Current Status and Future Perspectives of Dendritic Cell-Based Cancer Immunotherapy

FDA approves ipilimumab for treatment of melanoma

(2014) Janet Fricker   BRITISH JOURNAL OF HOSPITAL MEDICINE

CD141+ dendritic cells produce prominent amounts of IFN-  after dsRNA recognition and can be targeted via DEC-205 in humanized mice

(2013) S. Meixlsperger et al.   BLOOD

Targeting dendritic cells--why bother?

(2013) M. Kreutz et al.   BLOOD

Update on the role of ipilimumab in melanoma and first data on new combination therapies

(2013) Michele Maio et al.   CURRENT OPINION IN ONCOLOGY

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial

(2012) Eva Ellebaek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

(2012) Willemijn Hobo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NK Cells: Key to Success of DC-Based Cancer Vaccines?

(2012) E. Lion et al.   ONCOLOGIST

Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs

(2012) Erik Berk et al.   VACCINE

Trial watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Inflammation restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation

(2011) C. H. M. J. Van Elssen et al.   BLOOD

Remembering Ralph Steinman

(2011) Jacques Banchereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell Based Tumor Vaccination in Prostate and Renal Cell Cancer: A Systematic Review and Meta-Analysis

(2011) Andreas Draube et al.   PLoS One

Therapeutic Response in Patients with Advanced Malignancies Treated with Combined Dendritic Cell–Activated T Cell Based Immunotherapy and Intensity–Modulated Radiotherapy

(2011) Kenichiro Hasumi et al.   Cancers

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

(2010) Karolina Palucka et al.   IMMUNITY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad Antigen Specificity

(2010) T. Tsuji et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells and immunity against cancer

(2010) K. Palucka et al.   JOURNAL OF INTERNAL MEDICINE

The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA

(2010) A.-O. Hovden et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immunotherapy of distant metastatic disease

(2009) D. Schadendorf et al.   ANNALS OF ONCOLOGY