Article
Oncology
Qianying Zhang, Peng Xing, Hong Ren, Xiaonong Chen, Jingyuan Xie, Wen Zhang, Pingyan Shen, Xiao Li, Nan Chen
Summary: This study compared the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus (TAC) with azathioprine (AZA) as maintenance therapy for active lupus nephritis (ALN). The study found that long-term maintenance therapies with MMF or TAC have similarly low rates of renal relapse and similar safety profiles compared with AZA.
FRONTIERS OF MEDICINE
(2022)
Article
Urology & Nephrology
Desmond Y. H. Yap, Philip Hei Li, Colin Tang, Benjamin Y. F. So, Lorraine P. Y. Kwan, Gary C. W. Chan, Chak Sing Lau, Tak Mao Chan
Summary: This study suggests that the addition of a calcineurin inhibitor to mycophenolate and corticosteroids can further reduce proteinuria and maintain disease control in LN patients who do not respond well to standard therapy.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park, Soo Wan Kim
Summary: The treatment with HGC-TAC nanomicelles significantly reduces kidney injury in lupus nephritis mice by targeting inflammation, fibrosis, and apoptosis, showing potential for improved therapeutic outcomes.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Rheumatology
Takeshi Zoshima, Satoshi Hara, Kazuyuki Suzuki, Misaki Yoshida, Masahiro Konishi, Shinya Hibino, Takuya Suda, Ryohei Hoshiba, Hiroyuki Kawahara, Shigeto Horita, Hiromi Nuka, Ichiro Mizushima, Mitsuhiro Kawano
Summary: The study aimed to investigate the long-term renal outcomes and overall survival of LN patients with low-level proteinuria, as well as the significance of renal biopsy in the early phase. The results showed that LN patients with low-level proteinuria had favorable long-term renal and life outcomes, and early renal biopsy could contribute to early diagnosis and treatment, improving prognosis.
Article
Rheumatology
Tsutomu Takeuchi, Naoko Wakasugi, Satoshi Uno, Hirofumi Makino
Summary: The study assessed the long-term safety and effectiveness of tacrolimus for treating lupus nephritis in the real-world clinical setting. Results showed that tacrolimus maintenance treatment over 5 years was well tolerated and effective in a large population of patients with LN.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Transplantation
Selcan Demir, Bora Gulhan, Seza Ozen, Kubra Celegen, Ezgi Deniz Batu, Nesrin Tas, Diclehan Orhan, Yelda Bilginer, Ali Duzova, Fatih Ozaltin, Rezan Topaloglu
Summary: This study found that male gender, failure to achieve remission at 6 and 12 months, and requiring dialysis at the time of diagnosis were the best predictors of poor renal outcome in pediatric LN. Therefore, appropriate and aggressive management is essential to achieve and maintain remission.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Na Tian, Qian Zhou, PeiRan Yin, WenFang Chen, LingYao Hong, QiMei Luo, MengHua Chen, XueQing Yu, Wei Chen
Summary: This study investigated the long-term kidney outcomes in patients with late-onset lupus nephritis (LN) and found that late-onset LN patients had more severe chronic lesions in kidney pathology but relatively favorable kidney outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Antoine Enfrein, Valerie Pirson, Veronique Le Guern, Adexandre Karras, Farah Tamirou, Nathalie Costedoat-Chalumeau, Frederic Houssiau
Summary: This retrospective study compared the prognosis of lupus nephritis in patients of African descent and Caucasians in European university hospitals. Patients of African descent had a higher rate of renal flare, leading to worse renal outcomes, while there was no significant difference in non-adherence to treatment between the two groups.
Article
Medicine, General & Internal
Eleni Kapsia, Smaragdi Marinaki, Ioannis Michelakis, George Liapis, Petros P. Sfikakis, Maria G. Tektonidou, John Boletis
Summary: This study retrospectively reviewed an inception cohort of 27 patients with histologically proven pure membranous lupus nephritis (MLN) to describe their clinical and laboratory characteristics, therapeutic strategies, treatment response, renal relapses, and long-term renal survival, and to identify prognostic factors for remission and relapse.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Shaofan Wang, Duqun Chen, Ke Zuo, Feng Xu, Weixin Hu
Summary: Patients with mesangial proliferative lupus nephritis (LN class II) have high rates of relapse and renal histological transformation, necessitating optimal maintenance therapy. The cumulative relapse rate is significantly higher in the glucocorticoid monotherapy group compared to combination therapy, and there were no significant differences between the proteinuria group and the hematuria group in terms of relapse, histological transformation, adverse events, and time from remission to relapse.
