Article
Microbiology
Igor A. A. Kryvoruchko, Valeriy V. V. Boyko, Massimo Sartelli, Yulia V. V. Ivanova, Denys O. O. Yevtushenko, Andrij S. S. Honcharov
Summary: A study on the treatment of acute necrotizing pancreatitis (ANP) found that using the step-up approach and Enhanced Recovery After Surgery (ERAS) principles can effectively reduce complications and 30-day mortality.
Article
Geriatrics & Gerontology
Fang He, Hong-ming Zhu, Bang-yi Li, Xiao-cui Li, Shuang Yang, Zhe Wang, Mei Zhang
Summary: This study identified factors such as idiopathic etiology, pre-existing pulmonary diseases, increased hematocrit level or pleural effusion, higher serum glucose, and lower serum calcium or PaO2 at admission that independently predicted more severe acute pancreatitis in elderly patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Peter J. Lee, Ali Lahooti, Stacey Culp, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Ila Lahooti, Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin Traian Babu, Haq Nawaz, Silvia Cristina Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Luis Lara, Samuel Han, Georgios I. Papachristou
Summary: This study aimed to determine the adjusted effects of body mass index (BMI) and alcoholic etiology on the risk of multisystem organ failure (MSOF) in patients with acute pancreatitis (AP). The results showed that alcoholic etiology was independently associated with increased risk of MSOF compared to non-alcohol etiologies, and obese men (but not women) were more susceptible to MSOF.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Infectious Diseases
Caihong Ning, Shuai Zhu, Shuyi Zhou, Chiayen Lin, Jiarong Li, Xintong Cao, Abdul Aziz F. K. Bonsu, Dingcheng Shen, Zhiyong Liu, Gengwen Huang
Summary: Significant conflicts exist regarding prophylactic antifungal treatment in acute pancreatitis, with SAP patients at higher risk for AFI than MSAP and mild AP patients. MOF may be the indication for prophylactic antifungal therapy in AP patients.
Article
Multidisciplinary Sciences
Dong Kee Jang, Dong-Won Ahn, Kook Lae Lee, Byeong Gwan Kim, Ji Won Kim, Su Hwan Kim, Hyoun Woo Kang, Dong Seok Lee, Soon Ho Yoon, Sang Joon Park, Ji Bong Jeong
Summary: The study suggests that liver cirrhosis significantly affects the severity of AAP, while MMA and abdominal muscle mass may serve as promising predictors.
Article
Surgery
Fons F. van den Berg, Yama Issa, Jeroen P. Vreijling, Markus M. Lerch, Frank Ulrich Weiss, Marc G. Besselink, Frank Baas, Marja A. Boermeester, Hjalmar C. van Santvoort
Summary: Genomic sequencing revealed that ZNF106 and SLC52A1 may be associated with the development of early multiple organ failure in acute pancreatitis.
Article
Gastroenterology & Hepatology
Anupam K. Singh, Jayanta Samanta, Jayendra Shukla, Chhagan Lal Birda, Jahnvi Dhar, Pankaj Gupta, Praveen Kumar-M, Vikas Gupta, Thakur Deen Yadav, Saroj K. Sinha, Rakesh Kochhar
Summary: In patients with necrotizing acute pancreatitis, the duration of organ failure is associated with increased mortality, and sequential multiple organ failure has a worse prognosis compared to single organ failure and simultaneous multiple organ failure.
