Journal
RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 40, Issue 1, Pages 23-30Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1062360409010032
Keywords
mouse embryogenesis; t-complex; Brachyury (Tail) gene; T-box genes
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Funding
- Russian Foundation [06-04-48866, 05-04-49926]
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The effects of t-haplotypes on embryonic morphology in house mouse Mus musculus were described. Lethal mutations, t-haplotypes, in homozygotes induce abnormal embryogenesis and zygotic death at different developmental stages, which depends on the time of their action in ontogeny. Death commonly occurs in the first semester of pregnancy from the morula to the mature embryo stage (day 9-10), and the embryogenetic abnormalities and their timing were Specific for each t-haplotype. Such mutations were analyzed to identify the gene products (proteins) affecting the nervous system development. The t-complex proved to contain tandem repeats coding for regulatory factors modulating the expression of specific structural genes in mouse neurons.
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