Article
Cell Biology
Eric Toh, Palwasha Baryalai, Aftab Nadeem, Kyaw Min Aung, Sa Chen, Karina Persson, Jenny L. Persson, Bernt Eric Uhlin, Sun Nyunt Wai
Summary: The bacterial cytotoxin MakA released by Vibrio cholerae inhibits cell growth and tumor cell proliferation by targeting the PIP5K1 alpha lipid signaling pathway and inducing G2/M cell cycle arrest.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Medicinal
Kun Zhang, Kaizhao Hu, Qian Li, Min Li, Ke Gao, Kecheng Yang, Bing Zhao, Xiao-Jing Shi, Lirong Zhang, Hong-Min Liu
Summary: Skp2 is a component of cullin-RING ligases, and its high expression is associated with aggressive tumor tissues and poor prognosis. In this study, a series of new Skp2 inhibitors were synthesized and their structure-activity relationship was systematically studied. Among them, compound 14i showed potent activity against Skp2 and exhibited effective anticancer effects on PC-3 and MGC-803 cells as well as xenograft mouse models.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shudong Niu, Kaixin Cheng, Longzhong Jia, Jing Liang, Lu Mu, Yibo Wang, Xuebing Yang, Chen Yang, Yan Zhang, Chao Wang, Lijun Huang, Huarong Wang, Shuang Zhang, Hua Zhang
Summary: This study demonstrated that ovarian granulosa cell tumors (GCTs) originate from mutant granulosa cells (GCs) and identified the upregulation of immune evasion genes Cd24a and Cd47 as a mechanism for the transition of mutant GCs to GCTs. Treatment with the Cd47 inhibitor RRX-001 effectively suppressed GCT growth in vivo.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Dexin Shen, Lingao Ju, Fenfang Zhou, Mengxue Yu, Haoli Ma, Yi Zhang, Tongzu Liu, Yu Xiao, Xinghuan Wang, Kaiyu Qian
Summary: Melatonin, as a potential therapy for prostate cancer, has significant antioxidant and anticancer abilities. Studies have shown that melatonin can inhibit the development of prostate cancer through different pathways, and the synergistic use with other drugs may have better effects.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Ji Wang, Zongyu Xiao, Peng Li, Chunwang Wu, Yan Li, Qing Wang, Yanming Chen, Honglong Zhou, Zhi Li, Zhaotao Wang, Qing Lan, Yezhong Wang
Summary: PRMT6, a type I arginine methyltransferase, asymmetrically di-methylates the arginine residues of both histones and non-histones. Increasing evidence indicates that PRMT6 plays a tumor mediator involved in human malignancies. Investigation of PRMT6 expression in glioma tissues demonstrated that PRMT6 is overexpressed, and elevated expression of PRMT6 is negatively correlated with poor prognosis in glioma/GBM patients. Silencing PRMT6 inhibited GBM cell proliferation and induced cell cycle arrest at the G0/G1 phase, while overexpressing PRMT6 had opposite results.
Article
Pathology
Ken Sasai, Kouichi Tabu, Takashi Saito, Yukio Matsuba, Takaomi C. Saido, Shinya Tanaka
Summary: GLI1 is able to transform immortalized human astrocytes, while FOXM1 fails to induce malignant transformation. The downregulation of p27(KIP1) contributes to the malignant features of transformed astrocytes. Models using immortalized/transformed astrocytes are useful for identifying essential changes required for glioma formation.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Oncology
Diana Gulei, Rares Drula, Gabriel Ghiaur, Anca Dana Buzoianu, Yelena Kravtsova-Ivantsiv, Ciprian Tomuleasa, Aaron Ciechanover
Summary: The ubiquitin-proteasome system (UPS) is crucial for protein degradation, and its dysregulation is closely related to malignant pathologies. KPC1, an E3 ubiquitin ligase component, plays a key role in cancer by regulating p27 signaling and the NF-xB pathway. KPC1 maintains the ubiquitination of cytoplasmic p27, influencing cell-cycle progression, and also induces the ubiquitination of p105 to control NF-xB signaling. Therapeutic reinforcement of the KPC1-p50 axis shows promising tumor suppressor activity in multiple malignancies.
Article
Biochemistry & Molecular Biology
Jolien Beeken, Sofie Kessels, Jean-Michel Rigo, Yeranddy A. Alpizar, Laurent Nguyen, Bert Brone
Summary: p27(kip1) plays a role in regulating morphological complexity in microglia and affects phagocytic uptake of synaptosomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yu-Lou Wu, Meng-Hsiu Wu, Liang-Tin Lin, Wen-Chien Huang, Jonathan D. Holz, Tzong-Jen Sheu, Jhih-Shian Lee, Richard N. Kitsis, Pei-Han Tai, Yi-Jang Lee
Summary: The study found that cofilin-1 plays a crucial role in cell senescence by affecting morphological changes and cell enlargement. It induces cell senescence through the regulation of p27(Kip1), independent of p53 and p16(INK4) expressions. Additionally, cofilin-1 upregulation can also induce the expression of p27(Kip1) by suppressing the TEAD1 transcription factor, which in turn leads to senescence-related phenotypes.
