Article
Health Care Sciences & Services
Chrystel Isca, Amelia Spinella, Angela Toss, Marco de Pinto, Guido Ficarra, Luca Fabbiani, Anna Iannone, Luca Magnani, Federica Lumetti, Pierluca Macripo, Caterina Vacchi, Elisa Gasparini, Simonetta Piana, Laura Cortesi, Antonino Maiorana, Carlo Salvarani, Massimo Dominici, Dilia Giuggioli
Summary: Several authors have reported an increased risk of cancer in SSc patients, with potential shared molecular pathways and mechanisms with breast cancer (BC). A study suggested a good prognosis for BC in SSc patients due to autoimmune factors. Analysis revealed higher TILs and PD-L1 expression in BC patients, indicating less aggressive behavior and potential for de-escalation strategy in cancer therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Angela Toss, Amelia Spinella, Chrystel Isca, Caterina Vacchi, Guido Ficarra, Luca Fabbiani, Anna Iannone, Luca Magnani, Paola Castrignano, Pierluca Macripo, Elisa Gasparini, Simonetta Piana, Laura Cortesi, Antonino Maiorana, Carlo Salvarani, Massimo Dominici, Dilia Giuggioli
Summary: The study revealed that patients with systemic sclerosis have a higher risk of developing breast cancer, with the majority being diagnosed around the age of 45 and receiving early treatment, resulting in a good prognosis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Rheumatology
Sabrina Hoa, Selma Lazizi, Murray Baron, Mianbo Wang, Marvin J. Fritzler, Marie Hudson
Summary: There is an association between cancer and specific autoantibodies in SSc patients, with increased cancer risk in patients positive for anti-topoisomerase I and anti-U1-RNP antibodies. However, synchronous cancer is rare in this cohort of Canadian SSc patients.
Review
Oncology
Qiuchi Chen, Jie Xiong, Yuxi Ma, Jielin Wei, Cuiwei Liu, Yanxia Zhao
Summary: Breast cancer is the most common cancer in females and brain metastasis is the second most frequent type. Although advanced treatment has improved survival in breast cancer patients, the prognosis of brain metastasis is still poor. The management of brain metastasis remains challenging and systemic treatments play a crucial role in controlling the disease and improving survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Shivam Singh, Heena Saini, Ashok Sharma, Subhash Gupta, V. G. Huddar, Richa Tripathi
Summary: Breast cancer is the second most common malignancy in women, with a high mortality rate. Chemotherapy has the potential to prevent and control breast cancer, but drug resistance hinders its effectiveness. MicroRNAs (miRNAs) are potential biomarkers for early cancer detection and can be used to design more specific treatment plans to analyze drug resistance and sensitivity in breast cancer treatment. This review discusses the significance of miRNA biomarkers in overcoming chemotherapy resistance and designing tailored therapy for enhanced efficacy against breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Sudpreeda Chainitikun, Sadia Saleem, Bora Lim, Vicente Valero, Naoto T. Ueno
Summary: The review focuses on the development of systemic treatment of IBC from the past to the present, including chemotherapy and targeted therapies. The effects on pathologic complete response (pCR), survival outcomes, predictive markers, and adverse events of these therapies are discussed, along with current standard treatment stratified by molecular subtypes. The future trend of systemic therapy, including immunotherapy and ongoing IBC clinical trials, is also addressed.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Oncology
Hongnan Mo, Binghe Xu
Summary: Triple-negative breast cancer is the most aggressive subtype of breast cancer, where chemotherapy shows activity in some patients but drug resistance remains a challenge. Significant progress in genetic analysis has led to the identification of novel targets and improved precision in therapeutic interventions, advancing treatment strategies.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Heng Li, Liping Ding, Xiaoping Hong, Yulan Chen, Rui Liao, Tingting Wang, Shuhui Meng, Zhenyou Jiang, Dongzhou Liu
Summary: The study revealed stable differences and similarities between systemic sclerosis and lung cancer, with common changes in immune-related genes. Enhanced innate immunity and weakened negative regulation of cell cycle may be common mechanisms of the two diseases, which may be associated with the high risk of lung cancer in systemic sclerosis patients.
