Article
Cell & Tissue Engineering
JeongHyun Shim, Kyoung-Tae Kim, Kwang Gi Kim, Un-Yong Choi, Jae Won Kyung, Seil Sohn, Sang Heon Lim, Hyemin Choi, Tae-Keun Ahn, Hye Jeong Choi, Dong-Eun Shin, Inbo Han
Summary: In patients with OVCFs, the combination therapy of WJ-MSCs and teriparatide is feasible and tolerable, improving fracture healing and symptom scores.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Xiangcheng Gao, Jinpeng Du, Yongyuan Zhang, Yining Gong, Bo Zhang, Zechao Qu, Dingjun Hao, Baorong He, Liang Yan
Summary: Through a retrospective study, we found that the independent influencing factors of bone cement displacement after PVA in Kummell's disease include thoracolumbar junction, Kummell's disease staging, anterior cortex defect, vertebral endplates defect, cement distribution, cement leakage, restoration of local Cobb angle, and postoperative anti-osteoporosis treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Qiujiang Li, Xingxia Long, Yinbin Wang, Xiaomin Fang, Donggeng Guo, Jinhan Lv, Xuehua Hu, Lijun Cai
Summary: A nomogram was developed to predict NVCFs after vertebral augmentation in patients with OVCFs. The model showed good discrimination and calibration in both the training and validation cohorts, providing a useful tool for identifying high-risk patients for postoperative VCFs. Postoperative management strategies should be considered for patients identified as high risk by this nomogram.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Jing Tang, Jin Liu, Zuchao Gu, Bin Song
Summary: This study demonstrated the effectiveness of vertebral augmentation in treating OVCFs, with higher incidence of cement leakage and recollapse of treated vertebrae associated with PKP in patients with gas-filled IVCs. Liquid-filled IVCs may not promote bone cement distribution effectively.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Orthopedics
Youzhi An, Lili Li, Xuelin Lin, Zhen Zhang, Zhaoyun Zheng, Chengjiang Wang
Summary: This study aimed to investigate the risk of sandwich vertebral fractures in the treatment of osteoporotic vertebral compression fractures via percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). The study found that PVP had a higher risk of sandwich vertebral fractures compared to PKP, potentially due to the larger amount of bone cement, higher rate of cement leakage, and larger Cobb angle.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Anesthesiology
Lei Ning, Jungao Zhu, Shen Tian, Ziang Hu, Chao Liu, Xiangde Zhao, Xiang Li, Shunwu Fan, Shuanglin Wan
Summary: The main cause of refracture after percutaneous kyphoplasty (PKP) is osteoporosis. Elderly women are more susceptible to refracture than elderly men. Patients with a history of previous fractures, previous osteoporosis, stomach ulcers, and ovariectomy are more likely to experience refractures. Antiosteoporosis treatment (calcium + vitamin D or zoledronate) after PKP can reduce the risk of refracture.
Article
Geriatrics & Gerontology
Christian Pfeifle, Petr Kohut, Jan-Sven Jarvers, Ulrich J. Spiegl, Christoph-Eckhard Heyde, Georg Osterhoff
Summary: This study assessed the impact of time to surgery on 1-year survival in patients with osteoporotic vertebral compression fractures. The findings showed that time-to-surgery had no significant effect on one-year mortality in geriatric patients with these fractures, suggesting that treatment decisions should be individualized.
Review
Clinical Neurology
Juan P. Cabrera, Gaston Camino-Willhuber, Alfredo Guiroy, Charles A. Carazzo, Martin Gagliardi, Andrei F. Joaquim
Summary: A systematic review comparing the clinical and radiological outcomes of vertebral augmentation + short-segment fixation (VA + SSF) versus VA alone in Kummell's disease found no significant difference in pain and functional recovery between the two groups, but suggested that VA + SSF may provide superior long-term results.
NEUROSURGICAL REVIEW
(2022)
Review
Medicine, General & Internal
Yi Luo, Da-Mei Yang, Hong-Mei Yang, Di Wu, Feng-Ying Xie
Summary: With the increasing population aging, osteoporosis vertebral compression fractures (OVCFs) have become more common and resulted in severe back pain and functional impairment. Minimally invasive procedures such as percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) have revolutionized the treatment of OVCFs, but complications remain. Therefore, new implants for OVCFs have been developed to overcome the shortcomings of traditional procedures, although further clinical studies are needed to determine their effectiveness and indications.
FRONTIERS IN MEDICINE
(2023)
Article
Orthopedics
Peng-guo Gou, Zhi-hui Zhao, Jia-ming Zhou, Lin-hui Ren, Xiao-yun Wang, Yu-feng Mu, Yun-guo Wang, Feng Chang, Yuan Xue
Summary: In postmenopausal single-level Kummell's disease patients, conservative treatment with teriparatide was more effective than alendronate in preventing progressive vertebral collapse. Teriparatide promoted mineralized bone formation, reduced kyphosis angle, and increased anterior and posterior border heights and spinal canal diameter compared to alendronate.
