Article
Cardiac & Cardiovascular Systems
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G. Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Chen Yan
Summary: The study revealed that PDE10A contributes to SMC proliferation and intimal hyperplasia by antagonizing the CNP/NPR2/cGMP/PKG1alpha signaling pathway, suggesting that PDE10A may be a novel drug target for treating vascular occlusive disease.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Danielle Jacques
Summary: The vascular endothelium is crucial in embryogenesis and aging, and it lines the blood vessels as a cell monolayer. It is recognized by the immune system as part of the body, so any abnormality in the endothelium exposes tissues to the immune system, leading to inflammation and vascular diseases like atherosclerosis. The endothelium's secretory role allows it to release vasoconstrictors, vasorelaxants, and cardio-modulatory factors that maintain proper circulatory system functioning. Adhesion molecules play a significant role in cardiovascular physiology and pathology by providing a seal for the monolayer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jiayun Ying, Caiyan Zhang, Yaodong Wang, Tingyan Liu, Zhenhao Yu, Kexin Wang, Weiming Chen, Yufeng Zhou, Guoping Lu
Summary: This study suggests that elevated levels of plasma SDC1 are associated with poor prognosis in children with septic shock and sulodexide, a precursor for glycosaminoglycan synthesis, may have therapeutic potential for the treatment of sepsis-associated endothelial dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gang Liu, Ashleigh M. Philp, Tamera Corte, Mark A. Travis, Heidi Schilter, Nicole G. Hansbro, Chris J. Burns, Mathew S. Eapen, Sukhwinder S. Sohal, Janette K. Burgess, Philip M. Hansbro
Summary: Structural changes involving tissue remodelling and fibrosis are major features of many pulmonary diseases. Understanding the differences and similarities of remodelling can help identify common therapeutic targets and strategies for diseases like asthma, COPD, and IPF. Targeting transforming growth factor (TGF)-beta induced fibroblast activation may be a central pathway in the remodelling process.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Cardiac & Cardiovascular Systems
Austin J. Jolly, Sizhao Lu, Keith A. Strand, Allison M. Dubner, Marie F. Mutryn, Raphael A. Nemenoff, Mark W. Majesky, Karen S. Moulton, Mary C. M. Weiser-Evans
Summary: Cardiovascular diseases are characterized by chronic vascular dysfunction and remodelling events. Adventitial progenitor cells, specifically AdvSca1 cells, have been identified as important effectors of vascular remodelling, with the ability to differentiate into multiple cell types. However, their origins, signalling mechanisms, and microenvironmental factors are not fully understood. Recent research suggests the existence of smaller subpopulations within the adventitial progenitor cell population, adding complexity to their characterization. This review aims to outline the heterogeneity of Sca1+ adventitial progenitor cells, summarize their role in vascular homeostasis and remodelling, and discuss their translational relevance in humans.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang
Summary: This study reveals that C1QTNF4 is involved in the migration and proliferation of vascular smooth muscle cells. It inhibits abnormal neointimal formation by downregulating the FAK/PI3K/AKT pathway, thus protecting blood vessels. These findings provide new insights and potential treatments for vascular stenosis diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Heba Shawer, Katherine Norman, Chew W. Cheng, Richard Foster, David J. Beech, Marc A. Bailey
Summary: Studies have shown that ORAI1 signaling plays a crucial role in the pathologic remodeling of vascular smooth muscle cells, especially in atherosclerosis and neointimal hyperplasia. Many therapeutic strategies targeting the ORAI1 target have made progress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Joo-Hui Han, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study revealed that CIAPIN1 is overexpressed in the neointimal region, and its deficiency inhibits intimal hyperplasia and VSMC proliferation and migration while overexpression promotes these processes. CIAPIN1 negatively regulates Tp53 transcription, promoting cell cycle progression and migration, and increases JAK2 expression to enhance phenotypic switching in response to vascular injury. These findings suggest CIAPIN1 as a potential therapeutic target for vascular proliferative diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Article
Pharmacology & Pharmacy
Chunhua Fu, Yuanqing Lu, Mason A. Williams, Mark L. Brantly, Corey E. Ventetuolo, Laurence M. Morel, Borna Mehrad, Edward W. Scott, Andrew J. Bryant
Summary: The study investigated the impact of myeloid cell proliferation induced by emergency myelopoiesis on the development of pulmonary hypertension, as well as the therapeutic effect of PD-L1 in preventing pulmonary vascular remodeling. The results showed that PD-L1 could be a viable therapeutic target in pulmonary hypertension by acting through a signaling axis involving myeloid-derived suppressor cells.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Shuang Li, Yong-li Pan, Wenqiang Xin, Chunhua Yan
Summary: This meta-analysis found insufficient evidence to support the use of endothelin receptor antagonists for treating idiopathic pulmonary fibrosis. The analysis included 5 studies with a total of 1500 participants.
Article
Biotechnology & Applied Microbiology
Ming-Hui Zheng, Su-Kang Shan, Xiao Lin, Feng Xu, Feng Wu, Bei Guo, Fu-Xing-zi Li, Zhi-Ang Zhou, Yi Wang, Li-Min Lei, Ke-Xin Tang, Jia-Yue Duan, Yun-Yun Wu, Ye-Chi Cao, Xiao-Bo Liao, Ling-Qing Yuan
Summary: Vascular calcification is common in chronic renal failure (CRF) patients and significantly increases the risk of cardiovascular events. Previous studies have found that endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) can interact and regulate VSMCs calcification through paracrine effects. This study aims to investigate the effects of exosomes secreted by high phosphorus-induced adventitial fibroblasts (AFs) on VSMCs calcification and the underlying mechanism, further highlighting the importance of AFs in the high phosphorus vascular wall microenvironment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.