selection pathways and trade-offs between high and low Mrr1 activity, affecting drug resistance and survival traits. Such dynamic evolution within chronic infections highlights the need for a balanced approach in managing microbial populations.
Review
Gastroenterology & Hepatology
Shujie Dong, Huihong Qi, Yan Li, Peng Men, Maiwujudan Alifu, Yatong Zhang, Yongjun Li, Rongsheng Zhao
Summary: In cirrhotic patients with PVT, anticoagulation therapy helps increase the rate of PVT recanalization and improve survival, but may also carry higher risks of bleeding compared to no treatment.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Antonio Franco, Flavia Proietti, Veronica Palombi, Gabriele Savarese, Michele Guidotti, Costantino Leonardo, Fabio Ferro, Claudio Manna, Giorgio Franco
Summary: The treatment of varicocele in infertility is still a controversial issue. Recent scientific evidence shows that varicocele treatment can improve semen parameters and pregnancy rates. The aim of treatment in adults is to improve current fertility status, while in adolescents, it is to prevent testicular injury and maintain future fertility. Correct indication seems to be the key to successful varicocele treatment. This study reviews and summarizes the current evidence on varicocele treatment, focusing on surgical indications in adolescents and adults, as well as other specific situations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Wenfei Yao, Fei Chen, San Wang, Xiaofeng Zhang
Summary: The research found that exposure to the natural environment has significant positive effects on human emotional well-being, including increasing positive affect and decreasing negative affect. However, there is substantial heterogeneity and risk of bias among studies, and factors such as study region, design, and sample characteristics can impact the results.
FRONTIERS IN PUBLIC HEALTH
(2021)
News Item
Oncology
Joschka Hey, Maria Llamazares Prada, Christoph Plass
Summary: Developing methods to identify patients who may benefit from specific treatments is crucial. A recent study has established an HDAC6 score to predict how patients with breast cancer will respond to the HDAC6 inhibitor ricolinostat. The study also investigates the anti-tumor effects of the inhibitor through preclinical mechanistic work and a phase 1b clinical trial.
Review
Oncology
Gustavo A. Viani, Andre G. Gouveia, Alexander Louie, Martin Korzeniowski, Juliana F. Pavoni, Ana Carolina Hamamura, Fabio Y. Moraes
Summary: SABR for oligometastatic breast cancer is safe and effective, with high rates of local control and survival. Prospective design and bone-only metastases are significantly associated with better outcomes.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Immunology
Connor Prosty, Ryan Hanula, Khaled Katergi, Yves Longtin, Emily G. Mcdonald, Todd C. Lee
Summary: We evaluated clinical outcomes of patients with different test results (NAAT+/Toxin+ vs NAAT+/Toxin-) and treated or untreated cases through systematic review and meta-analysis. The results showed that patients with NAAT+/Toxin+ had a higher rate of recurrence, and treatment of NAAT+/Toxin- cases was associated with lower all-cause mortality. These findings suggest the importance of treating some NAAT+/Toxin- cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Davide Gravina, Johanna Louise Keeler, Melahat Nur Akkese, Sevgi Bektas, Paula Fina, Charles Tweed, Gerd-Dieter Willmund, Janet Treasure, Hubertus Himmerich
Summary: In recent years, the incidence of overweight and obesity among military personnel has been increasing worldwide. This study examines the effectiveness of weight loss interventions and the importance of current obesity treatments in this population. The findings suggest that current interventions can effectively reduce body weight and body mass index in military populations.
Article
Psychology, Biological
Amber Hye-Yon Lee, Yphtach Lelkes, Carlee B. Hawkins, Alexander G. Theodoridis
Summary: The study shows that most Americans have either balanced positive and negative attitudes towards partisanship or lean more towards the positive side, with only partisan leaners exhibiting negative partisanship.
NATURE HUMAN BEHAVIOUR
(2022)
Review
Psychology, Clinical
Rebecca Webb, Rod Bond, Borja Romero-Gonzalez, Rachel Mycroft, Susan Ayers
Summary: This study found that most interventions can reduce fear of childbirth among women, and other talking therapies may lower the rate of caesarean sections. Future high-quality randomized controlled trials are needed for further validation.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Multidisciplinary Sciences
Martina Zemp, Amos S. Friedrich, Jessica Schirl, Slava Dantchev, Martin Voracek, Ulrich S. Tran
Summary: According to family systems theory, family is considered an organized whole where relationships are interconnected. The meta-analytic results suggest a small positive correlation between interparental and sibling relationship quality. The percentage of male children in the sample is the only moderator affecting this correlation.
