Review
Biology
Anastasia-Vasiliki Madenidou, Sophie Mavrogeni, Elena Nikiphorou
Summary: Cardiovascular morbidity and mortality are higher in inflammatory arthritis (IA) compared to the general population. The European League Against Rheumatism (EULAR) published guidelines in 2016 on cardiovascular disease (CVD) risk management in IA and plans to update them based on emerging evidence. Evidence shows that both traditional CVD factors and inflammation contribute to the higher CVD burden in IA. Prompt screening and management of CVD and related risk factors are necessary, and non-invasive cardiovascular imaging plays an important role in accurately detecting cardiovascular lesions in IA patients.
Article
Biotechnology & Applied Microbiology
Chunyu Zhang, Wentao Huang, Chen Huang, Chengqian Zhou, Wei Wei, Yongsheng Li, Yukuan Tang, Yu Luo, Quan Zhou, Wenli Chen
Summary: Magnetic resonance imaging (MRI) is a potential diagnostic modality for early rheumatoid arthritis (RA). A peptide called UVHP was synthesized as a contrast agent, which targets the overexpression of VCAM-1 in RA cells and generates high contrast in MRI, with the characteristics of simplicity, low cost, and low toxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Polly Downton, Fabio Sanna, Robert Maidstone, Toryn M. Poolman, Edward A. Hayter, Suzanna H. Dickson, Nick A. Ciccone, James O. Early, Antony Adamson, David G. Spiller, Devin A. Simpkins, Matthew Baxter, Roman Fischer, Magnus Rattray, Andrew S. I. Loudon, Julie E. Gibbs, David A. Bechtold, David W. Ray
Summary: Chronic inflammation is associated with metabolic dysfunction, with a temporal crosstalk between inflammatory and metabolic processes. Research has shown that arthritis drives changes in lipid metabolism and mitochondrial function, leading to the accumulation of bioactive lipid species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Rheumatology
Julio Ramirez, Andrea Cuervo, Raquel Celis, Virginia Ruiz-Esquide, Raul Castellanos-Moreira, Jose Antonio Narvaez, Jose A. Gomez-Puerta, Jose L. Pablos, Raimon Sanmarti, Juan D. Canete
Summary: The study found that 1/3 of RA patients lost clinical remission and changed therapy throughout the 5-year follow-up, which was associated with BMI, lack of biological DMARDs therapy, first-year progression of MRI erosion score, and calprotectin serum levels. Significant radiographic progression was uncommon.
Article
Clinical Neurology
Qichang Fu, Yuting Wang, Yi Zhang, Yong Zhang, Xinbin Guo, Haowen Xu, Zhiqiang Yao, Meng Wang, Michael R. Levitt, Mahmud Mossa-Basha, Jinxia Zhu, Jingliang Cheng, Sheng Guan, Chengcheng Zhu
Summary: The study shows that AWE pattern and WEI are independently associated with aneurysm-related symptoms, with circumferential AWE and high WEI being more significantly associated with symptomatic UIAs. This provides an effective method for identifying unstable intracranial aneurysms.
Review
Medicine, General & Internal
Bas Dijkshoorn, Reinder Raadsen, Michael T. Nurmohamed
Summary: RA patients have a 1.5 times higher risk of developing cardiovascular diseases compared to the general population. This is partly due to systemic inflammation causing increased atherogenesis, and an increased prevalence of traditional cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Thermodynamics
Malgorzata Gizinska, Radoslaw Rutkowski, Lucyna Szymczak-Bartz, Wojciech Romanowski, Anna Straburzynska-Lupa
Summary: The study developed a thermal imaging method to screen and differentiate joint inflammation in rheumatoid foot patients compared to a healthy control group. Significant differences in temperatures were found between the study group and controls, but not between left and right feet. Further research is needed to confirm the results.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Medicine, General & Internal
Bojana Stamenkovic, Sonja Stojanovic, Valentina Zivkovic, Dragan Djordjevic, Mila Bojanovic, Aleksandra Stankovic, Natasa Rancic, Nemanja Damjanov, Marco Matucci Cerinic
Summary: The study aimed to investigate hand joint inflammation in systemic sclerosis (SSc) patients and examine the relationship between these subclinical inflammatory changes and clinical manifestations, disease activity, and functional capacity. The results showed that MRI can detect significant subclinical joint inflammation in SSc patients, which is associated with systemic inflammation, vascular complications, and more severe forms of the disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sevtap Tugce Ulas, Katharina Ziegeler, Sophia-Theresa Richter, Sarah Ohrndorf, Robert Biesen, Fabian Proft, Denis Poddubnyy, Torsten Diekhoff
Summary: This study compared the performance of dual-energy CT and CT subtraction in detecting arthritis, with CT-S having the highest diagnostic accuracy. Both iMap and MRI showed good correlation and interreader reliability. Musculoskeletal ultrasound remains the most available modality for arthritis imaging and served as the gold standard in this study.