CLINICAL RHEUMATOLOGY
(2022)
Article
Urology & Nephrology
Shudan Wang, Allan Spielman, Mindy Ginsberg, Michelle Petri, Brad H. Rovin, Jill Buyon, Anna Broder
Summary: This study assessed disease progression in SLE patients with low-grade proteinuria and identified risk factors for progressing to overt proteinuria. The findings showed that over half of the patients progressed to overt proteinuria in a short time period. Low complement and shorter SLE duration at low-grade proteinuria onset were associated with progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Eugene Yu-hin Chan, Desmond Yat-hin Yap, Wing-tung Wong, Wilfred Hing-sang Wong, Sze-wa Wong, Kyle Ying-kit Lin, Felix Yan-wai Hui, Jennifer Yee-ming, Sophia Suet-ying Lam, Jennie Kit-yee Wong, Fiona Fung-yee Lai, Tsz-wai Ho, Pak-chiu Tong, Wai-ming Lai, Tak Mao Chan, Alison Lap -tak Ma
Summary: This retrospective cohort study examined the long-term outcomes of childhood-onset lupus nephritis (cLN) and found improved patient and kidney survival rates, but a high prevalence of adverse outcomes including severe kidney failure, end-stage kidney disease, and death.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, General & Internal
Eun-Song Kang, Soo Min Ahn, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
Summary: Although non-proliferative lupus nephritis (LN) has been considered less severe, long-term renal outcomes in these patients are limited. This study found that approximately 30% of patients with non-proliferative LN had poor renal outcomes after long-term follow-up. Active management may be needed, especially for patients with eGFR < 60 mL/min/1.73 m2 at 6 months follow-up after LN diagnosis.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Valerie Pirson, Antoine Enfrein, Frederic A. Houssiau, Farah Tamirou
Summary: This study suggests that early remission in lupus nephritis patients is crucial for preserving long-term renal function, with absence of remission associated with higher risks of chronic kidney disease and end-stage renal disease. Patients achieving early remission had significantly better renal outcomes compared to late remitters.
LUPUS SCIENCE & MEDICINE
(2021)
Article
Urology & Nephrology
Isabelle Ayoub, Bethany J. Wolf, Linyu Geng, Huijuan Song, Aastha Khatiwada, Betty P. Tsao, Jim C. Oates, Brad H. Rovin
Summary: A machine learning approach combining traditional clinical data and novel urine biomarkers was used to develop prediction models for one-year treatment response in lupus nephritis. The models showed good predictive value, with the best performance seen in predicting eGFR response. The inclusion of both traditional clinical data and novel urine biomarkers, including cytokines, chemokines, and markers of kidney damage, was found to improve the prediction accuracy.
KIDNEY INTERNATIONAL
(2022)
Article
Transplantation
Desmond Y. H. Yap, Chun Hay Tam, Susan Yung, Sunny Wong, Colin S. O. Tang, Temy M. Y. Mok, Catherine K. Y. Yuen, Maggie K. M. Ma, Chak Sing Lau, Tak Mao Chan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Health Care Sciences & Services
Kwok-Ying Chan, Terrence Yip, Desmond Y. H. Yap, Mau Kwong Sham, Kwok Wai Tsang
JOURNAL OF PALLIATIVE MEDICINE
(2020)
Article
Immunology
Ivan Fan-Ngai Hung, Desmond Yat-Hin Yap, Terence Pok-Siu Yip, Ricky Ruiqi Zhang, Kelvin Kai-Wang To, Kwok-Hung Chan, Sydney Chi-Wai Tang, Sing-Leung Lui, Yotam Levin, Efrat Kochba, Johnson Yiu-Nam Lau, Man-Fung Yuen, Tak-Mao Chan, Kwok-Yung Yuen
Summary: Pretreatment with topical imiquimod before intradermal hepatitis B virus vaccination can improve seroprotection in dialysis patients, with high safety and favorable outcomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Kwok Ying Chan, Ho Yan Chin, Desmond Y. H. Yap, Cho Wing Li, Terence Yip, Kwok Wai Tsang, Wai On Tam, Ho Yan Au, Chi Yan Wong, Man Lui Chan, Mau Kwong Sham
Summary: The study showed that the structured ACP program achieved a high concordance rate for patients' final wishes, increased patient and family satisfaction, and reduced the number of acute admissions and length of stay in hospital.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Review
Urology & Nephrology
Desmond Y. H. Yap, Lawrence P. McMahon, Chuan-Ming Hao, Nan Hu, Hirokazu Okada, Yusuke Suzuki, Sung Gyun Kim, Soo Kun Lim, Kriengsak Vareesangthip, Chi-Chih Hung, Masaomi Nangaku
Summary: Renal anaemia is a common and important complication in patients with chronic kidney disease, and the use of HIF-PHI has emerged as a novel approach for its management. However, when prescribing this class of drug, potential benefits and harms need to be carefully considered.