Review
Oncology
Nicolo Matteo Luca Battisti, Kroopa Joshi, Mariam Syeda Nasser, Alistair Ring
Summary: As the population ages, the number of older breast cancer patients is increasing, yet they are often not receiving guideline-concordant care. More clinical studies and tools integrating global health considerations are needed to better inform chemotherapy decisions for older adults.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
N. Lynn Henry, Mark R. Somerfield, Zoneddy Dayao, Anthony Elias, Kevin Kalinsky, Lisa M. McShane, Beverly Moy, Ben Ho Park, Kelly M. Shanahan, Priyanka Sharma, Rebecca Shatsky, Erica Stringer-Reasor, Melinda Telli, Nicholas C. Turner, Angela DeMichele
Summary: This study aims to update the biomarkers that guide systemic therapy for metastatic breast cancer (MBC). The authors conducted a systematic review and identified 19 studies, providing recommendations for testing and treatment. However, there is insufficient evidence for some tests' eligibility and monitoring methods.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jing Chen, Jingjing Sun, Qunfeng Wang, Yanze Du, Jie Cheng, Juan Yi, Bei Xie, Suya Jin, Gang Chen, Lina Wang, Xiaoyuan Wang, Hulai Wei
Summary: Functional loss or deletion of the tumor suppressor gene PTEN significantly enhances the proliferation, invasion, and metastasis of breast cancer cells. Inhibition of PTEN in the overall microenvironment also promotes the proliferation and metastasis of breast cancer cells. These findings suggest that PTEN mediates the proliferation, invasion, and metastasis of mouse breast cancer cells by regulating the PI3K-Akt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Vivian Koelbel, Andre Pfob, Benedikt Schaefgen, Peter Sinn, Manuel Feisst, Michael Golatta, Christina Gomez, Anne Stieber, Paul Bach, Geraldine Rauch, Joerg Heil
Summary: By analyzing data from a prospective multicenter trial, it was found that the presence of accompanying ductal carcinoma in situ (DCIS), multicentric disease on imaging before NST, and age were key characteristics associated with false-negative vacuum-assisted biopsy (VAB) results. Performing a clear representative VAB procedure for patients without accompanying DCIS or multicentric disease may reliably exclude residual cancer in the breast without the need for surgery, reducing the false-negative rate.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Benjamin Chaigne, Sarah Leonard-Louis, Luc Mouthon
Summary: Scleroderma associated myopathy (SScAM) is a heterogeneous musculoskeletal manifestation of systemic sclerosis (SSc) that lacks a clear definition. However, SScAM is associated with disability, poor quality of life, and mortality. This review provides an overview of the most up-to-date literature on SScAM, including clinical and antibody associations, recent histopathological findings, prognosis, and treatment.
AUTOIMMUNITY REVIEWS
(2023)
Article
Allergy
David F. Fiorentino, Livia Casciola-Rosen
Summary: Rheumatic diseases have a complex association with cancer, and studying this connection can provide insights into the mechanisms of autoimmunity and cancer immunity. Systemic sclerosis and dermatomyositis are closely related to internal malignancy, and studying autoantibodies can reveal the relationship between these diseases and cancer. The discovery of disease-specific autoantigens plays an important role in understanding disease emergence and developing effective anti-tumor responses.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Oncology
Nicholas P. McAndrew, Lisa Bottalico, Clementina Mesaros, Ian A. Blair, Patricia Y. Tsao, Jennifer M. Rosado, Tapan Ganguly, Sarah J. Song, Phyllis A. Gimotty, Jun J. Mao, Angela DeMichele
Summary: Chronic inflammation has been proposed as a mechanism of resistance to aromatase inhibitors in breast cancer. A study found that elevated serum inflammatory biomarkers CRP and SAA were significantly associated with an increased risk of recurrence in hormone receptor positive breast cancer, while high-risk IL-6 promoter polymorphisms were strongly associated with HER2+ breast cancer relapse.