Review
Orthopedics
Siegfried J. Adelhoefer, Marcos R. Gonzalez, Angad Bedi, Arne Kienzle, Henrik C. Baecker, Octavian Andronic, Daniel Karczewski
Summary: Knowledge of Candida spondylodiscitis is limited, and there is controversy regarding the most effective diagnostic and therapeutic approaches. This systematic review analyzed all reported cases to date and found that most patients affected by Candida spondylodiscitis were males in their sixties, with one in four being immunocompromised. Within two years of diagnosis, approximately one in five patients died, but younger age and prolonged antifungal treatment may have a protective effect.
INTERNATIONAL ORTHOPAEDICS
(2023)
Editorial Material
Obstetrics & Gynecology
Cynthia Abraham
Summary: The optimal management strategy for proliferative endometrium in menopause has not yet been determined.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Helington Castro Kruger, Jordano Francio, Arthur Sorgatto da Silva, Gabriela Silva Neubern de Oliveira, Joao Armando Brancher, Leticia Ramos Dantas, Rodrigo Cardoso de Oliveira, Felipe Francisco Tuon, Everdan Carneiro
Summary: The study demonstrated that the CH paste formulated with aroeira showed antibacterial activity against Enterococcus faecalis without interfering with pH, calcium ion release, or cell viability, indicating its potential as a vehicle for CH paste.
AUSTRALIAN ENDODONTIC JOURNAL
(2022)
Article
Orthopedics
Luiz Gustavo Dal Oglio da Rocha, Victoria Stadler Tasca Ribeiro, Ana Paula de Andrade, Geiziane Aparecida Goncalves, Leticia Kraft, Juliette Cieslinski, Paula Hansen Suss, Felipe Francisco Tuon
Summary: This study compared the formation of Staphylococcus aureus and Candida albicans biofilms on the surface of titanium alloy and PEEK interbody cages used in spine surgery. The results showed that titanium-alloy models were associated with less staphylococcal and Candida biofilm formation compared to PEEK models.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2022)
Letter
Public, Environmental & Occupational Health
Adam Coelho de Aguiar, Joao Felipe Perlin Silva, Luca Matsuda Kim, Renan Kimura Rosot, Roberto Espinola Filho, Leticia Sera Castanho, Juliette Cieslinski, Victoria Stadler Tasca Ribeiro, Felipe Francisco Tuon
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
June Alisson Westarb Cruz, Maria Alexandra Viegas Cortez da Cunha, Thyago Proenca de Moraes, Sandro Marques, Felipe Francisco Tuon, Arivelton Loeschke Gomide, Gisele de Paula Linhares
Summary: This research describes and analyzes the complementarity of Private Health before the Brazilian Unified Health System, highlighting its main characteristics, scenarios, and trends in the face of the health system and the Brazilian market. This descriptive and exploratory research uses secondary data from various sources, submitted to quantitative data analysis methods. The object of the research is the history of private health in Brazil and its main actors.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Cell Biology
Paula Hansen Suss, Victoria Stadler Tasca Ribeiro, Carlos Eduardo Motooka, Leticia Corso de Melo, Felipe Francisco Tuon
Summary: This study aimed to develop a decellularization protocol that allows the removal of cells and myelin sheath without detrimental effects on nerve architecture. The addition of sonication to detergent-based decellularization methods was found to increase the effectiveness of removing unwanted cellular components from peripheral nerve allografts, as confirmed by histology and scanning electron microscopy.
CELL AND TISSUE BANKING
(2022)
Article
Cell Biology
Leticia Ramos Dantas, Victoria Stadler Tasca Ribeiro, Leticia Kraft, Ricardo Aurino Pinho, Paula Hansen Suss, Franciane Thais Falcao Vasconcellos, Lucia de Noronha, Felipe Francisco Tuon
Summary: The decellularization of bovine bone is an effective method for repairing bone defects. The new protocol used in this study successfully removed bone marrow components and cell debris, while preserving the structure of collagen fibers and extracellular matrix. However, the decellularized bovine bone showed moderate toxicity.
