Journal
RNA BIOLOGY
Volume 6, Issue 4, Pages 395-398Publisher
LANDES BIOSCIENCE
DOI: 10.4161/rna.6.4.9318
Keywords
alternative splicing; U1-independent pre-mRNA splicing; U1 snRNP; 5 ' splice site; Fox-1
Categories
Ask authors/readers for more resources
In metazoan organisms, alternative splicing is a central mechanism for the regulation of gene expression. However, many questions remain about the underlying molecular mechanisms. Our recent work suggests that U1 snRNP-independent pre-mRNA splicing occurs in humans, which contributes to the regulation of alternative splicing. So far it has been reported that several pre-mRNAs were spliced efficiently in a U1 snRNP-independent manner in vitro. Although the molecular mechanism and functional significance of U1-independent pre-mRNA splicing are not well understood, a model of how the 5' splice site is recognized U1-independently has been proposed. In this review, we first overview a model in which the 5' splice site is recognized by SR proteins and U6 snRNA. We then discuss our novel model and the functional significance of U1-independent pre-mRNA splicing in the regulation of alternative splicing, based on our recent work.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available