Article
Polymer Science
Alexey V. Dubrovskii, Alexey V. Berezhnov, Aleksandr L. Kim, Sergey A. Tikhonenko
Summary: The research focused on the arrangement of polyelectrolytes in multilayered PMC capsules and found that the dissociation of different layers is equal regardless of the presence or absence of the shell. The study also revealed that FITC-labeled polyallylamine migrates to the periphery of the microcapsule due to increased osmotic pressure caused by the flow of ions. This effect is enhanced by the lower charge density and less interaction of FITC-polyallylamine with polystyrene sulfonate in the microcapsule structure.
Article
Chemistry, Physical
Raluca Ghiman, Roxana Pop, Dumitrita Rugina, Monica Focsan
Summary: This review focuses on the existing microencapsulation technologies of plant-derived bioactive compounds, providing details on the fabrication processes used to achieve high encapsulation efficiency. Special attention is given to specific cellular uptake, intracellular localization, and transport of micro delivery systems, as well as their therapeutic potential for the treatment of various chronic diseases. An outlook into future research on novel micro capsules for biomedical and pharmaceutical applications is also provided.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Daria Kalenichenko, Galina Nifontova, Alexander Karaulov, Alyona Sukhanova, Igor Nabiev
Summary: The engineering of drug delivery systems and contrasting labels for simultaneous imaging and treatment of malignant tumors is essential for developing new tools for cancer therapy and diagnosis. Polyelectrolyte microcapsules (MCs) offer a promising platform for designing multipurpose agents with various components, including high- and low-molecular-weight substances, metal nanoparticles, and organic fluorescent dyes. In this study, size-homogenous MCs with different structures were developed, containing doxorubicin (DOX) and fluorescent semiconductor nanocrystals (quantum dots, QDs), paving the way for delivery of antitumor drugs and fluorescence imaging.
Article
Biochemistry & Molecular Biology
Aleksandr L. Kim, Egor V. Musin, Munojat J. Oripova, Yulia I. Oshchepkova, Shavkat I. Salikhov, Sergey A. Tikhonenko
Summary: Atrial fibrillation is a common cardiac arrhythmia, and Amiodarone is a highly effective but toxic treatment. A drug delivery system using polyelectrolyte microcapsules is a potential solution. Different encapsulation methods for Amiodarone were compared, and the adsorption method was found to be the most suitable, with over 30% of the drug being encapsulated in the microcapsules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Iva Rezic, Maja Somogyi Skoc, Mislav Majdak, Slaven Juric, Katarina Sopko Stracenski, Marko Vincekovic
Summary: The development of antimicrobial polymers is crucial in combating microbial resistant strains. This study aimed to functionalize polymer surfaces with antimicrobial core/shell microcapsules to enhance their antimicrobial properties. The release of active substances from these microcapsules was monitored to calculate the minimal concentration of antimicrobial silver required to achieve desired release amounts over time.
Article
Polymer Science
Alexey V. Dubrovskii, Aleksandr L. Kim, Egor V. Musin, Bulat R. Ramazanov, Sergey A. Tikhonenko
Summary: Polyelectrolyte microcapsules, obtained by adsorbing oppositely charged polyelectrolytes onto colloidal particles, have been found to possess buffer capacity. Microcapsules with BSA exhibit higher buffer capacity in acidic medium compared to those without protein. The composition of microcapsules affects their buffer capacity behavior.
Article
Biochemistry & Molecular Biology
Sarah K. Wypysek, Silvia P. Centeno, Till Gronemann, Dominik Woell, Walter Richtering
Summary: Microgels with specific architectural and chemical design can selectively absorb and release small molecules, or protect their cargo from the environment. This study focuses on the synthesis and analysis of hollow anionic p(N-isopropylacrylamide-co-itaconic acid) microgels, as well as investigating their interactions with cytochrome c protein at different pH values. The results reveal that cytochrome c is mainly trapped within the microgel, with pH controlling its localization.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jing-Kun Yan, Zi-Wei Wang, Jie Zhu, Yujia Liu, Xu Chen, Lin Li
Summary: This study successfully developed a new method for encapsulating curcumin using polyelectrolyte nanoparticles. Compared with free curcumin, curcumin loaded in the nanoparticles demonstrated improved performance, including better redispersion, thermal stability, photostability, and sustained release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Alexey Dubrovskii, Aleksandr L. Kim, Egor Musin, Sergey A. Tikhonenko
Summary: Polyelectrolyte microcapsules (PMCs) are being studied for their buffer capacity, which is influenced by factors such as salt concentration, type, and incubation temperature. Increasing NaCl concentration to 1 M enhances buffer capacity of PMCs at pH >= 5, while higher concentrations do not further change the buffer capacity. Additionally, heated PMCs showed a decrease in buffer capacity with increasing temperature, which could be attributed to changes in the composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
John Kwame Bediako, Youssef El Ouardi, Emile Salomon Massima Mouele, Bismark Mensah, Eveliina Repo
Summary: In recent years, polyelectrolyte-incorporated functional materials have been widely used for effective remediation of pollutants in water and wastewater. Polyelectrolytes are special polymers with repeating charged moieties, while polyelectrolyte complexes are obtained by mixing oppositely charged polyelectrolytes. This review discusses the recent advances in using polyelectrolyte and polyelectrolyte complex-incorporated adsorbents for water and wastewater remediation, including heavy metal removal, desalination, and dye removal.
Article
Polymer Science
Jessica de Carvalho Arjona, Maria das Gracas Silva-Valenzuela, Shu-Hui Wang, Francisco Rolando Valenzuela-Diaz
Summary: Urea, the most widely used fertilizer globally, is encapsulated with biodegradable polymer PHB and its nanocomposites PHB/MMT and PHB/OMMT for controlled-release. The microcapsules, particularly PHB/OMMT, show higher degradation rates in sandy soils, indicating promising applications for environmentally friendly fertilization.
