Article
Multidisciplinary Sciences
Shreya Das, Mohd Saqib, Ryan C. Meng, Sridar Chittur, Ziqiang Guan, Fengyi Wan, Wei Sun
Summary: Hemachromatosis increases susceptibility to siderophilic bacterial infections. The study found that infection with Yersinia pseudotuberculosis Delta fur mutant disrupts the intestinal barrier and triggers inflammatory responses in hemochromatotic mice, leading to severe systemic infection and mortality. Inhibiting specific molecule activity or intervening in the inflammatory signaling pathways can partially or completely rescue hemochromatotic mice from lethal infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Surgery
Siv Fonnes, Tilde Rasmussen, Amanda Brunchmann, Barbara Juliane Holzknecht, Jacob Rosenberg
Summary: This systematic review and meta-analysis aimed to characterize the suspected or confirmed abdominal diseases and surgeries associated with Yersinia infection. The results showed that approximately half of the patients with mesenteric lymphadenitis and terminal ileitis were serologically positive for Yersinia spp. Infections, which may lead to unnecessary surgeries for suspected appendicitis.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anna K. Miller, Gloria Tavera, Ricardo L. Dominguez, M. Constanza Camargo, Tim Waterboer, Keith T. Wilson, Scott M. Williams, Douglas R. Morgan
Summary: The primary cause of gastric cancer is chronic infection with Helicobacter pylori (H. pylori), particularly the high-risk genotype cagA, and risk modification by human genetic variants. Variants such as rs2302615 in ornithine decarboxylase (ODC1) are associated with gastric cancer risk.
Article
Multidisciplinary Sciences
Mei-Ling Yang, Sheryl Horstman, Renelle Gee, Perrin Guyer, TuKiet T. Lam, Jean Kanyo, Ana L. Perdigoto, Cate Speake, Carla J. Greenbaum, Lut Overbergh, Richard G. Kibbey, Kevan C. Herold, Eddie A. James, Mark J. Mamula, Nisha Callebaut
Summary: This study implicates the citrullination of glucokinase in autoimmune diabetes inflammation, triggering autoimmunity and affecting glucokinase biological functions. The study also identifies glucokinase as a Type 1 diabetes biomarker, providing new insights into how inflammation drives post-translational modifications and affects beta cell metabolism.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Haiying Huang, Yiming Jiang, Jianhua Zhao, Shasha Li, Sarah Schulz, Li Deng
Summary: The study demonstrates that BTEX plays a major role in shaping the structure of microbial communities in contaminated groundwater, and functional bacteria are crucial for water purification. Investigating the assembly pattern of microbial communities provides insights into the ecological controls of contaminant degradation in groundwater.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Infectious Diseases
Takehiro Hashimoto, Ryuichi Takenaka, Haruka Fukuda, Kazuhiko Hashinaga, Shin-ichi Nureki, Hideki Hayashidani, Teruo Sakamoto, Osamu Shigemitsu
Summary: This case study describes a case of septic shock caused by Yersinia pseudotuberculosis infection in an immunocompetent patient. Appropriate microorganism tests and antibiotic therapy are essential for successful treatment of Y. pseudotuberculosis bacteremia.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Yuiko Goto, Yoko Sato, Hitoshi Ikeda, Chisato Onitsuka, Hiroki Sato, Kaho Akimoto, Takaya Ebato, Hiromitsu Suganuma, Tomoko Kawahara, Hatsuko Mikuni, Yoshitaka Uchida, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara
Summary: This study found that the expression of type III interferons (IFNs) is associated with disease severity in COVID-19 patients. The low expression of IL-28A/IFN-lambda 2 may predict the severity of COVID-19 and possibly through the mechanism of delayed viral elimination.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kristina M. Garske, Asha Kar, Caroline Comenho, Brunilda Balliu, David Z. Z. Pan, Yash V. Bhagat, Gregory Rosenberg, Amogha Koka, Sankha Subhra Das, Zong Miao, Janet S. Sinsheimer, Jaakko Kaprio, Kirsi H. Pietilainen, Paivi Pajukanta
Summary: Obesity-induced adipose tissue dysfunction can lead to chronic low-grade inflammation and other comorbidities. This study used human primary preadipocytes from monozygotic twins with different body mass index (BMI) to investigate the impact of increased BMI on subnuclear chromatin compartmentalization and downstream inflammation. The results showed that open chromatin co-accessibility was altered in higher BMI twins compared to lower BMI twins, suggesting a mechanism through which obesity may induce inflammation through gene-environment interactions. Furthermore, variants within these regions were found to contribute to systemic inflammation in association with BMI and C-reactive protein levels.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ko Sato, Ikumi Matsumoto, Koya Suzuki, Atsushi Tamura, Aki Shiraishi, Hiroshi Kiyonari, Jun Kasamatsu, Hideki Yamamoto, Tomomitsu Miyasaka, Daiki Tanno, Anna Miyahara, Tong Zong, Takafumi Kagesawa, Akiho Oniyama, Kotone Kawamura, Yuki Kitai, Aya Umeki, Emi Kanno, Hiromasa Tanno, Keiko Ishii, Sachiko Tsukita, Kazuyoshi Kawakami
Summary: The lung-specific claudin-18 (luCldn-18) plays a crucial role in host defense against Cryptococcus deneoformans infection, as deficiency in luCldn-18 increases susceptibility to pulmonary infection. On the other hand, Cldn-4 does not have a significant role in fungal clearance. Deficiency in luCldn-18 leads to decreased cytokine production, increased inflammatory cell infiltration, acidification in the alveolar space, and enhanced fungal replication.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Olga Portnyagina, Dmitry Chistyulin, Sergey Dyshlovoy, Viktoriya Davidova, Valentina Khomenko, Ludmila Shevchenko, Olga Novikova
Summary: The study revealed the impact of Yersinia ruckeri's outer membrane porin YrOmpF on host macrophage activation and eukaryotic cell life cycle, identifying key structural elements. Additionally, YrOmpF showed twice the cytotoxicity on human monocytes compared to noncancer cells, and induced S-phase arrest in both normal and cancer cells. Antibodies against YrOmpF were found to decrease toxicity and improve viability in mouse peritoneal macrophages.
