Article
Oncology
Fatima Tensaouti, Franck Desmoulin, Julia Gilhodes, Margaux Roques, Soleakhena Ken, Jean -Albert Lotterie, Georges Noel, Gilles Truc, Marie -Pierre Sunyach, Marie Charissoux, Nicolas Magne, Vincent Lubrano, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study aimed to identify different components of glioblastoma subtypes using a large MRSI dataset and determine their association with progression-free survival. The results showed that pre-radiotherapy MRSI can reveal tumor heterogeneity and clusters with metabolic abnormalities and high lactate are predictive of PFS.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Martin Glas, Matthew T. Ballo, Ze'ev Bomzon, Noa Urman, Shay Levi, Gitit Lavy-Shahaf, Suriya Jeyapalan, Terence T. Sio, Paul M. DeRose, Martin Misch, Sophie Taillibert, Zvi Ram, Andreas F. Hottinger, Jacob Easaw, Chae-Yong Kim, Suyash Mohan, Roger Stupp
Summary: TTFields treatment affects the rate of distant progression in newly diagnosed GBM patients, with distant lesions appearing further from the primary lesion in the TTFields treatment arm. Distant progression correlates with improved clinical outcomes in TTFields patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Woom-Yee Bae, Jae-Sun Choi, Seungyoon Nam, Joo-Won Jeong
Summary: This study elucidated a novel function of Arrb2 in directly regulating HIF-1α stability through facilitating ubiquitin-mediated degradation, leading to inhibition of tumor growth and angiogenesis in human glioblastoma. These findings suggest Arrb2 as a potential therapeutic target for glioblastoma.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Nabavizadeh, Stephen J. Bagley, Robert K. Doot, Jeffrey B. Ware, Anthony J. Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Erica L. Carpenter, Jacob Till, Fraser Henderson Jr, Austin R. Pantel, H. Isaac Chen, John Y. K. Lee, Nduka M. Amankulor, Donald M. O'Rourke, Arati Desai, MacLean P. Nasrallah, Steven Brem
Summary: 18F-fluciclovine PET combined with multiparametric MRI can accurately differentiate between pseudoprogression and tumor progression, which is of great value in neurooncology, and this method is widely available.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Oncology
John J. Walsh, Maxime Parent, Adil Akif, Lucas C. Adam, Samuel Maritim, Sandeep K. Mishra, Muhammad H. Khan, Daniel Coman, Fahmeed Hyder
Summary: The multifaceted changes in vascularity, cellularity, and metabolism in glioblastoma progression were captured using MRI and MRSI methods. Each tumor showed unique spatiotemporal patterns in tumor perfusion, permeability, cellularity, and extracellular pH, which can be useful for exploring tumorigenesis and developing targeted therapies for specific aspects of the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Ursule Dumont, Stephane Sanchez, Cendrine Repond, Marie-Christine Beauvieux, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore, Helene Roumes
Summary: Neonatal hypoxia-ischemia (nHI) is a major cause of death or disabilities in infants, with no pharmacological treatment currently available. Research has shown that supplementation of trans-resveratrol in pregnant rat females can significantly reduce brain lesions caused by nHI and alleviate long-term consequences.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin A. Hoff, Benjamin Lemasson, Thomas L. Chenevert, Gary D. Luker, Christina I. Tsien, Ghoncheh Amouzandeh, Timothy D. Johnson, Brian D. Ross
Summary: This study suggests that PRMrFLAIR may serve as an early biomarker for disease progression in glioblastoma. Changes in PRMrFLAIR+ could potentially predict patient outcomes and stratify them for progression-free survival. The study demonstrates the potential of utilizing voxel-wise comparison of FLAIR signal for improved treatment monitoring in glioblastoma.
ACADEMIC RADIOLOGY
(2021)
Article
Medicine, General & Internal
Yen-Kuang Lin, Seok Hwang-Bo, Yu-Mi Seo, Young-Ah Youn
Summary: This study investigated the relationship between clinical seizures and amplitude-integrated electroencephalogram (aEEG) patterns in infants with hypoxic ischemic encephalopathy (HIE) and the extent of brain injury and neurodevelopmental outcomes. The results showed that HIE infants with clinical seizures exhibited delayed neurodevelopment, and risk factors for clinical seizures included male infants and hospital stays longer than 11 days.
