Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Chang-Hee Suh
Summary: This study found that the impact of low-dose glucocorticoids on bone mineral density in patients with rheumatoid arthritis was not significant, while the disease activity index was a key factor affecting changes in bone density.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Shan Cao, Yixuan Li, Rui Song, Xianyi Meng, Maximilian Fuchs, Chunguang Liang, Katerina Kachler, Xinyu Meng, Jinming Wen, Ursula Schloetzer-Schrehardt, Verena Taudte, Arne Gessner, Meik Kunz, Ulrike Schleicher, Mario M. Zaiss, Alf Kastbom, Xiaoxiang Chen, Georg Schett, Aline Bozec
Summary: The study revealed that L-arginine can ameliorate arthritis and bone erosion by altering metabolic pathways in osteoclasts and perturbing purine metabolism.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
Christine W. Lary, Samuel Ghatan, Meghan Gerety, Alexandra Hinton, Archana Nagarajan, Clifford Rosen, Ryan D. Ross, David A. Bennett, Anita L. Destefano, Mohammad A. Ikram, Fernando Rivadeneira, Douglas P. Kiel, Sudha Seshadri, Alexa Beiser
Summary: This study found that baseline bone mineral density (BMD) is associated with incident dementia, while prior bone loss is not.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Immunology
Jie Chen, Qincheng Che, Yuying Kou, Xing Rong, Xiaojie Zhang, Minqi Li, Qiang Shu
Summary: This study evaluated the synergistic therapeutic effects of the combination of Iguratimod (IGU) and Tofacitinib (TOF) on refractory rheumatoid arthritis (RRA) and secondary osteoporosis. The results showed that the combination treatment significantly alleviated inflammation, bone erosion, and pyroptosis, indicating its potential importance in the treatment of RRA and secondary osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Qiyue Chen, Kai Fan, Guangbao Song, Xinqiong Wang, Jinwei Zhang, Huan Chen, Xuan Qin, Yao Lu, Weizhong Qi
Summary: This study found that osteoporosis in rheumatoid arthritis (RA) is related to the activation of the mechanistic target of mTORC1 pathway and chronic inflammation-regulated differentiation of preosteoblast through mitophagy. Parkin upregulation and mitochondrial damage were observed in TNF-a stimulated preosteoblasts. Rapamycin upregulation of Parkin-mediated mitophagy attenuated mitochondrial impairment caused by TNF-a in preosteoblasts. In vivo experiments demonstrated that the combination therapy with TNF-a neutralizing antibody and Rapamycin significantly reduced osteoporosis in AIA mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Giovanni Adami, Angelo Fassio, Maurizio Rossini, Camilla Benini, Riccardo Bixio, Denise Rotta, Ombretta Viapiana, Davide Gatti
Summary: The study uncovered unique bone profile in RA, including lower bone density and distinct biomarker patterns compared to controls. Association between bone biomarkers and clinical variables were revealed, and machine learning models and principal component analysis successfully differentiated RA patients based on bone biomarker profiles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiang Gao, Qingyun Wu, Xinle Zhang, Jia Tian, Dahong Liang, Yalin Min, Jiaqi Lu, Xuemei Zhang, Liao Cui, Bilian Xu, Yanzhi Liu
Summary: This study investigated the potential of salvianolate treatment in ameliorating osteopenia in prednisone-treated RA rats. The results showed that Salvianolate significantly improved bone density and bone quality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Katherine D. Wysham, Joshua F. Baker, Radhika Narla
Summary: In this chapter, we focus on the screening of osteoporosis among rheumatoid arthritis patients, including the appropriate methods and technologies, as well as laboratory testing, and how to select treatment options based on individual patient's condition.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Review
Cell Biology
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao
Summary: The translation discusses the role of osteoclasts in bone development and remodeling, as well as the significance of epigenetic regulation and microRNAs in gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Natalia Mena-Vazquez, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Arkaitz Mucientes, Sara Manrique-Arija, Jose Rioja, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: Patients with late-onset rheumatoid arthritis (LORA) have poorer control of inflammation after diagnosis and more comorbidities compared to patients with young-onset rheumatoid arthritis (YORA) and healthy controls.
