Article
Rheumatology
Mikkel Ostergaard, Ronald F. van Vollenhoven, Anna Rudin, Merete Lund Hetland, Marte Schrumpf Heiberg, Dan C. Nordstrom, Michael T. Nurmohamed, Bjorn Gudbjornsson, Lykke Midtboll Ornbjerg, Pernille Boyesen, Kristina Lend, Kim Horslev-Petersen, Till Uhlig, Tuulikki Sokka, Gerdur Grondal, Simon Krabbe, Joakim Lindqvist, Inger Gjertsson, Daniel Glinatsi, Meliha Crnkic Kapetanovic, Anna-Birgitte Aga, Francesca Faustini, Pinja Parmanne, Tove Lorenzen, Cagnotto Giovanni, Johan Back, Oliver Hendricks, Daisy Vedder, Tuomas Rannio, Emma Grenholm, Maud Kristine Ljosa, Eli Brodin, Hanne Lindegaard, Annika Soderbergh, Milad Rizk, Alf Kastbom, Per Larsson, Line Uhrenholt, Soren Andreas Just, David J. Stevens, Trine Bay Laurbjerg, Gunnstein Bakland, Inge Christoffer Olsen, Espen A. Haavardsholm, Jon Lampa, NORD-STAR Study Grp
Summary: This study compared the clinical and radiographic outcomes of different biological treatments with active conventional therapy in patients with early rheumatoid arthritis (RA). The results showed that abatacept and certolizumab pegol had higher clinical remission rates compared to active conventional therapy, while tocilizumab did not show significant differences. Radiographic progression was low and similar across treatments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Ian R. White, Sarah E. Kleinstein, Christophe Praet, Chris Chamberlain, Duncan McHale, Jessica M. Maia, Pingxing Xie, David B. Goldstein, Thomas J. Urban, Patrick R. Shea
Summary: This study aimed to identify genetic variants predictive of CZP response, but did not find a clear predictor of CZP response.
Article
Medicine, General & Internal
Emna Hannech, Soumaya Boussaid, Sonia Rekik, Samia Jemmali, Houda Ajlani, Elhem Cheour, Hela Sahli, Mohamed Elleuch
Summary: Tuberculosis should be considered when a patient with rheumatic disease deteriorates while under biological therapy. Rheumatologists should monitor and screen for infections before and after prescribing biological therapy.
CLINICAL CASE REPORTS
(2021)
Article
Medicine, General & Internal
Yuji Nozaki, Toshihiko Hidaka, Jinhai Ri, Tetsu Itami, Daisuke Tomita, Akinori Okada, Chisato Ashida, Fusayo Ikeda, Atsuhiro Yamamoto, Keiko Funahashi, Koji Kinoshita, Tsukasa Matsubara, Masanori Funauchi, Itaru Matsumura
Summary: The study indicates that in RA patients treated with CZP, there is no significant difference in treatment effectiveness, disease activity rate, and inhibitory effect on radiographic joint damage between those with and without concomitant use of MTX or between those receiving high and low MTX doses. CZP shows potential as a useful biological agent for controlling RA disease activity and bone destruction in patients intolerant to high doses of MTX.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Niyaz Yoosuf, Mateusz Maciejewski, Daniel Ziemek, Scott A. Jelinsky, Lasse Folkersen, Malin Muller, Peter Sahlstrom, Nancy Vivar, Anca Catrina, Louise Berg, Lars Klareskog, Leonid Padyukov, Boel Brynedal
Summary: Our study identified new biomarkers for predicting response to anti-TNF treatment, revealed pathways affected by treatment, and proposed new predictive models for RA patients.
Article
Biochemistry & Molecular Biology
Shipeng Zhang, Yimeng Lei, Tao Sun, Ziyu Gao, Zhuoqi Li, Hui Shen
Summary: This study found that Metrnl is involved in the pathogenesis of rheumatoid arthritis and the increase in serum Metrnl levels is closely related to disease activity.