Article
Gastroenterology & Hepatology
Henrik Leonard Husu, Miia Maaria Valkonen, Ari Kalevi Leppaniemi, Panu Juhani Mentula
Summary: IPN in patients with necrotizing SAP is associated with worse outcomes. Risk factors for IPN include extensive anatomical spread of necrotic collections, postinterventional pancreatitis, preceding bacteremia, and preceding open abdomen treatment. Patients with IPN have longer ICU and hospital stays, higher risk for necrosectomy, and higher readmission rate to ICU.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Medicine, General & Internal
E. De-Madaria, J. L. Buxbaum, P. Maisonneuve, A. Garcia Garcia de Paredes, P. Zapater, L. Guilabert, A. Vaillo-Rocamora, M. A. Rodriguez-Gandia, J. Donate-Ortega, E. E. Lozada-Hernandez, A. J. R. Collazo Moreno, A. Lira-Aguilar, L. P. Llovet, R. Mehta, R. Tandel, P. Navarro, A. M. Sanchez-Pardo, C. Sanchez-Marin, M. Cobreros, I Fernandez-Cabrera, F. Casals-Seoane, D. Casas Deza, E. Lauret-Brana, E. Marti-Marques, L. M. Camacho-Montano, V Ubieto, M. Ganuza, F. Bolado
Summary: In this study, early aggressive fluid resuscitation in patients with acute pancreatitis resulted in a higher incidence of fluid overload without improvement in clinical outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Longxiang Cao, Yingjie Chen, Siyao Liu, Wei Huang, Dong Wu, Donghuang Hong, Zuozheng Wang, Yi Sun, Kaixiu Qin, Feng Guo, Cuizhu Luo, Qinghai Jiao, Xiang Luo, Jing Zhou, Gang Li, Bo Ye, Tao Chen, Man Liu, Wenjian Mao, Lanting Wang, Shuai Li, John A. Windsor, Yuxiu Liu, Lu Ke, Zhihui Tong, Weiqin Li
Summary: This study evaluated the association between plasmapheresis and the incidence and duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP). The results showed that although plasmapheresis can lower plasma triglyceride levels, it was not associated with the incidence and duration of organ failure after adjusting for confounders, but was associated with increased ICU requirements.
Article
Gastroenterology & Hepatology
Piero Alberti, Elizabeth Pando, Rodrigo Mata, Laura Vidal, Nuria Roson, Richard Mast, David Armario, Xavier Merino, Cristina Dopazo, Laia Blanco, Mireia Caralt, Concepcion Gomez, Joaquim Balsells, Ramon Charco
Summary: In this study, we compared the predictive value of the modified CT severity index, CT severity index, and APACHE-II score in assessing severity and local complications of acute pancreatitis. The CT indexes outperformed APACHE-II in predicting severity parameters, with CTSI showing a slight advantage over MCTSI. CTSI accurately predicted complications such as pancreatic infections and the need for intervention.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Endocrinology & Metabolism
Chengcheng Sheng, Zongxu Xu, Jun Wang
Summary: This study aimed to establish a nomogram model for early prediction of persistent organ failure (POF) in acute pancreatitis in pregnancy (APIP) patients. The study found that hypertriglyceridemia was the leading cause of organ failure-related APIP. Lactate dehydrogenase, triglycerides, serum creatinine, and procalcitonin were identified as independent risk factors for POF in APIP patients. The nomogram model showed effective prediction of POF using these four indicators in APIP patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
He Zhang, Lin Gao, Wen-Jian Mao, Jie Yang, Jing Zhou, Zhi-Hui Tong, Lu Ke, Wei-Qin Li
Summary: Early intervention within 4 weeks does not worsen the clinical outcomes in NAP patients complicated by POF.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Jan Csomor, Petr Hribek, Tomas Kupsa, Ondrej Bradac, Petr Urbanek
Summary: This study establishes a simple scoring system to predict the severity of acute pancreatitis at the time of hospital admission. The scoring system consists of five parameters that are significantly associated with the severity of the disease.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2023)
Article
Gastroenterology & Hepatology
Jie Wang, Qing-xie Liu, Dong-ling Teng, Yan-bing Ding, Guo-tao Lu, Wei-juan Gong, Qing-tian Zhu, Fei Han, Wei-ming Xiao
Summary: This study found that elevated serum ferritin levels are associated with the severity of acute pancreatitis. Quantitative assessment of serum ferritin can predict the severity of the disease and organ failure in patients with acute pancreatitis.
