Review
Pharmacology & Pharmacy
Cecilia Nalli, Jessica Galli, Daniele Lini, Angela Merlini, Silvia Piantoni, Maria Grazia Lazzaroni, Victoria Bitsadze, Jamilya Khizroeva, Sonia Zatti, Laura Andreoli, Elisa Fazzi, Franco Franceschini, Alexander Makatsariya, Yehuda Shoenfeld, Angela Tincani
Summary: The management of reproductive issues in women with inflammatory arthritis has evolved with the availability of biologic agents, leading to discussions about medication use during pregnancy and breastfeeding. While controlling maternal disease with safe drugs is crucial for the health of both the mother and the baby, concerns remain about the potential impact on the fetus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Ruth E. Costello, Belay B. Yimer, Polly Roads, Meghna Jani, William G. Dixon
Summary: The study found an association between the use of glucocorticoids and incident hypertension in patients with rheumatoid arthritis, especially at doses >= 7.5 mg. Clinicians should consider cardiovascular risk when prescribing glucocorticoids, and ensure regular monitoring and treatment of blood pressure.
Article
Rheumatology
Stefka Neycheva, Emilia Naseva, Zguro Batalov, Rositsa Karalilova, Anastas Batalov
Summary: The advent of biologic disease-modifying antirheumatic drugs has changed the treatment and prognosis of rheumatoid arthritis. Adherence to prescribed medications is crucial for achieving therapeutic results. This study aimed to assess the impact of various factors on adherence to biologic treatment among Bulgarian patients with rheumatoid arthritis. Findings showed that disease activity and functional capacity remained significant predictors of treatment adherence. Improvement strategies should consider these influencing factors.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Marta Rojas-Gimenez, Clementina Lopez-Medina, Jerusalem Calvo-Gutierrez, Maria Angeles Puche-Larrubia, Ignacio Gomez-Garcia, Pedro Segui-Azpilcueta, Maria del Carmen Abalos-Aguilera, Desiree Ruiz, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras
Summary: The objective of this study was to assess the association between carotid intima-media thickness (CIMT) and the presence of atheromatous plaque with different rheumatoid arthritis (RA) treatments. The results showed that patients on tumor necrosis factor alpha (TNF alpha) inhibitors had smaller CIMTs, suggesting a potential protective effect against subclinical atherosclerosis. However, these findings should be confirmed in larger prospective studies.
Review
Cell Biology
Brianna Hurysz, Nunzio Bottini
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease associated with dysregulation of proteoglycans. Modulating the function and signaling of proteoglycans, as well as targeting citrullinated aggrecan with tolerizing agents, may provide a potential approach to improve current RA therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Immunology
Alison D. Petro, Joseph Dougherty, Bryant R. England, Harlan Sayles, Michael J. Duryee, Carlos D. Hunter, Joel M. Kremer, Dimitrios A. Pappas, William H. Robinson, Jeffrey R. Curtis, Geoffrey M. Thiele, Ted R. Mikuls
Summary: In rheumatoid arthritis patients, the number of positive autoantibodies is dose-dependently associated with treatment response to biologics, with anti-CCP antibody positivity having the strongest impact.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xingzhi Guo, Li Chong, Xin Zhang, Rui Li
Summary: Rheumatoid arthritis patients have a decreased risk of Parkinson's disease, partially due to the use of immunosuppressants.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Susanne N. Wijesinghe, Mark A. Lindsay, Simon W. Jones
Summary: Research on osteoarthritis and rheumatoid arthritis has shown that oligonucleotide therapies may be a potential method to treat these diseases by modulating cellular pathways to alter joint pathology and prevent disease progression.
Article
Rheumatology
Stefka Neycheva, Emilia Naseva, Zguro Batalov, Rositsa Karalilova, Anastas Batalov
Summary: This study assessed the compliance and persistence of biologic disease-modifying anti-rheumatic drugs (bDMARDs) among Bulgarian patients with rheumatoid arthritis (RA) and found low compliance rates. Treatment interruption and nonadherence to recommended therapy were associated with disease progression and patient disability, leading to negative impacts on finances, psychosocial factors, and physical well-being.