ORTHOPAEDIC SURGERY
(2021)
Review
Orthopedics
Jie Cheng, Songli Ju, Zihan Zhang
Summary: For young patients with fragility fractures, especially in young women, more attention should be paid to glucocorticoid excess caused by Cushing's syndrome, due to a higher rate of misdiagnosis and different treatment strategies.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Clinical Neurology
Ji-Kang Ding, Bin Zhao, Yi-fan Zhai
Summary: Percutaneous vertebroplasty (VP) provides substantial benefit to patients with painful osteoporotic vertebral compression fractures (OVCF). However, the reoccurrence of vertebral fracture after VP is a major concern. This meta-analysis found that the incidence of subsequent fractures after VP was 23.4%, with the majority of fractures occurring in the vertebral bodies adjacent to the treated vertebra.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Tengfei Song, Fan Sun, Shu Liu, Tianwen Ye
Summary: The study aimed to investigate the safety and effectiveness of percutaneous lordoplasty (PLP) in the treatment of severe osteoporotic vertebral compression fracture (OVCF). The results showed that PLP can effectively reduce pain, improve the quality of life, and correct spinal deformity. The procedure had a low rate of complications. Therefore, PLP may be a safe, cost-effective, and minimally invasive alternative for the treatment of severe OVCF.
FRONTIERS IN NEUROLOGY
(2023)
Article
Orthopedics
Feng Wang, Tong Tong, De-chao Miao, Lin-feng Wang, Yong Shen
Summary: This study aimed to explore the clinical correlation between osteoporosis thoracolumbar vertebral compression fracture (thoracolumbar OVCF) and lumbar spondylolisthesis (LS). The results showed that patients with LS are more likely to suffer from OVCF in the future, and LS is one of the important risk factors for secondary OVCF.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Medicine, General & Internal
Moon-Soo Han, Gwang-Jun Lee, Seul-Kee Lee, Jung-Kil Lee, Bong Ju Moon
Summary: This study investigates the relationship between clinical and radiological features and bone turnover markers (BTMs) during teriparatide therapy for osteoporotic vertebral compression fractures. The results show that the levels of serum osteocalcin and serum C-terminal telopeptide of type I collagen increase significantly, while parathyroid hormone (PTH) levels decrease significantly during the teriparatide treatment, suggesting the progression of fracture.
Correction
Peripheral Vascular Disease
Massimo Volpe, Giovanna Gallo, Maria Grazia Modena, Claudio Ferri, Giovambattista Desideri, Giuliano Tocci
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2022)
Article
Cardiac & Cardiovascular Systems
Angelo B. Cefalu, Raffaella Garbelotto, Giuliana Mombelli, Matteo Pirro, Paolo Rubba, Marcello Arca, Claudio Borghi, Katia Bonomo, Stefano Gonnelli, Katia Massaroni, Giampaolo Tirone, Maurizio Averna
Summary: The ODYSSEY APPRISE trial evaluated the efficacy and safety of alirocumab in patients with hypercholesterolemia and high cardiovascular risk in a real-life setting. This report focuses on the Italian cohort in the trial. The results show that alirocumab effectively reduced LDL-C levels and was well tolerated in the Italian subgroup, confirming its benefits in reducing cardiovascular risk for patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Cell Biology
Tannaz Jamialahmadi, Fatemeh Baratzadeh, Zeljko Reiner, Massimo R. Mannarino, Vladimiro Cardenia, Luis E. Simental-Mendia, Matteo Pirro, Gerald F. Watts, Amirhossein Sahebkar
Summary: This study found that statin therapy can decrease serum levels of oxLDL but does not affect circulating levels of anti-oxLDL antibodies.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Alice Indini, Daniela Massi, Matteo Pirro, Fausto Roila, Francesco Grossi, Amirhossein Sahebkar, Nicole Glodde, Tobias Bald, Mario Mandala
Summary: Immune checkpoint inhibitors (ICIs) show impressive antitumor activity in melanoma patients, but most patients have limited benefit due to the development of resistance mechanisms. Resistance to immunotherapy is a complex phenomenon influenced by genetic and epigenetic mechanisms and the tumor microenvironment. Inflamed and non-inflamed tumors have different characteristics and responses to immunotherapy. Reliable predictive biomarkers and strategies to overcome resistance are still needed.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, General & Internal
Massimo Raffaele Mannarino, Vanessa Bianconi, Elena Cosentini, Filippo Figorilli, Cecilia Colangelo, Francesco Giglioni, Rita Lombardini, Rita Paltriccia, Matteo Pirro
