Journal
RHEUMATOLOGY
Volume 50, Issue 11, Pages 1955-1968Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/ker302
Keywords
Pregnancy; Rheumatoid arthritis; Disease activity; Pregnancy outcome; Drug treatment; Anti-TNF; Review
Categories
Funding
- Abbott
- UCB
- Wyeth/Pfizer
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It has long been known that pregnancy and childbirth have a profound effect on the disease activity of rheumatic diseases. For clinicians, the management of patients with RA wishing to become pregnant involves the challenge of keeping disease activity under control and adequately adapting drug therapy during pregnancy and post-partum. This article aims to summarize the current evidence on the evolution of RA disease activity during and after pregnancy and the use of anti-rheumatic drugs around this period. Of recent interest is the potential use of anti-TNF compounds in the preconception period and during pregnancy. Accumulating experience with anti-TNF therapy in other immune-mediated inflammatory diseases, such as Crohn's disease, provides useful insights for the use of TNF blockade in pregnant women with RA, or RA patients wishing to become pregnant.
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