Article
Medicine, General & Internal
August Wrotek, Oliwia Wrotek, Teresa Jackowska
Summary: This study aimed to analyze the prognostic value of platelet parameters in children hospitalized with laboratory-confirmed influenza. The study found that abnormalities in platelet count and mean platelet volume/platelet count ratio were associated with increased odds of complications and a more severe disease course.
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Virology
Zhonglan Wu, David Harrich, Zhongyang Li, Dongsheng Hu, Dongsheng Li
Summary: From 2002 to 2019, three deadly human coronaviruses emerged, causing outbreaks of SARS, MERS, and Covid-19. Covid-19 shares similarities with the 2009 H1N1 pandemic in terms of global spread and characteristics of high viral shedding and transmission by pre-symptomatic individuals. To control Covid-19 transmission, identifying transmission sources through virus shedding testing and interrupting chains of transmission through social distancing and masking are essential.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Immunology
Kailey Hughes, Donald B. Middleton, Mary Patricia Nowalk, Goundappa K. Balasubramani, Emily T. Martin, Manjusha Gaglani, H. Keipp Talbot, Manish M. Patel, Jill M. Ferdinands, Richard K. Zimmerman, Fernanda P. Silveira
Summary: This study evaluated the vaccine effectiveness against influenza hospitalization among immunocompromised adults during the 2017-2018 influenza season. The results showed that while immunocompromised adults had a higher vaccination rate, their protection against influenza was lower, with a vaccine effectiveness of 33% in the overall adult population. Further research is needed to assess vaccine effectiveness among different immunocompromising conditions and explore ways to improve effectiveness for immunocompromised individuals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Krystal Lau, Ilaria Dorigatti, Marisa Miraldo, Katharina Hauck
Summary: This study estimated hospitalization rates, severity rates, mortality rates, and time lags between infections and hospitalizations of H1N1 pandemic patients in England during and after the pandemic period. Results showed increased severity in the post-pandemic flu season, highlighting the importance of continued vigilance by policymakers and researchers. Analysis of administrative hospital data and epidemiological modeling estimates can provide valuable insights for responding to COVID-19 and future pandemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Hyun-Jong Lee, Gwanghui Ryu, Ki-Il Lee
Summary: This study compared the symptomatic characteristics of influenza A/H3N2 and A/H1N1 subtypes in primary healthcare settings in Korea. The results showed that the H3N2-dominant season had higher average body temperature and more patients with high fever compared to the H1N1-dominant season. On the other hand, symptoms such as myalgia, cough, and sore throat were more common in the H1N1-dominant season. Antiviral drugs were prescribed to the majority of febrile patients in both seasons.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Ivan Martinez-Baz, Ana Navascues, Maria Eugenia Portillo, Itziar Casado, Ujue Fresan, Carmen Ezpeleta, Jesus Castilla
Summary: The study estimated the average effect of influenza vaccination on preventing laboratory-confirmed influenza hospitalization in diabetic patients, showing that influenza vaccination can significantly reduce the probability of hospitalization for diabetic patients and that vaccination in prior seasons also maintained a notable protective effect.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Eunmi Yang, Eun-Ji Choi, Han-Seung Park, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Han Kim
Summary: The study compared the clinical characteristics and outcomes of IFDs between patients with AML who received posaconazole prophylaxis and those without antifungal prophylaxis, finding a significantly lower incidence of IFDs in the prophylaxis group. Invasive mold infection was identified as the most common IFD regardless of antifungal prophylaxis.
Letter
Critical Care Medicine
Hyemin Chung, Sang-Bum Hong, Jin Won Huh, Heungsup Sung, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Younsuck Koh, Sang-Ho Choi
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Infectious Diseases
Yun Woo Lee, So Yun Lim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Yang Soo Kim, Sang-Ho Choi
Summary: This study evaluated the clinical characteristics and outcomes of Enterococcus raffinosus bacteremia in adults. The study found that E. raffinosus bacteremia mainly originated from biliary tract infection, had high resistance rates to penicillin and ampicillin, but had a low bacteremia-related mortality rate.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Haein Kim, Hyeonji Seo, Hyemin Chung, Sunghee Park, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Yong Pil Chong
Summary: The value of follow-up blood culture (FUBC) in the management of Gram-negative bacteremia (GNB) is controversial. This study evaluated bedside risk predictors and found that hemodialysis, fever on the day of FUBCs, intravascular device, no use of in vitro active antibiotic within 24 h, non-fermenting bacteria, and multidrug resistance were independent risk factors for positive FUBCs in GNB. The yield of FUBCs increased as the number of bedside risk predictors increased, and positive FUBCs were significantly associated with 30-day mortality.