FRONTIERS IN MEDICINE
(2022)
Review
Rheumatology
Silvia Hayer, Margriet J. Vervoordeldonk, Maria C. Denis, Marietta Armaka, Markus Hoffmann, Johan Backlund, Kutty Selva Nandakumar, Birgit Niederreiter, Christina Geka, Anita Fischer, Nina Woodworth, Stephan Blueml, George Kollias, Rikard Holmdahl, Florence Apparailly, Marije Koenders
Summary: Animal models for inflammatory arthritides like rheumatoid arthritis and psoriatic arthritis are widely used for research, but many publications lack detailed descriptions and evaluations of arthritis pathology. The European consortium BeTheCure developed SMASH recommendations for standardised histological evaluation to improve information and promote reproducibility in preclinical research on inflammatory arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Endocrinology & Metabolism
Yifan Zhang, Jun Ma, Xingfu Bao, Min Hu, Xiaoxi Wei
Summary: This article summarizes the roles and mechanisms of RORs in skeletal diseases, providing evidence for potential therapeutic strategies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Ruobing Zhao, Yan Chen, Dongxue Wang, Chunyu Zhang, Henan Song, Guoxin Ni
Summary: Bone diseases are common and detrimental to the daily activities and quality of life of middle-aged and elderly individuals. It is essential to identify key regulatory factors and potential therapeutic targets for bone diseases. Irisin, a newly discovered myokine, has been found to have beneficial effects on various diseases, especially bone-related disorders. Research has indicated that irisin plays a role in bone diseases such as osteoarthritis and osteoporosis, suggesting its potential as a molecule for the prevention and treatment of bone diseases. This review summarizes the specific regulatory mechanisms of irisin in different bone diseases and provides a theoretical basis for its application in the diagnosis and treatment of these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhang
Summary: The study successfully delivered celastrol using enzyme-responsive nanoparticles to induce apoptosis of OCs and macrophages in rheumatoid arthritis joints, reducing inflammation and showing therapeutic effects in a rat model.
NATURE COMMUNICATIONS
(2021)
Article
Rheumatology
Karen Holten, Nina Paulshus Sundlisater, Siri Lillegraven, Joseph Sexton, Lena Bugge Nordberg, Ellen Moholt, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Espen A. Haavardsholm, Anna-Birgitte Aga
Summary: Fatigue is a common symptom in early RA patients, with a rapid and sustained reduction during treatment. Low objective disease activity and high patient global assessment at baseline were predictors of clinically relevant fatigue at 24 months.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Ingrid Egeland Christensen, Siri Lillegraven, Pawel Mielnik, Gunnstein Bakland, Liz Loli, Joe Sexton, Till Uhlig, Tore K. Kvien, Sella A. Provan
Summary: The study estimated the incidence of serious infections (SIs) in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with TNFi, and compared the risk of SIs between the two groups. The results showed that patients with PsA had a lower risk of SIs compared to those with RA during TNFi treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Alexander Mathiessen, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Ida K. Haugen
Summary: The pathologies and symptom duration of hand osteoarthritis (OA) are related to central sensitization, with erosive hand OA potentially causing greater central sensitization. Structural and inflammatory severity are not associated with central sensitization, while symptom duration does not contribute to central sensitization.
Article
Rheumatology
Vibeke Videm, Mari Hoff, Marthe Halsan Liff
Summary: The study aimed to investigate the association between motivation for physical activity (PA) and cardiorespiratory fitness in patients with rheumatoid arthritis (RA). The results showed that motivation for PA was significantly associated with measured VO2peak in RA patients, and this effect was mediated by whether the patient fulfilled the current recommendations for PA. Therefore, addressing and stimulating motivation is crucial in intervening to increase PA and cardiovascular fitness in RA patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Nina Paulshus Sundlisaeter, Ulf Sundin, Anna-Birgitte Aga, Joseph Sexton, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Espen A. Haavardsholm, Siri Lillegraven
Summary: This study investigated the limiting factors of achieving ACR/EULAR Boolean remission in rheumatoid arthritis (RA) patients. Patient global assessment and tender joints were found to be the most common factors limiting remission. Although imaging inflammation levels were not elevated in patients failing to meet the criteria, the odds of using biologic disease modifying anti-rheumatic drugs (DMARDs) were higher.