Article
Urology & Nephrology
Christy W. H. Au, Desmond Y. H. Yap, Jasper F. W. Chan, Terence P. S. Yip, Tak M. Chan
Summary: The study showed that catheter-related infections of Serratia species in PD patients have low risk of progressing to peritonitis and favorable response to medical therapy, while Serratia peritonitis is associated with high rates of catheter removal and peritoneal failure.
Article
Dermatology
Christina S. M. Wong, Desmond Y. H. Yap, Patrick Ip, Wilfred H. S. Wong, Gilbert T. Chua, Chi-Keung Yeung, Henry H. L. Chan, Janette S. Y. Kwok
Summary: The study found an association between HLA-B*15:11 and carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs) in Chinese patients. The incidence of SCARs in HLA-B*15:11 carriers receiving CBZ treatment was significantly higher compared to those not using CBZ.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Urology & Nephrology
Eugene Yu Hin Chan, Desmond Yat Hin Yap, Wilfred Hing Sang Wong, Tsz Wai Ho, Pak Chiu Tong, Wai Ming Lai, Tak Mao Chan, Alison Lap Tak Ma
Summary: The study evaluated the demographics and long-term patient outcomes of children with end-stage kidney disease in Hong Kong. It found an increasing incidence of pediatric end-stage kidney disease with considerable waiting time for kidney transplants, and mortality risk comparable to other developed countries, being highest among the dialysis population.
Article
Urology & Nephrology
Desmond Y. H. Yap, Philip Hei Li, Colin Tang, Benjamin Y. F. So, Lorraine P. Y. Kwan, Gary C. W. Chan, Chak Sing Lau, Tak Mao Chan
Summary: This study suggests that the addition of a calcineurin inhibitor to mycophenolate and corticosteroids can further reduce proteinuria and maintain disease control in LN patients who do not respond well to standard therapy.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Urology & Nephrology
Eugene Yu-hin Chan, Desmond Yat-hin Yap, Manuela Colucci, Alison Lap-tak Ma, Rulan S. Parekh, Kjell Tullus
Summary: Rituximab is an established therapy for children with idiopathic nephrotic syndrome, providing short- to medium-term disease remission and avoiding steroid toxicities. Recent trials focus on using rituximab as a first-line agent for milder disease severity. The treatment response to rituximab depends on various factors, including patient characteristics, dosing regimen, and the use of immunosuppression. Repeated treatments lead to an improving response overall, but relapse eventually occurs in 80% of patients, necessitating additional courses of rituximab. The long-term safety profile and the development of reliable predictors for treatment success and side effects are areas of concern.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Health Care Sciences & Services
Ho Yan Au, Kwok Ying Chan, Desmond Y. H. Yap, Terence Yip, Chi Yan Wong
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Editorial Material
Health Care Sciences & Services
Kwok Ying Chan, Desmond Y. H. Yap, Ho Yin Chung, Tak Mao Chan, Harinder Singh Harry Gill, Chak Sing Lau
Summary: As the number of patients with concomitant long-standing systemic rheumatic diseases and age-related comorbidities increases, there is a growing need to integrate palliative care into rheumatology. Additionally, there is an emerging area of service need for patients with advanced malignancy who develop rheumatological problems and require palliative care.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Biochemistry & Molecular Biology
Ming Xie, Ruiyan Xie, Pengcheng Huang, Desmond Y. H. Yap, Peng Wu
Summary: Chromatin regulators play important roles in the pathogenesis of renal ischemia-reperfusion injury (IRI). In this study, a risk prediction model for renal IRI was developed based on the upregulated expression of five chromatin regulator genes (DUSP1, GADD45A, GADD45B, GADD45G, HSPA1A), which are associated with key signaling pathways. GADD45A and GADD45B were found to be correlated with pDCs and enriched in the MAPK pathway. Candidate drugs targeting GADD45A and GADD45B may have therapeutic potential for renal IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Psychiatry
Kwok Ying Chan, Desmond Y. H. Yap, Harinder Singh Harry Gill
Summary: This Viewpoint highlights specific issues regarding palliative care for individuals with severe mental illnesses.
Letter
Hematology
Kwok Ying Chan, Harinder Singh Harry Gill, Desmond Y. H. Yap
LANCET HAEMATOLOGY
(2022)