Review
Biochemistry & Molecular Biology
Ana Garcia-Osta, Jinya Dong, Maria Jesus Moreno-Aliaga, Maria Javier Ramirez
Summary: The cell cycle is regulated by factors such as p27(Kip1), which controls different functions in the nucleus and cytoplasm. In Alzheimer's disease, alterations to cell cycle events and increased neurogenesis have been observed, suggesting a role for p27(Kip1) in the disease process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yilin Fan, Tobias Meyer
Summary: Cell density and mitogen signals compete to regulate the levels of cyclin D1 and p27, determining whether cells proliferate or enter quiescence. The history of competing signals experienced by mother cells is funneled into a precise activator-inhibitor balance that controls the fate of daughter cells.
Article
Biochemistry & Molecular Biology
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: The study found that Tat-p27 can inhibit neuronal damage by reducing oxidative stress, alpha-synuclein expression, and inflammatory responses.
NEUROCHEMICAL RESEARCH
(2021)
Article
Cell Biology
Qun Xie, Ruirui Zhang, Dandan Liu, Jing Yang, Qiang Hu, Chao Shan, Xiaohan Li
Summary: This study investigated the effects of Apigenin and miR-512-3p in melanoma treatment. The results showed that Apigenin inhibited the expression of miR-512-3p and halted cell proliferation in melanoma cells. Furthermore, Apigenin treatment suppressed tumor growth in vivo by decreasing miR-512-3p levels and increasing p27 Kip1 protein levels.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Beilei Zhang, Yue Gao, Rui Yang, Zhijun Ouyang, Hongwei Yu, Han Wang, Xiangyang Shi, Mingwu Shen
Summary: Unobtrusive metastasis and invasion are the major causes of cancer patient death, and the lack of specificity and abrupt release of anticancer drugs applied to primary tumors cause serious side effects in cancer management. Therefore, the development of controlled local drug delivery systems that can effectively treat primary tumors and inhibit tumor metastasis is crucial for improved cancer therapeutics.
ADVANCED FIBER MATERIALS
(2022)
Article
Oncology
Irina Jilishitz, Jason Luis Quinones, Priyank Patel, Grace Chen, Jared Pasetsky, Allison VanInwegen, Scott Schoninger, Manasi P. Jogalekar, Vladislav Tsiperson, Lingyue Yan, Yun Wu, Susan R. S. Gottesman, Jonathan Somma, Stacy W. Blain
Summary: Using NP-ALT as a therapeutic approach can effectively inhibit CDK4/6 and CDK2 by targeting the tyrosine phosphorylation of p27Kip1. This treatment shows efficacy in HR+ breast cancer cells, CDK4i-resistant cells, and can induce necroptosis, particularly in cells with an ER gain of function mutation.
MOLECULAR CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Rebeca Liebana-Garcia, Marta Olivares, Clara Bullich-Vilarrubias, Inmaculada Lopez-Almela, Marina Romani-Perez, Yolanda Sanz
Summary: Obesity has become an epidemic linked to energy-dense diets and sedentary lifestyles, with the gut microbiome playing a role in interacting with the host and diet to impact obesity. Understanding how obesogenic diets and the microbiome affect immunity can help design strategies to tackle obesity-related disorders more effectively.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Zoology
Jorge Rosell, Estefania Montero, Miguel Candelas, Jose Luis Crespo-Picazo, Daniel Garcia-Parraga, Elise E. B. LaDouceur, Juan Manuel Corpa, Joaquin Ortega
Summary: During a 12 month period, a group of 14 medusa-stage jellies of the genus Chrysaora, including Pacific sea nettle and Japanese sea nettle, developed progressive ulcerative umbrellar lesions in a public aquarium. Water quality abnormalities, particularly elevated NO2 and pH levels, were identified as main predisposing factors for the development of ulcerative lesions, while ciliated protozoa were considered secondary pathogens.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Romani-Perez, Inmaculada Lopez-Almela, Clara Bullich-Vilarrubias, Lola Rueda-Ruzafa, Eva M. Gomez Del Pulgar, Alfonso Benitez-Paez, Gerhard Liebisch, Jose Antonio Lamas, Yolanda Sanz
Summary: The study shows that H. biformis isolated from the feces of a metabolically healthy volunteer can improve hyperglycemia, glucose tolerance, and insulin signaling in the liver of obese mice. These effects are associated with the restoration of GLP-1 levels, enhancement of GLP-1 neural signaling, and modification of cecal microbiota. This suggests the potential use of H. biformis in managing type 2 diabetes in obesity by optimizing the sensitivity and function of the GLP-1 system.
