Article
Pathology
Filippo Cappello, Valentina Angerilli, Luca Dal Santo, Giada Munari, Marianna Sabbadin, Marcello Lo Mele, Gianmaria Pennelli, Claudio Luchini, Paola Parente, Stefano Lazzi, Matteo Fassan
Summary: Adenomatous dysplasia may develop in sessile serrated lesions (SSL) as part of the serrated lesion. However, some of these lesions may represent collisions between a serrated polyp and a conventional adenoma. Based on mutational analysis and MMR status, we found that adenomatous dysplasia in SSL may develop as part of the serrated lesion, while polyps morphologically classified as mixed lesions are more likely to be collision lesions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Jooyoung Lee, Jung Ho Bae, Su Jin Chung, Hae Yeon Kang, Seung Joo Kang, Min-Sun Kwak, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Eun Hyo Jin, Ji Min Choi, Yoo Min Han, Joo Sung Kim
Summary: Comprehensive optical diagnosis training with WASP classification significantly increased the overall SDR of expert endoscopists, while it did not have a significant impact on ADR.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Summary: The term sessile serrated lesion (SSL) was introduced in the 2019 WHO Classification of Tumours of the Digestive System as an early precursor lesion in the serrated neoplasia pathway. These lesions can quickly progress into dysplastic or invasive carcinomas with high lymphatic invasion potential.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Toshihiro Nishizawa, Shuntaro Yoshida, Akira Toyoshima, Tomoharu Yamada, Yoshiki Sakaguchi, Taiga Irako, Hirotoshi Ebinuma, Takanori Kanai, Kazuhiko Koike, Osamu Toyoshima
Summary: This study aimed to develop a diagnostic score system for sessile serrated lesions (SSLs). The research found that tumor size, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs, and serrated polyps with these features should be removed during colonoscopy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Daisuke Ohki, Nobutake Yamamichi, Yoshiki Sakaguchi, Yu Takahashi, Natsuko Kageyama-Yahara, Mitsue Yamamichi, Chihiro Takeuchi, Yosuke Tsuji, Yasuhiro Sakai, Kouhei Sakurai, Shuta Tomida, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: This study elucidates the gene expression characteristics of sessile serrated adenoma/polyp (SSA/P), showing a strong resemblance to microsatellite instability-high (MSI-H) colorectal cancer (CRC). The downregulation of CDX2 expression plays an essential molecular mechanism in the initial stage of SSA/P tumorigenesis.
Review
Cell Biology
Iris D. Nagtegaal, Dale C. Snover
Summary: The precursor lesion for around 30% of colon carcinomas, known as sessile serrated adenoma, remains controversial and has sparked debates over alternative names. Despite the term sessile serrated lesion being adopted by the World Health Organization in 2019, universal acceptance is still lacking.
Article
Oncology
Jung Ho Kim, Jeong Hoon Hong, Yoon-La Choi, Ji Ae Lee, Mi-kyoung Seo, Mi-Sook Lee, Sung Bin An, Min Jung Sung, Nam-Yun Cho, Sung-Su Kim, Young Kee Shin, Sangwoo Kim, Gyeong Hoon Kang
Summary: The study revealed that NTRK-rearranged colorectal tumors develop exclusively through the serrated neoplasia pathway and can be initiated from non-dysplastic SSLs without BRAF/KRAS mutations prior to full occurrence of MSI-high/CIMP-high.
JOURNAL OF PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jun Li, Kan Chen, Yunlei Wei, Di Zhang, Yuxin Wang, Xiaojia Hou, Ruijin Wu, Kangsheng Peng, Lei Li, Chao Huang, Yilong Wang, Linjuan Xun, Feng Liu
Summary: This study compared the effectiveness of LCI and NBI in detecting colorectal SSLs, and found no significant difference between the two methods. Both LCI and NBI were equally effective in detecting polyps and adenomas. Factors associated with SSL detection were bowel preparation score, withdrawal time, and operator experience.
Article
Gastroenterology & Hepatology
Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong-Soo Lee, Hye-Sook Chang, Hye Won Park, Gwang-Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jaewon Choe, Dong-Hoon Yang
Summary: This study found that individuals with synchronous SSL did not have a significantly increased risk of metachronous HRA/AA, but did have an increased risk of metachronous SSL compared to those without SSL.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Paul P. Shao, Changhan R. Shao, Tahmineh Romero, Felix W. Leung
Summary: This study found that water exchange significantly increases the detection rate of sessile serrated adenomas/polyps, and is superior to Endocuff and cap colonoscopy in detecting them.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Summary: This study found no significant difference in the risk of metachronous colorectal neoplasia between serrated polyps and conventional adenomas, supporting current surveillance guidelines. Patients with both serrated polyps and high-risk adenomas may have an increased risk, warranting further investigation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Shin Ju Oh, Jung-Wook Kim, Chi Hyuk Oh
Summary: We report a rare case of a large pedunculated polyp with typical histological features of SSLs in the rectum. Endoscopic mucosal resection using a detachable snare was performed on the tumor for definite diagnosis and treatment.
