Article
Gastroenterology & Hepatology
Vikram Rangan, Judy Nee, Brian Li, Anthony J. Lembo, David A. Leiman
Summary: This study aimed to identify specific HRM findings predictive of symptoms in patients with ineffective esophageal motility (IEM). The results showed that the percentage of ineffective swallows in IEM patients independently predicted the severity of dysphagia.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Otorhinolaryngology
Simone Miller, Martin Ptok, Michael Jungheim
Summary: This study investigated the UES reaction to different levels of acidity during swallowing, finding prolonged Restitution Times with stronger acid boluses. Significant differences were found towards neutral and less acidic boluses. Post-Swallow Maximum and Period of Sphincter Activity varied significantly, with higher values for the strongest acid bolus. Relaxation Times showed a slight trend of prolongation with higher bolus acidity, suggesting reflexive protective mechanisms triggered by receptors in the pharyngeal mucosa or UES.
Article
Gastroenterology & Hepatology
Isis K. Araujo, Sabine Roman, Marie Napoleon, Francois Mion
Summary: The study found that using solid food swallows (SFS) during esophageal motility assessment can improve diagnostic accuracy and is important for diagnosing clinically relevant disorders. The application of solid food swallows in HRM has a significant impact on changing diagnoses and can be widely used in daily clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Virali Shah, Alexandra Mignucci, Alla Turshudzhyan, Michael Yodice, Micheal Tadros
Summary: This study assessed the benefits and limitations of Apple Viscous Swallows (AVS) and Multiple Rapid Swallows (MRS) in diagnosing esophageal disorders. The results showed that MRS could more accurately detect abnormal motility/pressurization patterns, while AVS had a higher test completion rate and better detection of severe hypokinetic disorders.
Article
Gastroenterology & Hepatology
Samuel Tanner, Herit Vachhani, Martha Harrison, Zubair Malik, Ron Schey, Henry P. Parkman
Summary: This study compared the high-resolution esophageal manometry metrics in supine versus upright position and found that upright positioning can alter esophageal motility patterns, especially affecting patients' bolus clearance rate.
Article
Surgery
Federica Riccio, Mario Costantini, Renato Salvador
Summary: Accurate diagnosis is crucial for successful treatment of achalasia, with barium swallow, upper endoscopy, and high-resolution manometry providing essential information about anatomy, absence of other diseases, and type of achalasia. Prognostic value is also found in high-resolution manometry, with best treatment results obtained in type II achalasia according to the Chicago classification. Additional imaging tests such as abdominal CT scanning and endoscopic ultrasound may be necessary if malignancy is suspected.
WORLD JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Serkan Bilgin, Ahmet Kayali, Adnan Yamanoglu, Huseyin Acar, Zeynep Karakaya, Firdevs Topal, Elif Saritas Yuksel, Fatih Esad Topal
Summary: In patients with dysphagia and normal CM, over 40% were completely asymptomatic at follow-up, while less than half reported significant symptoms, with the remaining responders admitting to moderate to mild symptoms.
Article
Gastroenterology & Hepatology
Garrett Greenan, Benjamin D. Rogers, Daniel Sifrim, C. Prakash Gyawali
Summary: Multiple rapid swallows (MRS) and solid bolus swallows (SBS) are complementary in predicting post-anti-reflux surgery (ARS) symptom burden.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Santosh Sanagapalli, Joshua McGuire, Rupert W. Leong, Kalp Patel, Amanda Raeburn, Humayra Abdul-Razakq, Andrew Plumb, Matthew Banks, Rehan Haidry, Laurence Lovat, Vinay Sehgal, David Graham, Sarmed S. Sami, Rami Sweis
Summary: Provocative testing during high-resolution esophageal manometry is highly accurate in identifying clinically relevant esophagogastric junction outflow obstruction (EGJOO) that benefits from therapy. It should be routinely performed as part of the manometric protocol to differentiate cases requiring treatment and guide management decisions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Wenjun Kou, Dustin A. Carlson, Alexandra J. Baumann, Erica N. Donnan, Jacob M. Schauer, Mozziyar Etemadi, John E. Pandolfino
Summary: This study developed an automatic diagnosis platform using machine learning and artificial intelligence to accurately identify esophageal motility disorders. The platform achieved high accuracy in diagnosing these disorders by utilizing a combination of deep-learning models and feature-based models, along with a model selection and balancing strategy.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Mentore Ribolsi, Matteo Ghisa, Edoardo Savarino
Summary: The article discusses investigations conducted using conventional manometry and high-resolution manometry (HRM) to explore the field of esophageal motility and understand the potential link between motor features and gastroesophageal reflux disease (GERD) pathogenesis. HRM studies have provided insights into the esophageal motor function in patients with various esophageal disorders, as well as the correlation between reduced esophageal motility, disruption of the esophagogastric junction, and gastroesophageal reflux burden.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)