Article
Immunology
Dongying Chen, Xiaoyan Cai, Hui Ouyang, Shiwen Yuan, Xiaodong Wang, Lian Lin, Zhiqing Chen, Mingcheng Huang
Summary: In this study, increased expression of eEF2K was found in synovial tissues and FLSs of RA patients. Knockdown or inhibition of eEF2K reduced inflammation, migration/invasion, glucose uptake and lactate productions in RA FLSs. eEF2K knockdown also suppressed the activation of NF-KB and AKT pathways in RA FLSs. Lactate was involved in the inhibitory effect of eEF2K knockdown on inflammation and migration. NH125 treatment attenuated the severity of arthritis in collagen-induced arthritis mice.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai
Summary: This study demonstrates the presence of GSDME-mediated pyroptosis in RA synovial tissues and its association with cell migration, invasion, and release of inflammatory cytokines.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Summary: Fibroblast-activated protein-a (FAP) is overexpressed by activated fibroblasts during fibrosis or inflammation. It plays important roles in regulating the cellular responses in the synovial region of rheumatoid arthritis (RA), and its overexpression is regulated by the initial inflammatory microenvironment and epigenetic signaling. Targeted therapies for FAP are currently being developed. This review discusses the features of FAP in FLSs and its role in RA pathophysiology, as well as advances in targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mingcheng Huang, Keping Wu, Shan Zeng, Wenfen Liu, Tianjiao Cui, Zhiqing Chen, Lian Lin, Dongying Chen, Hui Ouyang
Summary: The study demonstrated that punicalagin has anti-inflammatory and anti-bone destruction effects in rheumatoid arthritis by inhibiting the proliferation and migration of FLSs and modulating NF-kappa B pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yong Chen, Baojiang Wang, Yanjuan Chen, Qunyan Wu, Wing-Fu Lai, Laiyou Wei, Kutty Selva Nandakumar, Dongzhou Liu
Summary: HAPLN1 plays a role in promoting cell proliferation and pro-inflammatory phenotype in rheumatoid arthritis, contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yanping Luo, Yunxuan Lei, Xin Guo, Dehao Zhu, Haiyang Zhang, Zizhen Guo, Zichong Xu, Hanqing Zhao, Yebin Xi, Xiaochun Peng, Lianbo Xiao, Zhaojun Wang, Xiaoyin Niu, Guangjie Chen
Summary: Fibroblast-like synoviocytes (FLS) play important roles in the pathological processes of rheumatoid arthritis (RA). CK2, elevated in RA FLS, was found to be associated with abnormal phenotypes. Targeted inhibition of CK2 using CX-4945 suppressed RA FLS proliferation, migration, and invasion, and reduced inflammation-related factors secretion. Further investigation revealed that CX-4945 can alleviate the severity of RA by modulating the p53 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Yuan Dai, Panwang Liu, Wen Wen, Ping Li, Chen Yang, Ping Wang, Shijun Xu
Summary: Increased glycolytic in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) contributes to disease pathogenesis and sustained proliferation. Sarsasapogenin (SA), the principal active ingredient of total saponins of anemarrhena (TSA), can inhibit glycolysis and induce apoptosis in FLS, suppressing their proliferation and invasion. This study provides insights into the therapeutic potential of targeting PKM2 and glycolysis in RA treatment.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu Tai, Bei Huang, Pai-pai Guo, Zhen Wang, Zheng-wei Zhou, Man-man Wang, Han-fei Sun, Yong Hu, Sheng-lin Xu, Ling-ling Zhang, Qing-tong Wang, Wei Wei
Summary: Our study demonstrates the impact of TNF-alpha on cAMP homeostasis and the interaction between TNF-alpha and EP4 signaling, revealing the potential role of TRAF2 and GRK2 in the treatment of inflammatory diseases. The findings provide valuable insights into a novel form of cross-talk between cytokine receptors and G protein-coupled receptors, suggesting TRAF2-GRK2 interaction as a potential new drug target.
ACTA PHARMACOLOGICA SINICA
(2022)