Journal
RHEUMATOLOGY INTERNATIONAL
Volume 34, Issue 8, Pages 1037-1045Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-014-2993-3
Keywords
Autoimmunity; Renal physiology; Acid-base balance
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Renal acid-base homeostasis is a complex process, effectuated by bicarbonate reabsorption and acid secretion. Impairment of urinary acidification is called renal tubular acidosis (RTA). Distal renal tubular acidosis (dRTA) is the most common form of the RTA syndromes. Multiple pathophysiologic mechanisms, each associated with various etiologies, can lead to dRTA. The most important consequence of dRTA is (recurrent) nephrolithiasis. The diagnosis is based on a urinary acidification test. Potassium citrate is the treatment of choice.
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