Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
James Saleeb-Mousa, Demitris Nathanael, Andrew M. Coney, Manish Kalla, Keith L. Brain, Andrew P. Holmes
Summary: Obstructive sleep apnoea (OSA) is associated with a higher risk of atrial fibrillation (AF), affecting its induction, maintenance, severity, and treatment. The current prevention method, continuous positive airway pressure (CPAP), has limited effectiveness due to poor compliance. Understanding the underlying mechanisms of arrhythmia in OSA can lead to the development of better therapies and treatment selection to complement CPAP. Chronic intermittent hypoxia (CIH) in OSA leads to long-term changes in ion channel currents, inflammation, and fibrosis, contributing to atrial remodeling and dysregulation of electrical function. Atrial stretch during apneas further promotes structural remodeling and affects calcium handling. This review provides a comprehensive overview of the mechanistic insights and their roles in arrhythmia.
Article
Clinical Neurology
Renata L. Riha, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, John Arthur Kvamme, Pavol Joppa, Jan Hedner
Summary: The study compared the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between OSA patients who had undergone tonsillectomy and those who had not. Patients who had undergone tonsillectomy presented with less severe OSA at the time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Adam Domonkos Tarnoki, David Laszlo Tarnoki, Csaba Olah, Marcell Szily, Daniel T. Kovacs, Andras Dienes, Marton Piroska, Bianka Forgo, Marina Pinheiro, Paulo Ferreira, Laszlo Kostyal, Martina Meszaros, Judit Pako, Laszlo Kunos, Andras Bikov
Summary: This study found that patients with OSA had more lumbar abnormalities compared to non-OSA controls, and markers of OSA severity were correlated with the development of lumbar spondylosis in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Andras Bikov, Helga Szabo, Marton Piroska, Laszlo Kunos, Marcell Szily, Balazs Ligeti, Nora Makra, Dora Szabo, David Laszlo Tarnoki, Adam Domonkos Tarnoki
Summary: Obstructive sleep apnoea (OSA) is associated with subtle changes in the gut microbiome, and further studies should investigate the role of gut dysbiosis in OSA.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Mia Tranfic Duplancic, Renata Pecotic, Linda Lusic Kalcina, Ivana Pavlinac Dodig, Maja Valic, Marija Roguljic, Dunja Rogic, Ivana Lapic, Katarina Grdisa, Kristina Peros, Zoran Dogas
Summary: The aim of this cross-sectional study was to objectively assess the salivary flow rate and composition and periodontal inflammation in obstructive sleep apnoea (OSA) patients. The study found that subjects without OSA had higher salivary cortisol concentrations than OSA groups, and higher plaque scores were associated with a higher AHI. Subjects with hyposalivation had higher concentrations of salivary electrolytes and lower salivary pH levels.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Angelo Zinellu, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro G. Fois, Arduino A. Mangoni, Pietro Pirina
Summary: A systematic review and meta-analysis found significantly lower serum concentrations of PON-1 in OSA patients, indicating impaired antioxidant defence system possibly related to intermittent hypoxia.
Article
Environmental Sciences
Suhan Wang, Hailin Xiong, Longlong Wang, Guo Pei, Miaochan Lao, Yanxia Xu, Linjiong Liu, Siqi Luo, Yunquan Zhang, Qiong Ou
Summary: This study investigated the association of residential greenness with obstructive sleep apnoea (OSA) indexes in adults in Guangdong Province, Southern China. The results showed a significant association between residential greenness levels and OSA indexes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Vusal Nacafaliyev, Pinar Ortan, Sevgi Sidika Sayin
Summary: This study found a significant relationship between obstructive sleep apnea syndrome (OSAS) and the incidence of silent brain infarcts (SBI). Patients with moderate and severe OSAS had a higher risk of developing SBI, possibly due to desaturations during sleep.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Timothy P. Howarth, Natalie Gentin, Nayellin Reyes-Chicuellar, Catherine Jonas, Bruce Williamson, Greg Blecher, John Widger, Subash S. Heraganahally
Summary: This study found that Indigenous Australian children have issues with sleep quality, including a higher prevalence and severity of obstructive sleep apnoea, higher daytime sleepiness scores, later bedtimes, and reduced total sleep time compared to their non-Indigenous peers.
Article
Medicine, General & Internal
Yuan Zhang, Michael Elgart, Nuzulul Kurniansyah, Brian W. Spitzer, Heming Wang, Doyoon Kim, Neomi Shah, Martha Daviglus, Phyllis C. Zee, Jianwen Cai, Daniel J. Gottlieb, Brian E. Cade, Susan Redline, Tamar Sofer
Summary: This study applied genetic analysis methods to investigate the associations between obstructive sleep apnoea (OSA) and related phenotypes. The findings revealed shared genetic underpinnings between anthropometric, blood pressure, and glycaemic phenotypes with OSA, with evidence of causal relationships among some phenotypes.