Review
Immunology
Ping Jiang, Kai Wei, Cen Chang, Jianan Zhao, Runrun Zhang, Lingxia Xu, Yehua Jin, Linshuai Xu, Yiming Shi, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: This review discusses the role of Secreted frizzled-related protein 1 (SFRP1) in the pathogenesis of rheumatoid arthritis-fibroblast-like synoviocytes (RA-FLS), including its regulation of cell proliferation, migration, and cell pyroptosis. The review also summarizes different experimental platforms and recent research results, emphasizing the epigenetic regulation of SFRP1 in RA-FLS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dorra Elhaj Mahmoud, Wajih Kaabachi, Nadia Sassi, Amel Mokhtar, Myriam Moalla, Lobna Ben Ammar, Samia Jemmali, Sonia Rekik, Lamjed Tarhouni, Maryam Kallel-Sellami, Elhem Cheour, Lilia Laadhar
Summary: RA td-FLS, fd-FLS, and fibrocytes from patients express similar levels of Wnt5a and its receptors/coreceptors. Wnt5a stimulates pro-inflammatory targets in RA td-FLS, especially IL1 beta, IL8, and IL6, and this inflammation is enhanced in the presence of SFRP5. Additionally, Wnt5a and SFRP5 inhibit the expression of TCF4 and the canonical coreceptor LRP5.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Fang-yuan Liu, Meng-qing Wang, Ming-ming Liu, Tao Li, Xiao-hua Wang, Fei Jiang, Xin-jie Wu, Juan Cheng, Li Cai, Rong Li
Summary: This study investigated the therapeutic roles of shikonin (SKN) on rheumatoid arthritis (RA) by evaluating its effects on cellular inflammation, migration, and invasion of RA fibroblast-like synoviocytes (FLS). The results showed that SKN reduced paw swelling, arthritis index, and pathological damage in rat adjuvant-induced arthritis (AIA) models. In vitro, SKN inhibited the production of pro-inflammatory factors and suppressed TNF-alpha-induced migration, invasion, and cytoskeletal reorganization of RA FLS. Mechanistically, SKN interrupted the Wnt/beta-catenin pathway.
Article
Immunology
Xiao Wang, Dexi Zhou, Wanwan Zhou, Jian Liu, Qiuyun Xue, Yurong Huang, Chenglong Cheng, Yuting Wang, Jun Chang, Peng Wang, Chenggui Miao
Summary: CAR from CCO can inhibit the circPTN/miR-145-5p/FZD4 signal axis by combining with FZD4, thereby improving the pathology of RA. This finding is of great importance for the treatment of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu Tai, Bei Huang, Pai-pai Guo, Zhen Wang, Zheng-wei Zhou, Man-man Wang, Han-fei Sun, Yong Hu, Sheng-lin Xu, Ling-ling Zhang, Qing-tong Wang, Wei Wei
Summary: Our study demonstrates the impact of TNF-alpha on cAMP homeostasis and the interaction between TNF-alpha and EP4 signaling, revealing the potential role of TRAF2 and GRK2 in the treatment of inflammatory diseases. The findings provide valuable insights into a novel form of cross-talk between cytokine receptors and G protein-coupled receptors, suggesting TRAF2-GRK2 interaction as a potential new drug target.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Immunology
Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Summary: Fibroblast-activated protein-a (FAP) is overexpressed by activated fibroblasts during fibrosis or inflammation. It plays important roles in regulating the cellular responses in the synovial region of rheumatoid arthritis (RA), and its overexpression is regulated by the initial inflammatory microenvironment and epigenetic signaling. Targeted therapies for FAP are currently being developed. This review discusses the features of FAP in FLSs and its role in RA pathophysiology, as well as advances in targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Hui Jiang, Jian Liu, Chang Fan, Jing Wang, Weiping Li
Summary: The study revealed that lncRNAS56464.1 promotes the proliferation of FLS by interacting with miR-152-3p and targeting the miR-152-3p/Wnt pathway, contributing to the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Parisa Zafari, Mahdi Taghadosi, Fatemeh Faramarzi, Misagh Rajabinejad, Alireza Rafiei
Summary: This study demonstrates that DMF treatment can suppress the proliferation and promote apoptosis of RA synovial cells, and reduce the release of inflammatory factors. These findings suggest that DMF may be considered as a therapeutic approach in the treatment of RA.
Article
Rheumatology
Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study applied the 2022 ACR/EULAR criteria for GPA to reclassify previously diagnosed Korean patients and found that a portion of patients could be reclassified as having GPA. Further discussion on the distortion of the CHCC definition and the weightage of the items is required for the 2022 ACR/EULAR criteria, despite being the product of the most advanced methodological process.
