Article
Cell Biology
Anahita Ebrahimpour, Mohammad Sarfi, Setareh Rezatabar, Sadra Samavarchi Tehrani
Summary: This study summarizes the roles and interactions of lncRNAs and miRNAs in glioma, providing insights into the pathogenesis and development of glioma.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Genetics & Heredity
Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Hamed Mirzaei
Summary: Glioma is a common invasive primary tumor of the central nervous system, and treatment resistance remains a problem. Non-coding RNAs play a role in the mechanisms of treatment resistance. This review discusses the pathways by which microRNAs and long non-coding RNAs affect resistance to chemotherapy and radiotherapy, and offers potential therapeutic options for future glioma treatment.
Review
Endocrinology & Metabolism
Mirjana T. Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R. Isenovic
Summary: Diabetic cardiomyopathy (DCMP) is a leading cause of morbidity and mortality in diabetic patients, and non-coding RNAs such as miRNAs and lncRNAs have been found to play a protective role in regulating processes related to DCMP. This paper reviews the literature on the roles of miRNAs and lncRNAs in DCMP in diabetes and demonstrates their potential for future DCMP treatment in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hui Liu, Zuofei Chi, Hong Jin, Wei Yang
Summary: The study found that miR-188-5p acts as a tumor suppressor in multiple myeloma, inhibits cell proliferation, and enhances apoptosis by directly binding to MALAT1 to regulate cellular processes.
Article
Environmental Sciences
Zarrin Banikazemi, Mojgan Farshadi, Ali Rajabi, Mina Homayoonfal, Nasrin Sharifi, Reza Sharafati Chaleshtori
Summary: This article reviews the biological effects of miRNA and lncRNA alterations following exposure to nanoplastics, which may increase the risk of chronic diseases such as cancer.
Review
Oncology
Maryam Hashemipour, Homa Boroumand, Samaneh Mollazadeh, Vida Tajiknia, Zahra Nourollahzadeh, Mina Rohani Borj, Hossein Pourghadamyari, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: miRNAs and lncRNAs play essential biological roles through various mechanisms, regulating gene expression and driving pathways in gynecological cancers. Exosomes serve as natural carriers of non-coding RNAs, focusing research on exosomal microRNAs and long non-coding RNAs for potential therapeutic applications.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Review
Oncology
Aryan Rezaee, Sara Ahmadpour, Ameneh Jafari, Sarehnaz Aghili, Seyed Saeed Tamehri Zadeh, Ali Rajabi, Arash Raisi, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Marzieh Derakhshan
Summary: Gynecologic cancer is a significant cause of death in women worldwide. Recent research has shown that non-coding RNAs play a critical role in the metastasis and invasion of gynecologic cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Physiology
Ailing Chen, Renqiang Yu, Shiwen Jiang, Yankai Xia, Ying Chen
Summary: Preeclampsia is a clinical syndrome characterized by multiple-organ dysfunction in pregnant women after 20 weeks of gestation, with termination of pregnancy being the only current prevention method. Non-coding RNAs play important roles in regulating physiological functions and may impact the pathogenesis of preeclampsia.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Ebrahim Balandeh, Kimia Mohammadshafie, Yaser Mahmoudi, Mohammad Hossein Pourhanifeh, Ali Rajabi, Zahra Razaghi Bahabadi, Amir Hossein Mohammadi, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: Non-coding RNAs play a crucial role in regulating angiogenesis in glioblastoma, affecting gene transcription and the expression of angiogenesis-inducing molecules through various mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Giada De Benedittis, Cinzia Ciccacci, Andrea Latini, Lucia Novelli, Giuseppe Novelli, Paola Borgiani
Summary: Sjogren's Syndrome is a chronic autoimmune inflammatory disease with a multifactorial pathology involving genetic predisposition, epigenetic mechanisms, and environmental factors. Recent studies indicate a significant regulatory role of non-coding RNAs in the disease, particularly microRNAs and long non-coding RNAs. Limited data is available on the genetic variability of non-coding RNAs in SS susceptibility, highlighting the need for further research to understand underlying pathogenic processes and develop targeted therapies.
Article
Biotechnology & Applied Microbiology
Lingshan Kong, Yanjing Zhuo, Jieru Xu, Xiangxu Meng, Yue Wang, Wenxiu Zhao, Hanggui Lai, Jinhui Chen, Jian Wang
Summary: This study identified and characterized genes, lncRNAs, and miRNAs involved in anther development of C. oleifera. The results revealed the regulatory roles of lncRNAs and miRNAs in anther development and provided insights into the molecular mechanisms underlying this process.
Review
Cardiac & Cardiovascular Systems
Yuhong Zeng, Na Wu, Zhihui Zhang, Li Zhong, Guowei Li, Yafei Li
Summary: Arrhythmias are characterized by heart rate disturbances and rhythm abnormalities, leading to significant morbidity and mortality. Current treatments lack effectiveness and often have adverse effects due to limited understanding of the pathological mechanism. Non-coding RNAs have been shown to be involved in arrhythmias and offer potential for new therapeutic targets. This review focuses primarily on atrial fibrillation (AF), the most common arrhythmia, to provide insight into the mechanistic role of non-coding RNAs and facilitate the development of targeted therapies.
Review
Endocrinology & Metabolism
Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Zhengwei Xu, Hao Yang, Dingjun Hao
Summary: Low back pain is a common musculoskeletal symptom that severely affects quality of life. Intervertebral disc degeneration is considered a major cause, and non-coding RNAs play crucial roles in its development. Their potential as therapeutic targets for IDD remain to be explored.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Yajie Liao, Xudong Wu, Mengyu Wu, Yuan Fang, Jie Li, Weiqiang Tang
Summary: Lung cancer is the second most common cancer globally and the leading cause of tumor-related mortality. Angiogenesis, a critical feature in cancer development, is a promising target for lung cancer treatment. Non-coding RNAs (ncRNAs) have been found to play crucial roles in tumor angiogenesis, and this review focuses on discussing the regulatory functions of different ncRNAs in lung cancer angiogenesis, including downstream targets and signaling pathways. The potential applications of ncRNAs as biomarkers or novel anti-angiogenic tools in lung cancer are also explored.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