RHEUMATOLOGY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Tai-Li Chen, Kai-Hung Chang, Kuei-Ying Su
Summary: This article provides a review of the association between inflammatory arthritis, such as RA and SpA, and the development of osteoporosis. It discusses the mechanisms, pathophysiology, and treatment options related to bone destruction in patients with RA and SpA. Inflammatory cytokines, autoantibodies, and multiple signaling pathways play essential roles in bone destruction in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Juan Wen, Huimin Li, Huan Dai, Shu Hua, Xing Long, Huang Li, Saso Ivanovski, Chun Xu
Summary: This review systematically summarizes nanoparticle-based therapies for the management of osteoarthritis (OA) and rheumatoid arthritis (RA). The interaction between nanoparticles and joint tissues, including articular fluids and cells, is explored. Current nanoparticles designed for OA/RA treatment are analyzed, and challenges and future clinical translation of nanoparticle-based therapies are discussed.
MATERIALS TODAY BIO
(2023)
Article
Immunology
Yuzhuo Zhang, Jiangpeng Lin, Zhixuan You, Hengjia Tu, Peng He, Jiarong Li, Rui Gao, Ziyu Liu, Zhiyuan Xi, Zekun Li, Yi Lu, Qiyuan Hu, Chenhui Li, Fan Ge, Zhenyu Huo, Guibin Qiao
Summary: By conducting a comprehensive analysis on the cancer risk of rheumatoid arthritis (RA) patients using different types of disease-modifying anti-rheumatic drugs (DMARDs), this study found that conventional synthetic DMARDs (csDMARDs) were associated with increased risks of lung cancer, lymphoma, and melanoma, while biologic DMARDs (bDMARDs) did not show a significant risk increase. In addition, tumor mutational burdens (TMBs) were not correlated with cancer risks in RA patients following immunosuppressive therapy, suggesting that immunosuppression induced by treatment may not increase the risk of cancer in RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Muznay N. Khawaja, Eaman Alhassan, Jawad Bilal, Shraddha Jatwani, Bella Mehta, Varun Bhalla, Daniel J. Morgan, Bernadette C. Siaton, Marc C. Hochberg
Summary: Medical overuse can increase healthcare costs and potentially harm patients. Studies in musculoskeletal disease and rheumatology have identified cases of overtesting and overtreatment, such as unnecessary tests and excessive prescriptions. Efforts to reduce medical overuse include initiatives like the Choosing Wisely Campaign.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Xiaofeng Zeng, Dongbao Zhao, Sebastiao C. Radominski, Mauro Keiserman, Chang K. Lee, Sebastian Meerwein, Jeffrey Enejosa, Yunxia Sui, Mohamed-Eslam F. Mohamed, Won Park
Summary: In Chinese, Brazilian, and South Korean patients with active rheumatoid arthritis who had an inadequate response to csDMARDs, the study demonstrated that UPA 15 mg in combination with csDMARDs showed significant clinical improvement over 12 weeks, with an acceptable safety profile.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Nutrition & Dietetics
Jean-Baptiste Bouillon-Minois, Louisa Khaled, Florence Vitte, Ludovic Miraillet, Romain Eschalier, Matthieu Jabaudon, Vincent Sapin, Lucas Derault, Samy Kahouadji, Marina Brailova, Julie Durif, Jeannot Schmidt, Fares Moustafa, Bruno Pereira, Emmanuel Futier, Damien Bouvier
Summary: The study establishes the reference values for ionized magnesium (iMg) and finds a strong correlation between plasmatic magnesium (pMg) and iMg. The interpretation of iMg is not influenced by pH and albumin variations. The incidencce of ionized hypomagnesemia among de novo atrial fibrillation patients is 8.5%.
