Article
Psychology, Multidisciplinary
Paulo A. S. Moreira, Richard A. Inman, C. Robert Cloninger
Summary: Research and clinical practice often use representative data to compare and understand the personality characteristics of specific groups or individuals. Recent genomic evidence shows that human personality is organized hierarchically, with multi-trait profiles regulating emotional reactivity and goals/values, and three phenotypic networks regulating learning. This study provides a comprehensive description of personality features at a societal level using a stratified sample of Portuguese adults and highlights the prevalence of different temperament and character profiles.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Ali Kheradmand, Elham Sadat Amirlatifi, Zahra Rahbar
Summary: Nowadays, smartphone use is increasing drastically. This study aims to evaluate the association of smartphone addiction with personality traits. A correlational research method was used to survey 382 students from Tehran universities, using the smartphone addiction scale (SAS) questionnaire and the Cloninger temperament and character inventory (TCI) questionnaire. The results showed that individuals prone to smartphone addiction had higher scores in novelty-seeking, harm avoidance, and self-transcendence, while lower scores in persistence and self-directedness. High reward dependence and low cooperativeness also had some influence but were not statistically significant. These findings suggest that traits such as high novelty-seeking, harm avoidance, self-transcendence, low persistence, and self-directedness may contribute to smartphone addiction.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Tatjana Jukic, Branka Aukst Margetic, Nenad Jaksic, Vlatka Boricevic
Summary: This study found that individuals with gallstones have more pronounced metabolic risk factors, higher prevalence of smoking and alcohol usage, and higher levels of harm avoidance and lower levels of self-directedness. The logistic regression showed that harm avoidance was a significant predictor of the presence of gallstones.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Clinical Neurology
Mathilde Boussac, Christophe Arbus, Olivier Colin, Chloe Laurencin, Alexandre Eusebio, Elodie Hainque, Jean Christophe Corvol, Nathalie Versace, Olivier Rascol, Vanessa Rousseau, Estelle Harroch, Fabienne Ory-Magne, Margherita Fabbri, Caroline Moreau, Anne-Sophie Rolland, Bechir Jarraya, David Maltete, Sophie Drapier, Ana-Raquel Marques, Nicolas Auzou, Thomas Wirth, Mylene Meyer, Bruno Giordana, Melissa Tir, Tiphaine Rouaud, David Devos, Christine Brefel-Courbon
Summary: This study aimed to evaluate personality dimensions in Parkinson's disease patients and compare them with a French cohort. The results showed significant differences in certain personality dimensions between Parkinson's disease patients and the French normative cohort. Moreover, some personality dimensions were found to be associated with anxiety-depressive state, quality of life, and impulsivity.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Medicine, General & Internal
Andrea Duarte Doetzer, Roberto Hirochi Herai, Marilia Afonso Rabelo Buzalaf, Paula Cristina Trevilatto
Summary: Temporomandibular joint dysfunction (TMD) is a multifactorial condition impairing human health and quality of life. Research shows that different types of TMD have distinct protein expression profiles, contributing to a better understanding of the pathology's development.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Multidisciplinary Sciences
Danilo Garcia, Maryam Kazemitabar, Kristina Stoyanova, Drozdstoy Stoyanov, C. Robert Cloninger
Summary: This study aims to explore the associations of different Joint Personality Networks with well-being in a low-income country. The results suggest that stable temperament and healthy character configuration have a positive impact on well-being, and the influence of different character configurations and values on well-being may vary.
Article
Cell Biology
Xiaojun Liu, Chenchen Zhao, Yupeng Han, Ruixia Feng, Xiaona Cui, Yaoyao Zhou, Zhisong Li, Qian Bai
Summary: This study investigates the expression profiles of circRNAs, lncRNAs, and mRNAs in the trigeminal ganglion associated with TMD inflammation pain. The results suggest that apoptosis and neuroinflammation are important pathogenic mechanisms underlying TMD pain. The identified differentially expressed genes may serve as promising therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shruti Handa, David A. Keith, Jeanelle Abou-Ezzi, Annika Rosen
Summary: This study characterized patients with chronic neuropathic orofacial pain according to the ICOP criteria, identifying persistent idiopathic facial pain and post traumatic trigeminal neuropathic pain as commonly misdiagnosed categories.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mengjie Wu, Jingyi Cai, Yeke Yu, Sihui Hu, Yingnan Wang, Mengrui Wu
Summary: This study summarized commonly used therapeutic agents and novel bioactive molecules in the management of TMD, as well as discussed emerging therapy strategies, strengthening our understanding of pharmacological approaches for TMD therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychology, Multidisciplinary
Mehdi Zemestani, Farzin Niakan, Kamal Shafeizadeh, Mark D. Griffiths
Summary: The present study aimed to examine the indirect relationships between psychobiological components of personality, affect, and internet gaming disorder (IGD) among Iranian university students. The findings showed that negative affect mediated the relationships between certain temperament and character dimensions of personality and IGD, suggesting the importance of negative affect in the development of IGD.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Tommi Aho, Hanna Harno, Jari Lipsanen, Eija Kalso, Reetta Sipila
Summary: This study found that personality characteristics have an impact on the long-term well-being and health-related quality of life (HrQoL) of breast cancer survivors. It also revealed that temperament and character affect the dimensions of HrQoL through pain-related and psychological factors in these survivors. These findings have important implications for clinical interventions and effective pain management to enhance the psychosocial well-being and HrQoL of breast cancer survivors.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Integrative & Complementary Medicine
Han Chae, Young Il Cho, Soo Jin Lee
Summary: The study examined the biopsychological features of Yin-Yang personality using a revised version of the Sasang Personality Questionnaire (rSPQ), finding that the rSPQ demonstrated robust psychometric properties and accurately captured the distinctive psychological characteristics of Yin-Yang. The results highlighted the organized subscale structure and clinical validity of rSPQ, providing a foundation for cross-cultural psychology and integrative medicine research.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Review
Medicine, General & Internal
Giovanni Genovese, Alessandro Meduri, Maria Rosaria Anna Muscatello, Sebastiano Gangemi, Clemente Cedro, Antonio Bruno, Pasquale Aragona, Gianluca Pandolfo
Summary: This study aimed to investigate the relationship between personality disorders and central serous chorioretinopathy (CSC) patients, finding that CSC patients exhibit high levels of aggressiveness and anxiety traits along with low sociability. The authors proposed a disease model where stress exacerbates prior specific traits, suggesting that maladaptive personality traits might play a crucial role in the manifestation and progression of the disease.
