Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

Infliximab Reduces the Frequency of Interleukin 17-Producing Cells and the Amounts of Interleukin 17 in Patients With Rheumatoid Arthritis

(2016) Hui Shen et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway

(2012) Saba Alzabin et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

(2012) Jenny L. McGovern et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis

(2012) Junwei Chen et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62LloFoxP3+CD4+ T cells with limited suppressor activity

(2011) Kevin S. Goudy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combined Treatment of Etanercept and MTX Reverses Th1/Th2, Th17/Treg Imbalance in Patients with Rheumatoid Arthritis

(2011) Chen Lina et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Disturbed Th17/Treg balance in patients with rheumatoid arthritis

(2011) Qian Niu et al.   RHEUMATOLOGY INTERNATIONAL

The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis

(2011) Wenhong Wang et al.   RHEUMATOLOGY INTERNATIONAL

Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy

(2011) Der-Yuan Chen et al.   ARTHRITIS RESEARCH & THERAPY

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs

(2010) J. S. Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production

(2010) J. P. van Hamburg et al.   ARTHRITIS AND RHEUMATISM

Therapeutic efficacy of experimental rheumatoid arthritis with low-dose methotrexate by increasing partially CD4+CD25+Treg cells and inducing Th1 to Th2 shift in both cells and cytokines

(2010) Song Xinqiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cytokines and Regulatory T Cells in Rheumatoid Arthritis and Their Relationship with Response to Corticosteroids

(2010) B. de PAZ et al.   JOURNAL OF RHEUMATOLOGY

Alterations in Cytokine Profile and Dendritic Cells Subsets in Peripheral Blood of Rheumatoid Arthritis Patients before and after Biologic Therapy

(2009) Luciana Marti et al.   Annals of the New York Academy of Sciences

Alterations of the CD4+, CD8+ T Cell Subsets, Interleukins-1β, IL-10, IL-17, Tumor Necrosis Factor-α and Soluble Intercellular Adhesion Molecule-1 in Rheumatoid Arthritis and Osteoarthritis: Preliminary Observations

(2009) Mahmoud R. Hussein et al.   PATHOLOGY & ONCOLOGY RESEARCH

The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients

(2009) Cai Yue et al.   RHEUMATOLOGY INTERNATIONAL

Anti‐inflammatory effects of atorvastatin on peripheral blood mononuclear cells and synovial fibroblasts in rheumatoid arthritis

(2009) S. Blaschke et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies

(2009) Ellen M Moran et al.   ARTHRITIS RESEARCH & THERAPY

CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis

(2008) Guang Ming Han et al.   CELLULAR IMMUNOLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA