Article
Biochemical Research Methods
Alex Gonzalez-Vergara, Benjamin Benavides, Marcela Julio-Pieper
Summary: Neuropeptides are diverse signaling molecules found in the central and peripheral nervous systems, including the enteric nervous system. Studying their role in diseases and therapeutic potential requires addressing analytical challenges, particularly in the low abundance of neuropeptides in the ENS tissue. This review discusses these challenges and opportunities for technical development.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Neurosciences
Jean-Baptiste Cavin, Preedajit Wongkrasant, Joel B. Glover, Onesmo B. Balemba, Wallace K. MacNaughton, Keith A. Sharkey
Summary: The enteric nervous system regulates the functions of the gastrointestinal tract, and its response to changes in the gut lumen is not well understood. This study used live-cell confocal recordings to investigate neuronal response to luminal mechanical and chemical stimuli. The results show that intestinal distension regulates the excitability of enteric neural circuits via mechanosensitive channels, and the content of the intestinal lumen dynamically regulates the excitability of enteric neural circuits.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Physiology
Keith A. Sharkey, Gary M. Mawe
Summary: The gastrointestinal tract is the most complex organ system in the body, controlling digestion and defense functions through the enteric nervous system. This system interacts with the immune system, gut microbiota, and epithelium to maintain mucosal defense and barrier function. Recent developments have improved our understanding of the molecular architecture, function, and regulation of the enteric nervous system, highlighting its importance in maintaining intestinal homeostasis.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Veterinary Sciences
Roberto Chiocchetti, Giorgia Galiazzo, Fiorella Giancola, Claudio Tagliavia, Chiara Bernardini, Monica Forni, Marco Pietra
Summary: The distribution of serotonin transporter immunoreactivity in the dog intestine is similar to that in rats and humans, suggesting a conserved role in serotonin reuptake mechanism.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Anatomy & Morphology
Doriane Hazart, Brigitte Delhomme, Martin Oheim, Clement Ricard
Summary: This study proposes a fast and label-free 3D imaging method for the enteric nervous system (ENS) in the gastrointestinal tract. By using a high refractive-index aqueous solution as a tissue-clearing agent, combined with autofluorescence detection and rapid volume imaging technology, detailed 3D high-resolution images of unlabeled mouse ileum and colon can be obtained. This method has the advantages of fast clearing speed and imaging speed, and is expected to have wide applications in both basic and clinical research.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Biochemistry & Molecular Biology
Ines Hecking, Lennart Norman Stegemann, Verena Theis, Matthias Vorgerd, Veronika Matschke, Sarah Stahlke, Carsten Theiss
Summary: Research has found that the enteric nervous system (ENS), through its connection to the microbiome and the immune system, may play a role in the pathological changes seen in neurodegenerative diseases. Vascular endothelial growth factor (VEGF) has shown neuroprotective effects in both the central and peripheral nervous systems, and can directly protect enteric neurons in the ENS. These findings suggest a promising approach for neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Stefanie Volkart, Urs Kym, Olivier Braissant, Edgar Delgado-Eckert, Samer Al-Samir, Rebecca Angresius, Zihe Huo, Stefan Holland-Cunz, Stephanie J. J. Gros
Summary: This study analyzed the distribution and localization of AQP1 in the entire intestinal tract of mice. A specific pattern of AQP1 expression was found throughout the gastrointestinal tract. AQP1 expression correlated with the expression profiles of hypoxia-dependent proteins and was associated with changes in intestinal wall anatomy and bacterial stool microbiome composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Dominic R. Parker, Lukasz Wiklendt, Adam Humenick, Bao Nan Chen, Tiong Cheng Sia, David A. Wattchow, Phil G. Dinning, Simon J. H. Brookes
Summary: This study found that sympathetic axons in the myenteric plexus preferentially target cholinergic excitatory cells over nitrergic neurons, which likely plays a role in the inhibitory modulation of human colonic motility by the sympathetic nervous system.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Microbiology
Fernando A. Vicentini, Catherine M. Keenan, Laurie E. Wallace, Crystal Woods, Jean-Baptiste Cavin, Amanda R. Flockton, Wendy B. Macklin, Jaime Belkind-Gerson, Simon A. Hirota, Keith A. Sharkey
Summary: The study demonstrates the role of the gut microbiota in regulating the structure and function of the GI tract in a sex-independent manner. The microbiota is essential for maintaining ENS integrity by regulating enteric neuronal survival and promoting neurogenesis. Molecular determinants such as LPS and SCFA play a key role in regulating enteric neuronal survival and neurogenesis.
