Review
Clinical Neurology
Ajith Malige, Andrew Kantzos, Gbolabo O. Sokunbi
Summary: The study aimed to investigate the impact of structural thoracic deformities on the outcomes of permanent spinal cord stimulator placement. The findings suggested that the presence of mild structural deformities does not negatively affect the effectiveness of permanent SCS placement, indicating that this population should not be excluded from benefiting from such therapies.
Article
Clinical Neurology
Alan H. Daniels, Wesley M. Durand, Alyssa J. Steinbaum, Renaud Lafage, D. Kojo Hamilton, Peter G. Passias, Han Jo Kim, Themistocles Protopsaltis, Virginie Lafage, Justin S. Smith, Christopher Shaffrey, Munish Gupta, Eric O. Klineberg, Frank Schwab, Jeffrey L. Gum, Gregory Mundis, Robert Eastlack, Khaled Kebaish, Alex Soroceanu, Richard A. Hostin, Doug Burton, Shay Bess, Christopher Ames, Robert A. Hart
Summary: This study aimed to investigate the outcomes of patients undergoing ASD surgery with prior use of SCS or ITP. The results showed that the risk of complications was not significantly higher in patients receiving SCS or ITP, and there were no significant differences in health-related quality of life before and after surgery compared to patients who did not receive these treatments.
Review
Anesthesiology
Jo Ann Shoup, JoEllen Welter, Ingrid A. Binswanger, Florian Hess, Alexander Dullenkopf, Jennifer Coker, Jeffrey Berliner
Summary: This scoping review analyzed research findings on the use of prescription opioids in patients with spinal cord injury (SCI), identifying a lack of information on income, ethnicity, and race in most studies. Risk factors for opioid use in chronic SCI included middle age, lower income, osteoarthritis diagnosis, prior opioid use, and lower-level spinal injury.
Article
Medicine, Research & Experimental
Eris Spirollari, Sima Vazquez, Christina Ng, Alexandria F. Naftchi, Gillian Graifman, Ankita Das, Jacob D. Greisman, Jose F. Dominguez, Merritt D. Kinon, Vishad V. Sukul
Summary: The study aims to understand the demographics, clinical characteristics, and utilization patterns of open and percutaneous SCS procedures. The results showed that patients who underwent open SCS placement were older, predominantly Caucasian, and had longer hospital stays and more implant-related complications.
Article
Clinical Neurology
Marcus Romaniuk, Giyth Mahdi, Rohin Singh, Jack Haglin, Nolan J. Brown, Oren Gottfried
Summary: This study evaluates the monetary and procedural trends of spinal cord stimulators in the Medicare database from 2000 to 2019.
WORLD NEUROSURGERY
(2022)
Review
Neurosciences
Alexandra Tinnermann, Christian Buechel, Julien Cohen-Adad
Summary: Functional magnetic resonance imaging has been used to investigate pain perception in both health and disease, with recent developments allowing for simultaneous recording of neural activity in the brain and spinal cord. However, challenges remain in data acquisition and analysis strategies for this promising technique.
Article
Rheumatology
Ian C. Scott, James Bailey, Chris White, Christian D. Mallen, Sara Muller
Summary: This study found that opioid prescribing is common in the management of inflammatory arthritis (IA) pain, despite limited evidence of efficacy and potential harms.
Article
Biology
Alexandra Tinnermann, Christian Sprenger, Christian Buechel
Summary: This study investigated the effects of the opioid remifentanil on healthy male participants using combined corticospinal functional MRI. The results showed that opioids altered activity in regions involved in pain processing and pain modulation and coupling strength could differentiate between opioid analgesia and unspecific reductions in pain.
Article
Clinical Neurology
Ian Robertson, Daniel I. Rhon, Julie M. Fritz, Alexander Velosky, Bryan K. Lawson, Krista B. Highland
Summary: This study aimed to characterize factors associated with prescribing variation of opioids, non-opioid pain medications, and benzodiazepines in the US Military Health System. It found significant variation in factors such as procedure type, policy period, and medication receipt, highlighting the need for evidence-based interventions.
Article
Surgery
Jessica C. Young, Nabarun Dasgupta, Brooke A. Chidgey, Michele Jonsson Funk
Summary: This study aimed to evaluate the risk of long-term opioid therapy after surgery among an opioid-naive population using different cutoffs based on days supplied, total morphine milligram equivalents, and quantity of pills dispensed. The results showed that patients receiving larger volumes of opioids had a higher risk of long-term opioid therapy.