MICROBIAL PATHOGENESIS
(2021)
Article
Hematology
Moses M. Kasembeli, Efiyenia Kaparos, Uddalak Bharadwaj, Ahmad Allaw, Alain Khouri, Bianca Acot, David J. Tweardy
Summary: STAT3 mutations in the DNA-binding domain and Src-homology 2 domain have been found to cause immunodeficiency, malignancy, and autoimmunity. The study reveals that these mutations affect the stability of STAT3 monomer and homodimer, as well as its activation processes. Specifically, mutations in the DNA-binding domain result in reduced DNA binding, while mutations in the Src-homology 2 domain lead to increased DNA binding. Furthermore, mutations related to immunodeficiency show decreased conformational stability, affecting various activation events. Interventions targeting these mutations may have therapeutic potential.
Article
Microbiology
Jenna J. Guthmiller, Olivia Stovicek, Jiaolong Wang, Siriruk Changrob, Lei Li, Peter Halfmann, Nai-Ying Zheng, Henry Utset, Christopher T. Stamper, Haley L. Dugan, William D. Miller, Min Huang, Ya-Nan Dai, Christopher A. Nelson, Paige D. Hall, Maud Jansen, Kumaran Shanmugarajah, Jessica S. Donington, Florian Krammer, Daved H. Fremont, Andrzej Joachimiak, Yoshihiro Kawaoka, Vera Tesic, Maria Lucia Madariaga, Patrick C. Wilson
Summary: The study reveals that individuals with more severe SARS-CoV-2 infection have a stronger overall antibody response to the spike and nucleocapsid proteins, and a larger memory B cell response against the spike. Additionally, these individuals develop antibodies that cross-react with other viral antigens, suggesting potential protection against reinfection.
Article
Multidisciplinary Sciences
Salyan Bhattarai, Qian Li, Jun Ding, Feng Liang, Ekaterina Gusev, Orsolya Lapohos, Gregory J. Fonseca, Eva Kaufmann, Maziar Divangahi, Basil J. Petrof
Summary: The authors of this study investigate the trained immunity of immune cells in Duchenne Muscular Dystrophy (DMD) and identify TLR4 as a key regulator of this process. Trained immunity contributes to dysregulated inflammation in DMD, and this mechanism is dependent on functional and epigenetic changes in TLR4 and bone marrow-derived macrophages.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Adane Bitew, Nuhamen Zena, Abera Abdeta
Summary: This study aimed to determine the common etiology and prevalence of urinary tract infection in pediatric patients, analyze the antibiotic susceptibility profile of bacterial isolates, and identify associated risk factors. The results showed a high prevalence of urinary tract infection, with Enterobacteriaceae as the major causative agents. Length of hospital stay and catheterization were significantly associated with urinary tract infection. Both Gram-negative and Gram-positive bacteria exhibited high resistance to commonly used antibiotics.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Psychiatry
Annica J. Rasmusson, Maike Gallwitz, Bardia Soltanabadi, Diana M. Ciuculete, Jonas Mengel-From, Kaare Christensen, Marianne Nygaard, Mette Soerensen, Adrian E. Bostrom, Robert Fredriksson, Eva Freyhult, Jessica Mwinyi, Darina Czamara, Elisabeth B. Binder, Helgi B. Schioth, Janet L. Cunningham
Summary: This study found an inverse correlation between depressive symptoms in young Scandinavian adults and the methylation level of TLR4, as well as a correlation with the plasma levels of the inflammatory protein MIP-1 beta.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)