Article
Rheumatology
Megan M. Simonds, Samuel T. Freer, Lina Al-Jaberi, AnneMarie C. Brescia
Summary: This study examines the effects of inhibiting TNF alpha signaling with adalimumab on fibroblast-like synoviocytes (FLS) isolated from synovial fluid of patients with juvenile idiopathic arthritis (JIA). The results suggest that adalimumab can reduce inflammation in FLS associated with TNF alpha.
RHEUMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Patrizia Defabianis, Franco Garofalo, Federica Romano
Summary: Early diagnosis is crucial for reducing long-term disability in JIA patients. This study evaluated salivary gland function in JIA patients, finding differences between oligoarticular and polyarticular subtypes. Impairment of salivary gland function may serve as a risk indicator for JIA1.
Review
Pharmacology & Pharmacy
Varvara Choida, Margaret Hall-Craggs, Bethany R. Jebson, Corinne Fisher, Maria Leandro, Lucy R. Wedderburn, Coziana Ciurtin
Summary: This study evaluated the role of biomarkers in predicting and assessing biologic treatment response and clinical remission in JIA, proposing new strategies for biomarker use. Various types of biomarkers were reviewed, identifying candidates with potential clinical utility and highlighting the need for new biomarker discovery and improved clinical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Sarah M. McAlpine, Sarah E. Roberts, Breanna K. V. Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence Gyorgy, Fruzsina Erdelyi, Thomas B. Issekutz, Beata Derfalvi
Summary: This study evaluated the expression of microRNAs in synovial fluid, plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA). The results showed dysregulated expression of multiple microRNAs in JIA, both locally and systemically. These findings provide important insights into the pathogenesis of JIA and may have implications for targeted therapies.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Pediatrics
Melike Mehves Kaplan, Tuba Kurt, Merve Cansu Polat, Muge Sezer, Zahide Ekici Tekin, Elif celikel, Vildan Gungorer, Niluefer Tekgoz, Cueneyt Karagol, Serkan Coskun, Nimet Oner, Banu Celikel Acar
Summary: The aim of this study was to assess the predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis (oJIA) who achieved clinical remission off medication. A retrospective observational study was conducted on 126 patients who achieved remission off medication. The study found that the number of intraarticular corticosteroid injections (IACIs) and the length of follow-up were significantly related to relapse in oJIA patients who achieved remission off medication.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
Joeri W. van Straalen, Roline M. Krol, Gabriella Giancane, Violeta Panaviene, Laura Marinela Ailioaie, Pavla Dolezalova, Marco Cattalini, Gordana Susic, Flavio R. Sztajnbok, Despoina Maritsi, Tamas Constantin, Sujata Sawhney, Marite Rygg, Sheila Knupp Oliveira, Ellen Berit Nordal, Claudia Saad-Magalhaes, Nadina Rubio-Perez, Marija Jelusic, Sytze de Roock, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart
Summary: IBD development in JIA is associated with enthesitis-related arthritis and a family history of autoimmune disease. An increased incidence of IBD was observed with etanercept therapy regardless of concomitant methotrexate use.
Article
Immunology
Federica Raggi, Martina Bartolucci, Davide Cangelosi, Chiara Rossi, Simone Pelassa, Chiara Trincianti, Andrea Petretto, Giovanni Filocamo, Adele Civino, Alessandra Eva, Angelo Ravelli, Alessandro Consolaro, Maria Carla Bosco
Summary: This study provides the first detailed longitudinal characterization of the EV-proteome in OJIA patients and identifies a panel of deregulated EV-prots that may serve as early molecular indicators for OJIA development, with potential diagnostic and therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Martijn J. H. Doeleman, Sytze de Roock, Mohsin El Amrani, Erik M. van Maarseveen, Nico M. Wulffraat, Joost F. Swart
Summary: The objective of this study was to assess the relationship between adalimumab trough concentrations and treatment response in paediatric patients with JIA. The results showed that adalimumab trough concentrations were significantly lower in patients with secondary failure compared to patients with primary failure or an adequate response. This suggests that trough concentration measurements could identify JIA patients who require increased adalimumab doses.
Article
Rheumatology
B. Schiappapietra, C. Bava, S. Rosina, A. Pistorio, F. Mongelli, S. Pederzoli, S. Verazza, S. Lanni, V Muratore, S. Davi, S. Dalpra, G. C. Varnier, M. Bertamino, C. Suffia, G. Bracciolini, G. Giancane, A. Consolaro, A. Ravelli
Summary: The number of affected joints and the CRP level in the first 6 months were identified as the strongest predictors of polyarticular extension in children with oligoarticular-onset JIA.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Wojdas, Klaudia Dabkowska, Kornelia Kuznik-Trocha, Grzegorz Wisowski, Iwona Lachor-Motyka, Katarzyna Komosinska-Vassev, Krystyna Olczyk, Katarzyna Winsz-Szczotka
Summary: This study assessed the effects of ETA therapy on ECM metabolism in JIA patients. The results showed that GAGs and TAS concentrations were significantly lower in patients with aggressive JIA, while MMP-1 and MMP-3 levels were significantly higher. Anti-cytokine therapy did not normalize any of the assessed parameters.
Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Medicine, Research & Experimental
M. Amelie Jule, J. Kacie Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, L. Maria Taylor, Julie Ng, A. James Lederer, M. Siobhan Case, H. Margaret Chang, M. Ezra Cohen, Fatma Dedeoglu, M. Melissa Hazen, S. Jonathan Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, S. Mindy Lo, Esra Meidan, E. Jordan Roberts, F. Mary Beth Son, P. Robert Sundel, Y. Pui Lee, Talal Chatila, A. Peter Nigrovic, A. Lauren Henderson
Summary: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is characterized by Th1 polarization, particularly prominent in CD4+ T cells, while not compromising the regulatory identity of Tregs. Single-cell RNA-Seq revealed heterogeneous effector and regulatory subpopulations in synovial fluid, including IFN-induced Tregs, peripheral helper T cells, and cytotoxic CD4+ T cells.
Article
Rheumatology
Melike Mehves Kaplan, Zahide Ekici Tekin, Vildan Gungorer, Elif Celikel, Tuba Kurt, Merve Cansu Polat, Muge Sezer, Nilufer Tekgoz, Cuneyt Karagol, Serkan Coskun, Nimet Oner, Banu Celikel Acar
Summary: This study evaluated the relationship between small joint involvement and demographic, clinical, and laboratory findings in patients with oligoarticular juvenile idiopathic arthritis (oJIA). The results showed that small joint involvement was more common in patients with extended oJIA compared to persistent oJIA. Patients with small joint involvement had higher levels of inflammatory markers at admission and during follow-up, as well as a higher need for medication.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Yavuz Ozer, Mehmet Yildiz, Hande Turan, Gurkan Tarcin, Dilek Bingol Aydin, Aybuke Gunalp, Fatih Haslak, Elif Kilic Konte, Esma Aslan, Oya Koker, Elvan Bayramoglu, Sezgin Sahin, Amra Adrovic, Kenan Barut, Ozgur Kasapcopur, Olcay Evliyaoglu
Summary: This study aims to evaluate the effect of juvenile idiopathic arthritis (JIA) and biologic disease-modifying anti-rheumatic drugs (bDMARDs) on ovarian reserve in children. The results show that bDMARDs are reassuring in terms of ovarian reserve in girls with JIA, as they have little impact on anti-Mullerian hormone (AMH).
