Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Poonam Sagar, Stanzin Angmo, Rajat Sandhir, Vikas Rishi, Hariom Yadav, Nitin Kumar Singhal
Summary: Iron is essential for mammals but its homeostasis must be accurately regulated for proper physiological functioning. Hepcidin plays a crucial role in maintaining iron balance in the body, while inflammatory disorders can disrupt this balance. Therapeutic approaches targeting the hepcidin-FPN axis have been developed to address iron-related disorders.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Food Science & Technology
Mauricio Restrepo-Gallego, Luis E. Diaz, Patricia H. C. Rondo
Summary: Iron deficiency is the leading cause of anemia, and assessing iron nutritional status requires consideration of various laboratory tests and indicators. Using multiple indicators in combination may be the best practice due to the influence of different factors on these indicators. Constant validation, improvement of assessment methods, and identification of new indicators are key to refining the assessment of iron nutritional status and selecting appropriate treatment for improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Naseem Mohammad Alshwaiyat, Aryati Ahmad, Hamid Ali Nagi Al-Jamal
Summary: This study aimed to evaluate the effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia. The results showed that weight loss intervention led to significant improvements in iron status and its markers. These findings suggest that diet-induced weight loss can improve iron status and related clinical markers in this population.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Hanna K. von Siebenthal, Valeria Galetti, Michael B. Zimmermann, Nicole U. Stoffel
Summary: This study found that the regulatory pathways of iron absorption are intact in infancy, and iron absorption in infants begins to increase at threshold ferritin and hepcidin values similar to adult values. These findings are important for the management of iron nutrition in infants and young children.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Peng Sun, Yueqin Zhou, Suhua Xu, Xiaotong Wang, Xiuxiu Li, Hailin Li, Zongyu Lin, Fenglian Huang, Lewei Zhu, Yanna Zhu
Summary: This study aimed to investigate the association between first-trimester maternal serum hepcidin and third-trimester iron deficiency anemia (IDA). The study found that higher levels of first-trimester hepcidin were negatively associated with the risk of third-trimester IDA, suggesting that elevated hepcidin may predict a reduced risk for developing IDA.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Summary: In this study, the TSAT/hepcidin ratio was found to be a useful tool for distinguishing IRIDA from IDA, with excellent performance in early diagnosis. This method helps identify IRIDA related to gene mutations, while recent iron therapy and moderate-to-severe inflammation should be excluded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Naseem Mohammad Alshwaiyat, Aryati Ahmad, Wan Mohd Razin Wan Hassan, Hamid Ali Nagi Al-Jamal
Summary: Obesity is associated with iron deficiency anemia, possibly due to disruptions in iron homeostasis and increased hepcidin levels mediated by chronic inflammation. Significant weight loss in overweight and obese individuals may improve iron status by reducing inflammation and increasing iron absorption, but additional randomized controlled trials are needed to confirm this effect.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Xiaoyang Liu, Xuening Yu, Shijie Dou, Fawen Yin, Deyang Li, Dayong Zhou
Summary: This study successfully formed a complex of oyster-protein hydrolysates and ferrous chloride, which showed better iron absorption than ferrous sulfate and had better protective effects against iron-deficiency anemia. Three representative peptides that were absorbed intact were identified.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Valentina Talarico, Laura Giancotti, Giuseppe Antonio Mazza, Roberto Miniero, Marco Bertini
Summary: Iron absorption primarily takes place in the proximal duodenum, which is typically damaged in CD, leading to decreased iron absorption and IDA. The most common extra-intestinal manifestation of CD is IDA, which can be managed effectively with GFD.
Article
Nutrition & Dietetics
Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farese, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, Andre Bado, Herve Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim
Summary: After sleeve gastrectomy, levels of iron-related markers such as sTfR and PPIX decreased while serum hepcidin levels increased. DMT1 abundance was negatively correlated with serum hepcidin levels, and ferroportin abundance remained unchanged. These results suggest effective iron recovery pathways post-operatively involving suppression of inflammation and improvement in iron absorption and erythropoiesis.
Article
Nutrition & Dietetics
Andrew D. Jones, Zhen Shi, Nathalie J. Lambrecht, Yaping Jiang, Jingmin Wang, Margit Burmeister, Ming Li, Betsy Lozoff
Summary: This study found that both pregnant women and neonates' hepcidin levels were responsive to iron status. Maternal prepregnancy overweight status was associated with lower cord blood hepcidin concentrations, likely due to lower iron status among the infants born to these mothers.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Article
Gastroenterology & Hepatology
Roberta Loveikyte, Arno R. Bourgonje, Johannes J. van der Reijden, Marian L. C. Bulthuis, Lukas J. A. C. Hawinkels, Marijn C. Visschedijk, Eleonora A. M. Festen, Hendrik M. van Dullemen, Rinse K. Weersma, Harry van Goor, Andrea E. van der Meulen-de Jong, Gerard Dijkstra
Summary: Absolute iron deficiency is the main factor determining hepcidin levels, even in an inflammatory state. Induction therapy can decrease hepcidin levels, which may improve the availability of iron. Therefore, hepcidin is a potential diagnostic biomarker for iron deficiency and can assist in therapeutic decision making.
INFLAMMATORY BOWEL DISEASES
(2023)