Article
Food Science & Technology
Chunwei Li, Xiankang Fan, Yangying Sun, Changyu Zhou, Daodong Pan
Summary: Goose liver oil microcapsules prepared with konjac glucomannan and soybean protein isolate exhibited high encapsulation efficiency and improved thermal and oxidative stability compared to free goose liver oil. The microcapsules showed a smooth spherical surface morphology and homogeneous internal structure. They also demonstrated good gastric juice permeability and controlled release in the intestinal region.
Article
Food Science & Technology
Alberto Baldelli, Melinda Ren, Diana Yumeng Liang, Sapphire Lai, Bryant Hartono, Kyle Sum, Anubhav Pratap-Singh
Summary: Mineral deficiencies are a major issue affecting millions of people globally, especially in developing countries. Food fortification is a viable solution to enhance mineral content in commonly consumed food items. However, the drawbacks of nutrient loss during fortification can be mitigated through encapsulation using spray drying techniques. However, further research is required to fully comprehend the particle formation process and identify optimal materials for effective mineral encapsulation. This review article provides a comprehensive guideline for selecting appropriate bulk and wall materials to create mineral capsules for incorporation into common foods such as dairy products, carbohydrates, tea, and coffee.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Bruna C. Leopercio, Mariano Michelon, Marcio S. Carvalho
Summary: This study experimentally investigates the flow of monodispersed gellan gum microcapsules through a constricted capillary tube by measuring the evolution of pressure difference and flow visualization. The maximum pressure difference and capsule deformation for capsules with different diameter and shell thickness were obtained. Mapping the conditions at which the capsule membrane ruptures during the flow and releases its internal phase was also conducted.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Bruna C. Leopercio, Sergio Ribeiro, Frederico Gomes, Mariano Michelon, Marcio S. Carvalho
Summary: Magnetized microcapsules produced by microfluidics are studied for their response to external magnetic fields, with the response found to be dependent on the concentration of the ferrofluid, capsule diameter, and shell thickness.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Cell Biology
M. M. Yurinskaya, O. Yu Kochetkova, L. I. Shabarchina, O. Yu Antonova, A. V. Suslikov, M. B. Evgen'ev, M. G. Vinokurov
CELL STRESS & CHAPERONES
(2017)
Article
Biochemistry & Molecular Biology
O. Yu. Kochetkova, M. M. Yurinskaya, L. I. Shabarchina, A. V. Suslikov, A. A. Naumov, S. A. Tikhonenko, M. G. Vinokurov
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2016)
Article
Materials Science, Biomaterials
Alexey V. Dubrovskii, Olga Yu. Kochetkova, Aleksandr L. Kim, Egor V. Musin, Olga Yu. Seraya, Sergey A. Tikhonenko
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Materials Science, Biomaterials
Alexey V. Dubrovskii, Olga Yu. Kochetkova, Aleksandr L. Kim, Egor V. Musin, Olga Yu. Seraya, Sergey A. Tikhonenko
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Microbiology
L. V. Trilisenko, O. Yu. Kochetkova, V. M. Vagabov, I. S. Kulaev
Article
Microbiology
V. M. Vagabov, L. V. Trilisenko, O. Yu. Kochetkova, A. P. Ilchenko, I. S. Kulaev
Article
Chemistry, Multidisciplinary
Olga Y. Antonova, Olga Y. Kochetkova, Yuri M. Shlyapnikov
Summary: Nanostructured synthetic scaffolds mimicking the natural extracellular matrix have been studied, with ultra-thin nylon-4,6 nanofibers showing enhanced efficiency in promoting neuron growth compared to thicker nanofibers. Both types of scaffolds improved synaptogenesis and cell connections, though with different mechanisms of interaction. The findings demonstrate the potential of ultra-thin nanofiber scaffolds for clinical applications in nervous tissue regeneration.
Article
Biochemistry & Molecular Biology
Olga Y. Antonova, Olga Y. Kochetkova, Igor L. Kanev, Elena A. Shlyapnikova, Yuri M. Shlyapnikov
Summary: The method of generating neurospheres using scaffolds composed of electrospun nylon fibers offers advantages of speed, low consumption, and closer resemblance to nervous tissue, making it a promising tool in neuroscience research.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Polymer Science
Olga Yu. Kochetkova, Tatiana S. Demina, Olga Yu. Antonova
Summary: Several variants of hybrid polyelectrolyte microcapsules were designed and produced, demonstrating high efficiency of carrying hydrophilic and hydrophobic compounds. The microcarriers showed high storage stability and no apparent toxic effects on live cells. Interaction with macrophages resulted in deformation and degradation of the microcapsules, accompanied by release of their contents. These results highlight the functional efficiency and potential of these novel hybrid microcarriers in delivering drugs with different properties in complex therapy.
Article
Chemistry, Multidisciplinary
Olga Yu. Antonova, Olga Yu. Kochetkova, Igor L. Kanev
Summary: This study proposes two alternative approaches for obtaining biocompatible photothermal scaffolds and determines their effects. Photothermal stimulation on neuroblastoma cells enhances neurite outgrowth and promotes neuronal maturation, and can stimulate directional growth of differentiated neural cells. Surface decoration of fibers with nanoparticles has a significant impact on neurite elongation and branching, while the effect is more pronounced when nanoparticles are incorporated inside the fibers.
Correction
Cell Biology
M. M. Yurinskaya, O. Yu. Kochetkova, L. I. Shabarchina, O. Yu. Antonova, A. V. Suslikov, M. B. Evgen'ev, M. G. Vinokurov
CELL STRESS & CHAPERONES
(2017)