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Collet, Jean-Sebastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuele Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stephane Guillouet, Cecile Perrio, Myriam Bernaudin, Samuel Valable
Summary: Conventional MRI plays a crucial role in managing high-grade glioma patients, but multiparametric MRI and PET tracers provide additional information to characterize tumor metabolism and heterogeneity. This study focused on evaluating proliferation, hypervascularization, and hypoxia in glioblastoma patients, finding marked differences in tracer uptake and rCBV maps between individuals, with certain tumor regions extending beyond the contrast enhancement volume.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Jiun-Lin Yan, Cheng-Hong Toh, Li Ko, Kuo-Chen Wei, Pin-Yuan Chen
Summary: The study utilized multimodal MRI, machine learning, and neural network analysis to predict progression patterns of GBM. Different progression phenotypes were found to be clinically significant, affecting treatment and prognosis. Results showed neural network models can efficiently predict tumor progression patterns, highlighting the importance of these patterns as prognostic factors.
Article
Biochemistry & Molecular Biology
Lin Zhang, Yuanyuan Cao, Xiaoxiao Guo, Xiaoyu Wang, Xiao Han, Kouminin Kanwore, Xiaoliang Hong, Han Zhou, Dianshuai Gao
Summary: Hypoxia, a common feature of the tumor microenvironment, promotes the progression of glioblastoma through reactive oxygen species (ROS) and hypoxia-inducible factor-1 alpha (HIF-1 alpha). ROS scavengers N-acetyl-l-cysteine (NAC) and diphenyleneiodonium chloride (DPI) can inhibit hypoxia-induced proliferation, migration, and invasion of glioblastoma cells. Hypoxia-induced ROS activates the HIF-1 alpha-SERPINE1 signaling pathway, leading to increased cell migration and invasion through epithelial-mesenchymal transition (EMT). Targeting ROS may be a promising therapeutic strategy for glioblastoma.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Oncology
Clara Le Fevre, Jean-Marc Constans, Isabelle Chambrelant, Delphine Antoni, Caroline Bund, Benjamin Leroy-Freschini, Roland Schott, Helene Cebula, Georges Noel
Summary: This review presents various imaging techniques and potential imaging biomarkers to differentiate pseudoprogression from true progression, improving diagnostic accuracy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Jianhua Qin, Yu Tang, Bao Wang
Summary: This study explores the feasibility of generating regional F-18-fluoromisonidazole (F-18-FMISO) positron emission tomography (PET) images using advanced magnetic resonance (MR) images and their predictive value for survival in glioblastoma patients. It demonstrates that multiple advanced MR images can be used to generate qualified regional F-18-FMISO PET images using neural networks. The generated images have predictive value in the prognostic evaluation of glioblastoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Needa Virani, Jihun Kwon, Heling Zhou, Ralph Mason, Ross Berbeco, Andrea Protti
Summary: The study used BOLD MRI to detect hypoxia regions in a murine glioblastoma model, optimizing parameters through MRI sequences and post-image analysis. Results showed strong correlation between BOLD MRI and pimonidazole measurements, indicating the potential for monitoring hypoxia during tumor development and therapy.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Nutrition & Dietetics
Helene Roumes, Stephane Sanchez, Imad Benkhaled, Valentin Fernandez, Pierre Goudeneche, Flavie Perrin, Luc Pellerin, Jerome Guillard, Anne-Karine Bouzier-Sore
Summary: Polyphenols extracted in an eco-sustainable manner have neuroprotective effects and can prevent brain lesions and associated deficits in a rat model of neonatal hypoxia-ischemia.
Article
Neurosciences
Lucie Friedauer, Christian Foerch, Joachim Steinbach, Elke Hattingen, Patrick N. Harter, Moritz Armbrust, Hans Urban, Eike Steidl, Elisabeth Neuhaus, Sophie von Brauchitsch
Summary: This study defines the acute superficial siderosis syndrome and describes its typical imaging and histopathological characteristics. Early recognition of this syndrome may help eliminate the source of bleeding in a timely manner to prevent clinical deterioration.