EUROPEAN RADIOLOGY
(2022)
Review
Medicine, Research & Experimental
Celian Peyronnel, Perle Totoson, Helene Martin, Celine Demougeot
Summary: Rheumatoid arthritis (RA) is associated with excessive cardiovascular mortality due to premature atherosclerosis, with endothelial activation (EA) playing a key role. EA involves loss of vascular integrity, expression of leucocyte adhesion molecules, transition to a prothrombotic phenotype, cytokine production, shedding of membrane microparticles, and recruitment of endothelial progenitor cells. Circulating markers of EA may serve as potential biomarkers for vascular pathology and cardiovascular (CV) risk. This review presents the biology of EA, analyzes available data on EA markers in RA in relation to vascular pathology and CV events, discusses their relevance as biomarkers of CV risk, and proposes future directions.
Review
Rheumatology
Sarah Ohrndorf, Anne-Marie Glimm, Mads Ammitzboll-Danielsen, Mikkel Ostergaard, Gerd R. Burmester
Summary: The fluorescence optical imaging (FOI) technique, approved for clinical use in the EU and USA, has shown good agreement and potential in imaging joint inflammation and vascular changes. FOI may be a useful tool in rheumatology clinical practice when other imaging modalities are not readily available.
Article
Rheumatology
Joyce Aarts, Debbie M. Roeleveld, Monique M. Helsen, Birgitte Walgreen, Elly L. Vitters, Jay Kolls, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Marije Koenders
Summary: The study revealed that systemic overexpression of IL-22 has clear anti-inflammatory effects during collagen-induced arthritis, with reduced disease severity and incidence. Additionally, the protective effect of systemic IL-22 is likely mediated through upregulation of the negative immune regulator SOCS3.
Article
Rheumatology
Xanthe Marijn Edmee Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette van der Helm-van Mil
Summary: MRI-detected tenosynovitis shows high sensitivity for early ACPA-positive and ACPA-negative RA, indicating that involvement of both juxta-articular (tenosynovitis) and intra-articular synovium is characteristic of RA. Sensitivity for RA is significantly higher than other diseases associated with enthesitis, such as spondyloarthritis and psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Aikaterini Arida, Aigli-Ioanna Legaki, Evrydiki Kravvariti, Athanasios Protogerou, Petros P. Sfikakis, Antonios Chatzigeorgiou
Summary: The study reveals the significant role of the PCSK9/LDLR system in atherosclerosis related to rheumatoid arthritis, suggesting its potential use as a screening tool for disease progression in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Rheumatology
Michaela Koehm, Sarah Ohrndorf, Ann C. Foldenauer, Tanja Rossmanith, Marina Backhaus, Stephanie G. Werner, Gerd R. Burmester, Siegfried Wassenberg, Benjamin Koehler, Harald Burkhardt, Frank Behrens
Summary: The study evaluated the efficacy of FOI technology in detecting early musculoskeletal inflammatory signs in patients with skin psoriasis, providing a useful method for early diagnosis of psoriatic arthritis.
Article
Cardiac & Cardiovascular Systems
Jasmin D. Haslbauer, Sarah Lindner, Silvia Valbuena-Lopez, Hafisyatul Zainal, Hui Zhou, Tommaso D'Angelo, Faraz Pathan, Christophe A. Arendt, Gesine Bug, Hubert Serve, Thomas J. Vogl, Andreas M. Zeiher, Gerry Carr-White, Eike Nagel, Valentina O. Puntmann
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Muhammad Imran, Louis Wang, Jane McCrohon, Chung Yu, Cameron Holloway, James Otton, Justyn Huang, Christian Stehning, Kirsten Jane Moffat, Joanne Ross, Valentina O. Puntmann, Vassilios S. Vassiliou, Sanjay Prasad, Eugene Kotlyar, Anne Keogh, Christopher Hayward, Peter Macdonald, Andrew Jabbour
JACC-CARDIOVASCULAR IMAGING
(2019)
Article
Cardiac & Cardiovascular Systems
Luca Arcari, Rocio Hinojar, Juergen Engel, Tilo Freiwald, Steffen Platschek, Hafisyatul Zainal, Hui Zhou, Moises Vasquez, Till Keller, Andreas Rolf, Helmut Geiger, Ingeborg Hauser, Thomas J. Vogl, Andreas M. Zeiher, Massimo Volpe, Eike Nagel, Valentina O. Puntmann
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Faraz Pathan, Hafisyatul Aiza Zainal Abidin, Quang Ha Vo, Hui Zhou, Tommaso D'Angelo, Elen Elen, Kazuaki Negishi, Valentina O. Puntmann, Thomas H. Marwick, Eike Nagel
Summary: LA strain derived from different vendors and imaging modalities shows varying degrees of correlation and systematic differences, indicating the need for future studies to focus on improving imaging techniques for better reproducibility and addressing systematic biases in measurements.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Letter
Cardiac & Cardiovascular Systems
Jedrzej Hoffmann, Valentina O. Puntmann, Karel Fiser, Tina Rasper, Alexander Berkowitsch, Maria Ludovica Carerj, Eike Nagel, Stefanie Dimmeler, Andreas M. Zeiher