Article
Clinical Neurology
Thomas Ragukonis
Summary: This case series aimed to investigate adverse events associated with off-label MRI use in patients with implanted SCSs. The results showed a low rate of adverse events related to off-label MRI use with no serious adverse events reported.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Laura Agullo, Isidro Aguado, Javier Muriel, Cesar Margarit, Alba Gomez, Monica Escorial, Astrid Sanchez, Alicia Fernandez, Ana M. Peiro
Summary: Variability in analgesic response due to genetic polymorphisms can be reduced through genotype-guided opioid prescribing. This study found that genotype-guided treatment led to improved pain relief, increased quality of life, and reduced adverse events and opioid dose in chronic pain patients. The findings suggest that implementing genotype-guided treatment could have positive clinical and economic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Stuart H. Hershman
Summary: Orthopaedic surgeons should have a basic understanding of the function of spinal cord stimulators and intrathecal pain pumps, as they may encounter patients with these devices and need to manage potential complications and perioperative considerations. Referral for spine surgery may be necessary due to residual stenosis or deformity contributing to symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Medicine, General & Internal
Sebastiano Mercadante, Augusto Caraceni, Arturo Cuomo, Massimo Mammucari, Paolo Marchetti, Rocco Domenico Mediati, Silvia Natoli, Giuseppe Tonini
Summary: After one-month follow-up, cancer patients experienced a lower number of breakthrough pain episodes and peak intensity, potentially due to optimization of background analgesia. The principal characteristics of breakthrough pain did not change significantly, highlighting the importance of careful and continuous assessment for patients to alleviate the burden induced by breakthrough pain episodes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Kim J. Blomqvist, Moritz O. B. Skogster, Mika J. Kurkela, Marko P. Rosenholm, Fredrik H. G. Ahlstro, Mikko T. Airavaara, Janne T. Backman, Pekka V. Rauhala, Eija A. Kalso, Tuomas O. Lilius
Summary: The blood-brain barrier limits drug delivery to the central nervous system, but the glymphatic system provides a route for drugs to reach deep brain structures. This study found that hyperosmotic interventions can enhance the delivery of intrathecally administered morphine to the spinal cord, improving its efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Orthopedics
Cody C. Wyles, Mario Hevesi, Eleanor R. Trousdale, Daniel S. Ubl, Halena M. Gazelka, Elizabeth B. Habermann, Robert T. Trousdale, Mark W. Pagnano, Tad M. Mabry
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2019)
Article
Medicine, General & Internal
Matthew J. Ziegelmann, Jason P. Joseph, Amy E. Glasgow, Mark D. Tyson, Raymond W. Pak, Halena M. Gazelka, Ashton L. Schatz, Bradley C. Leibovich, Elizabeth B. Habermann, Matthew T. Gettman
MAYO CLINIC PROCEEDINGS
(2019)
Review
Medicine, General & Internal
Tim J. Lamer, Susan M. Moeschler, Halena M. Gazelka, W. Michael Hooten, Markus A. Bendel, M. Hassan Murad
MAYO CLINIC PROCEEDINGS
(2019)
Article
Anesthesiology
Thomas P. Pittelkow, Jonathan M. Hagedorn, Markus A. Bendel, Jason S. Eldrige, Matthew J. Pingree, W. David Mauck, Halena M. Gazelka, Tim J. Lamer, Rebecca A. Sanders, Heather A. Billinges, Susan M. Moeschler
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2020)
Article
Anesthesiology
Jonathan Michael Hagedorn, Thomas Pittelkow, Nafisseh Warner, Timothy Furnish, Scott Brancolini, Darrell R. Schroeder, Halena Gazelka, Susan Moeschler
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2019)
Article
Surgery
Matthew Ziegelmann, Jason Joseph, Amy Glasgow, Mark Tyson, Raymond Pak, Halena Gazelka, Bradley Leibovich, Elizabeth Habermann, Matthew Gettman
AMERICAN JOURNAL OF SURGERY
(2020)
Review
Medicine, General & Internal
Nafisseh S. Warner, Matthew A. Warner, Julie L. Cunningham, Halena M. Gazelka, W. Michael Hooten, Bhanu Prakash Kolla, David O. Warner
MAYO CLINIC PROCEEDINGS
(2020)
Review
Hematology
Holly L. Geyer, Halena Gazelka, Ruben Mesa
Review
Medicine, General & Internal
Halena M. Gazelka, Janette C. Leal, Maria I. Lapid, Teresa A. Rummans
MAYO CLINIC PROCEEDINGS
(2020)
Article
Medicine, General & Internal
Halena M. Gazelka, Casey M. Clements, Julie L. Cunningham, Holly L. Geyer, Jenna K. Lovely, Cheri L. Olson, Lindsey M. Philpot, Steven B. Porter, Terrence J. Witt, Kathryn W. Zavaleta, Elizabeth B. Habermann
MAYO CLINIC PROCEEDINGS
(2020)
Article
Medicine, General & Internal
Nafisseh S. Warner, Dawn Finnie, David O. Warner, W. Michael Hooten, Karen F. Mauck, Julie L. Cunningham, Halena Gazelka, Mohamad Bydon, Paul M. Huddleston, Elizabeth B. Habermann
MAYO CLINIC PROCEEDINGS
(2020)
Article
Medicine, General & Internal
Nafisseh S. Warner, Elizabeth B. Habermann, W. Michael Hooten, Andrew C. Hanson, Darrell R. Schroeder, Jennifer L. St Sauver, Paul M. Huddleston, Mohamad Bydon, Julie L. Cunningham, Halena M. Gazelka, David O. Warner
Article
Clinical Neurology
Ronan J. Doherty, Waseem Wahood, Yagiz U. Yolcu, Jad Zreik, Anshit Goyal, Halena M. Gazelka, Elizabeth B. Habermann, Arjun Sebastian, Mohamad Bydon
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Review
Medicine, General & Internal
Edward C. Covington, Charles E. Argoff, Jane C. Ballantyne, Penney Cowan, Halena M. Gazelka, W. Michael Hooten, Stefan G. Kertesz, Ajay Manhapra, Jennifer L. Murphy, Steven P. Stanos, Mark D. Sullivan
MAYO CLINIC PROCEEDINGS
(2020)
Review
Medicine, General & Internal
Michael J. O'Rourke, Maureen C. Keshock, Christine E. Boxhorn, Darin J. Correll, Avital Y. O'Glasser, Halena M. Gazelka, Richard D. Urman, Karen Mauck
Summary: There is a lack of guidelines for preoperative dosing of opioid and nonopioid pain medications for surgical patients, but the Society for Perioperative Assessment and Quality Improvement has developed consensus recommendations in this area to improve patient care.
MAYO CLINIC PROCEEDINGS
(2021)