Article
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang Ho Ryan Choi, Juanda L. Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Janindra Warusavitarne, Ana Wilson, Trevor A. Graham, Ailsa Hart
Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.
Article
Gastroenterology & Hepatology
Aonghus Lavelle, Stephane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamaziere, Emilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol
Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.
Article
Surgery
Ryuichi Kuwahara, Hiroki Ikeuchi, Kurando Kusunoki, Tomohiro Minagawa, Yuki Horio, Kei Kimura, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Motoi Uchino
Summary: This study compared the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease. The study found that patients with cancer/dysplasia had a longer duration of disease, better nutritional status, and milder inflammation compared to refractory patients.
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Adam Faye, James C. Slaughter, Noam Harpaz, Steven H. Itzkowitz, Shailja C. Shah
Summary: Colorectal strictures in patients with inflammatory bowel disease (IBD) are not independently associated with the risk of advanced colorectal neoplasia (ACRN) or colectomy, according to a retrospective cohort analysis. Further multicenter, prospective studies are needed to confirm these findings.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Olivia Yvellez, Victoria Rai, Philip H. Sossenheimer, John Hart, Jerrold R. Turner, Christopher Weber, Katia El Jurdi, David T. Rubin
Summary: Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A novel cumulative inflammatory index was found to predict CRN development in UC patients. Overall, cumulative histologic inflammation was significantly associated with the development of CRN in UC patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Multidisciplinary Sciences
Hongqiang Du, Huawei Xia, Tongtong Liu, Yingjie Li, Jilong Liu, Bingteng Xie, Jingxuan Chen, Tong Liu, Lili Cao, Shengde Liu, Siji Li, Peiyan Wang, Dandan Wang, Zeming Zhang, Yunfei Li, Xiaohuan Guo, Aiwen Wu, Mo Li, Fuping You
Summary: The study revealed that Elf4(-/-) mice developed colon tumors after undergoing 3 cycles of DSS treatment, indicating prevalent ELF4 suppression in both UC patients and mouse models. Oral administration of montmorillonite powder can prevent ELF4 reduction and reduce the risk of colon tumor development.
Review
Oncology
Guillaume Le Cosquer, Etienne Buscail, Cyrielle Gilletta, Celine Deraison, Jean-Pierre Duffas, Barbara Bournet, Geraud Tuyeras, Nathalie Vergnolle, Louis Buscail
Summary: Proctocolectomy with ileal pouch-anal anastomosis is the recommended surgical intervention for ulcerative colitis and familial adenomatous polyposis. However, there is a risk of high-grade dysplasia and cancer in the anal transitional zone and ileal pouch after 20 years, with estimated rates of 2% to 4.5% and 3% to 10% in ulcerative colitis and familial polyposis, respectively. Risk factors for ulcerative colitis include pre-operative dysplasia or cancer, disease duration > 10 years, and severe villous atrophy. For familial polyposis, risk factors include > 1000 pre-operative polyps, stapled anastomosis, and duration of follow-up. While anal transitional zone and ileal pouch cancers rarely occur after proctectomy, the high mortality rate associated with this complication necessitates close endoscopic monitoring.
Review
Immunology
Maorun Zhang, Xiaoping Li, Qi Zhang, Jiahua Yang, Gang Liu
Summary: Colitis-associated colorectal cancer (CAC) is a severe complication of ulcerative colitis (UC), characterized by multiple lesions, worse pathological type, and poor prognosis. Macrophages, as innate immune cells, play a crucial role in both inflammatory response and tumor immunity. Enhanced macrophage infiltration in UC leads to the production of inflammatory cytokines, promoting UC tumorigenesis. Macrophage polarization into M1 has an anti-tumor effect, while M2 polarization promotes tumor growth. Targeting macrophages has shown effectiveness in preventing and treating CAC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tawnya M. Hansen, Zoann Nugent, Charles N. Bernstein, N. Jewel Samadder, Sanjay K. Murthy, Harminder Singh
Summary: The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years. There is a high proportion of post colonoscopy CRC among IBD-CRC patients, which has remained unchanged over the years and requires detailed root-cause analysis and interventions.
Article
Medicine, General & Internal
Kei Nakazawa, Sadaharu Nouda, Kazuki Kakimoto, Naohiko Kinoshita, Yasuyoshi Tanaka, Hideki Tawa, Ryoji Koshiba, Yutaka Naka, Yuki Hirata, Kazuhiro Ota, Ken Kawakami, Toshihisa Takeuchi, Takuya Inoue, Takako Miyazaki, Makoto Sanomura, Shiro Nakamura, Yutaka Saito, Kazuhide Higuchi
Summary: In this study, we aimed to differentiate between adenomatous polyps (APs) and hyperplastic polyps (HPs) using colon capsule endoscopy (CCE) with the CIELAB color space method. The results showed that the FICE Delta E' was significantly higher for APs compared to HPs, indicating the potential of this method to reduce unnecessary colonoscopy procedures.
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Immunology
Chen Zhang, Jiantao Zhang, Yanli Zhang, Zian Song, Jing Bian, Huanfa Yi, Zhanchuan Ma
Summary: This study investigated the pathogenesis of ulcerative colitis (UC) and found that neutrophils may promote the conversion of UC into colitis-associated colorectal cancer (CAC). By analyzing transcriptome data, 65 differentially expressed genes related to UC were identified, as well as immune-related biological pathways. The association between neutrophils and UC was confirmed using CIBERSORT and WGCNA analysis. These findings were validated in a mouse model, and 5 genes were identified as potential biomarkers. The results contribute to a better understanding of the pathogenesis of CAC and provide new insights for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kevin Baker, Charlotte O'Donnell, Maura Bendix, Samuel Keogh, James Byrne, Michael O'Riordain, Peter Neary, Aileen Houston, Elizabeth Brint
Summary: IL-36 cytokines play a significant role in the pathogenesis of colon cancer by activating pro-tumorigenic phenotypes and inducing pro-inflammatory response. Targeting IL-36R signaling may be a useful therapy for colorectal cancer patients with IL-36R(+) tumor cells.
