Asymmetric hydrogenation of (E)-dimethyl-2-acetamido-2-phenylvinylphosphonate in supercritical carbon dioxide in the presence of metal complex catalysts with phosphite-type ligands

Asymmetric hydrogenation of (E)-dimethyl-2-acetamido-2-phenylvinylphosphonate was performed in CH2Cl2 and supercritical carbon dioxide with the participation of Rh and Ir complexes with chiral phosphite-type ligands. Iridium catalysts dissolved in supercritical CO2 allow high enantioselectivity (up to 98.5% ee) and conversion to be obtained. Rhodium catalysts yield exclusively racemic reaction products.