Article
Dermatology
Qixin Zhang, Fei Liu, Yao Li, Lin Ji, Yanchun Yu, Xingju Yang
Summary: This meta-analysis evaluated the impact of colostomy or ileostomy on post-operative wound complications. The results demonstrated that neither LC nor LI significantly reduced the incidence of post-operative infections or anastomotic fistulae.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Psychiatry
Wymann Shao Wen Tang, Li Ling Christine Chiang, Kay Wee Kwang, Melvyn Wei Bin Zhang
Summary: This meta-analysis examines the prevalence of depression among patients with enterostomy and identifies potential factors contributing to heterogeneity. The pooled prevalence of depression is found to be 41.6%, with indications for enterostomy formation and geographical region identified as potential sources of heterogeneity.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Surgery
Koichiro Kumano, Daichi Kitaguchi, Yohei Owada, Eiki Kinoshita, Shoko Moue, Kinji Furuya, Yusuke Ohara, Tsuyoshi Enomoto, Tatsuya Oda
Summary: This study compares stoma-related complications between loop ileostomy and loop colostomy after rectal resection and discusses the characteristics of diverting stoma types. The results show that stoma-related complications are significantly higher in the loop ileostomy group, suggesting early closure of the stoma. Loop colostomy has lower stoma-related morbidities, but post-closure leakage is a calculated risk.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Oncology
S. H. J. Ketelaers, R. G. Orsini, G. A. P. Nieuwenhuijzen, H. J. T. Rutten, J. W. A. Burger, J. G. Bloemen
Summary: This study focused on the outcomes of diverting ostomy in elderly patients with advanced rectal cancer after low anterior resection (LAR). The results showed that most elderly patients successfully reversed their ostomy with limited complications, but there is still a risk of non-reversal and ostomy recreation over time.
Article
Surgery
Iku Higashimoto, Jin Teshima, Yohei Ozawa, Masahiro Usuda, Go Miyata
Summary: This study compared the surgical outcomes of ileostomy and transverse colostomy and determined which method is more suitable for a diverting stoma. The study found that the incidence of prolapse was higher in the transverse colostomy group, while high-output stoma and skin irritation were more frequent in the ileostomy group. The median interval to stoma closure was shorter in the ileostomy group, and the incidence of wound infection was higher in the transverse colostomy group after secondary closure surgery. The findings suggest that ileostomy should be the preferred procedure for short-term temporary diverting stoma.
Review
Surgery
Zheng Ge, Xiang Zhao, Zitian Liu, Guangwei Yang, Qunzheng Wu, Xiaoyang Wang, Xiang Zhang, Zhiqiang Cheng, Kexin Wang
Summary: This study compared the incidence of postoperative complications between ileostomy and colostomy procedures based on data analysis of 30 studies. The results showed no significant differences in complications except for stoma prolapse. Meta-analysis and TSA indicated that the incidence of ileostomy prolapse was lower than colostomy, with statistical significance. Other than the four listed complications, there were differences in the incidence of various complications between the two groups.
Article
Surgery
Carolina Vigna, Kevin Arndt, Jeremy Dressler, Donna Loehner, Evangelos Messaris
Summary: Umbilical stomas have been found to be a safe alternative to conventional stomas, providing superior cosmetic outcomes. Peristomal skin irritation is a major complication secondary to difficulties with the management of the pouching system.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Zhiqiang Cheng, Shuohui Dong, Dongsong Bi, Yanlei Wang, Yong Dai, Xiang Zhang
Summary: The study finds that early closure of ileostomy after colorectal surgery can reduce the incidence of small-bowel obstruction/postoperative ileus and require less total operative time, but may increase the risk of surgical site infection. Early closure may lead to a slightly longer postoperative length of hospital stay. There is no significant difference between early and late closure in terms of morbidity, reoperation, or leak of the primary anastomosis.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Takuya Shiraishi, Hiroomi Ogawa, Satoh Naomi, Ikuma Shioi, Yuta Shibasaki, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Makoto Sohda, Ken Shirabe, Hiroshi Saeki
Summary: This study aimed to identify risk factors associated with stoma-related complications after emergency surgery and evaluate surgical techniques for good stoma creation in the emergency setting. The study found that higher BMI and lower stoma height are independent risk factors for stoma-related complications. Using the skin bridge technique could reduce the risk of complications.
ANTICANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Roberto Peltrini, Giuseppe Magno, Daniela Pacella, Biancamaria Iacone, Antonia Rizzuto, Umberto Bracale, Francesco Corcione
Summary: This study aimed to evaluate whether patients undergoing ileostomy reversal after urgent or elective stoma construction have different postoperative outcomes. A retrospective observational study was conducted, and the complete data records of 145 patients were evaluated. The results showed no difference in postoperative complication rate after stoma closure between the urgent and elective surgery groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Traci L. Hedrick, Alexis Sherman, Shirley Cohen-Mekelburg, Jill K. J. Gaidos
Summary: The purpose of this article is to review the available evidence and provide expert advice on the management of patients with an enteral stoma. It incorporates important and recently published studies in this field and reflects the experiences of a multidisciplinary group of authors composed of gastroenterologists, a colorectal surgeon, a wound ostomy and continence nurse, and ostomates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kevin K. Allart, Charles Sabbagh, Abdennaceur Dhahri, Rachid Badaoui, Jean-Marc Regimbeau
Summary: This study evaluated the feasibility of day-case surgery for elective stoma closure, showing a high success rate and acceptable complication and readmission rates in selected patients.
DISEASES OF THE COLON & RECTUM
(2021)
Review
Medicine, General & Internal
Izabela Michonska, Ewelina Polak-Szczybylo, Aneta Sokal, Sara Jarmakiewicz-Czaja, Agnieszka Ewa Stepien, Katarzyna Deren
Summary: The incidence of colorectal cancer and inflammatory bowel diseases is on the rise in developed countries, leading to an increase in the prevalence of stomas. However, research on nutrition in stoma patients is limited. This review aims to assess the impact of nutrition on intestinal stomas and analyze possible sequelae, such as malnutrition and vitamin deficiencies. Current research indicates a significantly increased risk of malnutrition and vitamin deficiencies, particularly in B vitamins, among individuals with stomas, as well as abnormalities in electrolyte concentrations and increased stoma discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
James Ashcroft, Aminder Anthony Singh, Bhavna Ramachandran, Amir Habeeb, Victoria Hudson, Jeremy Meyer, Constantinos Simillis, Richard Justin Davies
Summary: This network meta-analysis identified early feeding as the most efficacious therapeutic intervention to reduce post-operative ileus in patients undergoing colorectal surgery, in addition to highlighting other therapies that require further investigation by high quality study. In patients undergoing colorectal surgery, emphasis should be placed on early feeding as soon as can be appropriately initiated to support the return of gastrointestinal motility.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Imerio Angriman, Gianluca Buzzi, Edoardo Giorato, Maria Barbierato, Francesco Cavallin, Cesare Ruffolo, Silvia Degasperi, Valentina Mari, Ottavia De Simoni, Michela Campi, Francesca Zingales, Gabriele Roveron, Massimo Iafrate, Salvatore Pucciarelli, Romeo Bardini, Marco Scarpa
Summary: The study aimed to assess stoma morbidity after surgery for CD and identified a high rate of postoperative complications in CD patients with stomas, with some complications specifically related to CD. Revisional surgery is often required for CD-related complications in stoma patients.
Article
Chemistry, Analytical
Kai Zhang, Zhenqiang Fan, Yue Huang, Minhao Xie, Jianfeng Zhao, Jiaying Wang
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Biophysics
Kai Zhang, Zhenqiang Fan, Bo Yao, Yuedi Ding, Jing Zhao, Minhao Xie, Jianbin Pan
Summary: Siglec-5 is an inhibitory receptor for leukocytes in the human body, and the development of novel assays for Siglec-5 can aid in studying related disease pathogenesis and developing therapeutic drugs. A biosensor based on CRISPR-Cas12a and MXene has been developed for sensitive detection of Siglec-5, extending the application of CRISPR-Cas12a to biosensor construction and providing a common method for biomarker detection. This work represents the first investigation into the Trans-Cleavage activity of CRISPR-Cas12a for Mxene-based ECL biosensor establishment.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Kai Zhang, Zhenqiang Fan, Bo Yao, Tingting Zhang, Yuedi Ding, Sha Zhu, Minhao Xie
Summary: In this study, an entropy-driven electrochemiluminescence (ECL) biosensor was constructed for ultra sensitive bioassay of NF-kappa B p50, providing a repeatable approach for TFs detection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Kai Zhang, Lei Zhou, Tingting Zhang, Zhenqiang Fan, Minhao Xie, Yuedi Ding, Hao Li
