Review
Rheumatology
F. A. Figus, M. Skoczynska, R. McConnell, G. Massazza, A. Iagnocco
Summary: Polymyalgia rheumatica (PM) is an inflammatory rheumatic disorder characterized by pain and stiffness, mainly in the neck, shoulders, and pelvic girdle, possibly associated with giant cell arteritis. Various imaging techniques can be used to study PM features and their potential complications or associations with giant cell arteritis, each with different advantages and disadvantages. Through a literature review of the past 10 years, this review aims to clarify the current uses of imaging in PM for diagnosis and follow-up.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Trinh Nguyen, Akshya Gupta, Shweta Bhatt
Summary: Lymphomatous involvement of the genitourinary system, particularly the kidneys, is often underestimated and underreported on conventional diagnostic imaging. This is due to its variable imaging appearance and overlapping features with other conditions. By presenting a spectrum of typical and atypical appearances of renal lymphoma using multimodality imaging, this article highlights the importance of imaging in the detection, diagnosis, staging, and surveillance of patients with lymphoma.
INSIGHTS INTO IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
K. S. M. van der Geest, G. Treglia, A. W. J. M. Glaudemans, E. Brouwer, F. Jamar, R. H. J. A. Slart, O. Gheysens
Summary: [18F]FDG-PET/CT scanning can effectively diagnose polymyalgia rheumatica by identifying significant uptake of FDG at specific anatomic sites. The technique shows promise as an important diagnostic tool for patients with suspected PMR, but standardized interpretation criteria and procedural recommendations are necessary for its use.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Endocrinology & Metabolism
Ali Pirasteh, Petra Lovrec, Lisa Bodei
Summary: Neuroendocrine tumors (NETs) are complex tumors occurring in various organs, often metastatic at diagnosis. Accurate staging is crucial for therapy planning. Imaging plays a key role in disease detection, diagnosis, staging, and follow-up, with various techniques developed and optimized to assess and monitor tumor burden in patients with NETs.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Clinical Neurology
Yanzhao Dong, Ahmad Alhaskawi, Haiying Zhou, Xiaodi Zou, Zhenfeng Liu, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Alenikova Olga, Sahar Ahmed Abdalbary, Yongsheng Chi, Hui Lu
Summary: Peripheral nerve injuries (PNIs) can result from various causes and have different severity levels and clinical manifestations. Imaging techniques play a crucial role in the accurate diagnosis, treatment planning, and monitoring of PNIs. This article provides an overview of the causes, severity, and clinical manifestations of PNIs, emphasizing the importance of imaging in their management.
FRONTIERS IN NEUROLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Patricia Moya-Alvarado, Alejandro Fernandez Leon, Maria Emilia Corica, Valle Camacho Marti, Diego Alfonso Lopez-Mora, Ivan Castellvi, Hector Corominas
Summary: PMR is a common inflammatory rheumatic disease, and the use of (18)FDG-PET/CT scan in the diagnostic process can help rule out other conditions. This study found that the (18)FDG-PET/CT scan is a very useful technique for the study of Polymyalgia Rheumatica and improves diagnostic accuracy by identifying various PMR-like conditions.
Article
Medicine, General & Internal
Louise Schouborg Brinth, Annette Hansen, Dorte Vendelbo Jensen, Ole Rintek Madsen, Rikke Broholm, Martin Krakauer
Summary: FDG-PET is useful for demonstrating inflammation in specific sites typical for PMR. Scoring systems based on FDG uptake can improve diagnostic accuracy. Most scoring systems perform well in glucocorticoid-naive patients, and a simplified scoring system focusing on a few selected anatomical regions shows high sensitivity and specificity. However, glucocorticoid treatment within 4 weeks prior to FDG-PET significantly affects the diagnostic accuracy of all scoring systems.
Review
Oncology
Sharyn I. Katz, Christopher M. Straus, Leonid Roshkovan, Kevin G. Blyth, Thomas Frauenfelder, Ritu R. Gill, Ferry Lalezari, Jeremy Erasmus, Anna K. Nowak, Victor H. Gerbaudo, Roslyn J. Francis, Samuel G. Armato III
Summary: This article summarizes the challenges in radiologic assessment of malignant pleural mesothelioma (MPM) and provides technical requirements and future directions for multimodal imaging.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Ponsiglione, Arnaldo Stanzione, Gaia Spadarella, Agah Baran, Luca Alessandro Cappellini, Kevin Groot Lipman, Peter Van Ooijen, Renato Cuocolo
Summary: The overall methodological rigor of radiomics studies in the ovarian field is not ideal, with a lack of prospective design and formal validation of results. This limits the reproducibility of results and potential translation to clinical setting.