Review
Gastroenterology & Hepatology
Jordan E. Axelrad, Raymond K. Cross
Summary: Patients with chronic ulcerative and Crohn's colitis have a higher risk of developing colorectal neoplasia (CRN [dysplasia and cancer]) compared to the general population. Risk factors for CRN include the extent of colitis, cumulative inflammatory burden, family history of colorectal cancer, and primary sclerosing cholangitis. Best practices for preventing CRN involve controlling colonic inflammation, conducting high quality surveillance colonoscopy with or without enhanced imaging techniques, removing visible dysplasia if possible, and considering colectomy for patients with unresectable dysplasia, invisible multifocal low-grade dysplasia, or invisible high-grade dysplasia. The decision to stop dysplasia surveillance should be individualized and based on factors such as age, frailty, comorbid conditions, life expectancy, previous surveillance exam results, and risk factors for CRN.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Jose Maria Huguet, Luis Ferrer-Barcelo, Patricia Suarez, Eva Sanchez, Jose David Prieto, Victor Garcia, Javier Sempere
Summary: The detection of dysplasia in IBD patients is important and chromoendoscopy with targeted biopsy remains the preferred technique. However, other techniques such as virtual chromoendoscopy are being compared due to their similar results and fewer technical difficulties. New endoscopy techniques and improved devices have the potential to revolutionize the screening and follow-up of dysplasia in IBD patients. Further research is needed to define the optimal follow-up strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Guray Can, Emrah Posul, Bulent Yilmaz, Hatice Can, Ugur Korkmaz, Fatih Ermis, Mevlut Kurt, Ulku Dagli
KOREAN JOURNAL OF INTERNAL MEDICINE
(2019)
Meeting Abstract
Immunology
Nuretdin Suna, Digdem Ozer Etik, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Fatih Hilmioglu, Sedat Boyacioglu, Mehmet Haberal
Meeting Abstract
Immunology
Digdem Ozer Etik, Nuretdin Suna, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Turan Colak, Fatih Hilmioglu, Sedat Boyacioglu, Mehmet Haberal
Meeting Abstract
Immunology
Ulku Dagli, Digdem Ozer Etik, Aydincan Akdur, Haldun Selcuk, Fatih Hilmioglu, Sedat Boyacioglu, Gokhan Moray, Mehmet Haberal
Article
Gastroenterology & Hepatology
Tan Attila, Erkan Parlak, Emrah Alper, Selcuk Disibeyaz, Bahattin Cicek, Bulent Odemis
TURKISH JOURNAL OF GASTROENTEROLOGY
(2018)
Letter
Gastroenterology & Hepatology
Selcuk Disibeyaz, Erkin Oztas, Tuncer Temel, Nilgun Isiksalan Ozbulbul
TURKISH JOURNAL OF GASTROENTEROLOGY
(2019)
Letter
Gastroenterology & Hepatology
Erkin Oztas, Muhammet Yener Akpinar, Yasemin Ozderin Ozin, Selcuk Disibeyaz
TURKISH JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Transplantation
Digdem Ozer Etik, Nuretdin Suna, Serkan Ocal, Haldun Selcuk, Ulku Dagli, Turan Colak, Fatih Hilmioglu, Ahmet Sedat Boyacioglu, Mehmet Haberal
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2019)
Article
Gastroenterology & Hepatology
Fatih Karaahmet, Murat Kekilli
Summary: Mirizzi syndrome is a gallstone disease characterized by compression of extrahepatic biliary duct with an impacted stone. This study aimed to analyze the incidence, clinical presentation, operative details and postoperative complications of Mirizzi syndrome in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Among the 1018 consecutive patients who underwent ERCP, 12 had Mirizzi syndrome and 503 had cholelithiasis and CBD stones. The ERCP-related complication rates were the same in both groups, and surgery was the definitive treatment for Mirizzi syndrome.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Ece Unal Cetin, Fatih Kamis, Adil Ugur Cetin, Yavuz Beyazit, Murat Kekilli
Summary: Elevated levels of YKL-40 and chitotriosidase in acute pancreatitis patients indicate the potential involvement of macrophages in the pancreatic microenvironment during the progression of acute pancreatitis. The study found a significant correlation between YKL-40 and chitotriosidase. The cut-off points for YKL-40 and chitotriosidase in detecting acute pancreatitis were determined with high sensitivity and specificity.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Omer Kutlu, Zeynal Dogan, Hatice Meral Eksioglu, Murat Kekilli
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Gastroenterology & Hepatology
Murat Toruner, Hale Akpinar, Filiz Akyuz, Ulku Dagli, Hulya Over Hamzaoglu, Ahmet Tezel, Belkis Unsal, Suleyman Yildirim, Aykut Ferhat Celik
TURKISH JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Microbiology
Guven Guney, Yilmaz Bas, Murat Kekilli, Emre Demir
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2019)
Meeting Abstract
Gastroenterology & Hepatology
U. Dagli, D. Ozer Etik, N. Demir, S. Ocal, H. Selcuk, F. Hilmioglu, S. Boyacioglu
JOURNAL OF CROHNS & COLITIS
(2018)
Article
Medicine, General & Internal
Ali Demir, Ibrahim Erayman, Oguz Dogan, Murat Kekilli
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)