Article
Rheumatology
John B. Arnold, Jill Halstead, Carmen Martin-Hervas, Andrew J. Grainger, Anne-Maree Keenan, Catherine L. Hill, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond
Summary: This study compared MRI-detected structural abnormalities in patients with symptomatic midfoot osteoarthritis, patients with persistent midfoot pain, and asymptomatic controls. The findings suggest a prevalence of osteoarthritis in individuals with persistent midfoot pain but no signs of OA on radiography, particularly in specific joints. However, the MRI abnormalities were not strongly associated with pain or foot-related disability.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Rheumatology
Ambrish Singh, Pablo Molina-Garcia, Salman Hussain, Alok Paul, Siddharth Kumar Das, Ying-Ying Leung, Catherine L. Hill, Debashish Danda, Jonathan Samuels, Benny Antony
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of osteoarthritis (OA). The study found that colchicine did not show significant benefits in reducing pain and improving physical function compared to placebo or other active comparators. The results suggest that future trials should focus on subgroups of OA patients with inflammation and mineralization who might benefit from colchicine.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher McMaster, David F. L. Liew, Susan Lester, Adam Rischin, Rachel J. Black, Vibhasha Chand, Ashley Fletcher, Marissa N. Lassere, Lyn March, Philip C. Robinson, Rachelle Buchbinder, Catherine L. Hill
Summary: This study aimed to determine the COVID-19 vaccine hesitancy rates among inflammatory arthritis patients and identify factors associated with changing vaccine hesitancy over time. The findings showed that beliefs about medication harm and overuse before the pandemic were associated with COVID-19 vaccine hesitancy. Furthermore, individuals who did not seek vaccine information from healthcare professionals were more likely to develop vaccine hesitancy during the pandemic.
Article
Medicine, Research & Experimental
Guoqi Cai, Graeme Jones, Flavia M. Cicuttini, Anita E. Wluka, Yuanyuan Wang, Catherine Hill, Helen Keen, Benny Antony, Xia Wang, Barbara de Graaff, Michael Thompson, Tania Winzenberg, Kathy Buttigieg, Dawn Aitken
Summary: This study aims to evaluate the effectiveness of diacerein in knee osteoarthritis patients with effusion-synovitis, and provide high-quality evidence. The results may have significant benefits for patients with an inflammatory phenotype.
Review
Rheumatology
Oscar Russell, Susan Lester, Rachel J. Black, Catherine L. Hill
Summary: This article, using a scoping review approach, identified that socioeconomic status (SES) affects medication use in rheumatoid arthritis (RA) patients. However, the use of different SES definitions hinders comparisons between studies.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Medicine, General & Internal
Peter J. Roberts-Thomson, Karen A. Patterson, Jennifer G. Walker
Summary: Nailfold capillaroscopy (NFC) is a simple noninvasive microscopic technique used to identify abnormal morphological changes in the nailfold capillaries. It plays a fundamental role in understanding the pathological processes of scleroderma spectrum disorders, and can be performed using ophthalmoscope, dermatoscope, or smart phone for diagnosis. NFC has the potential to be a biomarker in the management of scleroderma spectrum disorders.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Suellen A. A. Lyne, Carlee Ruediger, Susan Lester, Peter T. T. Chapman, Ernst Michael Shanahan, Catherine L. Hill, Lisa Stamp
Summary: This study investigated the epidemiology and clinical features of giant cell arteritis (GCA) in Canterbury, New Zealand, focusing on extra-cranial large vessel disease. It identified two distinct subsets of the disease - cranial and large vessel disease, suggesting the need for alternative diagnostic and therapeutic approaches for patients with large vessel disease.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Carlee Ruediger, Jem Ninan, Kathryn Dyer, Suellen Lyne, Joanna Tieu, Rachel J. Black, Thomas Dodd, Susan Lester, Catherine L. Hill
Summary: This study aimed to determine the relationship between a histological diagnosis of Giant Cell Arteritis (GCA) and the optimal length of temporal artery biopsy (TAB) in the South Australian population. The results confirmed that TAB biopsy length is a determinant of histological diagnosis of temporal arteritis, with a TAB length of 15 mm or longer being optimal. However, around half of the biopsies in this study were shorter than the optimal length, potentially leading to under-diagnosis of biopsy-proven GCA in SA.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Mwidimi Ndosi, Celia Almeida, Jill Dawson, Emma Dures, Rosemary Greenwood, Alison Bromhead, Catherine Guly, Steve Stern, Catherine Hill, Sarah Mackie, Joanna C. Robson
Summary: The study aimed to determine the final scale structure and measurement properties of the GCA patient reported outcome (GCA-PRO) in assessing the impact of GCA on health-related quality of life (HRQoL). It found that the final GCA-PRO is a 30-item, four-domain scale with robust evidence of validity and reliability in measuring HRQoL in people with GCA.