EUROPEAN RADIOLOGY
(2023)
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aylina Glasenapp, Katja Derlin, Marcel Gutberlet, Annika Hess, Tobias L. Ross, Hans-Juergen Wester, Frank M. Bengel, James T. Thackeray
Summary: The study focused on investigating the interplay between ventricle loading conditions, tissue inflammation, and progressive fibrosis in pressure overload heart failure using noninvasive multimodality molecular imaging. Inflammation and fibrosis play crucial roles in the early response to pressure overload and can be sensitively monitored by multimodality imaging, which may guide novel treatment strategies in nonischemic heart failure.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Review
Rheumatology
Dario Camellino, Eric L. Matteson, Frank Buttgereit, Christian Dejaco
NATURE REVIEWS RHEUMATOLOGY
(2020)
Review
Rheumatology
E. Hysa, A. Sobrero, D. Camellino, F. Rumi, G. Carrara, M. Cutolo, C. A. Scire, M. A. Cimmino
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Article
Endocrinology & Metabolism
Andrea Giusti, Dario Camellino, Daniele Saverino, Erika Iervasi, Giuseppe Girasole, Gerolamo Bianchi, Socrates E. Papapoulos
Letter
Rheumatology
Dario Camellino, Eric L. Matteson, Frank Buttgereit, Christian Dejaco
NATURE REVIEWS RHEUMATOLOGY
(2021)
Review
Rheumatology
Dario Camellino, Christina Duftner, Christian Dejaco
Summary: PMR is an inflammatory rheumatic disease characterized by pain and stiffness in the neck, shoulder, and pelvic girdles in elderly people. Current research focuses on imaging techniques, particularly FDG-PET/CT, which can help detect underlying GCA in PMR patients with incomplete response to glucocorticoids and/or relapses. These imaging studies provide new insights into the anatomical basis of inflammation in PMR, especially at the hip and spine, aiding in distinguishing the disease from other conditions.
Article
Rheumatology
Enrico Tombetti, Elvis Hysa, Justin C. Mason, Marco A. Cimmino, Dario Camellino
Summary: Large vessel vasculitides (LVVs) are inflammatory conditions of large-sized arteries, with early diagnosis and monitoring being crucial. Blood biomarkers play a significant role in disease diagnosis and prognosis definition, but there is currently a lack of accurate and reliable biomarkers identified.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Meeting Abstract
Rheumatology
G. Botticella, M. Pizzonia, B. Cossu, R. Bruno, D. Camellino, G. Girasole, A. Giusti, M. Pedrazzoni, S. Alexovits, F. Pleitavino, F. Santolini, A. Nencioni, G. Bianchi
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
D. Camellino, C. Dejaco, A. Giusti, F. Martini, R. Cosso, G. Girasole, G. Bianchi
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
E. Hysa, D. Camellino, C. Bernini, E. Gotelli, S. Paolino, C. Schenone, G. Ferrari, A. Sulli, M. Cutolo, M. A. Cimmino
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
D. S. Gozzoli, A. Hemmig, L. Hemkens, L. Werlen, H. Ewald, C. Berger, D. Kyburz, S. Imfeld, M. Aschwanden, M. Stegert, D. Camellino, M. A. Cimmino, C. Campochiaro, A. Tomelleri, L. Henckaerts, D. Blockmans, P. Moya, H. Corominas, R. Buchanan, C. Owen, Y. Van Sleen, E. Brouwer, H. Ymashita, T. Daikeler
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
N. Ughi, R. Padoan, C. Crotti, S. Sciascia, G. Carrara, A. Zanetti, D. Rozza, S. Monti, D. Camellino, F. Muratore, G. Emmi, L. Quartuccio, S. Morbelli, K. El Aoufy, S. Tonolo, R. Caporali, S. De Vita, C. Salvarani, M. A. Cimmino
Summary: The recommendations have been updated based on new evidence for diagnosing and treating primary large-vessel vasculitis, emphasizing the prompt commencement of high dose oral glucocorticoids to induce clinical remission, and suggesting the use of adjunctive therapy in selected patients.
Review
Rheumatology
Andrea K. Hemmig, Daniele Gozzoli, Laura Werlen, Hannah Ewald, Markus Aschwanden, Daniel Blockmans, Elisabeth Brouwer, Russell R. C. Buchanan, Dario Camellino, Corrado Campochiaro, Marco A. Cimmino, Hector Corominas, Viktoria Gloy, Liesbet Henckaerts, Diego Kyburz, Patricia Moya-Alvarado, Claire E. Owen, Mihaela Stegert, Alessandro Tomelleri, Yannick van Sleen, Hiroyuki Yamashita, Stephan Imfeld, Christoph T. Berger, Lars G. Hemkens, Thomas Daikeler
Summary: The study aimed to determine the prevalence and predictors of subclinical giant cell arteritis in patients with newly diagnosed polymyalgia rheumatica. It found that over a quarter of PMR patients may have subclinical GCA and the prediction model had only modest diagnostic accuracy, suggesting a paradigm shift towards implementing imaging studies in the assessment of PMR patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Review
Rheumatology
Elvis Hysa, Milena Bond, Lisa Ehlers, Dario Camellino, Louise Falzon, Christian Dejaco, Frank Buttgereit, Daniel Aletaha, Andreas Kerschbaumer
Summary: This study provides a systematic review of current evidence on Treat to Target (T2T) strategies in PMR and GCA. It highlights the gaps in knowledge and provides valuable information for developing treatment recommendations.
Article
Rheumatology
D. Camellino, F. Paparo, S. D. Morbelli, G. Pesce, M. Bauckneht, M. Bagnasco, M. Cutolo, G. Sambuceti, M. A. Cimmino
Summary: FDG-PET imaging was used to evaluate joint and vessel uptake in patients with PMR. Patients showed a typical joint pattern, with imaging being the only tool to assess the presence of LVV, as clinical and laboratory findings were insufficient predictors.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
A. Sobrero, S. Paolino, E. Hysa, D. Camellino, V. Tomatis, M. Cutolo, M. A. Cimmino
Summary: Polymyalgia rheumatica (PMR) shows no seasonality of onset, except for cases associated with temporal arteritis (TA). This suggests a possible risk factor with seasonal variation in the pathogenesis of PMR.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)