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Philipp de Leuw, Christophe T. Arendt, Annette E. Haberl, Daniel Froadinadl, Gerrit Kann, Timo Wolf, Christoph Stephan, Gundolf Schuettfort, Moises Vasquez, Luca Arcari, Hui Zhou, Hafisyatul Zainal, Monika Gawor, Eleftherios Vidalakis, Michael Kolentinis, Moritz H. Albrecht, Felicitas Escher, Thomas J. Vogl, Andreas M. Zeiher, Eike Nagel, Valentina O. Puntmann
Summary: The study aimed to explore the relationship between cardiac imaging measures and cardiovascular outcomes in PLWH on HAART. The findings showed significant associations between diffuse myocardial fibrosis and LV remodeling with adverse cardiovascular events in PLWH, suggesting the potential for personalized screening and early intervention strategies to reduce the burden of HF in this population.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Chris Anthony, Muhammad Imran, Jim Pouliopoulos, Sam Emmanuel, James Iliff, Zhixin Liu, Kirsten Moffat, Min Ru Qiu, Catriona A. McLean, Christian Stehning, Valentina Puntmann, Vass Vassiliou, Tevfik F. Ismail, Ankur Gulati, Sanjay Prasad, Robert M. Graham, Jane McCrohon, Cameron Holloway, Eugene Kotlyar, Kavitha Muthiah, Anne M. Keogh, Christopher S. Hayward, Peter S. Macdonald, Andrew Jabbour
Summary: This study aimed to assess the feasibility of cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization for monitoring acute cardiac allograft rejection (ACAR)-induced myocarditis after heart transplantation. The results showed that CMR-based multiparametric assessment was highly reproducible and reliable, with higher specificity and negative predictive value for detecting ACAR compared to single CMR mapping. Compared to biopsy-based surveillance, CMR-based surveillance strategy could reduce hospitalization and infection rates.
Article
Biochemistry & Molecular Biology
Valentina O. Puntmann, Simon Martin, Anastasia Shchendrygina, Jedrzej Hoffmann, Mame Madjiguene Ka, Eleni Giokoglu, Byambasuren Vanchin, Niels Holm, Argyro Karyou, Gerald S. Laux, Christophe Arendt, Philipp De Leuw, Kai Zacharowski, Yascha Khodamoradi, Maria J. G. T. Vehreschild, Gernot Rohde, Andreas M. Zeiher, Thomas J. Vogl, Carsten Schwenke, Eike Nagel
Summary: Cardiac symptoms are a common late complication of COVID-19 infection in previously healthy individuals. Ongoing inflammatory cardiac involvement may explain the persistence of these symptoms, and magnetic resonance imaging and measurement of cardiac injury biomarkers can assist in detecting this inflammation.
Editorial Material
Cardiac & Cardiovascular Systems
Valentina O. Puntmann, Eike Nagel
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Valentina Puntmann, Anastasia Shchendrygina, Carlos Rodriguez Bolanos, Mame Madjiguene Ka, Silvia Valbuena, Andreas Rolf, Felicitas Escher, Eike Nagel
Summary: Post-acute cardiovascular sequelae of COVID-19 (PASC) is a recognized complication of severe acute respiratory syndrome coronavirus 2 infection, causing cardiac injury and inflammation, leading to long-term symptoms and health issues.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Arcari, Juergen Engel, Tilo Freiwald, Hui Zhou, Hafisyatul Zainal, Monika Gawor, Stefan Buettner, Helmut Geiger, Ingeborg Hauser, Eike Nagel, Valentina O. Puntmann
Summary: The study demonstrates close associations between cardiac biomarkers including high sensitivity cardiac troponin T (hs-cTnT) and NT-pro-brain natriuretic peptide (NT-pro BNP) with quantitative imaging measures of myocardial fibrosis and edema by T1 and T2 mapping in patients with chronic kidney disease. Native T1 and T2 were significantly associated with worsening CKD in patients, and hs-cTnT and NT-pro BNP correlated with T1 and T2 mapping in patients with lower estimated glomerular filtration rate, suggesting the role of diffuse non-ischemic tissue processes in CKD-related cardiac remodeling.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Review
Cardiac & Cardiovascular Systems
Anastasia Shchedrygina, Eike Nagel, Valentina O. Puntmann, Silvia Valbuena-Lopez
Summary: COVID-19 has been found to cause considerable morbidity and mortality worldwide, with the heart being frequently affected as well. The impact of COVID-19 on the myocardium and the cardiovascular outcomes in survivors remain uncertain. Patients hospitalized with COVID-19 often exhibit myocardial injury, which is associated with a worse prognosis. Additionally, COVID-19 survivors may be at risk of developing persistent residual myocardial injury due to the inflammatory nature of the virus.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Michalis Kolentinis, Melanie Le, Eike Nagel, Valentina O. Puntmann
EUROPEAN CARDIOLOGY REVIEW
(2020)
Correction
Cardiac & Cardiovascular Systems
V. O. Puntmann, M. L. Carerj, I Wieters
Article
Cardiac & Cardiovascular Systems
Melanie T. P. Le, Niloufar Zarinabad, Tommaso D'Angelo, Ibnul Mia, Robert Heinke, Thomas J. Vogl, Andreas Zeiher, Eike Nagel, Valentina O. Puntmann
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2020)