Article
Infectious Diseases
Moonsuk Bae, Yunseo Jeong, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jiwon Jung
Summary: The study found that in patients with uncomplicated Pseudomonas aeruginosa bloodstream infection, there was no significant difference in recurrence rates or 30-day mortality between short-course and prolonged-course antimicrobial therapy. Prolonged therapy did not significantly reduce the risk of P. aeruginosa infection recurrence within 180 days compared to short-course therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Kyung Hwa Jung, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Summary: The study identified hematologic malignancy and ulcerative colitis as independent risk factors for the relapse of gastrointestinal cytomegalovirus disease. Approximately 10% of the participants experienced disease relapse after antiviral treatment. Prolonged antiviral treatment may not be helpful in preventing relapse of GI CMV disease.
Article
Virology
Hyemin Chung, Eunsil Kim, Bomin Kwon, Yeong-Geon Cho, Seongman Bae, Jiwon Jung, Min-Jae Kim, Yong-Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang-Soo Kim
Summary: This study investigated the kinetics of Gn-specific antibodies in patients with severe fever with thrombocytopenia syndrome (SFTS). The results showed that the peak of anti-Gn-specific IgM occurred later than that of anti-NP-specific IgM, and anti-Gn-specific IgG lasted for at least 3 years.
Article
Immunology
Hyeonji Seo, Jeong-Young Lee, Seung Hee Ryu, Sun Hee Kwak, Eun Ok Kim, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Heungsup Sung, Mi-Na Kim, Yang Soo Kim, Jiwon Jung
Summary: The study suggests that patients with negative CPE culture had lower rates of infection and transmission compared to those with positive CPE culture. The Xpert Carba-R assay is clinically useful not only for rapid identification of CPE but also for predicting the risks of infection and transmission when performed along with culture.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Jin-Young Huh, Sang-Ho Choi, Kyung-Wook Jo, Jin Won Huh, Sang-Bum Hong, Tae Sun Shim, Chae-Man Lim, Younsuck Koh
Summary: This study investigated the risk factors for progression from non-severe Legionella pneumonia (LP) to severe LP. The results showed that a low platelet count and delayed antibiotic treatment were significantly associated with the progression to severe LP from non-severe LP.
ACUTE AND CRITICAL CARE
(2022)
Article
Medicine, General & Internal
Jiyoung Lee, Euijin Chang, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang -Oh Lee, Sang -Ho Choi, Yang Soo Kim, Seongman Bae
Summary: This study evaluated the rate and composition of bacterial co-infection in COVID-19 patients and assessed the association between the use of empirical antibacterials and mortality. The results showed that bacterial co-infection was infrequent in the patients, and the co-infected organisms varied depending on the previous use of antibacterial drugs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Infectious Diseases
Sang -Ho Choi, Antoni Cesar, Timothy Arthur Chandos Snow, Naveed Saleem, Nishkantha Arulkumaran, Mervyn Singer
Summary: For hospitalized adults with mild-to-moderate community-acquired pneumonia (CAP), respiratory fluoroquinolone monotherapy or β-lactam plus macrolide combination therapy are suggested as first-line options according to guidelines. However, the efficacy of these regimens has not been adequately evaluated.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Immunology
Yun Woo Lee, Jin Won Huh, Sang-Bum Hong, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Heungsup Sung, Kyung-Hyun Do, Sang-Oh Lee, Chae-Man Lim, Yang Soo Kim, Younsuck Koh, Sang-Ho Choi
Summary: We investigated the distribution and characteristics of severe Corynebacterium striatum pneumonia in South Korea from 2014 to 2019. The majority of cases were hospital-acquired and more than half of the patients were immunocompromised. The proportion of C. striatum cases among patients with severe hospital-acquired pneumonia increased over time, while methicillin-resistant Staphylococcus aureus (MRSA) infections decreased. C. striatum was responsible for a significant proportion of severe hospital-acquired pneumonia cases, and the mortality rates were high, similar to those caused by MRSA. This pathogen is emerging as a possible cause of severe pneumonia, especially among immunocompromised patients.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Hyeonji Seo, Haein Kim, Seongman Bae, Seonghee Park, Hyemin Chung, Heung-Sup Sung, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Ki Young Son, Yong Pil Chong
Summary: This study found no significant differences in clinical deterioration between patients treated with fluvoxamine and placebo among adult patients with symptomatic COVID-19 admitted to the CTC. Factors such as age, fever, and pneumonia may be independent risk factors for clinical deterioration.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Hyeonji Seo, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jiwon Jung
Summary: This study identified that patients with KPC-producing K. pneumoniae and Escherichia coli bacteremia had a higher 30-day mortality rate, which may be related to high APACHE II scores and not receiving appropriate definitive treatment. Combination regimens with conventional drugs such as colistin, aminoglycoside, and tigecycline did not significantly affect mortality outcomes.
INFECTION AND CHEMOTHERAPY
(2021)