MEDICINA-LITHUANIA
(2021)
Article
Psychology, Developmental
Paulo A. S. Moreira, Richard A. Inman, C. Robert Cloninger
Summary: Recent research suggests that adaptive functioning and well-being in adolescents depend on the integration of learning and memory systems regulating associative conditioning, intentionality, and self-awareness. Different integrated configurations of these systems are associated with internalizing and externalizing problems. Adolescents with stable temperament and healthy characters are less likely to have clinical problems, and the integration of these profiles is crucial for mental health.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2021)
Review
Rheumatology
Rodrigo R. N. Rizzo, Michael C. Ferraro, Michael A. Wewege, Aidan G. Cashin, Hayley B. Leake, Edel T. O'Hagan, Matthew D. Jones, Sylvia M. Gustin, Andrew J. McLachlan, Richard Day, James H. McAuley
Summary: This meta-analysis examines the efficacy and safety of medicines targeting neurotrophic factors for low back pain (LBP) and sciatica. The findings suggest that anti-nerve growth factor (NGF) medications may offer modest pain relief for chronic LBP, but the effect may vary depending on the dose and type of medication. For sciatica, neither anti-NGF nor glial cell line-derived neurotrophic factor (pro-GDNF) medications appear to reduce pain. It is important to note that these neurotrophic factor-targeting medications may have different adverse effects compared to commonly prescribed medications for LBP and sciatica.
Article
Behavioral Sciences
Taryn Chalmers, Shamona Eaves, Ty Lees, Chin-Teng Lin, Phillip J. Newton, Roderick Clifton-Bligh, Craig S. McLachlan, Sylvia M. Gustin, Sara Lal
Summary: This study explores the relationship between neurocognitive parameters and heart rate variability (HRV) in nurses during acute stress situations. The findings show differences in cognitive performance and HRV parameters between nurses and non-nurses, highlighting the potential use of HRV markers in relation to cognitive performance and autonomic dysfunction.
BRAIN AND BEHAVIOR
(2022)
Correction
Clinical Neurology
Brooke Naylor, Negin Hesam-Shariati, James H. McAuley, Simon Boag, Toby Newton-John, Caroline D. Rae, Sylvia M. Gustin
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Md Akhlasur Rahman, Niraj Singh Tharu, Sylvia M. Gustin, Yong-Ping Zheng, Monzurul Alam
Summary: Spinal cord injury (SCI) is a debilitating injury with severe complications, but recent development of noninvasive electrical neuromodulation treatments offers hope for rehabilitation. Trans-spinal direct current stimulation (tsDCS) and trans-spinal pulsed current stimulation (tsPCS) have shown promising results in improving sensorimotor and autonomic functions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
C. Peck, C. Greene, R. Ohrbach
AUSTRALIAN DENTAL JOURNAL
(2023)
Article
Neurosciences
Sabrina Salberg, Angela Doshen, Glenn R. Yamakawa, Jillian Vinall Miller, Melanie Noel, Luke Henderson, Richelle Mychasiuk
Summary: Persistent postsurgical pain affects 20% of youth, with females experiencing chronic pain more than males. This study investigated the neurobiological changes underlying the transition from acute to persistent pain following surgery in adolescence, finding that injury resulted in persistent pain in both sexes, with females displaying greater sensitivity. Gray matter density changes in specific brain areas were observed, driven by different genders. The study emphasizes the importance of studying both sexes and adolescents to better understand postoperative pain.
