Review
Immunology
Maurizio Cutolo, Stefano Soldano, Alberto Sulli, Vanessa Smith, Emanuele Gotelli
Summary: Vitamin D, a steroid hormone, has complex influences on the immune system and may affect various clinical conditions. Its serum concentrations fluctuate seasonally due to UV-B exposure, and low levels of 25OHD are implicated in the pathogenesis and clinical manifestations of diseases like rheumatoid arthritis and systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Michael Koutsilieris, Yehuda Shoenfeld
Summary: Vitamin D is a steroid hormone that has potent immune-modulating properties. Research has shown that vitamin D deficiency may be related to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. It may also play a role in the pathogenesis of these diseases.
Review
Biochemistry & Molecular Biology
Nipith Charoenngam
Summary: Vitamin D plays a crucial role in maintaining skeletal and immune health, and research has shown an association between vitamin D levels and rheumatic diseases. However, the specific benefits of vitamin D supplements for treating and preventing rheumatic diseases are still debated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tian-Ping Zhang, Hong-Miao Li, Qian Huang, Li Wang, Xiao-Mei Li
Summary: The study revealed that genetic variations in CYP2R1 and CYP27B1 were associated with the genetic background of rheumatoid arthritis (RA), while altered methylation levels of VDR and CYP27B1 were related to the risk of RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaoyu Xu, Hongyu Luo, Qian Chen, Zikang Wang, Xixuan Chen, Xiaping Li, Huan Chen, Miao Wang, Yingyue Xu, Min Dai, Jianwei Wang, Xuekuan Huang, Bin Wu, Yanping Li
Summary: This study used network pharmacology and molecular docking to explore the mechanism of vitamin D in rheumatoid arthritis (RA). The results showed that vitamin D plays a vital role in treating RA by regulating cell proliferation, immune response, apoptotic process, and the nuclear factor-kappa B (NF-κB) signalling pathway. ALB, TNF, CASP3, and TP53 may be important punctuation points or diagnostic markers for future RA treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Maciej K. Stawicki, Adrian Goralczyk, Justyna Mlynczyk, Anna Kondratiuk, Jerzy Konstantynowicz
Summary: This study evaluated the prevalence of vitamin D deficiency in children with juvenile idiopathic arthritis (JIA) and found that vitamin D deficiency is independent of disease activity or inflammatory markers. However, MTX treatment may lead to inadequate vitamin D levels. Therefore, vitamin D supplementation should be considered for all children receiving long-term MTX therapy.
Article
Agriculture, Multidisciplinary
Dongdong Zhang, Xiaoqin Zhong, Cheng Cheng, Zhiwei Su, Yuan Xue, Yaping Liu, Yujing Zhang, Mingming Feng, Ze Xu, Tong Zhao, Luoya Zhang, Haoyue Huang, Wenjie Li, Xing Li
Summary: The potential role of vitamin D in beta-cell function is still debated. A randomized, placebo-controlled trial was conducted to investigate the effect of vitamin D and calcium supplementation on beta-cell function in a Chinese population with prediabetes. The results showed that oral administration of vitamin D and calcium increased insulin secretion. Vitamin D-insufficient individuals had improved glucose tolerance after treatment with vitamin D + calcium. Further research is needed to confirm these findings. Given the low vitamin D content in natural foods, fortification of processed foods with vitamin D is necessary.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Regina Sakalyte, Jaroslav Denkovskij, Eiva Bernotiene, Sigita Stropuviene, Silvija Ona Mikulenaite, Giedrius Kvederas, Narunas Porvaneckas, Vytautas Tutkus, Algirdas Venalis, Irena Butrimiene
Summary: This study investigated the expression and secretion of activated rheumatoid arthritis synovial fibroblasts and their correlation with rheumatoid arthritis and other forms of arthritis. The results showed that NLRP3 was associated with inflammatory activation, and vitamin D may have a protective effect on inflammatory responses. Inflammatory responses may also be age-related.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Isabel Cardoso, Ina Olmer Specht, Fanney Thorsteinsdottir, Marta Jadwiga Thorbek, Amelie Keller, Maria Stougaard, Arieh S. Cohen, Mina Nicole Handel, Lars Erik Kristensen, Berit Lilienthal Heitmann
Summary: The study found that vitamin D concentrations at birth were not associated with the risk of developing rheumatoid arthritis in early adulthood.
