Article
Clinical Neurology
Qing Fu, Ding-Xi Liu, Xiao-Yong Zhang, Xian-Bo Deng, Chuan-Sheng Zheng
Summary: PETRA-MRA demonstrated better visualization of aneurysms and lower acoustic noise levels compared to TOF-MRA, leading to superior diagnostic performance in depicting saccular UIAs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Naoyuki Takei, Tsuyoshi Ueyama, Keita Fujii, Hidemasa Takao, Koichiro Yasaka, Yusuke Watanabe, Kouhei Kamiya, Osamu Abe
Summary: This study developed an accelerated cervical MRA and evaluated its diagnostic performance. The results showed that FLEXA had significantly higher artery-to-background signal ratio, lower image blurring, and better diagnostic performance for luminal abnormalities and plaques compared to cMRA.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Carlos Perez-Vega, Ricardo A. Domingo, Shashwat Tripathi, Andres Ramos-Fresnedo, Jaime L. Martinez Santos, Rudy J. Rahme, William D. Freeman, Sukhwinder S. Sandhu, David A. Miller, Bernard R. Bendok, Waleed Brinjikji, Alfredo Quinones-Hinojosa, Fredric B. Meyer, Rabih G. Tawk, W. Christopher Fox
Summary: Patients with Loeys-Dietz syndrome have an increased risk of intracranial aneurysms, especially in those with a history of smoking. The prevalence rate of intracranial aneurysms in this series was 30%. Screening imaging should be considered at diagnosis, and patients should be encouraged to quit smoking. Further studies are needed to determine the risk of aneurysm rupture and treatment considerations in this unique population.
Article
Radiology, Nuclear Medicine & Medical Imaging
Javier Montalt-Tordera, Michael Quail, Jennifer A. Steeden, Vivek Muthurangu
Summary: Deep learning can improve contrast in low-dose cardiovascular MRA. Evaluation of image quality and diagnostic confidence showed comparability between enhanced LD-MRA and HD-MRA. Vessel diameter measurements also demonstrated comparability.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Gong, Chen Cao, Yu Guo, Binge Chang, Zhiguo Sheng, Wen Shen, Ying Zou, Xiudi Lu, Jiahua Xing, Shuang Xia
Summary: The study compared the reproducibility and diagnostic agreement of HR-VWI and TOF-MRA with DSA for intracranial arterial stenosis evaluation. HR-VWI showed better reproducibility and diagnostic agreement with DSA than TOF-MRA, and also provided additional vessel wall information.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Filiz Osmanodja, Julie Roesch, Michael Knott, Arnd Doerfler, David Grodzki, Michael Uder, Rafael Heiss
Summary: This study evaluated the performance of a modern 0.55 T MRI in the diagnosis of intracranial aneurysms (IA) and compared it with digital subtraction angiography (DSA) as the standard of reference. The results showed that 0.55 T MRI could accurately detect and assess IA. Therefore, 0.55 T MRI is a reliable tool for the detection of IA.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Clinical Neurology
Filiz Osmanodja, Jan F. Scheitz, Jochen B. Fiebach, Ramanan Ganeshan, Kersten Villringer
Summary: The study found that intracranial time-of-flight (TOF) MRA can be a valuable diagnostic tool for predicting extracranial stenosis of the internal carotid artery (ICA).
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ioannis Koktzoglou, Rong Huang
Summary: This study evaluated the application of deep machine learning (DML) to 3D quantitative time-of-flight (qTOF) magnetic resonance angiography (MRA) for measuring blood flow velocity within intracranial arteries. The results showed that DML-based analysis improved the agreement with 3D phase contrast (PC) MRA and reduced the calculation time significantly. DML image analysis provides an efficient and accurate method for velocity quantitation in intracranial qTOF MRA.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Engineering, Biomedical
Meng Chen, Chen Geng, Dongdong Wang, Zhiyong Zhou, Ruoyu Di, Fengmei Li, Sirong Piao, Jiajun Zhang, Yuxin Li, Yakang Dai
Summary: A CCDU-Net method based on deep learning technology was proposed in this study for accurately segmenting cerebral aneurysms. The experimental results showed that this method outperformed other existing methods.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Medicine, Research & Experimental
Rui Li, Song Jin, Tao Wu, Xiao Zang, Meng Li, Jinfeng Li
Summary: Silent MRA is superior to 3D-TOF MRA for visualization of the carotid siphon and may be an alternative in the diagnosis of atherosclerosis of the carotid siphon.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Clinical Neurology
Jae Ho Kim, Sung Jun Ahn, Mina Park, Yong Bae Kim, Bio Joo, Woosung Lee, Sang Hyun Suh
Summary: This study compared the imaging quality and visibility of clip-adjacent arteries between pointwise encoding time reduction with radial acquisition (PETRA) subtraction-based MRA and time-of-flight magnetic resonance angiography (TOF-MRA). The results showed that PETRA-MRA had acceptable image quality and greater visibility of the adjacent vessels near the clipped aneurysms compared to TOF-MRA. PETRA-MRA could be a beneficial alternative for follow-up imaging of clipped aneurysms.
JOURNAL OF NEUROSURGERY
(2022)
Article
Chemistry, Analytical
Jeong-Heon Kim, Ju-Yeon Jung, Yeong-Bae Lee, Chang-Ki Kang
Summary: This study developed an MRI-compatible flow delivery system and individualized models of Circle of Willis (CoW) to predict stroke onset. Different CoW disease models showed variations in flow patterns and cerebral blood flow, with decreased possibility of cerebral infarction for some models and increased possibility for others.
Article
Radiology, Nuclear Medicine & Medical Imaging
Garrett Smith, Ibrahim Sacit Tuna, C. Tara Massini, Fatih Tufan, Mehmet Sait Albayram
Summary: This study aimed to evaluate the capacity of high-resolution contrast enhanced 3D time-of-flight (TOF) MR angiography using new generation 3 T imaging technology to provide detailed visualization of CN VI anatomy, particularly within the cavernous sinus and petroclival regions. The results showed that the average visibility of CN VI was best achieved in Dorello's canal, and overall visibility was best achieved in the axial view. Strong agreement in assessment of nerve visibility between reviewers was identified, along with the identification of a putative CN6 duplication and a small schwannoma, highlighting the fidelity of the approach. This imaging technique can visualize CN VI anatomy in the petrocavernosal region and cavernous sinus, and may be useful for evaluating vascular pathologies.
Article
Neurosciences
Song Tan, Yuzhao Lu, Bin Li, Qin Wu, Xiaobing Zhou, Yang Wang
Summary: The study demonstrates that Silent MRA is superior to TOF MRA and shows excellent consistency with DSA in the follow-up of endovascular-treated intracranial aneurysms. Therefore, Silent MRA is clinically useful for the evaluation and monitoring of endovascular-treated aneurysms.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Sung-Hye You, Byungjun Kim, Kyung-Sook Yang, Bo Kyu Kim, Jaeil Ryu
Summary: This study evaluated the diagnostic performance of PETRA-MRA compared to TOF-MRA and CE-MRA in patients who underwent endovascular coiling. PETRA showed superior sensitivity in detecting residual flow and in-stent flow assessment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Overhoff, Peter Kohlmann, Alex Frydrychowicz, Sergios Gatidis, Christian Loewe, Jan Moltz, Jan-Martin Kuhnigk, Matthias Gutberlet, H. Winter, Martin Voelker, Horst Hahn, Stefan O. Schoenberg
Summary: The DRG-ORG IRP is a web/cloud-based radiomics platform that allows data sharing, annotation, validation, and certification in AI, radiomics analysis, and diagnostics. Initial studies have shown successful application in automated myocardial segmentation and LGE detection.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Steffen Goerke, Johannes Breitling, Andreas Korzowski, Daniel Paech, Moritz Zaiss, Heinz-Peter Schlemmer, Mark E. Ladd, Peter Bachert
Summary: This study successfully reduced the acquisition time of 3T APT and rNOE CEST-MRI, while maintaining the contrast behavior and reproducibility.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Orzada, Thomas M. Fiedler, Harald H. Quick, Mark E. Ladd
Summary: This study proposes an iterative expansion method of an existing algorithm, gradually reducing the number of virtual observation points to improve the speed of online monitoring and pulse design, and evaluates it on different simulated arrays. The new algorithm significantly reduces the number of virtual observation points and compression time, with speed-up factors of up to 2.5.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Ludwig, Frederik Bernd Laun, Mark Edward Ladd, Peter Bachert, Tristan Anselm Kuder
Summary: The study investigated the relationship between measured AXR and diffusion restrictions, membrane permeability, and real exchange rate, demonstrating a proportional relationship with membrane permeability but exceptions in certain conditions. AXR was found to depend on factors such as cell size, permeability, and packing density. The research concluded that current experimental settings are suitable for measuring AXR in vivo, except for single-voxel analysis due to limited SNR, and detecting changes in membrane permeability in diseased tissue remains challenging due to other influencing factors.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ricardo Otazo, Philippe Lambin, Jean-Philippe Pignol, Mark E. Ladd, Heinz-Peter Schlemmer, Michael Baumann, Hedvig Hricak
Summary: MRI-guided RT has become an important tool in cancer treatment, offering superior soft-tissue contrast and the ability to monitor tissue physiologic changes. Institutions are already using offline MRI for treatment planning, and MRI-guided linear accelerator systems allow the use of MRI during treatment, providing better adaptation to anatomic changes. Challenges in advancing MRI-guided RT include real-time volumetric anatomic imaging, image distortion due to magnetic field inhomogeneities, reproducible quantitative imaging, and biological validation of quantitative imaging.
