Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Torsten Diekhoff, Iris Eshed, Felix Radny, Katharina Ziegeler, Fabian Proft, Juliane Greese, Dominik Deppe, Robert Biesen, Kay Geert Hermann, Denis Poddubnyy
Summary: The study found that compared to CT and MRI, X-ray had lower sensitivity and inferior specificity for axSpA. However, CT showed the best inter-rater reliability, highlighting the importance of structural lesions for the differential diagnosis in axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Zhixiu Li, Sjef M. van der Linden, Muhammad Asim Khan, Heinz Baumberger, Hermine van Zandwijk, Mohammad Kazim Khan, Peter M. Villiger, Matthew A. Brown
Summary: The objective of this study is to assess heterogeneity in axial spondyloarthritis (axSpA) and its sources. The results suggest that women clinically diagnosed with axSpA but without radiographic sacroiliitis have distinct characteristics compared to men with non-radiographic axSpA.
Editorial Material
Rheumatology
Denis Poddubnyy, Torsten Diekhoff, Xenofon Baraliakos, Kay Geert A. Hermann, Joachim Sieper
Summary: This article discusses whether MRI can replace radiographs for diagnostic evaluation and classification of axial spondyloarthritis, and provides answers to specific questions based on current data.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Xabier Michelena, Sizheng Steven Zhao, Sayam Dubash, Linda E. Dean, Gareth T. Jones, Helena Marzo-Ortega
Summary: This study aimed to describe the baseline characteristics, bDMARD response and drug survival of axSpA patients in the UK according to radiographic status. Results showed comparable levels of biologic response and drug survival between nr-axSpA and r-axSpA patients.
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Rick Wilbrink, Anneke Spoorenberg, Suzanne Arends, Kornelis S. M. van der Geest, Elisabeth Brouwer, Hendrika Bootsma, Frans G. M. Kroese, Gwenny M. Verstappen
Summary: This study compared the composition of peripheral B-cell compartment in axSpA patients and pSS patients, revealing a significant increase in the frequency of CD21(low) B cells compared to healthy donors. This suggests an active involvement of B-cells in the pathogenesis of axSpA, contradicting previous beliefs.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Multidisciplinary Sciences
Luca Franco, Raj Sengupta, Logan Wade, Dario Cazzola
Summary: The study introduced a wearable sensor protocol for assessing spinal ROM and kinematics, showing low error in measurements and high level of agreement in reliability analysis. The protocol demonstrated potential for clinical application, but further validation on Axial Spondyloarthritis patients is needed.
Article
Rheumatology
Matilda Morin, Thomas Frisell, Olof Stephansson, Karin Hellgren
Summary: This study aimed to assess the risks of adverse pregnancy outcomes in women with axial spondyloarthritis and investigate how the outcomes varied over time and with anti-rheumatic treatment. The results showed increased risks of preterm birth, pre-eclampsia, elective caesarean delivery, and serious infant infection in women with axial spondyloarthritis compared to the general population. However, there was a trend of improvement in pregnancy outcomes over time, coinciding with increased use of biological DMARDs.
LANCET RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi
Summary: HLA-B27 positive patients with axial spondyloarthritis (AxSpA) tend to have lower disease activity compared to HLA-B27 negative patients, as indicated by higher BASDAI scores. HLA-B27 positive patients with mild back pain are more likely to be diagnosed with AxSpA, suggesting a cognitive bias introduced by the HLA-B27 test.
SCIENTIFIC REPORTS
(2021)
Article
Nursing
Souraya Sidani, Dana R. Epstein, Mary Fox, Joyal Miranda
CLINICAL NURSING RESEARCH
(2018)
Review
Endocrinology & Metabolism
Amanda C. Kentner, Sherry L. Grace
FRONTIERS IN NEUROENDOCRINOLOGY
(2017)
Review
Cardiac & Cardiovascular Systems
Mahshid Moghei, Karam Turk-Adawi, Wanrudee Isaranuwatchai, Nizal Sarrafzadegan, Paul Oh, Caroline Chessex, Sherry L. Grace
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Gabriela Lima de Melo Ghisi, Claudia Victoria Anchique Santos, Briseida Benaim, Francisco Lopez-Jimenez, Artur Haddad Herdy, Jose Medina Inojosa, Carmen M. Terzic, Lisiane Janovik, Maria Fernanda Rojas, Sherry L. Grace
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2017)
Review
Rheumatology
Katayoon Bidad, Eric Gracey, Kasey S. Hemington, Josiane C. S. Mapplebeck, Karen D. Davis, Robert D. Inman
NATURE REVIEWS RHEUMATOLOGY
(2017)
Review
Rheumatology
Vidya Ranganathan, Eric Gracey, Matthew A. Brown, Robert D. Inman, Nigil Haroon
NATURE REVIEWS RHEUMATOLOGY
(2017)
Article
Audiology & Speech-Language Pathology
Boaz M. Ben-David, Michal Icht
LANGUAGE AND SPEECH
(2018)
Correction
Rheumatology
J. S. Smolen, M. Schols, J. Braun, Douglas Veale
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Jonathan Chan, Ismail Sari, David Salonen, Mark S. Silverberg, Nigil Haroon, Robert D. Inman
ARTHRITIS CARE & RESEARCH
(2018)
Article
Rheumatology
Mansour Alazmi, Ismail Sari, Bharath Krishnan, Robert D. Inman, Nigil Haroon
ARTHRITIS CARE & RESEARCH
(2018)
Article
Gerontology
Emily C. King, Veronique M. Boscart, Brett M. Weiss, Tilak Dutta, Jack P. Callaghan, Geoff R. Fernie
JOURNAL OF APPLIED GERONTOLOGY
(2019)
Article
Immunology
Magar Ghazarian, Xavier S. Revelo, Mark K. Nohr, Helen Luck, Kejing Zeng, Helena Lei, Sue Tsai, Stephanie A. Schroer, Yoo Jin Park, Melissa Hui Yen Chng, Lei Shen, June Ann D'Angelo, Peter Horton, William C. Chapman, Diane Brockmeier, Minna Woo, Edgar G. Engleman, Oyedele Adeyi, Naoto Hirano, Tianru Jin, Adam J. Gehring, Shawn Winer, Daniel A. Winer
SCIENCE IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
Yuki Kagoya, Munehide Nakatsugawa, Toshiki Ochi, Yuchen Cen, Tingxi Guo, Mark Anczurowski, Kayoko Saso, Marcus O. Butler, Naoto Hirano