Article
Dermatology
A. Blauvelt, C. Paul, P. van de Kerkhof, R. B. Warren, A. B. Gottlieb, R. G. Langley, F. Brock, C. Arendt, M. Boehnlein, M. Lebwohl, K. Reich
Summary: The study reported 3-year safety data from three phase III trials of CZP in adults with plaque psoriasis, including a total of 995 patients. Overall, no new safety signals were identified, and the risk did not increase with longer or higher CZP exposure.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Pan Fu, Zhanglei Cao, Hua Huang, Qinwen Wen, Kaizhe Wang, Tong Kong, Xiudi Wu, Jianping Zheng
Summary: The purpose of this study was to investigate the relationship between clinical efficacy response and disease activity of MTX monotherapy with MTHFR and MTRR polymorphisms. The study revealed that the MTHFR C677T, MTHFR A1298C, and MTRR A66G polymorphisms may not predict MTX clinical treatment response and disease activity in patients with early RA.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Camille Valdeyron, Martin Soubrier, Bruno Pereira, Arnaud Constantin, Jacques Morel, Philippe Gaudin, Bernard Combe, Anne Sophie Gremeau, Lydie Dejou-Bouillet, Jean Luc Pouly, Vincent Sapin, Charlotte Oris, Florence Brugnon
Summary: This study investigated the impact of RA disease activity and treatments on ovarian reserve measured by serum AMH levels in the ESPOIR cohort, finding a gradual decrease in AMH levels over time in RA patients. No significant differences were found in comparison with normal values, and an inverse correlation was demonstrated between AMH variation and disease activity.
Article
Rheumatology
Xenofon Baraliakos, Sebastian Kruse, Simone E. Auteri, Natasha de Peyrecave, Tommi Nurminen, Thomas Kumke, Bengt Hoepken, Juergen Braun
Summary: Fat lesions on MRI T1 sequences are early indicators of structural spinal progression in patients with axial spondyloarthritis (axSpA). This study analyzed the impact of tumor necrosis factor inhibitor (TNFi) treatment over 4 years on fat lesions in spinal vertebral edges of axSpA patients.
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Claudia M. Brenis, Chamaida Plasencia-Rodriguez, Ana Martinez-Feito, Marta Novella-Navarro, Dora Pascual-Salcedo, Alejandro Balsa
Summary: The study found that TNFi survival did not depend on seropositivity status, but seropositive patients who received concomitant MTX had significantly longer median survival time. Additionally, the co-administration of prednisone in seropositive patients receiving TNFi was highly associated with TNFi discontinuation.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Meltem Turkmen, Sinan Dogan
Summary: The study demonstrated that Certolizumab pegol is an effective and safe therapeutic option for patients with moderate-to-severe chronic plaque psoriasis. CZP led to significant reductions in PASI, PGA, and cDAPSA scores at week 4 of treatment. No adverse effects were observed during CZP treatment, even during the COVID-19 pandemic.