Article
Surgery
Pichit Sittitrai, Donyarat Ruenmarkkaew, Hanpon Klibngern, Tapanut Ariyanon, Nutthiya Hanprasertpong, Somkamon Boonyaprapa, Maysayawan Sreesawat
Summary: This study evaluated the efficacy of perioperative and postoperative calcium and vitamin D supplementation in reducing symptomatic hypocalcemia. The results showed that perioperative supplementation significantly decreased the occurrence of symptomatic hypocalcemia and shortened the recovery period, while there were no significant differences in other indicators between the two groups.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Sneha Verma, Ved Chaturvedi, N. K. Ganguly, Shivani Arora Mittal
Summary: Vitamin D plays an important role in regulating the immune system and its deficiency is associated with immune-related diseases. Studies have found lower levels of Vitamin D to be associated with diseases like Rheumatoid Arthritis and COVID-19, although contrasting data exists.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Immunology
Tavitiya Sudjaritruk, Torsak Bunupuradah, Linda Aurpibul, Suparat Kanjanavanit, Tawalchaya Chotecharoentanan, Natthanidnan Sricharoen, Pradthana Ounchanum, Piyarat Suntarattiwong, Krittaporn Pornpaisalsakul, Thanyawee Puthanakit
Summary: Among Thai adolescents with perinatally acquired HIV, high-dose vitamin D and calcium supplementation significantly increased lumbar spine bone mineral density and promoted bone health.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jill Hahn, Nancy R. Cook, Erik K. Alexander, Sonia Friedman, Joseph Walter, Vadim Bubes, Gregory Kotler, I-Min Lee, JoAnn E. Manson, Karen H. Costenbader
Summary: Vitamin D supplementation for five years, with or without omega 3 fatty acids, reduced autoimmune disease by 22%, while omega 3 fatty acid supplementation with or without vitamin D reduced the autoimmune disease rate by 15% (not statistically significant). Both treatment arms showed larger effects than the reference arm (vitamin D placebo and omega 3 fatty acid placebo).
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Chemistry, Medicinal
Mona Maddahi, Elyas Nattagh-Eshtivani, Mohammadhassan Jokar, Mehdi Barati, Hamed Tabesh, Mohammad Safarian, Maryam Khosravi
Summary: This study aimed to evaluate the effects of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis. The results of a randomized, double-blind, placebo-controlled clinical trial showed that propolis supplementation significantly reduced cardiovascular risk factors and could be a promising treatment strategy for cardiovascular complications among rheumatoid arthritis patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Rheumatology
Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G. S. Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M. R. Pereira, Clovis Artur Silva, Nadia Emi Aikawa, Eloisa Bonfa
Summary: This study evaluated the effect of discontinuing methotrexate (MTX) for 2 weeks after each dose of the Sinovac-CoronaVac vaccine on immunogenicity and safety in patients with rheumatoid arthritis (RA). The results showed that the group that discontinued MTX had a higher rate of seroconversion and higher antibody titers compared to the group that continued MTX. However, there was an increased risk of flare after the second MTX withdrawal.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Oncology
Rita Peila, Mace Coday, Tracy E. Crane, Nazmus Saquib, Aladdin H. Shadyab, Fred K. Tabung, Xiochen Zhang, Jean Wactawski-Wende, Thomas E. Rohan
Summary: This study found that a healthy lifestyle is associated with a reduced risk of pancreatic cancer in postmenopausal women.
CANCER CAUSES & CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Rheumatology
Gregg E. Dinse, Christine G. Parks, Clarice R. Weinberg, Caroll A. Co, Jesse Wilkerson, Darryl C. Zeldin, Edward K. L. Chan, Frederick W. Miller
Summary: This study found a significant increase in the prevalence of antinuclear antibodies (ANA) in the US in recent years. The increase was more pronounced in adolescents, men, older adults, and non-Hispanic white individuals. These increases could not be explained by changes in weight, smoking, or alcohol consumption.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Oncology
Vicky C. Chang, Gabriella Andreotti, Maria Ospina, Christine G. Parks, Danping Liu, Joseph J. Shearer, Nathaniel Rothman, Debra T. Silverman, Dale P. Sandler, Antonia M. Calafat, Laura E. Beane Freeman, Jonathan N. Hofmann
Summary: This study investigated the association between glyphosate exposure and urinary oxidative stress biomarkers in farmers. The results showed that urinary glyphosate concentrations were positively associated with levels of oxidative stress biomarkers, such as 8-OHdG and MDA. The findings support the association between glyphosate exposure and oxidative stress in humans.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Rheumatology
Christine G. Parks, Mary Pettinger, Anneclaire J. de Roos, Hilary A. Tindle, Brian T. Walitt, Barbara V. Howard
Summary: Objective: This study examines the association between psychosocial stressors and the development of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in postmenopausal women. Methods: The study analyzes data from the Women's Health Initiative Observational Study cohort, including information on stressful life events, caregiving, and social support. Results: The findings indicate that reporting multiple life events, experiencing abuse, interpersonal events, financial stress, and providing caregiving are associated with an increased risk of developing RA or SLE.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Environmental Sciences
Christine G. Parks, Darya Leyzarovich, Shelly-Ann Love, Stuart Long, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler
Summary: This study found that high levels of pesticide exposure may increase the risk of shingles in elderly pesticide applicators.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Christine G. Parks, Lauren E. Wilson, Michela Capello, Kevin D. Deane, Samir M. Hanash
Summary: Autoantibodies to tumor-associated antigens (anti-TAA) have the potential to be biomarkers for breast cancer. However, their relationship with systemic autoimmunity as measured by antinuclear antibodies (ANA) is unclear. This study aims to investigate the relationship between anti-TAAs and ANA among women with and without breast cancer.