Journal
RHEUMATOLOGY
Volume 52, Issue 8, Pages 1358-1367Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/ket126
Keywords
phosphatidylethanolamine; antiphospholipid antibodies; thrombosis; pregnancy morbidity; antiphospholipid syndrome; seronegative antiphospholipid syndrome; anti-beta 2 glycoprotein I antibodies
Categories
Ask authors/readers for more resources
APS is an autoimmune disease that leads to arterial and/or venous thrombosis, recurrent pregnancy loss and persistently positive aPLs. Patients with clinical manifestations highly suggestive of APS but persistently negative conventional aPLs are classified as having seronegative APS. Ongoing research has revealed the existence of non-criteria antibodies proposed to be relevant to APS and that can be potentially included in the disease's classification criteria. We present a literature review on the most promising antibodies of this heterogeneous aPL family, which includes antibodies to a zwitterionic phospholipid, namely phosphatidylethanolamine, phospholipid-binding plasma proteins, phospholipid-protein complexes and anionic phospholipids other than cardiolipin. Although these molecules can increase the diagnostic yield of APS, their clinical relevance is still debatable and needs to be confirmed by interlaboratory efforts toward standardizing diagnostic tools, in addition to experimental data and larger longitudinal studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available