New insights into repeat instability

DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions

(2010) Olivier Sordet et al.   CELL CYCLE

Repeat instability as the basis for human diseases and as a potential target for therapy

(2010) Arturo López Castel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Frataxin deficiency induces Schwann cell inflammation and death

(2009) Chunye Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells

(2009) Yunfu Lin et al.   DNA REPAIR

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants

(2009) B. Gomez-Gonzalez et al.   MOLECULAR AND CELLULAR BIOLOGY

G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter

(2009) D. Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

Pathogenic RNAs in microsatellite expansion disease

(2009) Jihae Shin et al.   NEUROSCIENCE LETTERS

R loops stimulate genetic instability of CTG{middle dot}CAG repeats

(2009) Y. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells

(2009) D. Mittelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetic Defect Caused by a Triplet Repeat Expansion in Arabidopsis thaliana

(2009) S. Sureshkumar et al.   SCIENCE

Progressive GAA·TTC Repeat Expansion in Human Cell Lines

(2009) Scott Ditch et al.   PLoS Genetics

Recognition of the unique structure of DNA:RNA hybrids

(2008) Nicholas N. Shaw et al.   BIOCHIMIE

Conformational Changes and Aggregation of Expanded Polyglutamine Proteins as Therapeutic Targets of the Polyglutamine Diseases: Exposed β-Sheet Hypothesis

(2008) Yoshitaka Nagai et al.   CURRENT PHARMACEUTICAL DESIGN

DNA triplexes and Friedreich ataxia

(2008) Robert D. Wells   FASEB JOURNAL

G4-forming Sequences in the Non-transcribed DNA Strand Pose Blocks to T7 RNA Polymerase and Mammalian RNA Polymerase II

(2008) Silvia Tornaletti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes

(2008) G.-F. Richard et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Transcription destabilizes triplet repeats

(2008) Yunfu Lin et al.   MOLECULAR CARCINOGENESIS

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Long intronic GAA•TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia

(2008) E. Soragni et al.   NUCLEIC ACIDS RESEARCH

The Antisense Transcriptomes of Human Cells

(2008) Yiping He et al.   SCIENCE

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES

Simple sequence repeats: genetic modulators of brain function and behavior

(2008) John W. Fondon et al.   TRENDS IN NEUROSCIENCES