Review
Biochemistry & Molecular Biology
Laura Lopez-Pingarron, Henrique Almeida, Marisol Soria-Aznar, Marcos C. Reyes-Gonzales, Ana B. Rodriguez-Moratinos, Antonio Munoz-Hoyos, Joaquin J. Garcia
Summary: The enteric nervous system (ENS) consists of two plexuses, submucosal and myenteric, which regulate gastrointestinal motility through communication with interstitial cells of Cajal (ICCs). ICCs generate slow waves that control smooth muscle contraction and are involved in enteric neurotransmission. Oxidative stress and neurological diseases can disrupt the interaction between ICCs, the ENS, and the central nervous system (CNS), leading to gastrointestinal motility disorders. This review discusses disturbances in enteric neurotransmission and ICC function that contribute to abnormal gut motility.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Biology
Tolga Aksu, Dhiraj Gupta, Jamario R. Skeete, Henry H. Huang
Summary: Atrial fibrillation (AF) is a common supraventricular arrhythmia associated with higher cardiovascular morbidity and mortality. Recent evidence suggests that catheter-based pulmonary vein isolation (PVI) may be a superior alternative to antiarrhythmic drug therapy for long-term freedom from AF episodes. Imbalances in the autonomic nervous system (ANS) may contribute to AF, leading to increased interest in neuromodulation techniques for the intrinsic cardiac ANS.
Article
Cardiac & Cardiovascular Systems
Min-young Kim, James Nesbitt, Simos Koutsoftidis, Joseph Brook, David S. Pitcher, Chris D. Cantwell, Balvinder Handa, Catherine Jenkins, Charles Houston, Stephen Rothery, Anand Jothidasan, Justin Perkins, Poppy Bristow, Nick W. F. Linton, Emm Drakakis, Nicholas S. Peters, Rasheda A. Chowdhury, Prapa Kanagaratnam, Fu Siong Ng
Summary: ET sites identified by HFS contain a higher density of smaller nerves than non-ET sites, mainly within the atrial myocardium. This has important clinical implications for targeting autonomic triggers of AF.
Review
Gastroenterology & Hepatology
Peter H. Neckel
Summary: This article aims to provide an annotated translation of Meissner's first description of the submucosal plexus, along with a brief biography of Georg Meissner and a review of the scientific literature and controversy surrounding his discovery.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Immunology
David A. D. Munro, Kiavash Movahedi, Josef Priller
Summary: This article reviews the relationships between macrophage populations in the central nervous system and focuses on the origins, phenotypes, and functions of cerebrospinal fluid (CSF) macrophages in both health and disease.
SCIENCE IMMUNOLOGY
(2022)
Article
Pediatrics
Katsuhiro Ogawa, Yusuke Oshima, Tsuyoshi Etoh, Yushi Kaisyakuji, Manabu Tojigamori, Yasuharu Ohno, Norio Shiraishi, Masafumi Inomata
Summary: This study successfully demonstrated the label-free detection of enteric nerve system (ENS) in human intestines using Raman spectroscopy for the diagnosis of Hirschsprung disease (HSCR). Raman spectroscopy could differentiate between ganglion and muscle layers, and confirmed the presence or absence of ENS in HSCR material.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Marine & Freshwater Biology
Anna Savelieva, Elena N. Temereva
INVERTEBRATE BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Elena N. Temereva
SCIENTIFIC REPORTS
(2020)
Article
Evolutionary Biology
Tatyana Kuzmina, Elena Temereva
Summary: The study describes the ultrastructure of the supraenteric and subenteric ganglia in the brachiopod Coptothyris grayi, revealing the organization of neurons and layers in each. The ganglia exhibit features that are considered primitive in the bilaterian ancestor, indicating they cannot be classified as true ganglia.
JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH
(2021)
Article
Zoology
Petr Kuznetsov, Anastassya Maiorova, Elena Temereva
Summary: Echiura, a small group of unsegmented marine worms, play an important role in benthic ecosystems worldwide. The study of Lissomyema mellita's anatomy reveals unique features such as glands in the anal lobe and ciliated grooves on the proboscis. The circulatory system of L. mellita shows complexity with novel vascular elements.
