Article
Medicine, General & Internal
Xin Wu, Jia-Yun Zhong, Geng Wang, Hu-Ji Xu
Summary: The proportion of abnormal bone mass in AS patients was higher than that in healthy individuals of the same age. The factors related to BMD in patients with AS are gender, CRP, and blood calcium. BMD of the femoral neck of AS patients decreases with the course of the disease, but BMD of the lumbar spine is not related to the course of the disease. BMD in AS patients is associated with multiple SNPs.
CHINESE MEDICAL JOURNAL
(2021)
Review
Endocrinology & Metabolism
Fei Yan, Linfeng Wu, Juan Lang, Zongju Huang
Summary: This study conducted a meta-analysis of 39 studies and found that patients with ankylosing spondylitis (AS) have decreased bone mineral density (BMD) and an elevated risk of fractures. The study also analyzed the risk factors associated with fractures in these patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medical Laboratory Technology
Jiayan Liu, Li Zhao, Xue Yang, Congjin Liu, Ning Kong, Yiyun Yu, Dandan Xuan, Weiguo Wan, Yu Xue
Summary: This study investigated bone mineral density, bone metabolism-related factors, and microRNA-218 in Chinese ankylosing spondylitis (AS) patients, and their correlation with disease activity and treatment with TNF-alpha inhibitors. The results showed that bone loss mainly occurred at the inflammatory sites in AS patients, depending on the severity of inflammation. Anti-inflammatory treatment is crucial for improving bone loss and bone metabolism disorders caused by AS.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Immunology
Jian Mei, Hongxin Hu, Haiqi Ding, Ying Huang, Wenming Zhang, Xiaoqing Chen, Xinyu Fang
Summary: The study using bidirectional Mendelian randomization analysis found no evident causal association between genetic liability to Ankylosing Spondylitis (AS) and the risk of osteoporosis (OP) or lower bone mineral density (BMD) in the European population, highlighting the second effect of AS on OP. However, genetically predicted decreased BMD/OP is a risk factor for AS with a causal relationship, suggesting that patients with OP should be aware of the potential risk of developing AS. Moreover, OP and AS share similar pathogenesis and pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Xinfeng Wu, Liang Zhang, Tao Bian, Siliang Man, Hongchao Li, Wei Liu, Yixin Zhou
Summary: This study aimed to measure volumetric bone mineral density (vBMD) in the hip of ankylosing spondylitis (AS) patients using quantitative computed tomography (QCT), and analyze its correlations with radiographic and clinical parameters. The results showed that low trabecular bone density in the hip was associated with the duration of disease progression and degree of hip involvement. It was also correlated with hip function status, although no significant relationship was found with disease activity.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Ji-Won Kim, Sunghoon Park, Ju-Yang Jung, Hyoun-Ah Kim, Seong-Ryul Kwon, Sang Tae Choi, Sung-Soo Kim, Sang-Hyeon Kim, Chang-Hee Suh
Summary: This study investigated the prevalence of and factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). The findings suggest that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Juergen Braun, Bjoern Buehring, Xenofon Baraliakos, Lianne S. Gensler, Brian Porter, Erhard Quebe-Fehling, Sibylle Haemmerle
Summary: The study confirms a high proportion of AS patients with reduced BMD. An increase in BMD in the lumbar spine after 2 years of secukinumab treatment in AS patients was found, which was likely unrelated to radiographic progression. No significant effects of secukinumab on bone turnover biomarkers were documented.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Ding Zhang, Jia Liu, Bing Gao, Yuan Zong, Xiaoqing Guan, Fengyi Zhang, Zhubin Shen, Shijie Lv, Li Guo, Fei Yin
Summary: This study identified key immune genes and mechanisms that play a role in low bone mineral density in ankylosing spondylitis patients. These key genes can serve as biomarkers for determining the risk of low bone mineral density in these patients and may impact the bone remodeling process through the infiltration of neutrophils and formation of NETs.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Pannarat Saisirivechakun, Ajanee Mahakkanukrauh, Chatlert Pongchaiyakul, Trirat Boonya-ussadorn, Pongthorn Narongroeknawin, Rattapol Pakchotanon, Paijit Assavatanabodee, Sumapa Chaiamnuay
Summary: Axial spondyloarthritis (axSpA) patients have an increased risk of osteoporosis and vertebral fractures. Dual X-ray absorptiometry (DXA) for measuring bone mineral density (BMD) has limitations in axSpA patients. The trabecular bone score (TBS) can indirectly assess bone microarchitecture and predict fracture risk. This study found that axSpA patients had lower TBS compared to healthy volunteers, higher lumbar BMD, and lower femoral neck BMD. Sacroiliac joint fusion and a high ASDAS score were associated with low TBS.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Alexandre Terrier, Olivier Fakih, Mickael Chouk, Clement Prati, Daniel Wendling, Sebastien Aubry, Frank Verhoeven
Summary: This study aimed to compare the SBAC-SI differences in AS, OCI, and DISH. The results showed that SBAC-SI was significantly higher in the OCI group compared to the AS group, which could help distinguish between these two diseases. In AS, the disease duration was negatively correlated with SBAC-SI, and HLA B27 was associated with lower SBAC-SI.
Article
Health Care Sciences & Services
Marwa M. Esawy, Amany M. Ebaid, Amir Abd-elhameed, Felwa A. Thagfan, Murad A. Mubaraki, Ahmed S. Alazzouni, Mohamed A. Dkhil, Marwa A. Shabana
Summary: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes severe pain and stiffness in the joints. The role of lncRNA H19 in AS was investigated and it was found to play a key role in the pathogenesis of the disease. The expression of lncRNA H19 was significantly upregulated in AS patients compared to healthy controls and was positively correlated with disease activity and inflammatory markers.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
Mary Lucy Marques, Nuno Pereira da Silva, Desiree van der Heijde, Monique Reijnierse, Xenofon Baraliakos, Juergen Braun, Floris A. van Gaalen, Sofia Ramiro
Summary: Objective: We analyzed the trabecular bone density of patients with r-axSpA using low-dose CT scans and assessed the inter-reader reliability. Our results showed that ldCT measurement of HU is a feasible method to assess vertebral bone density in r-axSpA with excellent inter-reader reliability from C3 to L5.