Article
Rheumatology
Hyunsue Do, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study investigated the frequency, types, and temporal relationship of cancer-associated vasculitis in Korean patients. The study found that the frequency of cancer-associated vasculitis was 0.034%, with thyroid cancer being the most common type of cancer and Behcet disease being the most frequent type of vasculitis associated with cancer.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Jung Y. Pyo, Sung S. Ahn, Jason J. Song, Yong-Beom Park, Sang-Won Lee
Summary: This study applied the 2022 ACR/EULAR criteria to Korean patients with previously diagnosed EGPA and found an 86.3% concordance rate. Some patients who failed to meet the new criteria may need to be reclassified.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Hyunsue Do, Jung Yoon Pyo, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study investigated the clinical implications of serious infections in patients with antineutrophil cytoplasmic anti-body-associated vasculitis (AAV) who received the first cycle of rituximab (RTX) during the first 6 months of follow-up. The study found that serious infections in AAV patients receiving RTX were associated with a significantly lower cumulative survival rate. However, no independent predictor of serious infections was identified. Therefore, RTX should be considered in refractory cases despite the increase in mortality rate.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jang Woo Ha, Joonnyung Heo, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study investigated the clinical and radiological features of acute brain infarction in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) using a cohort of Korean patients. The results showed that 4.6% of AAV patients experienced acute brain infarction, which was associated with age, BVAS score, and prior brain infarction.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Oh Chan Kwon, Min-Chan Park
Summary: This retrospective cohort study included 228 newly diagnosed SLE patients, and found that patients who were double-positive for anti-dsDNA and anti-Sm antibodies at the time of diagnosis had a higher risk of flare-ups, while single-positive patients had a relatively lower risk.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Oh Chan Kwon, Min-Chan Park, Yong-Gil Kim
Summary: Interleukin-32 (IL-32) is an important cytokine involved in innate and adaptive immune responses, and its role has been studied in various rheumatic diseases. IL-32 plays different roles in different types of rheumatic diseases and could serve as a biomarker for disease activity or specific manifestations. This narrative review summarizes the associations between IL-32 and various rheumatic diseases and discusses its putative role as a biomarker in each disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, See Young Lee, Jaeyoung Chun, Kyungdo Han, Yuna Kim, Ryul Kim, Min-Chan Park, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This population-based cohort study in Korea found that patients with immune-mediated inflammatory diseases (IMIDs) had a lower risk of all-cause mortality compared to individuals without IMIDs. The risks of cancer-specific and cardiovascular disease-specific mortalities were also lower in IMID patients.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Jin Seok Kim, Yong-Beom Park, Sang-Won Lee
Summary: This study examined the occurrence and characteristics of acute coronary syndrome (ACS) in Korean patients diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and identified male gender as a predictor of ACS. The incidence of ACS in AAV patients was 2.7%, with NSTEMI being the most common subtype.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Sung Soo Ahn, Sang-Won Lee
Summary: This article summarizes four guidelines for the management of AAV and introduces the summary of the 2022 Update of the EULAR Recommendations on the Management of AAV, presented in the EULAR Congress 2022.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Taejun Yoon, Jang Woo Ha, Jung Yoon Pyo, Jason Jungsik Song, Yong- Beom Park, Sung Soo Ahn, Sang-Won Lee
Summary: sTREM-1 may serve as an indicator of disease activity in MPA and GPA. This study found that sTREM-1 was associated with disease activity, clinical scores, and inflammatory markers, and higher sTREM-1 levels were associated with more severe disease activity.
Article
Rheumatology
Hyun Joon Choi, Pil Gyu Park, Yong-Beom Park, Ji Hye Huh, Sang-Won Lee
Summary: This study found that the hepatic steatosis index (HSI) at diagnosis of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can predict poor outcomes during the disease course, especially the increased risk of end-stage renal disease (ESRD).
JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
T. Yoon, J. Y. Pyo, S. S. Ahn, J. J. Song, Y-B Park, S-W Lee
Summary: This study investigated the potential of serum soluble interleukin-7 receptor alpha (sIL-7R alpha) levels to reflect the simultaneous activity of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The results showed that sIL-7R alpha levels were negatively correlated with activity of AAV, suggesting that it can serve as an additional biomarker for assessing the simultaneous activity of AAV.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Oh Chan Kwon, Kyungdo Han, Min-Chan Park
Summary: Patients with systemic sclerosis have a higher risk of kidney failure compared to the general population.
Article
Medicine, General & Internal
Taejun Yoon, Jang Woo Ha, Eunhee Ko, Jason Jungsik Song, Yong-Beom Park, Sung Soo Ahn, Sang -Won Lee
Summary: This study found that the serum concentrations of IL-23 and IL-27 are associated with AAV activity and MPA, while IL-35 and IL-39 are not useful in predicting AAV activity.
YONSEI MEDICAL JOURNAL
(2023)