Article
Neurosciences
Guanghai Zhao, Yongqiang Shi, Chaoyang Gong, Taicong Liu, Wei Nan, Lin Ma, Zuolong Wu, Chaoming Da, Kaisheng Zhou, Haihong Zhang
Summary: The research demonstrated that curcumin attenuates cancer-induced bone pain by producing significant analgesic activity and promoting the release of beta-endorphin and enkephalin in primary cultured rat dorsal root ganglion neurons. The analgesic effect of curcumin may be mediated by the up-regulation of proopiomelanocortin (Pomc) expression in DRG neurons.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Plant Sciences
Xishan Bai, Yanhong Li, Yuxiao Li, Min Li, Ming Luo, Kai Tian, Mengyuan Jiang, Yong Xiong, Ya Lu, Yukui Li, Haibo Yu, Xiangzhong Huang
Summary: This study found that doliroside B (DB) and its disodium salt (DBDS) can be used to treat pain by inhibiting COX-1 activity and reducing the production of NO, iNOS, and IL-6, exerting anti-inflammatory and neuroprotective effects.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Ke Wang, Yue Yong, Jia Zhou, Wen-xiong Zhou, Jun Guo, Tong-yu Chen
Summary: Surgical trauma decreased MOR gene expression in the thymus and dorsal root ganglia, but electroacupuncture treatment attenuated MOR expression in the thymus and increased DOR and KOR expression. Additionally, electroacupuncture significantly increased T cell populations in peripheral blood.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hongguang Ma, Mengchu Li, Piyusha P. Pagare, Huiqun Wang, Nima Nassehi, Edna J. Santos, S. Stevens Negus, Dana E. Selley, Yan Zhang
Summary: This study synthesized a series of bivalent ligands to investigate the functional interactions between opioid and chemokine receptors. Compound 1a showed promising antinociceptive effect and may serve as a novel chemical probe for developing more potent bivalent ligands for chronic pain management.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ying-Ting Hsu, Shen-Ren Chen, Yung-Chiao Chang, Hsiao-Fu Chang, Teng-Kuang Yeh, Jian-Ying Chuang, Horace H. Loh, Hsing-Pang Hsieh, Shau-Hua Ueng, Shiu-Hwa Yeh
Summary: The demand for a non-addictive analgesic medication is increasing due to clinical misuse. Compound 14 is a dual agonist of the mu opioid receptor (MOR) and nociceptin-orphanin FQ opioid peptide (NOP) receptor, providing pain relief at very small doses and reducing unwanted side effects. Evaluating its effects in wild type and humanized mice can help develop a safer prescription analgesic drug.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zachary W. Reichenbach, Kelly DiMattio, Suren Rajakaruna, David Ambrose, William D. Cornwell, Ronald J. Tallarida, Thomas Rogers, Lee-Yuan Liu-Chen, Ronald F. Tuma, Sara Jane Ward
Summary: Non-selective cannabinoid (CB) agonists can enhance the analgesic effects of morphine but inhibit its antinociceptive tolerance. Activation of CB2 receptors can reverse allodynia and hyperalgesia in chronic pain models, and co-administration of CB2 receptor selective agonists with morphine can synergistically enhance the effects. However, the interactions between CB2 receptor selective agonist O-1966 and morphine depend on the order of administration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Weiming Wang, Yan Liu, Xiaofang Yang, Jianhua Sun, Zenghui Yue, Dianrong Lu, Kehua Zhou, Yuanjie Sun, Aihua Hou, Zhiwei Zang, Xiaoqing Jin, Chao Liu, Yuhang Wang, Jinna Yu, Lili Zhu, Zhishun Liu
Summary: This randomized clinical trial found that 8-week EA treatment could increase weekly SBMs with a good safety profile and improve quality of life for the treatment of OIC. Electroacupuncture provided an alternative option for OIC in adult patients with cancer.
Article
Pharmacology & Pharmacy
Xin Wang, Xiaoli Gou, Xiaojuan Yu, Dongdong Bai, Bowei Tan, Pingfeng Cao, Meilin Qian, Xiaoxiao Zheng, Hairong Wang, Pingming Tang, Chen Zhang, Fei Ye, Jia Ni
Summary: Kappa opioid receptor (KOR) agonists have potential for pain relief and treating pruritus, but their development is hindered by sedation, dysphoria and diuresis. The study on HSK21542 showed it to be a selective and potent KOR agonist with peripheral selectivity, providing a safe and effective alternative for patients suffering from pain and pruritus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Michael J. Wedemeyer, Elaine M. Jennings, Hudson R. Smith, Teresa S. Chavera, Raehannah J. Jamshidi, Kelly A. Berg, William P. Clarke
Summary: The study identified that the scaffolding protein 14-3-3 gamma plays a crucial role in long-term inhibition of KOR in peripheral sensory neurons, and knocking down 14-3-3 gamma can eliminate this inhibitory effect, providing further evidence of its importance in analgesia.
Article
Medicine, Research & Experimental
Maria Guadalupe Valle-Dorado, Alberto Hernandez-Leon, Andres Nani-Vazquez, Guadalupe Esther Angeles-Lopez, Maria Eva Gonzalez-Trujano, Rosa Ventura-Martinez
Summary: The study found that the ethanolic and aqueous extracts of Mansoa alliacea exhibited antinociceptive effects in mice, possibly acting through opioid receptors and nitric oxide production.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Josue Jaramillo-Polanco, Cintya Lopez-Lopez, Yang Yu, Emma Neary, Alan Hegron, Meritxell Canals, Nigel W. Bunnett, David E. Reed, Alan E. Lomax, Stephen J. Vanner
Summary: This study found that chronic high-dose opioid exposure leads to opioid-induced hyperalgesia (OIH) in the gastrointestinal tract, which is mediated by DOPr signaling and dependent on receptor endocytosis and protein kinase C signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Licet Caridad Mena-Valdes, Yisel Blanco-Hernandez, Josue Vidal Espinosa-Juarez, Francisco Javier Lopez-Munoz
Summary: The study demonstrated that in a neuropathic pain model, haloperidol enhanced the analgesic effect of morphine, delayed the development of morphine tolerance, and did not show significant adverse effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shijia Liu, Dong-Il Kim, Tae Gyu Oh, Gerald M. Pao, Jong-Hyun Kim, Richard D. Palmiter, Matthew R. Banghart, Kuo-Fen Lee, Ronald M. Evans, Sung Han
Summary: Neurons expressing the mu-opioid receptor within the lateral parabrachial nucleus play a crucial role in opioid-induced respiratory depression (OIRD). Chemogenetic modulation of these neurons can rescue respiratory rhythms and serve as a potential therapeutic target for treating OIRD in patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Haiyan Wang, Min Huang, Wenying Wang, Yu Zhang, Xiaqing Ma, Limin Luo, Xiaotao Xu, Liang Xu, Haibo Shi, Yongming Xu, Aizhong Wang, Tao Xu
Summary: The study revealed that microglial TLR4 regulates TAK1 expression and phosphorylation, leading to NLRP3 activation that contributes to neuroinflammation and the development of morphine tolerance. Targeting TLR4-TAK1-NLRP3 signaling may offer alternative therapeutic strategies for chronic morphine-induced antinociceptive tolerance.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Sin Yin Lim, Pelin Cengiz
Summary: Opioid use for pain relief can lead to tolerance and hyperalgesia. There is a need for strategies to mitigate these effects. The BDNF-TrkB signaling pathway shows promise in reducing opioid tolerance and hyperalgesia.