Article
Neurosciences
Maximilian N. Voelker, Oliver Kraff, Steffen Goerke, Frederik B. Laun, Jannis Hanspach, Kerrin J. Pine, Philipp Ehses, Moritz Zaiss, Andrzej Liebert, Sina Straub, Korbinian Eckstein, Simon Robinson, Armin N. Nagel, Maria R. Stefanescu, Astrid Wollrab, Sabrina Klix, Joerg Felder, Michael Hock, Dario Bosch, Nikolaus Weiskopf, Oliver Speck, Mark E. Ladd, Harald H. Quick
Summary: This study evaluated the reproducibility of quantitative brain imaging at ten different 7 T sites and found high reproducibility with MP2RAGE measurements. QSM showed high inter-site reproducibility for relevant subcortical volumes. Although CEST imaging revealed systematic differences between sites, its reproducibility was comparable to literature results.
Article
Biophysics
Thomas M. Fiedler, Stephan Orzada, Martina Floeser, Stefan H. G. Rietsch, Harald H. Quick, Mark E. Ladd, Andreas K. Bitz
Summary: This study investigates the performance of integrated RF transmit arrays with high channel counts for body imaging at 7 T, optimizing the position and number of transmit elements. Results show that integrated multiring arrays can generate homogeneous B-1(+) field distributions for large FOVs, especially for coronal/sagittal slices, enabling body imaging at 7 T with a clinical workflow.
NMR IN BIOMEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tanja Platt, Mark E. Ladd, Daniel Paech
Summary: Ultrahigh magnetic fields, referred to as UHFs with B-0 >= 7T, offer higher signal-to-noise and contrast-to-noise ratios. While they provide advantages in resolving structures and visualizing physiological/pathophysiological effects, challenges such as inhomogeneities and higher energy deposition in the human body exist. This review discusses the advantages, challenges, and promising clinical applications of UHF.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Biochemical Research Methods
Julian Emmerich, Peter Bachert, Mark E. Ladd, Sina Straub
Summary: This study introduces an algorithm for separating positive and negative susceptibility sources within the same volume element, which is quantitatively validated in both simulation and phantom experiments. Promising results for in vivo usability are shown in multiple sclerosis lesions.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Spronk, Oliver Kraff, Jakob Kreutner, Gregor Schaefers, Harald H. Quick
Summary: This study introduces a numerical approach to simulate artifacts of metallic implants in an MR environment, aiming to improve the testing procedure for MR image artifacts in medical implants according to ASTM F2119. The numerical approach shows high similarity between simulated and measured artifact sizes, providing a calculation guideline to predict artifact size at different field strengths based on measurements obtained at other field strengths. This novel tool can enhance detailed artifact investigations and reduce the measurement effort required on different MRI systems and field strengths.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Julia P. Lingl, Arthur Wunderlich, Steffen Goerke, Daniel Paech, Mark E. Ladd, Patrick Liebig, Andrej Pala, Soung Yung Kim, Michael Braun, Bernd L. Schmitz, Meinrad Beer, Johannes Rosskopf
Summary: This prospective study demonstrates the high diagnostic potential of APTw CEST imaging in a routine clinical setting for differentiating brain tumors.
Article
Biophysics
Johannes Breitling, Andreas Korzowski, Neele Kempa, Philip S. Boyd, Daniel Paech, Heinz-Peter Schlemmer, Mark E. Ladd, Peter Bachert, Steffen Goerke
Summary: In this study, a simple method for motion correction in CEST-MRI data is proposed. The method utilizes weighted averaging of motion parameters from conventional rigid image registration to identify and mitigate misaligned images. The proposed method outperforms other motion-correction algorithms in terms of accuracy and robustness.
NMR IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rafael Heiss, Marc-Andre Weber, Eva Balbach, Rainer Schmitt, Christoph Rehnitz, Azien Laqmani, Andreas Sternberg, Jutta J. Ellermann, Armin M. Nagel, Mark E. Ladd, Matthias Englbrecht, Andreas Arkudas, Raymund Horch, Ali Guermazi, Michael Uder, Frank W. Roemer
Summary: This study compared the subjective image quality of 3T and 7T ultrahigh-field-strength wrist MRI and found that 7T MRI had potential advantages in cartilage assessment, while 3T MRI was superior in evaluating the triangular fibrocartilage complex and wrist ligaments.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mark E. Ladd, Harald H. Quick, Oliver Speck, Michael Bock, Arnd Doerfler, Michael Forsting, Juergen Hennig, Bernd Ittermann, Harald E. Moeller, Armin M. Nagel, Thoralf Niendorf, Stefan Remy, Tobias Schaeffter, Klaus Scheffler, Heinz-Peter Schlemmer, Sebastian Schmitter, Laura Schreiber, N. Jon Shah, Tony Stoecker, Michael Uder, Arno Villringer, Nikolaus Weiskopf, Moritz Zaiss, Maxim Zaitsev
Summary: Multiple sites in Germany operate human MRI systems at 7 Tesla or 9.4 Tesla. The German Ultrahigh Field Imaging (GUFI) network was established in 2013 to facilitate research cooperation and make this technology available to a larger community of researchers and clinicians worldwide. This paper summarizes the history, current status, motivation, and challenges of pursuing MRI at higher magnetic field strengths, focusing on the perspective in Germany.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