DERMATOLOGIC THERAPY
(2021)
Article
Immunology
Pablo Coto-Segura, Cristina Segu-Verges, Antonio Martorell, David Moreno-Ramirez, Guillem Jorba, Valentin Junet, Filippo Guerri, Xavier Daura, Baldomero Oliva, Carlos Cara, Olaya Suarez-Magdalena, Sonya Abraham, Jose Manuel Mas
Summary: This study used computational modeling to investigate the response variability of moderate-to-severe psoriasis patients to CZP treatment. By generating virtual populations and simulating different dosing regimens, the researchers identified drug efficacy differences in diverse subpopulations and revealed mechanisms of action for different dosing schemes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Menke J. de Smit, Johanna Westra, Marcel D. Posthumus, Gerald Springer, Arie Jan van Winkelhoff, Arjan Vissink, Elisabeth Brouwer, Marc Bijl
Summary: The study found that treatment with methotrexate (MTX) and anti-tumor necrosis factor-alpha (anti-TNF, etanercept) had negligible influence on the periodontal condition of rheumatoid arthritis (RA) patients, but significantly improved inflammatory markers of RA.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Orthopedics
J. Baloun, A. Pekacova, X. Svec, T. Kropackova, V. Horvathova, H. Hulejova, K. Prajzlerova, O. Ruzickova, O. Sleglova, J. Gatterova, M. Tomcik, M. Filkova, J. Vencovsky, K. Pavelka, L. Senolt
Summary: This study aimed to evaluate circulating microRNAs (miRNAs) in the plasma of patients with hand osteoarthritis (OA) compared to healthy control subjects. Three miRNAs were found to be associated with hand OA symptoms and may serve as candidate biomarkers.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Rheumatology
Simon I. Rothwell, Christopher W. Amos, Frederick G. Miller, Lisa E. Rider, Ingrid K. Lundberg, Peter Gregersen, Jiri Vencovsky, Neil McHugh, Vidya Limaye, Albert G. Selva-O'Callaghan, Michael M. Hanna, Pedro M. Machado, Lauren M. Pachman, Ann Reed, Oyvind Molberg, Olivier Benveniste, Pernille Mathiesen, Timothy Radstake, Andrea L. Doria, Jan De Bleecker, Boel De Paepe, Britta E. Maurer, William Ollier, Leonid P. Padyukov, Terrance O'Hanlon, Annette R. Lee, Lucy Wedderburn, Hector A. Chinoy, Janine Lamb
Summary: In this study, genetic analysis of samples from patients with idiopathic inflammatory myopathies (IIMs) identified novel gene variants and localized signals to specific immune cell types. These findings provide new insights into the pathogenesis of IIMs.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Hanna Kim, Didem Saygin, Christian Douglas, Jesse Wilkerson, Brian Erman, Angela Pistorio, John A. McGrath, Ann M. Reed, Chester Oddis, Claudia Bracaglia, Annet van Royen-Kerkhof, Blanca Bica, Pavla Dolezalova, Virginia P. L. Ferriani, Berit Flato, Ana G. Bernard-Medina, Troels Herlin, Frederick W. Miller, Jiri Vencovsky, Nicolino Ruperto, Rohit Aggarwal, Lisa G. Rider
Summary: The 2016 ACR-EULAR response criteria for JDM is a composite measure with six core set measures to calculate a total improvement score. This study evaluated the contribution of each measure, representation of muscle-related and patient-reported measures, and frequency of measure worsening across improvement categories. The results support the consistent performance of the ACR-EULAR MRC across multiple studies and its further use as an efficacy endpoint in JDM trials.
Article
Rheumatology
Sabina Oreska, Hana Storkanova, Aneta Pekacova, Jaroslav Kudlicka, Vladimir Tuka, Ondrej Mikes, Zdislava Krupickova, Martin Satny, Eva Chytilova, Jan Kvasnicka, Maja Spiritovic, Barbora Hermankova, Petr Cesak, Marian Rybar, Karel Pavelka, Ladislav Senolt, Herman Mann, Jiri Vencovsky, Michal Vrablik, Michal Tomcik
Summary: This study aimed to evaluate cardiovascular (CV) risk in patients with idiopathic inflammatory myopathies (IIM) compared with healthy controls (HC) and assess its association with disease-specific features. The study found a significantly higher prevalence of traditional CV risk factors, carotid artery disease (CARD), abnormal ankle-brachial index (ABI) and pulse wave velocity (PWV) in IIM patients compared with HC. Furthermore, the study demonstrated that the Systematic COronary Risk Evaluation (SCORE) was inaccurate in predicting CV risk in IIM.