Article
Rheumatology
Susan Bridgewater, Michael A. Shepherd, Jill Dawson, Pamela Richards, Christine Silverthorne, Mwidimi Ndosi, Celia Almeida, Rachel J. Black, Jonathan T. L. Cheah, Emma Dures, Nilasha Ghosh, Elizabeth A. Hoon, Suellen Lyne, Iris Navarro-Millan, Diyu Pearce-Fisher, Carlee Ruediger, Joanna Tieu, Kevin Yip, Sarah L. Mackie, Susan Goodman, Catherine Hill, Joanna C. Robson
Summary: This study aimed to explore the impact of glucocorticoid therapy on health-related quality of life (HRQoL) in patients with rheumatic diseases and develop a treatment-specific patient-reported outcome measure (PROM) for use in clinical trials and practice.
Article
Rheumatology
Alicia Callisto, Dylan Hansen, Jenny Walker, Gene Siew Ngian, Diane Apostolopoulos, David Liew, Vibhasha Chand, Catherine L. Hill, Kim Griggs, Alicia Calderone, Mandana Nikpour, Joanne Sahhar, Wendy Stevens, Susanna Proudman
Summary: This study aimed to investigate the impact of COVID-19 pandemic-related restrictions on health care access of patients with systemic sclerosis (SSc). The results showed that the pandemic led to worse mental health and reduced screening and diagnosis of pulmonary arterial hypertension (PAH) in SSc patients, which may have long-term implications.
ARTHRITIS CARE & RESEARCH
(2023)
Meeting Abstract
Rheumatology
Tony Merriman, Hirotaka Matsuo, Riku Takei, Megan Leask, Ruth Topless, Yuya Shirai, Zhiqiang Li, Murray Cadzow, Richard Reynolds, Kenneth Saag, Tayaza Fadason, Justin O'Sullivan, Nicola Dalbeth, Lisa Stamp, Abhishek Abhishek, Michael Doherty, Edward Roddy, Lennart Jacobsson, Meliha Kapetanovic, Mariano Andres, Fernando Perez-Ruiz, Rosa Torres Jimenez, Timothy Radstake, Timothy Jansen, Matthijs Janssen, Leo Joosten, Tania Octavia Crisan, Tom Huizinga, Frederic Liote, Pascal Richette, Thomas Bardin, Tristan Pascart, Geraldine McCarthy, Blanka Stiburkova, Anne Tausche, Till Uhlig, Veronique Vitart, Philip Riches, Stuart Ralston, Thomas MacDonald, Akiyoshi Nakayama, Masahiro Nakatochi, Kimiyoshi Ichida, Tappei Takada, Chaeyoung Lee, Matthew Brown, Philip Robinson, Catherine Hill, Hyon Choi, Nicholas Sumpter, Marilyn Merriman, Amanda Phipps-Green, Wenhua Wei, Sally McCormick, Olle Melander, Rene Toes, Hang-Korng Ea, Fina Kurreeman, Laura Helbert, Thibaud Boutin, Nariyoshi Shinomiya, Linda Bradbury, Russell Buchanan, Susan Lester, Malcolm Smith, Maureen Rischmueller, Eli Stahl, Jeff Miner, Daniel Solomon, Jing Cui, Kathleen Giacomini, Deanna Brackman, Eric Jorgenson, Suyash Shringapure, Alexander So, Yukinori Okada, Changgui Li, Yongyong Shi, Tanya Major
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Medicine, General & Internal
Ms Jing Ye, Premarani Sinnathurai, Catherine Hill, Claire Barrett, Louise Hardy, Rachelle Buchbinder, Samuel Whittle, Debra Rowett, Denise O'Connor, Lisa Pulver, Kylee Hayward, Quyen Du
INTERNAL MEDICINE JOURNAL
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ghazala Naureen, David Scott, Kerrie M. Sanders, Sara Vogrin, Lucy Busija, Karen Lim, Robin M. Daly, Diana Magliano, Tania Winzenberg, Graeme Jones, Vasant Hirani, Robert J. Cumming, Tiffany K. Gill, Catherine Hill, Sharon L. Brennan-Olsen
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Rheumatology
Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Catherine Hill, Janet Roddy, Jennifer Walker, Susanna Proudman, Mandana Nikpour
Summary: This study describes the epidemiology, determinants, and survival impact of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc). The study found that GAVE occurred relatively frequently in SSc patients, and was associated with age, disease subtype, antibody positivity, and patients' quality of life.
ARTHRITIS RESEARCH & THERAPY
(2022)