CELL AND TISSUE BANKING
(2022)
Letter
Infectious Diseases
Larissa Bail, Carmen Antonia Sanches Ito, Lavinia Nery Villa Stangler Arend, Keite da Silva Nogueira, Felipe Francisco Tuon
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Ana Paula de Andrade, Lavinia Nery Villa Stangler Arend, Victoria Stadler Tasca Ribeiro, Felipe Francisco Tuon
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
V. M. de Carvalho Hessel Dias, F. Tuon, P. de Jesus Capelo, J. P. Telles, C. M. C. B. Fortaleza, C. Pellegrino Baena
Summary: This study analyzed the incidence density trend of carbapenem-resistant Gram-negative bacteria and antimicrobial consumption in 99 critical care facilities in a low/middle-income country. The findings showed an increase in the incidence density of carbapenem-resistant Acinetobacter baumannii (CRAB) in 2020, which was strongly correlated with the incidence density of COVID-19. There was also an increase in polymyxin consumption in 2020, but it was not significantly correlated with CRAB or COVID-19 incidence density, likely due to empirical and untargeted prescribing.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Microbiology
Ariadne Decarli, Lais Vieira Nascimento, Larissa Hiromi Sayama Esteves, Patricia Arenas Rocha, Valeria Midori Gutoski Yuki, Juliette Cieslinski, Joao Paulo Telles, Victoria Stadler Tasca Ribeiro, Felipe Francisco Tuon
Summary: This study evaluated the clinical impact of an automated method for identification and susceptibility testing of microbial isolates. The results showed a significant reduction in report time, hospitalization time, and mortality.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Review
Parasitology
Felipe Francisco Tuon, Leticia Ramos Dantas, Regina Maia de Souza, Victoria Stadler Tasca Ribeiro, Valdir Sabbaga Amato
Summary: Human leishmaniasis is a widespread infectious disease with limited treatment options. Encapsulating therapeutic drugs in liposomes can increase drug concentration in host cells, reduce toxicity, and broaden the therapeutic spectrum.
PARASITOLOGY RESEARCH
(2022)
Article
Respiratory System
Larissa Hermann de Souza Nunes, Joao Felipe Bernardi Lora, Luiz Augusto Fanhani Cracco, Janice Alexandra da Costa Manuel, June Alisson Westarb Cruz, Joao Paulo Telles, Felipe Francisco Tuon
Summary: This study aimed to investigate the risk factors associated with the presence of P. aeruginosa, as well as the risk factors related to the recurrence and death of lower airway infections in inpatients. The results showed that previous pulmonary disease was associated with colonization by P. aeruginosa. Aminoglycosides were the most effective drugs in susceptibility tests and were successfully used as monotherapy. Septic shock was a risk factor for death in infected patients. The use of adequate antimicrobial therapy was associated with increased survival, regardless of the infection classification.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Ophthalmology
Jamile Reimann Mendonca, Leticia Ramos Dantas, Felipe Francisco Tuon
Summary: The use of contact lenses has increased the risk of microbial keratitis. This study tested the effectiveness of 14 multipurpose contact lens solutions against bacterial and fungal biofilms. The results showed that only five solutions had a significant effect on bacterial biofilms, while none were able to eradicate fungal biofilms. In conclusion, multipurpose contact lens solutions have better bactericidal activity against planktonic cells than biofilms.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Urology & Nephrology
Juliette Cieslinski, Victoria Stadler Tasca Ribeiro, Camila Kowodzeichak de Lima, Leticia Kraft, Paula Hansen Suss, Felipe FranciscoTuon
Summary: This study aimed to evaluate the recovery capability of strict, facultative, and aerobic microorganisms on bladder catheters using conventional culture, sonication, urinary analysis, and mass spectrometry. The results showed that sonicated catheters had a higher positivity rate than urine samples for anaerobic and aerobic microorganisms, indicating that bladder catheter sonication is more sensitive for detecting these microorganisms.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Infectious Diseases
Leticia Kraft, Victoria Stadler Tasca Ribeiro, Luiz Pedro Petroski, Roberto Hirochi Herai, Kamila Chagas Peronni, David Livingstone Alves Figueiredo, Fabio Araujo Motta, Felipe Francisco Tuon
Summary: This study describes a case of severe S. clavata infection in a Brazilian children's hospital, including characterization of antifungal minimal inhibitory concentration, S. clavata biofilm, and molecular features. The study found that S. clavata can form biofilms and is sensitive to certain antifungal drugs. These findings are important for the development of novel treatments, especially for biofilm-associated infections.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