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Noortje Groot, Anne Kardolus, Marc Bijl, Radboud J. E. M. Dolhain, Y. K. Onno Teng, Els Zirkzee, Karina de Leeuw, Ruth Fritsch-Stork, Alex Burdorf, Irene E. Bultink, Sylvia Kamphuis
Summary: In adults with childhood-onset systemic lupus erythematosus (cSLE), the disease significantly affects academic achievements and employment, even though patients adjust their educational and vocational choices. Support is necessary to help these patients find suitable education and jobs, and to guide potential adjustments during their careers.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Pierre Quartier, Ekaterina Alexeeva, Tamas Constantin, Vyacheslav Chasnyk, Nico Wulffraat, Karin Palmblad, Carine Wouters, Hermine Brunner, Katherine Marzan, Rayfel Schneider, Gerd Horneff, Alberto Martini, Jordi Anton, Xiaoling Wei, Alan Slade, Nicolino Ruperto, Ken Abrams
Summary: The study evaluated the efficacy and safety of two canakinumab monotherapy tapering regimens to maintain complete clinical remission in children with systemic JIA. Results showed that reducing canakinumab exposure may be feasible in patients who have achieved clinical remission, but consistent interleukin-1 inhibition is necessary to maintain this response.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Health Care Sciences & Services
Michelle M. A. Kip, Sytze de Roock, Gillian Currie, Deborah A. Marshall, Luiza R. Grazziotin, Marinka Twilt, Rae S. M. Yeung, Susanne M. Benseler, Maud A. Schreijer, Sebastiaan J. Vastert, Nico Wulffraat, Annet van Royen-Kerkhof, Joost F. Swart, Maarten J. IJzerman
Summary: The study aimed to quantify medication costs in juvenile idiopathic arthritis (JIA) based on subtype. The research found that medication costs varied considerably between subtypes, individuals, and over the treatment course, with polyarticular rheumatoid-factor positive and systemic JIA patients having the highest mean costs.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2021)
Meeting Abstract
Rheumatology
M. J. Wahadat, C. G. Van Helden-Meeuwsen, S. Van Tilburg, E. Schatorje, E. Hoppenreijs, P. C. E. Hissink Muller, J. M. Van den Berg, D. Schonenberg-Meinema, S. Kamphuis, M. Versnel
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
S. Bergkamp, M. J. Wahadat, V. Smith, S. Kamphuis, J. M. Van den Berg, D. Schonenberg-Meinema
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
G. Giancane, R. Papa, S. Vastert, F. Bagnasco, J. F. Swart, P. Quartier, M. Hofer, J. Anton, S. Kamphuis, H. Sanner, M. Glerup, F. De Benedetti, E. Tsitsami, A. Remesal, E. Moreno Ruzafa, J. De Inocencio, C. Myrup, C. Pallotti, I. Kone-Paut, K. Franck-Larsson, H. Malmstrom, S. Cederholm, A. Pistorio, N. Wulffraat, N. Ruperto
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Butsabong Lerkvaleekul, Saskia R. Veldkamp, Maria M. van der Wal, Ellen J. H. Schatorje, Sylvia S. M. Kamphuis, J. Merlijn van den Berg, Petra C. E. Hissink Muller, Wineke Armbrust, Sebastiaan J. Vastert, Judith Wienke, Marc H. A. Jansen, Annet Van Royen-Kerkhof, Femke van Wijk
Summary: Siglec-1 on monocytes is identified as a novel IFN-inducible biomarker in JDM, correlating with clinical disease activity and predicting treatment response. Patients with high Siglec-1 expression at diagnosis have a higher risk of requiring treatment intensification, and Siglec-1 expression is superior to the IFN score in predicting treatment response.
Article
Rheumatology
Gabriella Giancane, Riccardo Papa, Sebastiaan Vastert, Francesca Bagnasco, Joost F. Swart, Pierre Quartier, Jordi Anton, Sylvia Kamphuis, Helga Sanner, Mia Glerup, Fabrizio De Benedetti, Elena Tsitsami, Agustin Remesal, Estefania Moreno, Jaime De Inocencio, Charlotte Myrup, Chiara Pallotti, Isabelle Kone-Paut, Karin Franck-Larsson, Hakan Malmstrom, Susanna Cederholm, Angela Pistorio, Nico Wulffraat, Nicolino Ruperto
Summary: This study evaluated the long-term safety profile of anakinra in patients with sJIA. The results showed an overall decreasing incidence of adverse events over time.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
M. Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia G. van Helden-Meeuwsen, Sander J. van Tilburg, Noortje Groot, Ellen J. H. Schatorje, Esther P. A. H. Hoppenreijs, Petra C. E. Hissink Muller, Danielle M. C. Brinkman, Denis Dvorak, Marleen Verkaaik, J. Merlijn van den Berg, Katerina Bouchalova, Sylvia Kamphuis, Marjan A. Versnel
Summary: Translating existing transcriptomic data into simpler gene signatures suitable for stratifying SLE patients. The identified gene signatures were associated with disease activity and may guide future treatment choices.