Article
Environmental Sciences
Alicia Fillon, Nicole Fearnbach, Stephanie Vieira, Jade Gelinier, Sarah Bagot, Melina Bailly, Audrey Boscaro, Lena Pelissier, Julie Siroux, Vincent Grasteau, Jean Bertsch, Bruno Pereira, Martine Duclos, Celine Lambert, David Thivel
Summary: This study evaluates the effects of the Globe Trotter Initiative on physical activity level, sedentary time, physical fitness, and activity preferences in primary school children. The findings suggest that the intervention had beneficial effects on reducing sedentary time and increasing preference for physical activities among the participating students.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Environmental Sciences
Frederic Dutheil, Tharwa Oueslati, Louis Delamarre, Joris Castanon, Caroline Maurin, Frederic Chiambaretta, Julien S. S. Baker, Ukadike C. C. Ugbolue, Marek Zak, Ines Lakbar, Bruno Pereira, Valentin Navel
Summary: Myopia is a global public health problem that affects people's quality of life and work productivity. This study conducted a meta-analysis to investigate the effects of near work on myopia, including adults' occupational exposure. The results showed that near work conditions, including occupational exposure, were associated with myopia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Randy Coupet, Martin Schlaepfer, Thomas A. Neff, Pierre Boucher, Pierre Bailly, Martin Bellgardt, Rafael Badenes, Jose Carbonell, Tobias Becher, Caroline Varillon, Dominique Morand, Raiko Blondonnet, Jean-Michel Constantin, Bruno Pereira, Brian O'Gara, Matthieu Jabaudon
Summary: This study investigated 196 COVID-19 ARDS patients from 10 intensive care units in Europe and the US in 2021. The results showed that inhaled sedation did not significantly improve the number of ventilator-free days compared to intravenous sedation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Eve Faugeras, Lauren Veronese, Gaelle Jeannin, Henri Janicot, Sebastien Bailly, Jacques-Olivier Bay, Bruno Pereira, Anne Cayre, Frederique Penault-Llorca, Florent Cachin, Patrick Merle, Andrei Tchirkov
Summary: In patients with advanced non-small cell lung cancer (NSCLC), short telomeres, high levels of telomerase, and aberrant expression of shelterin genes TRF2, RAP1, and TIN2 are significantly associated with shorter survival. The determination of telomere parameters in NSCLC could be useful for individualized treatment decisions.
Article
Biochemistry & Molecular Biology
Xavier Poirot-Seynaeve, Perrine Smets, Bruno Pereira, Louis Olagne, Julien Stievenart, Vincent Sapin, Olivier Aumaitre, Marc Andre, Ludovic Trefond
Summary: Procalcitonin (PCT) may be useful for differentiating between infections and flare in patients suffering from antineutrophil-cytoplasmic-antibody (ANCA)-associated vasculitides (AAV). The study found that PCT levels were significantly higher in the infected group compared to the relapsing group. C-reactive protein (CRP) levels were also higher in cases of infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Thomas Bardin, Yves-Marie Ducrot, Quang Nguyen, Emmanuel Letavernier, Jeremy Zaworski, Hang-Korng Ea, Frederic Touzain, Minh Duc Do, Julien Colot, Yann Barguil, Antoine Biron, Matthieu Resche-Rigon, Pascal Richette, Corinne Collet
Summary: This study identified three rare LDHD gene variants associated with juvenile-onset gout in three different ethnicities. The variants were found to cause decreased urate clearance and increased levels of d-lactate in blood and urine.
Article
Genetics & Heredity
Charlene Gouhier, Hanae Pons-Rejraji, Sandra Dollet, Laure Chaput, Celine Bourgne, Marc Berger, Bruno Pereira, Andrei Tchirkov, Florence Brugnon
Summary: No significant impact of slow freezing on sperm telomere length (STL) was observed, despite increased sperm DNA oxidation and fragmentation. These findings are important for ensuring the safety of assisted reproductive techniques, fertility preservation, and sperm donation.
Article
Medicine, General & Internal
Amandine Puissegur, Marie Accoceberry, Marion Rouzaire, Bruno Pereira, Marie Herault, Clement Bruhat, Amelie Delabaere, Denis Gallot
Summary: We conducted a retrospective case-control study to identify risk factors for early perineal suture breakdown in patients with perineal tear or episiotomy complication. Instrumental delivery and a longer second phase of labor were confirmed as risk factors for early perineal suture breakdown.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Julie Maraud, Sabrina Bedhomme, Bruno Pereira, Sophie Trevis, Marine Jary, David Balayssac
Summary: Self-medication practices by cancer patients and survivors, including the use of dietary supplements and pain medications, were assessed in this French observational study. The study found that self-medication was commonly practiced to manage the adverse effects of anticancer therapies and to improve their efficacy. Patients had high confidence in the safety of self-medication, but it was associated with altered social functioning, pain, insomnia, and financial difficulties. These findings highlight the potential undermanagement of cancer and treatment-related adverse effects.