Article
Clinical Neurology
Alexander Grote, Dieter-Henrik Heiland, Julia Taube, Christoph Helmstaedter, Vidhya M. Ravi, Paulina Will, Elke Hattingen, Jan-Ruediger Schuere, Juri-Alexander Witt, Annika Reimers, Christian Elger, Johannes Schramm, Albert J. Becker, Daniel Delev
Summary: This study identifies a distinct mesial-temporal lobe epilepsy syndrome called "innate inflammatory gliosis only" characterized by chronic inflammation associated with astrocytes. Patients with this syndrome have poor seizure and neuropsychological outcomes after surgery compared to patients with hippocampus sclerosis. The findings suggest that this syndrome requires innovative pharmacotreatment strategies.
Article
Clinical Neurology
Nora F. Dengler, Christoph Scholz, Juergen Beck, Anne-Kathrin Uerschels, Ullrich Sure, Christian Scheller, Christian Strauss, Daniel Martin, Gabriele Schackert, Christian Heinen, Johannes Woitzik, Anna Lawson McLean, Steffen K. Rosahl, Jonas Kolbenschlag, Johannes Heinzel, Martin Schuhmann, Marco Soares Tatagiba, Waltraud Kleist-Welch Guerra, Henry W. S. Schroeder, Ignazio Gaspare Vetrano, Rezvan Ahmadi, Andreas Unterberg, Jennifer Reinsch, Anna Zdunczyk, Meike Unteroberdoerster, Peter Vajkoczy, Sarah Wehner, Michael Becker, Cordula Matthies, Jose Perez-Tejon, Annie Dubuisson, Damiano G. Barrone, Rikin Trivedi, Crescenzo Capone, Stefano Ferraresi, Jakob Kraschl, Thomas Kretschmer, Thomas Dombert, Frank Staub, Michael Ronellenfitsch, Gerhard Marquardt, Vincent Prinz, Marcus Czabanka, Anne Carolus, Veit Braun, Ralph Koenig, Gregor Antoniadis, Christian Rainer Wirtz, Lukas Rasulic, Maria Teresa Pedro
Summary: This is a registry study on peripheral nerve tumors (PNT) aiming to systematically investigate the epidemiology, clinical symptoms, treatment strategies and outcomes, genetic and histopathologic features, as well as imaging characteristics of PNT. The study aims to improve understanding of PNT and assist future interventional studies.
NEUROLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Makoto Kiyose, Eva Herrmann, Jenny Roesler, Pia S. Zeiner, Joachim P. Steinbach, Marie-Therese Forster, Karl H. Plate, Marcus Czabanka, Thomas J. Vogl, Elke Hattingen, Michel Mittelbronn, Stella Breuer, Patrick N. Harter, Simon Bernatz
Summary: By using MRI measurements and histopathological analysis, we can predict the primary tumor origin of brain metastases in a non-invasive manner and differentiate different types of brain metastases based on their proliferative status.
Article
Clinical Neurology
K. Bouhadjer, L. V. Romo, M. J. Brennan, B. M. Kozak, E. Hattingen, A. F. Juliano, H. D. Curtin, K. L. Reinshagen
Summary: Small vestibular aqueducts are more frequently seen in patients without Ménière disease and have no correlation with symptoms such as hearing loss and vertigo.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Stefan Weidauer, Elisabeth Neuhaus, Elke Hattingen
Summary: This article provides an overview of the neuroradiological features, clinical symptoms, and differential diagnostic considerations of the two types of superficial siderosis (SS) of the central nervous system (infratentorial and cortical).
CLINICAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Maximilian Rauch, Jan-Ruediger Schuere, Franziska Lieschke, Fee Keil, Eike Steidl, Se-Jong You, Christian Foerch, Elke Hattingen, Stefan Weidauer, Martin A. Schaller-Paule
Summary: This study re-evaluated the relationship between thalamic infarct localization and clinical symptoms using vascular and functional territorial thalamic maps. The results showed that sensorimotor hemiparesis and neglect were predictive for a specific region of thalamic infarct, while hemisensory syndrome did not allow for specific localization.
