Article
Medicine, General & Internal
Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Livia Caroline Machado da Silva, Gisele Vieira Hennemann Koury, Emanuel de Jesus Sousa, Antonio Jose Cerasi Jr, Givago Silva Souza, Juarez Antonio Simoes Quaresma, Luiz Fabio Magno Falcao
Summary: Determining the characteristics, type, and severity of olfactory dysfunction in patients with long COVID is crucial. This study aimed to describe the socio-demographic and clinical features of patients with persistent olfactory dysfunction. The results showed that olfactory dysfunction is one of the most common long-term neurological symptoms of COVID-19, and patients with this condition may experience severe hyposmia or anosmia for more than 1 year from the onset of symptoms.
Article
Neurosciences
Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Thalita da Rocha Bastos, Arthur Nascimento Rodrigues, Karem Harumy Yamamoto Santana, Lorena Henriete Araujo Dias, Lidiane Palheta Miranda dos Santos, Antonio Jose Cerasi, Michely Caroline Nascimento Mendes, Cleiziane Lima de Oliveira, Mariangela Moreno Domingues, Gisele Vieira Hennemann Koury, Pedro Fernando da Costa Vasconcelos, Givago Silva Souza, Juarez Antonio Simoes Quaresma, Luiz Fabio Magno Falcao
Summary: Poor sleep quality is commonly reported in patients with long COVID. Understanding the characteristics, severity, and relationship of long COVID with other neurological symptoms is crucial for prognosis and management of sleep quality.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Allergy
Alfred B. Addison, Billy Wong, Tanzime Ahmed, Alberto Macchi, Iordanis Konstantinidis, Caroline Huart, Johannes Frasnelli, Alexander W. Fjaeldstad, Vijay R. Ramakrishnan, Philippe Rombaux, Katherine L. Whitcroft, Eric H. Holbrook, Sophia C. Poletti, Julien W. Hsieh, Basile N. Landis, James Boardman, Antje Welge-Lussen, Devina Maru, Thomas Hummel, Carl M. Philpott
Summary: Through systematic review and expert discussion, members of the Clinical Olfactory Working Group overwhelmingly recommended olfactory training as a management option for postinfectious olfactory dysfunction, while no one recommended the use of monocycline antibiotics. The diagnostic role of oral steroids was discussed, with some group members in favor of vitamin A drops as a treatment option. Further research is needed to confirm the efficacy of other therapeutic options.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
Kristi Biswas, Vijay R. Ramakrishnan, Elisabeth Hollemann, Korinna Lorenz, Brett Wagner Mackenzie, Daniel N. Frank, Richard G. Douglas, Thomas Hummel
Summary: Bacterial composition is consistent in the sinuses of patients with postviral olfactory dysfunction. PVOD patients show a significant reduction in the genus Corynebacterium compared to controls.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Medicine, General & Internal
Min Young Seo, Won Suk Choi, Seung Hoon Lee
Summary: This study found that the subjective olfactory function significantly decreased in COVID-19 patients with olfactory dysfunction, but the objective olfactory function was not significantly different. 70% of patients recovered their olfactory function after 2 months of olfactory training.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Otorhinolaryngology
Laiquan Zou, Antje Haehner, Susanne Menzel, Nadine Gunder, Thomas Hummel
Summary: This study validated the reliability and validity of the brief version of Questionnaire of Olfactory Disorders (brief QOD) and demonstrated its suitability for assessing the subjective severity of olfactory dysfunction. It is important for purposes such as treatment counseling, disability assessment, treatment control, and research in patients with olfactory disorder.
Article
Multidisciplinary Sciences
Jonas K. Olofsson, Fredrik Ekesten, Steven Nordin
Summary: Parosmia, a distorted smell sensation, is a common outcome of respiratory virus infections. This study found that parosmia experiences are prevalent in the population and can persist for some individuals for several years, but they are mostly benign and do not significantly impact quality of life.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Lisa O'Byrne, Katie E. Webster, Samuel MacKeith, Carl Philpott, Claire Hopkins, Martin J. Burton
Summary: There is limited evidence on the efficacy and harms of treatments for persistent olfactory dysfunction following COVID-19 infection. Ongoing trials are being identified for further research and the living systematic review will continue to update regularly. Only one small study has been identified in this first version of the living review, and the benefits and harms of the intervention are very uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Vincenzo Bochicchio, Selene Mezzalira, Nelson Mauro Maldonato, Elena Cantone, Cristiano Scandurra
Summary: This study aimed to assess the association between different dimensions of olfactory dysfunction and psychological distress in people diagnosed with COVID-19. The results showed that impairment in olfactory quality of life was associated with psychological distress. This suggests a strong link between mood, perceived quality of life, and olfactory functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Elisa Cancian, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Philippe Robert, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: This study evaluated the efficacy of olfactory training (OT) on persistent post-viral olfactory disorders (PPVOD) after COVID-19 infection. The results showed that OT led to improvements in olfactory function and quality of life in patients with PPVOD. However, further research is needed to confirm the role of OT and explore new therapeutic strategies for the central aspects of PPVOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Luigi Angelo Vaira, Claudia Gessa, Giovanna Deiana, Giovanni Salzano, Fabio Maglitto, Jerome R. Lechien, Sven Saussez, Pasquale Piombino, Andrea Biglio, Federico Biglioli, Paolo Boscolo-Rizzo, Claire Hopkins, Valentina Parma, Giacomo De Riu
Summary: Persistent olfactory and gustatory dysfunctions are common symptoms of long-COVID-19 syndrome and significantly impact the mental health component of patients' quality of life.
Article
Virology
Emilia Cancellieri, Anna Kristina Hernandez, Helena Degkwitz, Elisabeth Kahre, Judith Blankenburg, Theresa S. S. Horst, Paula Czyborra, Paolo Boscolo-Rizzo, Thomas Hummel
Summary: This cross-sectional study investigated self-rated olfactory dysfunction in individuals with a history of COVID-19 infection and its relation to measured olfactory function after recovery. No significant differences in odor threshold and adult identification scores were found between recovery classes, but children with incomplete recovery had lower identification scores. Pediatric age groups had higher self-rated olfactory dysfunction during and after COVID-19 compared to older participants. The presence of parosmia was associated with incomplete recovery of olfaction after COVID-19.
Article
Surgery
Miles J. Pfaff, Anthony A. Bertrand, Kelsey J. Lipman, Aloukika Shah, Ian Nolan, Vikram Krishna, Harsh Patel, Jason Roostaeian, Justine C. Lee
Summary: Functional and aesthetic nasal operations significantly improve olfaction, which is directly correlated with nasal airflow and quality of life. Some studies report a transient worsening of these measures in the immediate postoperative period, which subsequently improved at later time points.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Wei Fu, Linxin Xu, Qiwen Yu, Jiajia Fang, Guohua Zhao, Yi Li, Chenying Pan, Hao Dong, Di Wang, Haiyan Ren, Yi Guo, Qingjun Liu, Jun Liu, Xing Chen
Summary: This study proposes an artificial intelligent olfactory (AIO) system for the diagnosis of Parkinson's disease (PD) through smell. The results show that analyzing the odor profile can accurately distinguish PD patients from healthy controls, which is helpful for further tracking and monitoring the treatment process.
Article
Otorhinolaryngology
Anna Oleszkiewicz, Laura Bottesi, Michal Pieniak, Shuji Fujita, Nadejda Krasteva, Gabriele Nelles, Thomas Hummel
Summary: This study found that performing OT twice a day was more effective in supporting olfactory rehabilitation and interventions targeted to verbal semantic fluency, especially in subjects with lower baseline scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