Article
Rheumatology
Blanka Stiburkova, Katerina Pavelcova, Monika Belickova, Samuel J. Magaziner, Jason C. Collins, Achim Werner, David B. Beck, Veronika Balajkova, Cyril Salek, Martin Vostry, Herman Mann, Jiri Vencovsky
Summary: This study reports a case of a European ancestry patient with clinical manifestations of VEXAS syndrome associated with a newly identified dysfunctional UBA-1 enzyme variant. Due to the patient's insufficient response to various immunosuppressive treatments, allogeneic hematopoietic stem cell transplantation was performed, which resulted in significant improvement of clinical and laboratory manifestations of the disease.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Barbora Hermankova, Maja Spiritovic, Sabina Oreska, Hana Storkanova, Herman Mann, Karel Pavelka, Ladislav Senolt, Jiri Vencovsky, Radim Becvar, Michal Tomcik
Summary: This study aimed to investigate the effect of an 8-week tailored physiotherapy program on the sexual health of women with SSc and IIM. The results showed significant improvements in the total scores of FSFI and BISF-W, as well as some domains, functional status, and physical component of quality of life in the intervention group compared to the control group.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Adela Navratilova, Viktor Becvar, Hana Hulejova, Michal Tomcik, Lucie Stolova, Herman Mann, Olga Ruzickova, Olga Sleglova, Jakub Zavada, Karel Pavelka, Jiri Vencovsky, Ladislav Senolt, Lucie Andres Cerezo
Summary: IL-40 is up-regulated in seropositive ERA and decreases after conventional therapy. Neutrophils are an important source of IL-40 in RA, and its release is potentiated by cytokines and NETosis. IL-40 may play a role in ERA.
Meeting Abstract
Rheumatology
R. Aggarwal, C. Charles-Schoeman, J. Schessl, Z. Bata-Csorgo, M. M. Dimachkie, Z. Griger, S. Moiseev, C. V. Oddis, E. Schiopu, J. Vencovsky, I. Beck-Mann, E. Clodi, T. Levine
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Sabina Oreska, Hana Storkanova, Maja Spiritovic, Barbora Hermankova, Michal Vrablik, Karel Pavelka, Ladislav Senolt, Herman Mann, Jiri Vencovsky, Michal Tomcik
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Sabina Oreska, Hana Storkanova, Maja Spiritovic, Barbora Hermankova, Michal Vrablik, Karel Pavelka, Ladislav Senolt, Herman Mann, Jiri Vencovsky, Michal Tomcik
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
D. Saygin, H. Kim, C. Douglas, J. McGrath, J. Wilkerson, B. Erman, I. E. Lundberg, C. Oddis, A. A. Amato, I. G. DeLaTorre, H. Chinoy, D. Fiorentino, L. Chung, Y. W. Song, K. Danko, F. W. Miller, N. Ruperto, J. Vencovsky, R. Aggarwal, L. G. Rider
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Jiri Vencovsky, Konrad Pisarczyk, Richard Leff, Eunmi Park, Kiruthi Palaniswamy, Li Long
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Lucia Vernerova, Martina Vokurkova, Sabina Oreska, Maja Spiritovic, Martin Klein, Tereza Kropackova, Veronika Horvathova, Michal Tomcik, Jozef Ukropec, Barbara Ukropcova, Jiri Vencovsky
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Martina Vokurkova, Lucia Vernerova, Maja Spiritovic, Hana Storkanova, Sabina Oreska, Martin Klein, Jozef Ukropec, Barbara Ukropcova, Michal Tomcik, Jiri Vencovsky
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Danlei Zhou, Emily H. King, Simon Rothwell, Olga Krystufkova, Antonella Notarnicola, Rabheh Abdul Aziz, Emeli Lundstrom, Stiburkova Blanka, Lauren M. Pachman, Gulnara Mamyrova, Boel de Paepe, Jan de Bleecker, Terrance P. O'Hanlon, Samantha Coss, Katherine Lintner Miller, Amanda Dang, G. Richard Yu, Joanne Drew, Vidya Sivaraman, Edward Oberle, Shoghik Akoghlanian, Kyla Driest, Charles H. Spencer, Yee Ling Wu, Stacy P. Ardoin, Lisa G. Rider, Hector Chinoy, Frederick W. Miller, Ingrid E. Lundberg, Leonid Padyukov, Jiri Vencovsky, Janine A. Lamb, Chack-Yung Yu
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)