Review
Chemistry, Multidisciplinary
Liyan Yang, Zhonglei Wang
Summary: Aflatoxins, produced by various Aspergillus fungi, are natural compounds with pentacyclic structures that pose a risk to human health. Over the past 55 years, there have been significant advancements in the total synthesis of aflatoxins, aiming to better understand their biological activity and presence in food industry samples.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Biplob Borah, Sidhartha Swain, Mihir Patat, L. Raju Chowhan
Summary: Quinazolinone, an important class of nitrogen-containing heterocyclic compounds, is frequently found in natural alkaloids and pharmaceutically active components. The synthetic and medicinal chemistry of quinazolinones has gained significant interest in recent years. The use of organocatalytic strategy allows for rapid synthesis of quinazolinones and provides new alternatives in synthetic and green chemistry.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Timea Szabo, Balazs Volk, Matyas Milen
Summary: Beta-carboline alkaloids are a diverse family of compounds with various biological activities, making them desirable drug candidates. Researchers have made significant progress in the synthesis of these alkaloids in recent years.
Review
Biochemistry & Molecular Biology
Xiangbo Zhao, Bastien Cacherat, Qifei Hu, Dawei Ma
Summary: The ent-kaurane diterpenoids are important natural products found in terrestrial plants, with a wide range of biological activities. Recent advances in total synthesis have been made in the field.
NATURAL PRODUCT REPORTS
(2022)
Article
Chemistry, Organic
Tetsuhiro Nemoto
Summary: This paper presents the advances in the synthesis of dragmacidin E, a bis-indole alkaloid isolated from a deep-water marine sponge in southern Australia. Synthetic studies conducted by the Funk, Feldman, Jia, and Nemoto groups are summarized, including the total synthesis of (±)-dragmacidin E achieved by Feldman et al. in 2011.
TETRAHEDRON LETTERS
(2023)
Review
Chemistry, Medicinal
Bi-Shuang Chen, Di Zhang, Fayene Zeferino Ribeiro de Souza, Lan Liu
Summary: This review discusses the research progress on marine-derived alkaloid synthesis via enzymatic reactions, as well as the advantages and disadvantages of their applications for industrial production and the green chemistry for marine natural product research.
Review
Chemistry, Medicinal
Laura Fernandez-Pena, Maria Joao Matos, Enol Lopez
Summary: Coumarin and its derivatives are of great interest to medicinal chemists and chemical biologists due to their wide range of biological and pharmacological properties. Interesting families of coumarins have been discovered from marine sources, which have significantly accelerated the drug discovery process through inspiring innovation and identification of analogues with remarkable biological properties. This review aims to showcase the most interesting marine-derived coumarins from a medicinal chemistry perspective, as well as the novel and useful synthetic routes described to achieve these chemical structures. The references for this overview were collected from PubMed, Mendeley, and SciFinder.
Review
Chemistry, Organic
Liangliang Song, Zhenwei Lv, Kui Zhang, Yile Wu, Erik V. Van der Eycken, Lingchao Cai
Summary: This review outlines recent advances in the asymmetric total synthesis of camptothecin, providing concise and scalable approaches for the academic community and pharmaceutical industry.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Polymer Science
Jorge A. Cruz-Morales, Carina Gutierrez-Flores, Daniel Zarate-Saldana, Manuel Burelo, Hector Garcia-Ortega, Selena Gutierrez
Summary: Rubber materials are widely used in various industries, and efforts have been made to develop synthetic substitutes for natural rubber. The synthesis of nanocomposites with synthetic rubber has been proposed to achieve similar properties as natural rubber.
Review
Chemistry, Multidisciplinary
Alexia N. Kim, Aurapat Ngamnithiporn, Emily Du, Brian M. Stoltz
Summary: This review discusses the general structure and biosynthesis of THIQ alkaloids and provides an overview of recent advancements in their total synthesis from 2002 to 2020. It highlights novel synthetic designs and modern chemical methodologies used in recent chemical syntheses.
Article
Chemistry, Organic
Martin Posta, Vaclav Zima, Lenka Postova Slavetinska, Marika Matousova, Petr Beier
Summary: The synthesis of a sulfur-containing karrikin compound and a class of karrikin derivatives with sulfur heteroatoms incorporated into the core backbone is reported. Their biological activity in inhibiting acetylcholinesterase is evaluated.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Zhou Lin, Yang Hong, Yang Chuan, Zhao Zhigang, Li Qinghan
Summary: Developing the construction methods of.-lactone derivatives has important value in organic synthesis due to their beneficial biological activities. Deconjugated butenolides have shown great potential in the synthesis of.-lactone derivatives and have attracted significant attention from chemists. This review focuses on the alpha- and beta-reactions of deconjugated butenolides, discussing reaction characteristics, mechanisms, and future prospects in this field.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Immunology
Nara Lins Meira Quintao, Jaqueline Pavesi Reis, Larissa Benvenutti, Roberta Nunes, Fernanda Capitanio Goldoni, Manuela Somensi Cozer, Priscila de Souza, Rita de Cassia Melo Vilhena de Andrade Fonseca da Silva, Jessica Melato, Carlos Rafael Vaz, Juliana Cristina Pereira Whitaker, Flavia Werner Jesuino, Mariana Couto Costa, Maria Veronica Davila Pastor, Angela Malheiros, Christiane Meyre-Silva, Jose Roberto Santin
Summary: P. malacophyllum may have potential in alleviating symptoms of primary dysmenorrhoea by reducing pain, inflammation, and uterine spasms. The isolated compounds and extracts were found to decrease abdominal writhing, neutrophil chemotaxis, and inflammatory mediator release, while attenuating neutrophil and mast cell infiltration in the uterus of mice with primary dysmenorrhoea.
INFLAMMOPHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Bruna Martins Guimaraes, Rayane de Oliveira Silva, Maria Veronica de Sales Barbosa, Jucleiton Jose Rufino de Freitas, Juliano Carlo Rufino Freitas, Ronaldo Nascimento de Oliveira, Joao Rufino de Freitas Filho
Summary: This review covers the recent advances in the natural occurrence, synthesis, mechanism, and pharmacological applications of N-glycopyranosides from 2010 to 2022.
Article
Chemistry, Multidisciplinary
Zhenjie Su, Pathan Mosim Amin, Shaozhong Wang
Summary: This paper presents a Au(I)-catalyzed ring-closing alkyne-carbonyl metathesis protocol for efficient synthesis of γ-butenolides. The reaction exhibits high atom economy, substrate flexibility, and functional group tolerance, and can be used to synthesize various naturally occurring butenolide-type compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