Article
Medicine, General & Internal
Kristin Holvik, Vidar Hjellvik, Oystein Karlstad, Nina Gunnes, Mari Hoff, Grethe S. Tell, Haakon E. Meyer
Summary: The association between the prescription-based Rx-Risk Comorbidity Index and mortality by history of hip fracture was studied in a prospective study using nationwide registry data in Norway. It was found that history of hip fracture and comorbidity assessed by Rx-Risk are independent risk factors for mortality in the community-dwelling older population in Norway, with comorbidity explaining a quarter of the excess mortality in persons with a history of hip fracture.
Article
Rheumatology
Ingrid Saether Houge, Mari Hoff, Oddrun Halsan, Vibeke Videm
Summary: This study explored the associations between patient-reported outcome measures (PROMs) and disease-specific measures with functional capacity in individuals with rheumatoid arthritis (RA). The findings showed that PROMs PGA and Exercise Self-Efficacy were significantly associated with functional capacity, while disease-specific measures such as DAS28-CRP and disease duration were not.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Hilde Berner Hammer, Silvia Rollefstad, Anne Grete Semb, Gro Jensen, Lars Fridtjof Karoliussen, L. Terslev, Espen A. Haavardsholm, Tore K. Kvien, Till Uhlig
Summary: The study found that crystal deposition in gout patients is associated with increased inflammation levels and carotid artery pathology, suggesting that crystal deposition may lead to subclinical inflammation with subsequent vascular implications. However, further longitudinal studies are needed to confirm these causal relationships.
Article
Rheumatology
T. Uhlig, L. F. Karoliussen, J. Sexton, T. K. Kvien, E. A. Haavardsholm, F. Perez-Ruiz, H. B. Hammer
Summary: This study investigates the relationship between fluctuation and change in serum urate (SU) levels and the occurrence of gout flares. The results show that fluctuations and changes in SU levels are related to gout flares, while changes between visits and reaching higher SU levels are not.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Leanne Chen, Gregory D. Gamble, Anne Horne, Jill Drake, Anthony J. Doyle, Till Uhlig, Lisa K. Stamp, Nicola Dalbeth
Summary: This study finds that the composition of the gouty tophus changes during urate-lowering therapy, with a decrease in the urate volume and a relatively slower decrease in the soft tissue volume, which may persist.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Ingrid Saether Houge, Mari Hoff, Vibeke Videm
Summary: Individuals with rheumatoid arthritis (RA) have lower cardiorespiratory fitness (CRF) than healthy individuals. This study found that both physical symptoms and negative emotions mediated the association between RA and reduced CRF, with similar effect sizes.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Till Uhlig, Lars F. Karoliussen, Joe Sexton, Sella Aarrestad Provan, Tore K. Kvien, Espen A. Haavardsholm, Hilde Berner Hammer
Summary: This study explored the longitudinal changes and predictors of work productivity in patients with gout. The results showed that work productivity and activity impairment improved during the first few months of treatment and remained stable at 1 and 2 years. Comorbidities and concerns about medication were associated with worse work impairment and activity impairment.
Article
Rheumatology
T. Uhlig, L. F. Karoliussen, J. Sexton, T. K. Kvien, E. A. Haavardsholm, W. J. Taylor, H. B. Hammer
Summary: This longitudinal study aimed to determine changes in beliefs about medicines during intervention with urate-lowering therapy (ULT). The study found that patients taking ULT gradually increased their beliefs in the necessity of medication and reduced concerns, but this improvement was unrelated to treatment outcomes.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Abdirizak Ali Osman, Mari Hoff, Vibeke Videm
Summary: The associations between physical activity and body composition in individuals with psoriatic arthritis (PsA) are not well understood. This study aimed to investigate the relationships between physical activity and visceral fat mass and percentage body fat in different age groups of PsA patients. The results showed that individuals with PsA had altered body composition, including higher visceral fat mass and percentage body fat, especially in those under 40 years of age. Moderate or high physical activity was associated with significantly lower values of the primary outcomes, including lower visceral fat mass and percentage body fat.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Rheumatology
Vibeke Videm, Ingrid Saether Houge, Mari Hoff
Summary: The presence of rheumatoid arthritis (RA) and levels of stress and depression are associated with the scores for facilitators and barriers to physical activity (PA). RA patients reported higher barriers and lower facilitators for PA, with varying individual profiles. The new questionnaire (FasBarPAQ) could be a useful tool for healthcare providers treating RA patients.
RHEUMATOLOGY INTERNATIONAL
(2023)