4.4 Article

The adenosine wedge: A new structural motif in ribosomal RNA

Journal

RNA
Volume 16, Issue 2, Pages 375-381

Publisher

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.1550310

Keywords

RNA structure; RNA motif; ribosomal RNA; A-minor; along-groove packing motif

Funding

  1. Canadian Institutes of Health Research [MOP-89923]

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Here, we present a new recurrent RNA arrangement, the so-called adenosine wedge (A-wedge), which is found in three places of the ribosomal RNA in both ribosomal subunits. The arrangement has a hierarchical structure, consisting of elements previously described as recurrent motifs, namely, the along-groove packing motif, the A-minor and the hook-turn. Within the A-wedge, these elements are involved in different types of cause-effect relationships, providing together for the particular tertiary structure of the motif.

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