Article
Oncology
Nicolas Saroul, Nicolas Tardif, Bruno Pereira, Alexis Dissard, Laura Montrieul, Phelipe Sanchez, Jerome Salles, Jens Erik Petersen, Towe Jakobson, Laurent Gilain, Thierry Mom, Yves Boirie, Olav Rooyakers, Stephane Walrand
Summary: Cancer cachexia, particularly muscle loss, in head and neck cancer (HNC) is not solely attributed to decreased food intake. The exact role of secreted factors from tumor cells in driving cancer cachexia is still unknown. This study used conditioned media from HNC cell lines and mix of sera from HNC patients to analyze their impact on skeletal muscle protein catabolism, and found similar metabolic responses in both cases. These findings suggest that muscle atrophy in HNC patients is not solely caused by reduced food intake.
Article
Pediatrics
Justine Paysal, Charlotte Oris, Ugo Troin, Pierre-Nicolas Limeri, Jeanne Allard, Marie Tadrent, Bruno Pereira, Etienne Merlin, Emmanuelle Rochette, Bertrand Evrard, Julie Durif, Vincent Sapin, Maguelonne Pons
Summary: This study aimed to compare the levels of blood tryptase and fecal calprotectin in newborns according to their term, trophicity, and sex. The results showed that blood tryptase levels were higher in premature newborns and in situations of antenatal use of corticosteroids and non-exclusive use of human milk. However, only prematurity significantly influenced tryptase levels according to regression analyses. Fecal calprotectin levels were much higher in female newborns compared to male newborns. The differences in tryptase levels could be due to early aggression of the still-immature digestive wall in premature newborns, while the influence of sex on fecal calprotectin levels remains unexplained.
Article
Rheumatology
Abhishek Abhishek, Sara K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang-Korng Ea, Georgios Filippou, John Fitzgerald, AnnaMaria Iagnocco, Frederic Liote, Geraldine M. McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andres, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L. Jansen, Minna J. Kohler, Lisa K. Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A. Fang, Fabiana A. Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M. Navarro, Piercarlo Sarzi-Puttini, Carlo Scire, Ettore Silvagni, Silvia Sirotti, John R. Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M. Hendry, Robert Terkeltaub, William J. Taylor, Hyon K. Choi
Summary: The ACR and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease, which include the presence of calcium pyrophosphate crystals in synovial fluid and certain symptoms and laboratory findings. These criteria are of great importance for advancing research in CPPD disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Abhishek Abhishek, Sara K. K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang Korng Ea, Georgios Filippou, John FitzGerald, AnnaMaria Iagnocco, Frederic Liote, Geraldine M. M. McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andres, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L. L. Jansen, Minna J. J. Kohler, Lisa K. K. Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A. A. Fang, Fabiana A. A. Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M. Navarro, Piercarlo Sarzi-Puttini, Carlo Scire, Ettore Silvagni, Silvia Sirotti, John R. R. Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M. M. Hendry, Robert Terkeltaub, William J. J. Taylor, Hyon K. K. Choi
Summary: The 2023 ACR/EULAR CPPD disease classification criteria have been developed to facilitate research in the field of symptomatic CPPD disease, providing excellent performance characteristics with high sensitivity and specificity.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Sylvain Mathieu, C. Lambert, Francoise Fayet, Marion Couderc, Marine Beauger, Sandrine Malochet, Marie-Eva Pickering, Anne Tournadre, Martin Soubrier
Summary: Patients with rheumatoid arthritis (RA) and hand osteoarthritis (HOA) both have an increased cardiovascular risk, but the causes are still debated. This study compared the CV risk factors and risk scores between HOA and RA patients and found that RA patients had significantly higher risk scores than HOA patients. The difference in risk scores became non-significant when RA patients had low disease activity.
RHEUMATOLOGY INTERNATIONAL
(2023)