Article
Zoology
Feodor A. Plandin, Elena N. Temereva
Summary: This study provides the first complete 3D reconstruction of the coelomic system in the craniide brachiopod Novocrania anomala, revealing its complexity and some similarities with other groups. These findings contribute to a better understanding of the body plan and evolution of brachiopods.
Article
Zoology
Nadezhda Rimskaya-Korsakova, Nadezda Karaseva, Timofei Pimenov, Hans Tore Rapp, Eve Southward, Elena Temereva, Katrine Worsaae
Summary: The study on the Siboglinum fiordicum reveals a different pattern of muscle and septum formation compared to other annelids, with the body being divided into two regions before segments are laid down. This unique formation process may represent an adaptation of these annelids to their sedentary-tubicolous lifestyle.
FRONTIERS IN ZOOLOGY
(2021)
Article
Multidisciplinary Sciences
Elena N. Temereva, Tatyana V. Kuzmina
Summary: Recent research has shown similarities in the organization of the nervous and muscular systems of the lophophore in phoronids, brachiopods, and bryozoans, leading to debate over the evolution of the lophophore in some lophophorates. A study of the brachiopod Coptothyris grayi revealed that its innervation lacks the accessory brachial nerve and exhibits several evolutionary trends in its complex morphology. In brachiopods, the evolution of the lophophore nervous system involved the appearance and strengthening of the second accessory brachial nerve, as well as the reduction of some brachial nerves, reflecting changes in the complexity of the lophophore musculature.
SCIENTIFIC REPORTS
(2021)
Article
Evolutionary Biology
Tatyana Kuzmina, Elena Temereva
Summary: Despite the diversity in morphology of brachiopod tentacle organ, the lophophore, the structure of tentacle muscles varies among different species, with three types of tentacle organization identified.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2022)
Article
Anatomy & Morphology
Petr Kuznetsov, Alexander Ereskovsky, Elena Temereva
Summary: This study provides a detailed description of the proboscis epithelium of females of B. viridis and describes for the first time the tissue structure and functions of different parts of the proboscis stem.
Article
Zoology
Elena Temereva, Nadezhda Rimskaya-Korsakova, Vyacheslav Dyachuk
Summary: Oweniidae are marine annelids with unique features in organ system, development, morphology, and ultrastructure. Analysis of the head region anatomy may provide insights into the unusual structures present in this group.
ZOOLOGICAL LETTERS
(2021)
Article
Anatomy & Morphology
Petr Kuznetsov, Elena Temereva
Summary: This study describes the ultrastructure of the proboscis blood vessels in females of B. viridis, provides accurate schemes, and suggests a new reconstruction of the axial blood vessel.
JOURNAL OF MORPHOLOGY
(2022)
Article
Biology
Elena Temereva
Summary: This research describes the nervous system of Novocrania anomala adults for the first time, and supports the Calciata hypothesis of brachiopod phylogeny through comparative analysis.
Article
Evolutionary Biology
Elena N. Temereva, Maria A. Isaeva, Igor A. Kosevich
Summary: This study investigates the morphology and innervation of the Lophophore of the ctenostome Flustrellidra hispida. The results suggest that the organization of the lophophore nervous system in F. hispida may reflect the ancestral state for all bryozoans. This finding sheds light on the evolutionary transformation of the lophophore nervous system in bryozoans.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2023)
Article
Evolutionary Biology
Elena Temereva, Nadezhda Rimskaya-Korsakova
Summary: This study reports the discovery of a nuchal-like organ in the larvae of siboglinids, suggesting its possible involvement in functions other than larval settlement, such as communication or initiating departure from the tube.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2023)
Article
Biodiversity Conservation
Anna A. Madison, Tatyana Kuzmina, Elena N. Temereva
Summary: The study describes the shells of juveniles of Lingula anatina from Vietnam and the Republic of the Philippines, revealing previously unknown features and proposing hypotheses on the evolution of brachiopod life cycles. The life cycle of extant lingulides, with planktotrophic juveniles hatching from egg envelopes, is suggested to be the most evolutionarily advanced and appeared in the early Silurian.