Article
Rheumatology
Dieneke Schonenberg-Meinema, Sandy C. Bergkamp, Amara Nassar-Sheikh Rashid, Mariken P. Gruppen, Maritza A. Middelkamp-Hup, Wineke Armbrust, Koert Dolman, A. Elisabeth Hak, Petra C. E. Hissink Muller, Marieke van Onna, Joost F. Swart, Taco W. Kuijpers, Sylvia S. M. Kamphuis, Vanessa Smith, J. Merlijn van den Berg
Summary: This longitudinal study found that the majority of capillary patterns in childhood-onset SLE (cSLE) are abnormal and can change over time. Regardless of disease activity, a capillary scleroderma pattern in cSLE may be associated with a higher risk of SLE-related disease damage.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Immunology
Erika Huijser, Cornelia G. van Helden-Meeuwsen, Dwin G. B. Grashof, Jessica R. Tarn, Zana Brkic, Josje M. A. Huisman, M. Javad Wahadat, Harmen J. G. van de Werken, Ana P. Lopes, Joel A. G. van Roon, Paul L. A. van Daele, Sylvia Kamphuis, Wan-Fai Ng, Siroon Bekkering, Leo A. B. Joosten, Willem A. Dik, Marjan A. Versnel
Summary: Trained immunity is a long-term reprogramming of innate immune cells that is linked to atherosclerosis. This study investigated the link between type I interferons and trained immunity in patients with primary Sjogren's syndrome. The findings suggest that type I interferon induces a trained immunity phenotype in monocytes, while trained immunity also affects the production of type I interferons.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Eve Mary Dorothy Smith, Amita Aggarwal, Jenny Ainsworth, Eslam Al-Abadi, Tadej Avcin, Lynette Bortey, Jon Burnham, Coziana Ciurtin, Christian M. Hedrich, Sylvia Kamphuis, Deborah M. Levy, Laura B. Lewandowski, Naomi Maxwell, Eric F. Morand, Seza Ozen, Clare E. Pain, Angelo Ravelli, Claudia Saad Magalhaes, Clarissa A. Pilkington, Dieneke Schonenberg-Meinema, Christiaan Scott, Kjell Tullus, Michael William Beresford
Summary: The application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) has the potential to improve care and health outcomes. An international T2T Task Force was formed and agreed on four overarching principles and fourteen points-to-consider for T2T in cSLE. These principles emphasize shared decision making, prevention of flare and organ damage, glucocorticoid sparing, and addressing factors impacting quality of life.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
M. Javad Wahadat, Hongchao Qi, Cornelia G. Van Helden-Meeuwsen, Erika Huijser, Lotte van den Berg, Annette Van Dijk-Hummelman, Jens C. Goepfert, Anne Heine, Marleen Verkaaik, Marco W. J. Schreurs, Willem A. Dik, Sylvia Kamphuis, Marjan A. Versnel
Summary: This study investigated the association between serum IFN alpha 2 levels measured by Simoa and the IFN-I gene signature (IGS) with disease activity in childhood-onset SLE patients. The results showed a positive correlation between serum IFN alpha 2 levels and IGS, and a significant decrease in IFN alpha 2 levels in the first 3 years after diagnosis. Serum IFN alpha 2 levels were significantly associated with disease activity scores, while IGS did not show this association. Both IFN-I assays were able to characterize disease activity states.
Meeting Abstract
Rheumatology
Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia van Helden-Meeuwsen, Sander van Tilburg, Noortje Groot, Ellen Schatorje, Esther Hoppenreijs, Petra Hissink Muller, Danielle Brinkman, Denis Dvorak, Marleen Verkaaik, Katerina Bouchalova, Merlijn van den Berg, Sylvia Kamphuis, Marjan Versnel
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Rheumatology
Hermine Brunner, Daniel Lovell, Michael Henrickson, Ruy Carrassco, Kirsten Minden, Lyudmila Grebenkina, James Nocton, Ingrid Louw, Linda Wagner-Weiner, Gabriel Vega Cornejo, Sylvia Kamphuis, Vyacheslav Chasnyk, Heather Walters, Simone Appenzeller, Jordi Anton, Alyssa Dominique, Robert Wong, Lixian Dong, Tzuyung Douglas Kou, Alberto Martini, Nicolino Ruperto
ARTHRITIS & RHEUMATOLOGY
(2021)