Summary: A biosensing method was developed to detect protein function under pathological conditions, showing oxidative stress-induced protein translocation and modification. Clinical samples confirmed the effectiveness of this method in studying the role of proteins in the progression of colorectal cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Bo Yao, Jing Zhang, Zhenqiang Fan, Yuedi Ding, Bin Zhou, Runlin Yang, Jianfeng Zhao, Kai Zhang
Summary: A novel Au@Ti3C2@PEI-Ru(dcbpy)(3)(2+) nanocomposite-based ECL biosensor was designed for the sensitive detection of the SARS-CoV-2 RdRp gene. The sensor showed a wide detection range and a low limit of detection, indicating its great potential for clinical medical applications. The use of a DNA walker amplification strategy also showed promising results for other detection methods.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biophysics
Zhenqiang Fan, Bo Yao, Yuedi Ding, Jing Zhao, Minhao Xie, Kai Zhang
Summary: A novel sensor for SARS-CoV-2 detection has been established utilizing an entropy-driven amplified electrochemiluminescence strategy, based on DNA tetrahedron design. By avoiding expensive enzyme reagents, the sensor efficiently detects viral RNA with high specificity and sensitivity, providing a reliable platform for large-scale screening of COVID-19 patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Yuedi Ding, Jun Fan, Zhenqiang Fan, Kai Zhang
Summary: The study demonstrated that ?-tocotrienol reversed the MDR of MCF-7/Adr cells by inhibiting the expression and function of mdr1/P-gp, as well as reducing the activation of the NF-?B signaling pathway.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Analytical
Zhenqiang Fan, Bo Yao, Yuedi Ding, Minhao Xie, Jianfeng Zhao, Kai Zhang, Wei Huang
Summary: A novel aptasensor was developed utilizing high affinity aptamers and non-toxic nanocomposites for the bioassays of Siglec-5. The sensor showed a low detection limit and significant potential for practical applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yuedi Ding, Zhenqiang Fan, Bo Yao, Dong Xu, Minhao Xie, Kai Zhang
Summary: A novel nanoparticle-based fluorescence probe was developed for NF-kappa B transcription factor detection and in situ imaging. The probe utilizes steric hindrance to quench and restore fluorescence signals, achieving a low detection limit and a good linear range.
Article
Biophysics
Kai Zhang, Zhenqiang Fan, Yuedi Ding, Jinlong Li, Hao Li
Summary: A low-cost and simple operation virus protein serum assay has been proposed, targeting the main protease of the virus through a short probe mimicking its substrate. Successful detection of the virus marker protein in the serum of infected patients encourages further development of this method for clinical practice.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Environmental
Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie
Summary: This study successfully constructed a method for SARS-CoV-2 nucleic acid detection using an exonuclease III cleavage reaction-based isothermal amplification combined with a pH-induced regenerative ECL biosensor mediated by CRISPR/Cas12a, providing ultra-sensitive and specific detection capabilities essential for large-scale screening in resource-limited areas.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Zhenqiang Fan, Bo Yao, Yuedi Ding, Dong Xu, Jianfeng Zhao, Kai Zhang
Summary: The study developed a dual-wavelength ratiometric electrochemiluminescence (ECL) biosensor based on entropy-driven and DNA walker cycle amplification strategies for detecting the RNA-dependent RNA polymerase (RdRp) gene of SARS-CoV-2. This method achieved high sensitivity detection of the SARS-CoV-2 RdRp gene, making it suitable for early clinical diagnosis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie
Summary: Early diagnosis and timely management of SARS-CoV-2 are essential for controlling the epidemic. This study developed a novel ECL biosensor for detecting the RdRp gene of SARS-CoV-2, utilizing CRISPR-Cas12a and a 3D DNA walker for amplification. The system showed a high sensitivity with a detection limit of 12.8 aM, demonstrating the potential for rapid and convenient detection of SARS-CoV-2-associated nucleic acids.
Article
Chemistry, Multidisciplinary
Kai Zhang, Jinlong Li, Zhenqiang Fan, Hao Li, Jing-Juan Xu
Summary: A new protocol has been established for the detection of SARS-CoV-2 using a peptidomimetic to covalently detect a viral marker protease.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhenqiang Fan, Yuedi Ding, Bo Yao, Jiaying Wang, Kai Zhang
Summary: In this study, we successfully detected NF-kappa B p50 by exploiting the double-stranded DNA binding property of transcription factor and the trans cleavage characteristic of CRISPR-Cas12a.
CHEMICAL COMMUNICATIONS
(2021)
