Article
Chemistry, Organic
Liao Chujie, Ruan Hongyao, Jiang Junfeng, Luo Lun, Hu Yanggen
Summary: In this study, 3-aryl-2-imino-benzo[e][1,3]-oxazin-4-ol derivatives were efficiently synthesized by aza-Wittig tandem reaction. Their structures were confirmed by NMR and HRMS, and the most active compound showed potential antitumor activities against HepG2 and HeLa cell lines. The compounds also exhibited antioxidant properties.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Eva Vrbkova, Lada Sekerova, Eliska Vyskocilova, Martin Zapletal, Libor Cerveny
Summary: Several types of modified zeolite BETA38 with different iron loading were prepared and characterized. The introduction of iron significantly enhanced the catalytic activity of the materials, regardless of the amount of iron loading. The material with 1wt% Fe loading exhibited high conversion rates in various reactions. Particularly, the Fe loaded Beta 38 showed a significant catalytic effect in the Prins reaction of benzaldehyde with isoprenol.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Biochemistry & Molecular Biology
Junfeng Shang, Yuxin Li, Na Yang, Lixia Xiong, Baolei Wang
Summary: A series of novel beta-naphthol derivatives containing benzothiazolylamino and various heteroaryl groups were efficiently synthesized via Betti reaction. Most of the compounds exhibited favorable insecticidal potentials, particularly towards oriental armyworm and diamondback moth.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shalima Kumari, Maridula Thakur, Chetan Chauhan, Meena Kumari
Summary: Cobalt(II) complexes of biphenyl-2-ol were synthesized and characterized. Complex 2 showed higher reactivity and antiviral activity compared to complex 1 and the free ligand. The complexes exhibited better antibacterial efficacy and enhanced antioxidant behavior.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Lara Saftic Martinovic, Nada Birkic, Vedran Miletic, Roberto Antolovic, Danijela Stanfel, Karlo Wittine
Summary: The antioxidant activity and chemical stability of D1 and D2 were compared with AA using ABTS and DPPH assays. The optimal storing conditions and pH for maintaining stability were determined using mass spectrometry. D1 showed higher stability in an acidic medium and all compounds had a similar binding affinity to the human peroxiredoxin binding site, suggesting their potential as antioxidants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kaori Miura, Hiroaki Matsuno, Yuji Iwaoka, Hideyuki Ito, Akihiro Tai
Summary: The study found that 2-Me-6-N-Palm-AA exhibited higher inhibitory activity in allergic reactions compared to 6-sPalm-AA-2G and might be a promising therapeutic candidate for allergic diseases.
Article
Chemistry, Multidisciplinary
Jiaming Liu, Ming Chen
Summary: A Rhenium-catalyzed stereoselective transposition of allylic alcohols is described. In the presence of 1 mol% of Re2O7, (E)- or (Z)-δ-hydroxymethyl-anti-homoallylic alcohols were converted into the acetals of 2-methyl-1,3-syn-diols with excellent diastereoselectivities. 1,3-syn-Diol acetals can also be synthesized from (E)-δ-hydroxymethyl-syn-homoallylic alcohols.
Article
Multidisciplinary Sciences
Hirosuke Oku, Ishmael Mutanda, Masakazu Fukuta, Masashi Inafuku
Summary: This study characterized the formation reaction of isoprene and 2-MBO by isoprene synthase IspS, and observed the non-enzymatic production of these compounds by Mn2+ metal ions. Factors such as Mn2+ concentration, temperature, and pH were found to influence the formation of isoprene and 2-MBO.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Hasnain Mehmood, Muhammad Haroon, Tashfeen Akhtar, Simon Woodward, Hina Andleeb
Summary: A series of 5-acetyl-2-(arylidenehydrazin-1-yl)-4-methyl-1,3-thiazoles were designed and synthesized as potent inhibitors of α-amylase. The compounds exhibited excellent α-amylase inhibition, surpassing the standard drug acarbose in terms of potency and binding affinity. Additionally, the compounds showed anti-glycation and anti-oxidant activities, indicating their potential in reducing diabetic complications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Guzow, Ewa Mulkiewicz, Michal Obuchowski, Wieslaw Wiczk
Summary: Research on benzoxazole moiety-based compounds shows that some of them have antibacterial and antifungal activity against Gram-positive bacteria and fungi, as well as toxicity towards cancer cells. Furthermore, certain compounds exhibit lower toxicity towards normal cells than cancer cells, indicating their potential as future anticancer agents. This extensive study has allowed the establishment of a structure-activity relationship, enabling the selection of candidates for further modifications to improve their biological activity for therapeutic purposes.
Article
Biochemistry & Molecular Biology
Raghavendra Reddy Gajjala, Raveendra Reddy Chinta, Venkata Subba Reddy Gopireddy, Sreelakshmi Poola, Satheesh Krishna Balam, Venkataramaiah Chintha, Visweswara Rao Pasupuleti, Vijaya Kumar Reddy Avula, Swetha Vallela, Grigory Vasilievich Zyryanov, Suresh Reddy Cirandur
Summary: A series of novel ethyl-4-(aryl)-6-methyl-2-(oxo/thio)-3,4-dihydro-1H-pyrimidine-5-carboxylates were synthesized and characterized. These compounds showed potential antioxidant activity and strong hydrogen bonding interactions with specific amino acid residues, inhibiting the growth of reactive oxygen species. They were also identified as safe drugs with potential blood-brain barrier penetration and central nervous system (CNS) activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Noudjoud Houas, Salah Chafaa, Nadjib Chafai, Samira Ghedjati, Meriem Djenane, Siham Kitouni
Summary: The new molecule HMHP showed stronger antioxidant activity compared to HIN in most tests, particularly demonstrating better performance in the DPPH test. Theoretical calculations using DFT and FT-IR were in line with experimental results, confirming the effectiveness of the synthesized compounds as antioxidants.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Thermodynamics
Karen Silva Vargas, Benjamin Katryniok, Marcia Araque
Summary: In this study, isobaric vapor-liquid equilibrium measurements were carried out for six binary systems to aid in distillation process design. The data obtained was validated for thermodynamic consistency and correlated using different models to determine binary interaction parameters. The results showed that the models used were effective in correlating the six binary systems, making them suitable for separation process development and optimization.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2021)
Article
Engineering, Electrical & Electronic
M. Neela, B. Premalatha, P. Punitha, T. C. Sabari Girisun
Summary: This study demonstrates the nonlinear absorption and optical limiting behavior of E25DCM crystal under laser excitation, along with characterizations of its structure, thermal behavior, and optical properties. The crystal exhibits excellent nonlinear optical characteristics and shows potential for use in developing laser safety devices.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Shynggys Sergazy, Zarina Shulgau, Aigerim Zhulikeyeva, Yerlan Ramankulov, Irina Palamarchuk, Ivan Kulakov
Summary: This study investigates the potential cytoprotective effects of derivatives and their impact on cell viability. The results demonstrate that certain derivatives exhibit pronounced cytoprotective activity in vitro and satisfy Lipinski's rule of five, indicating their potential as orally active drugs.
Article
Chemistry, Medicinal
N. I. Belaya, A. N. Nikolaevskii, T. N. Ivleva, O. G. Sheptura
PHARMACEUTICAL CHEMISTRY JOURNAL
(2009)
Article
Chemistry, Applied
A. N. Nikolaevskii, V. V. Morenko, O. P. Kniga, T. N. Ivleva
RUSSIAN JOURNAL OF APPLIED CHEMISTRY
(2011)