Article
Pharmacology & Pharmacy
Suzanne Arends, Freke Wink, Joyce Veneberg, Reinhard Bos, Eric van Roon, Eveline van der Veer, Fiona Maas, Anneke Spoorenberg
Summary: This study suggests that 2-year treatment with bisphosphonates in combination with calcium/vitamin D supplements significantly improves lumbar spine BMD in AS patients, but mild radiographic vertebral fractures still occurred.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Rheumatology
Pawel Zuchowski, Marta Dura, Daniel Jeka, Marzena Waszczak-Jeka
Summary: This study evaluated the usefulness of trabecular bone score (TBS) in assessing fracture risk in patients with ankylosing spondylitis (AS). TBS was found to be a more sensitive method in identifying patients with high fracture risk compared to bone mineral density (BMD) measurement using dual-energy X-ray absorptiometry (DXA). Age, TBS score, and the presence of syndesmophytes and bony bridges were considered relative risk factors.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Tatjana Trost Bobic, Ana Secic, Iris Zavoreo, Valentina Matijevic, Branimir Filipovic, Zeljka Kolak, Vanja Basic Kes, Dubravka Ciliga, Dubravka Sajkovic
ACTA CLINICA CROATICA
(2016)
Article
Medicine, General & Internal
Goranka Radmilovic, Valentina Matijevic, Iris Zavoreo
ACTA CLINICA CROATICA
(2016)
Article
Sport Sciences
Pavao Vlahek, Valentina Matijevic, Juraj Havas, Dario Dilber, Jurica Veronek, Vedran Balta
Summary: The study shows that ultramarathon runners have a higher percentage of lower-leg injuries and longer rehabilitation time. Their specific training habits with fewer rest days, full-time jobs, and higher academic degrees are contributing factors. Age also plays a role in injury occurrence and rehabilitation time.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2021)
Article
Medicine, General & Internal
Zrinka Djukic Koroljevic, Erina-Leona Cetinic, Valentina Matijevic
Summary: This study aimed to compare the incidence of mild psychomotor delay in infants born to mothers treated for thyroid dysfunction during the first trimester of pregnancy, regardless of the cause, with those whose mothers did not use medications prenatally. The results showed a significant positive correlation between drug-compensated thyroid dysfunction during pregnancy and psychomotor delay in infants. This research provides insights for planning a national screening program for infants at neurodevelopmental risk.
ACTA CLINICA CROATICA
(2022)
Article
Psychiatry
Bernarda Skegro, Sarah Bjedov, Mislav Mikus, Filip Mustac, Josko Lesin, Valentina Matijevic, Mario Coric, Vesna Elvedi Gasparovic, Filip Medic, Vesna Sokol Karadjole
Summary: The study revealed that a significant proportion of patients with endometriosis experience symptoms of depression, anxiety, and stress. There were moderate correlations between EHP-5 and depression, stress, and VAS score, as well as weak positive relationships between EHP-5 and anxiety and infertility. This indicates complex relationships between symptoms and conditions in endometriosis patients.
PSYCHIATRIA DANUBINA
(2021)
Article
Medicine, General & Internal
Irella Bogut, Zeljko Popovic, Zvonimir Tomac, Valentina Matijevic, Goranka Radmilovic
ACTA CLINICA CROATICA
(2019)
Article
Medicine, General & Internal
Valentina Matijevic, Bernarda Barbaric, Marija Kraljevic, Ivan Milas, Juraj Kolak
ACTA CLINICA CROATICA
(2019)
Article
Medicine, General & Internal
Pavao Vlahek, Valentina Matijevic
ACTA CLINICA CROATICA
(2018)
Meeting Abstract
Clinical Neurology
N. Blazevic, Z. Poljakovic, M. Krbot Skoric, M. Habek, D. Alvir, A. Bazina, J. Ljevak, V. Matijevic, K. Starcevic, S. Supe, I. Jurjevic, T. Gabelic
EUROPEAN JOURNAL OF NEUROLOGY
(2017)
Proceedings Paper
Clinical Neurology
Valentina Matijevic, Marija Kraljevic
3RD PAN-SLAVIC CONGRESS OF CHILD NEUROLOGY AND 21ST CNM CONGRESS
(2017)
Article
Medicine, General & Internal
Maja Lang Morovic, Valentina Matijevic, Kristina Divljakovic, Marija Kraljevic, Zdenka Dimic
ACTA CLINICA CROATICA
(2015)
Article
Medicine, General & Internal
Mara Tripkovic, Valentina Matijevic, Hrvoje Markovic, Nela Ercegovic
ACTA CLINICA CROATICA
(2015)
Article
Medicine, General & Internal
Valentina Matijevic, Jelena Bartolovic, Maja Crnkovic, Tena Kosicek, Irma Barisic
ACTA CLINICA CROATICA
(2014)
Review
Medicine, General & Internal
Valentina Matijevic, Ana Secic, Valentina Masic, Martina Sunic, Zeljka Kolak, Mateja Znika
ACTA CLINICA CROATICA
(2013)
Article
Medicine, General & Internal
Valentina Matijevic, Ana Secic, Tamara Kauzlaric Zivkovic, Jesenka Borosak, Zeljka Kolak, Zdenka Dimic
ACTA CLINICA CROATICA
(2013)