Summary: COVID-19 leads to dysregulation of lipid metabolism, resulting in lower TC, LDL-C, and HDL-C levels, as well as reduced TSH levels. This study explores the association between TSH levels and changes in lipid profile parameters during COVID-19. The results show a positive correlation between TSH and Delta-TC, Delta-LDL-C, and Delta-HDL-C, as well as a negative correlation with CRP. Additionally, TSH decreases with increasing COVID-19 severity. After adjusting for confounders, an independent association is found between TSH and Delta-TC, as well as Delta-LDL-C.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Massimo Raffaele Mannarino, Vanessa Bianconi, Elena Cosentini, Filippo Figorilli, Costanza Natali, Giulia Cellini, Cecilia Colangelo, Francesco Giglioni, Marco Braca, Matteo Pirro
Summary: The study tested the ability of the HACOR score, a scale based on clinical and laboratory parameters, to predict adverse outcomes in hospitalized COVID-19 patients with acute respiratory failure (ARF). The results showed that a high HACOR score was associated with the need for intubation or in-hospital death, making it a significant predictor for adverse clinical outcomes in patients with COVID-19-related ARF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Lorenzo Loffredo, Pasquale Pignatelli, Matteo Pirro, Giancarlo Ceccarelli, Alessandra Oliva, Enrico Maggio, Francesca Cancelli, Damiano D'Ardes, Maria Amitrano, Anna Maria Zicari, Bianca Laura Cinicola, Gloria Taliani, Roberto Cangemi, Miriam Lichtner, Marco Falcone, Federica Orlando, Francesco Pugliese, Mario Venditti, Claudio Maria Mastroianni, Francesco Violi
Summary: The P/F ratio is associated with thrombotic events in COVID-19 patients. A low P/F ratio is associated with thrombocytosis, which may lead to clot formation. This study suggests that the P/F ratio is closely related to thrombotic events in patients with COVID-19.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ilais Moreno Velasquez, Anders Malarstig, Damiano Baldassarre, Yan Borne, Ulf de Faire, Gunnar Engstrom, Per Eriksson, Philippe Giral, Steve E. Humphries, Sudhir Kurl, Karin Leander, Lars Lind, Anders Linden, Nicola Orsini, Matteo Pirro, Angela Silveira, Andries J. Smit, Elena Tremoli, Fabrizio Veglia, Rona J. Strawbridge, Bruna Gigante
Summary: The study found a causal relationship between plasma IL-8 and carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis. The association was confirmed through quantile regression analysis in the multicenter European study IMPROVE, and genetic variants were identified to be associated with both IL-8 levels and c-IMT measures. Replication and meta-analysis further supported the effect of IL-8 on c-IMT.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Virology
Vanessa Bianconi, Massimo R. Mannarino, Elena Cosentini, Filippo Figorilli, Cecilia Colangelo, Giulia Cellini, Marco Braca, Rita Lombardini, Rita Paltriccia, Amirhossein Sahebkar, Matteo Pirro
Summary: This study found that preadmission statin therapy is associated with a reduced risk of intensive care unit admission or in-hospital death among patients with COVID-19 at high CV risk. Furthermore, statin therapy is associated with improved endothelial function. However, the interaction between endothelial function and statin therapy is not associated with in-hospital outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition with a high prevalence in adults, children, and individuals with type 2 diabetes mellitus. It is a leading cause of liver-related morbidity and cardiovascular mortality. The use of nutraceuticals in managing NAFLD has been suggested, but there is currently insufficient evidence to support their routine use. Further rigorous trials are needed to evaluate their efficacy and safety.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Maciej Banach, Peter E. Penson, Michel Farnier, Zlatko Fras, Gustavs Latkovskis, Ulrich Laufs, Francesco Paneni, Paolo Parini, Matteo Pirro, Zeljko Reiner, Michal Vrablik, Carlos Escobar
Summary: Cardiovascular disease (CVD) is a chronic non-communicable disease and the leading cause of disability and mortality worldwide. The current lipid-lowering treatments need improvement, and bempedoic acid, as a new approach to reduce lipid levels, has the potential to lower the risk of CVD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Buamina Maitusong, Federica J. Laguzzi, Rona Strawbridge, Damiano Baldassarre, Fabrizio E. Veglia, Steve Humphries, Kai Savonen, Sudhir Kurl, Matteo J. Pirro, Andries Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander, IMPROVE Study Grp
Summary: The study found that certain genetic variants may modify the effect of smoking on carotid intima-media thickness, increasing the risk of atherosclerosis.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Filippo Figorilli, Massimo Raffaele Mannarino, Amirhossein Sahebkar, Matteo Pirro
Summary: Introduction: Atherosclerotic cardiovascular disease (ASCVD) is the main cause of morbidity and mortality worldwide. Dyslipidemia, especially elevation of LDL-cholesterol levels (LDL-C), is a major cardiovascular risk factor, but often goes undiagnosed due to its asymptomatic course. Strategies aimed at early identification of individuals with elevated LDL-C levels may allow for early intervention to prevent ASCVD development.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)