Article
Clinical Neurology
Rodrigo R. N. Rizzo, Benedict M. Wand, Hayley B. Leake, Edel T. O'Hagan, Matthew K. Bagg, Samantha Bunzli, Adrian C. Traeger, Sylvia M. Gustin, G. Lorimer Moseley, Saurab Sharma, Aidan G. Cashin, James H. McAuley
Summary: This study explores perceptions of facilitators or barriers to participation in a non-pharmacological intervention for chronic low back pain. The findings suggest the importance of psychological education, behavior change techniques, and systematic approaches to address misconceptions and maintain improvements after formal care.
Article
Neurosciences
Fernando A. Tinoco Mendoza, Timothy E. S. Hughes, Rebecca Robertson, Lewis S. Crawford, Noemi Meylakh, Paul M. Macey, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: The PAG is a critical region for pain-related responses and shows a crude somatotopy for contextually appropriate behavioral responses. Different regions in the PAG are activated by cutaneous and muscle pain. Using ultra-high field functional magnetic resonance imaging, it was found that the PAG exhibits different signal intensity changes in response to noxious stimuli. This suggests a preserved somatotopic organization in the PAG between animals and humans.
Review
Medicine, General & Internal
Michael A. Wewege, Matthew K. Bagg, Matthew Jones, Michael C. Ferraro, Aidan G. Cashin, Rodrigo R. N. Rizzo, Hayley B. Leake, Amanda D. Hagstrom, Saurab Sharma, Andrew J. McLachlan, Christopher G. Maher, Richard Day, Benedict M. Wand, Neil E. O'Connell, Adriani Nikolakopolou, Siobhan Schabrun, Sylvia M. Gustin, James H. McAuley
Summary: This study evaluated the comparative effectiveness and safety of analgesic medicines for acute non-specific low back pain through a systematic review and network meta-analysis. The results showed that the effectiveness and safety of analgesic medicines for acute non-specific low back pain are uncertain, and higher quality randomized controlled trials are needed for head-to-head comparisons.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Biology
Lewis S. Crawford, Noemi Meylakh, Paul M. Macey, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: An fMRI study with 47 participants has discovered that stimulus-independent and stimulus-dependent neural networks centered around the midbrain periaqueductal gray region are responsible for an individual's ability to experience placebo analgesia. The specific neural circuits that regulate placebo analgesic responsiveness are still unknown, but involvement of brainstem pain modulatory regions is considered crucial. This study demonstrates differences in neural circuit connectivity between placebo responders and non-responders, highlighting the importance of altered connections involving the hypothalamus, anterior cingulate cortex, and midbrain periaqueductal gray matter in the placebo analgesic response.
COMMUNICATIONS BIOLOGY
(2023)
Article
Psychiatry
Yann Quide, Nell Norman-Nott, Negin Hesam-Shariati, James H. McAuley, Sylvia M. Gustin
Summary: This study aimed to investigate the effects of chronic pain and depressive symptoms on emotional brain function. The results showed significant differences in connectivity strength between individuals with chronic pain and healthy controls, and the strength of connectivity varied with the severity of depressive symptoms. These findings have important implications for the choice of treatment for chronic pain.
Article
Health Care Sciences & Services
Nell Norman-Nott, Negin Hesam-Shariati, Chelsey R. Wilks, Jessica Schroeder, Jina Suh, Nancy E. Briggs, James H. McAuley, Yann Quide, Sylvia M. Gustin
Summary: This study aims to examine the efficacy of internet-delivered DBT skills training for chronic pain (iDBT-Pain) in reducing emotion dysregulation for individuals with chronic pain. The study will also explore the impact of iDBT-Pain on pain intensity and other related factors.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Edel T. O'Hagan, Aidan G. Cashin, Markus Huebscher, Saad Mohammad Alsaadi, Sylvia Gustin, James H. McAuley
Summary: This study investigated the relationship between sleep quality and next-day pain intensity in individuals with low back pain. The results showed that better self-reported sleep quality or a higher proportion of time spent in slow-wave sleep (SWS) was associated with lower next-day pain intensity. However, after adjusting for confounding factors, this relationship became non-significant.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Neurosciences
Lewis S. Crawford, Emily P. Mills, A. Peek, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: Prior experiences, conditioning cues, and expectations of improvement play important roles in placebo analgesia expression, which is mediated by the dorsolateral prefrontal cortex (DLPFC). This study investigated the biochemistry and function of DLPFC in 38 healthy individuals during placebo analgesia. The results showed that the concentration of glutamate in DLPFC was inversely correlated with pain rating variability, and there was altered functional connectivity between DLPFC and the midbrain periaqueductal gray. These findings suggest that DLPFC is involved in formulating stimulus-response relationships during conditioning and translating them into altered cortico-brainstem functional relationships for placebo analgesia expression.
Article
Neurosciences
Joe A. Braun, Mariya Patel, Luke A. Henderson, Tye Dawood, Vaughan G. Macefield
Summary: We recently demonstrated that transcranial alternating current stimulation of the dorsolateral prefrontal cortex can modulate muscle sympathetic nerve activity, heart rate, and blood pressure. In this study, we tested the effects of stimulation on the ventromedial prefrontal cortices and found partial entrainment of muscle sympathetic nerve activity, as well as modulation of blood pressure and heart rate. Stimulation of the left ventromedial prefrontal cortices resulted in a significant decrease in mean blood pressure.