Article
Gastroenterology & Hepatology
Sergei Vosko, Neal Shahidi, Mayenaaz Sidhu, W. Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Karen Byth, Eric Y. T. Lee, Nicholas G. Burgess, Michael J. Bourke
Summary: This study found significant differences in optical evaluation performance between flat and nodular large nonpedunculated colorectal polyps. Flat lesions can be presumed benign and managed accordingly, while nodular lesions are more likely to be missed for submucosal invasive cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pathology
Phoenix D. Bell, Joseph C. Anderson, Amitabh Srivastava
Summary: The serrated pathway of carcinogenesis is still not fully understood, and limitations in endoscopic detection and pathologic interpretation of serrated polyps have implications on risk prediction and surveillance recommendations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sho Suzuki, Satimai Aniwan, Han-Mo Chiu, Kannikar Laohavichitra, Sakkarin Chirapongsathorn, Takeshi Yamamura, Chen-Ya Kuo, Naohisa Yoshida, Tiing Leong Ang, Takahito Takezawa, Rungsun Rerknimitr, Hideki Ishikawa, Takuji Gotoda
Summary: This study compared the effects of linked-color imaging (LCI) and white-light imaging (WLI) on colorectal lesion detection and colonoscopy quality. The results showed that LCI had higher detection rates for adenomas and polyps, as well as an altered recommended surveillance schedule compared to WLI.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medical Laboratory Technology
Heather Dawson, Richard Kirsch, David Messenger, David Driman
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2019)
Article
Pathology
Matthew J. Cecchini, Joanna C. Walsh, Jeremy Parfitt, Subrata Chakrabarti, Rohann J. Correa, Mary J. MacKenzie, David K. Driman
Article
Education, Scientific Disciplines
Emily A. Goebel, Sayra M. Cristancho, David K. Driman
TEACHING AND LEARNING IN MEDICINE
(2019)
Article
Pathology
Dipti M. Karamchandani, Runjan Chetty, Tonya S. King, Xiuli Liu, Maria Westerhoff, Zhaohai Yang, Rhonda K. Yantiss, David K. Driman
Article
Gastroenterology & Hepatology
Boris Virine, Nilesh Chande, David K. Driman
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Medicine, General & Internal
Marc L. Chretien, David G. Bailey, Linda Asher, Jeremy Parfitt, David Driman, Jamie Gregor, George K. Dresser
Article
Cell Biology
Christopher Tran, Christopher Howlett, David K. Driman
Letter
Medicine, General & Internal
Christopher Tran, Mike Kadour, Matthew J. Cecchini, Ken A. Leslie, David K. Driman
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2021)
Editorial Material
Gastroenterology & Hepatology
Christophe Rosty, Fleur Webster, Iris D. Nagtegaal
Article
Pathology
Marcio M. Gomes, David Driman, Yoon Soo Park, Timothy Wood, Rachel Yudkowsky, Nancy Dudek
Summary: CBME is a global trend in medical education, and the study developed a WBA tool to assess residents' performance in intra-operative pathology consultations and conducted a validity investigation. The assessment was considered appropriate and feasible, with positive educational impact, but had low reliability due to assessment biases and cultural issues with entrustment.
Article
Pathology
Aysegul Sari, David P. Cyr, Amanpreet Brar, David E. Messenger, David K. Driman, Sameer Shivji, Naziheh Assarzadegan, Ari Juda, Carol J. Swallow, Erin D. Kennedy, Mantaj S. Brar, James Conner, Richard Kirsch
Summary: Routine elastin staining enhances the detection of venous invasion in colorectal cancer and improves its ability to predict prognosis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Anas Hussameddin, Rocio Sedano, Darryl Ramsewak, David Driman, Vipul Jairath
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Immunology
Salman Aziz, Michael Sey, Paul Marotta, David Driman, Jeremy Parfitt, Anouar Teriaky, Mayur Brahmania, Anton Skaro, Karim Qumosani
Summary: The study validated a risk assessment tool based on pathologic scoring, which can effectively predict hepatocellular carcinoma recurrence after liver transplantation. Patients were stratified into different risk groups based on the risk score, with lower risk score associated with higher recurrence-free survival.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Surgery
[Anonymous]
CANADIAN JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Marc L. Chretien, David G. Bailey, Linda Asher, Jeremy Parfitt, David Driman, Jamie Gregor, George K. Dresser
Summary: This study investigates the relationship between celiac disease and the absorption of non-metabolized antihistamines. The severity of the disease does not affect the bioavailability of the drug. The prolonged absorption time in the distal small intestine may be the key determinant. Patients with celiac disease may require alternative drug management when using grapefruit juice.