BMC GASTROENTEROLOGY
(2022)
Article
Surgery
N. A. Henriksen, L. N. Jorgensen, H. Friis-Andersen, F. Helgstrand
Summary: The study found that the recurrence rates were comparable between open and laparoscopic repair of umbilical and epigastric hernias. Open repair was associated with a significantly higher rate of readmission and reoperation, particularly due to surgical site infection, while the rate of reoperation for severe complications was higher after laparoscopic repair.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Meeting Abstract
Anesthesiology
C. Haahr-Raunkjaer, J. Molgaard, S. M. Rasmussen, M. Elvekjaer, M. P. Achiam, L. N. Jorgensen, M. I. Sogaard, K. K. Gronbaek, A. -B. Oxboll, H. B. D. Sorensen, C. S. Meyhoff, E. K. Aasvang
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Correction
Surgery
Kristian K. Jensen, Regnar B. Arnesen, Jan K. Christensen, Thue Bisgaard, Lars N. Jorgensen
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jeppe Thorlacius-Ussing, Christina Jensen, Emilie A. Madsen, Neel Nissen, Tina Manon-Jensen, Inna M. Chen, Julia S. Johansen, Hadi M. H. Diab, Lars N. Jorgensen, Morten A. Karsdal, Nicholas Willumsen
Summary: In the tumor microenvironment, the extracellular matrix (ECM) plays an important role in cancer development. A study found that type XX collagen (PRO-C20) is significantly elevated in various types of cancer, making it a potential biomarker for cancer and a prognostic marker for pancreatic ductal adenocarcinoma (PDAC).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
E. Oma, J. K. Christensen, J. Daes, L. N. Jorgensen
Summary: This study compared the changes in abdominal wall musculature following endoscopic anterior component separation (EACS) and open transverse abdominis release (TAR). The results showed that EACS led to greater lateral displacement and significant decrease in the thickness of the lateral abdominal wall muscles, while TAR showed less noticeable displacement and thickness reduction. Overall, neither technique seemed to compromise the integrity of the lateral abdominal wall.
Article
Oncology
Sofie Phillipsen, Louise Kongsmark Weltz, Jannie Dressler, Marie Konge Nielsen, Morten Rasmussen, Lars Nannestad Jorgensen, Anna Thit Johnsen
Summary: This study examined why some people do not participate in the Danish National Screening Program for Colorectal Cancer. The analysis revealed that barriers to screening include personal accountability for health, attitudes towards the healthcare system, and knowledge about the disease and screening.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Review
Microbiology
Jacob Antonsen, Matilde Winther-Jensen, Lasse T. Krogsboll, Tine Jess, Lars N. Jorgensen, Kristine H. Allin
Summary: This review found that the appendiceal microbiota has lower alpha-diversity compared to the fecal microbiota and an increased presence of bacteria commonly found in the oral cavity. Additionally, acute appendicitis is characterized by an altered microbiota with an increased abundance of oral-associated bacteria. However, no bacterial profile unique to either complicated or uncomplicated appendicitis was found.
FUTURE MICROBIOLOGY
(2023)
Article
Surgery
Henrik Buhl, Astrid Norgaard, Astrid Otkjaer, Lars Nannestad Jorgensen, Henrik Lovendahl Jorgensen
Summary: Preoperative anemia is strongly associated with mortality in elderly patients undergoing major abdominal surgery, and allogeneic red cell blood transfusion is found to increase mortality, except in patients with very low hemoglobin levels.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Meeting Abstract
Oncology
Emilie Albrecht Madsen, Jeppe Thorlacius-Ussing, Christina Jensen, Neel I. Nissen, Astrid Z. Johansen, Inna M. Chen, Julia S. Johansen, Tina Manon-Jensen, Hadi M. Diab, Lars N. Jorgensen, Morten Karsdal, Nicholas Willumsen
Meeting Abstract
Surgery
M. Vandenheede, M. Miserez, L. N. Jorgensen, F. Berrevoet
BRITISH JOURNAL OF SURGERY
(2022)
Article
Anesthesiology
Camilla Haahr-Raunkjaer, Jesper Molgaard, Mikkel Elvekjaer, Soren M. Rasmussen, Michael P. Achiam, Lars N. Jorgensen, Mette I. Sogaard, Katja K. Gronbaek, Anne-Britt Oxboll, Helge B. D. Sorensen, Christian S. Meyhoff, Eske K. Aasvang
Summary: This study aimed to assess the association between abnormal vital signs and subsequent serious adverse events (SAEs) in postoperative patients. The results showed that the overall duration of abnormal vital signs was not significantly associated with subsequent SAEs. However, patients with tachycardia and hypotension were more likely to experience serious adverse events.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)