CLINICAL NEURORADIOLOGY
(2023)
Article
Pediatrics
Katharina J. Wenger, Caroline E. Koldijk, Elke Hattingen, Luciana Porto, Wiebke Kurre
Summary: This study retrospectively characterized WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, aiming to learn more about the underlying disorders encountered in everyday clinical practice. The majority of WMSAs were acquired and were non-specific in brain MRI, followed by autoimmune disorders and non-genetic hypoxic and ischemic insults.
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Johann Philipp Zoellner, Annika Kirscht, Christina Julia Mueller, Christopher Nimsky, Maximilian Schulze, Elke Hattingen, Georgios Chatzis, Thomas M. Freiman, Adam Strzelczyk, Sven Fuest, Katja Menzler, Felix Rosenow, Susanne Knake
Summary: This study aimed to identify coexisting structural lesions in patients with epilepsy and known temporal encephaloceles (TEs). Results showed that TEs can occur with other lesions, potentially impacting surgical evaluation and approach. Additionally, TEs may be associated with malformations of cortical development.
Correction
Clinical Neurology
Lucas Hoffmann, Roland Coras, Katja Kobow, Javier A. A. Lopez-Rivera, Dennis Lal, Costin Leu, Imad Najm, Peter Nuernberg, Jochen Herms, Patrick N. N. Harter, Christian G. G. Bien, Thilo Kalbhenn, Markus Mueller, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Hajo Hamer, Sebastian Brandner, Karl Roessler, Ingmar Bluemcke, Samir Jabari
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Lucas Hoffmann, Roland Coras, Katja Kobow, Javier A. Lopez-Rivera, Dennis Lal, Costin Leu, Imad Najm, Peter Nuernberg, Jochen Herms, Patrick N. Harter, Christian G. Bien, Thilo Kalbhenn, Markus Mueller, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Hajo Hamer, Sebastian Brandner, Karl Roessler, Ingmar Bluemcke, Samir Jabari
Summary: Exome-wide sequencing studies have identified PTPN11 as a novel brain somatic epilepsy gene, while germline mutations of PTPN11 cause Noonan syndrome. In this study, the authors analyzed ganglioglioma (GG) with PTPN11 alterations and compared them to GG with BRAFV600E mutations. They found that GG with PTPN11 alterations had adverse postsurgical outcome and distinct genetic characteristics.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
P. F. Samp, F. Keil, R. du Mesnil, A. Birkhold, M. Kowarschik, E. Hattingen, J. Berkefeld
Summary: Detailed analysis of dural AVFs using the standardized display of 4D-DSA volumes was feasible and helpful in understanding the angioarchitecture in selected cases. However, limitations such as motion artifacts and suboptimal selection of the injected vessel were observed in some cases.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Leonore Purwien, Susanne Schubert-Bast, Matthias Kieslich, Michael W. Ronellenfitsch, Michael Merker, Marcus Czabanka, Laurent M. Willems, Felix Rosenow, Adam Strzelczyk
Summary: Midazolam has become the preferred benzodiazepine for both children and adults in pre- and in-hospital settings, with newer ASMs such as levetiracetam and lacosamide showing increased usage over time while older ASMs like phenobarbital, phenytoin, and valproate have decreased. Despite changes in medication patterns, mortality and outcomes have remained stable.
Letter
Clinical Neurology
Rafael Willems, Se-Jong You, Friederike Vollmer, Elke Hattingen, Stefan Weidauer
CLINICAL NEURORADIOLOGY
(2023)
Review
Neurosciences
Reinhold Nafe, Christophe T. Arendt, Elke Hattingen
Summary: The objective of this review article is to provide a comprehensive overview of the major features of human prion diseases, bridging the gap between basic research and clinical aspects. The article highlights current insights into the physiological functions of the prion protein and the process of pathological conversion. It discusses diagnostic, molecular, and clinical aspects of all human prion diseases, including rare diseases and potential transmission of prions from other species.
TRANSLATIONAL NEUROSCIENCE
(2023)