Review
Biochemistry & Molecular Biology
Marina Romani-Perez, Clara Bullich-Vilarrubias, Inmaculada Lopez-Almela, Rebeca Liebana-Garcia, Marta Olivares, Yolanda Sanz
Summary: Obesity is a major societal and health challenge globally, with the gut microbiota-diet interactions potentially playing a role in its development. Feeding time and dietary composition are important factors influencing gut microbiota structure and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ana Agusti, Isabel Campillo, Tiziano Balzano, Alfonso Benitez-Paez, Inmaculada Lopez-Almela, Marina Romani-Perez, Jeronimo Forteza, Vicente Felipo, Nicole M. Avena, Yolanda Sanz
Summary: Food addiction is associated with gut microbiota, which can control binge eating and anxiety by influencing the brain's reward response. Administration of a specific bacterium can improve these symptoms, potentially by impacting levels of dopamine, serotonin, and noradrenaline.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ana Garcia-Galan, Juan Seva, Angel Gomez-Martin, Joaquin Ortega, Francisco Rodriguez, Angel Garcia-Munoz, Christian De la Fe
Summary: Bovine respiratory disease (BRD) is a common health and economic problem that mainly affects feedlot calves. This study highlights the importance of Mycoplasma bovis in BRD affecting feedlot calves in Spain, showcasing high prevalence and resistance to antimicrobials commonly used for treatment.
Article
Anatomy & Morphology
M. P. Madrigal, B. Ballester-Lurbe, O. Gomez, J. A. Moreno-Bravo, E. Puelles, S. Jurado, J. M. Garcia-Verdugo, I. Perez-Roger, Jose Terrado
Summary: Rnd3 is a protein involved in oligodendrocyte maturation, with potential roles in the development of the central nervous system and demyelinating diseases. Its absence leads to hypomyelination, reduced oligodendrocyte numbers, and thinner myelin sheaths in mice, indicating its crucial role in myelination.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Cell Biology
Olga Gomez, Giuliana Perini-Villanueva, Andrea Yuste, Jose Antonio Rodriguez-Navarro, Enric Poch, Eloy Bejarano
Summary: Autophagy is a crucial process in maintaining brain health by clearing dysfunctional cellular components, but its decline with age can lead to neurodegenerative disorders. Glycative stress, characterized by the accumulation of AGEs, negatively impacts brain health and may interfere with autophagic function. While autophagy can help remove harmful AGEs, excessive glycative stress may hinder its cytoprotective role in neurons and glial cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Cristina Cueto-Urena, Enric Mocholi, Josep Escriva-Fernandez, Susana Gonzalez-Granero, Sabina Sanchez-Hernandez, Amalia Solana-Orts, Begona Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, Jose Manuel Garcia-Verdugo, Francisco Martin, Paul J. Coffer, Ignacio Perez-Roger, Enric Poch
Summary: This study reveals that loss of Rnd3 expression affects mitochondrial oxidative metabolism and renders cells dependent on glycolysis for energy, suggesting a possible connection to neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Estefania Montero, Carlos Rojo-Solis, Noelia de Castro, Miguel Fernandez, Valentin Perez, Juan M. Corpa, Joaquin Ortega
Summary: This study describes the clinical signs and lesions associated with mycobacteriosis in Syngnathids, and provides the molecular characterization of the causative mycobacteria. It also reports the first description of mycobacteriosis found in Syngnathus acus.
Article
Biochemical Research Methods
Josep Escriva-Fernandez, Cristina Cueto-Urena, Amalia Solana-Orts, Elisa Lledo, Begona Ballester-Lurbe, Enric Poch
Summary: In this study, a CRISPR interference strategy was employed to repress Rnd3 expression in MM cell lines. Lentiviral particles were used to transduce the cell lines and downregulate Rnd3 expression. Transcriptomic analysis revealed distinct gene expression profiles in the Rnd3 knockdown cells compared to the control cells.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Agriculture, Dairy & Animal Science
Joaquin Ortega, Juan M. Corpa, Diego Castillo, Brian G. Murphy
Summary: This study describes the pathological findings of ovine pulmonary adenocarcinoma in small ruminants from Spain, with a focus on the mixed form. Most observed tumors displayed characteristics of both classical and atypical forms, classified as mixed.
Article
Food Science & Technology
Marina Romani-Perez, Clara Bullich-Vilarrubias, Inmaculada Lopez-Almela, Yolanda Sanz
Summary: This study reveals sex-dependent differences in the regulation of energy metabolism by the sodium channel Nav1.8, and suggests that activation of these neurons can improve oral glucose tolerance in females and inhibit glucagon secretion induced by glucose.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pathology
Joaquin Ortega, Jeanette Wyneken, Michael M. Garner
Summary: This study provides a comprehensive description of clinical, gross, and histologic findings in bearded dragons with aneurysms. The most common location for aneurysms was the cranial coelom, accompanied by thrombi formation and hematomas. The study suggests that the development of aneurysms in bearded dragons may be associated with degenerative changes in the vessel walls.
VETERINARY PATHOLOGY
(2023)
