Article
Engineering, Biomedical
Leonie Waldburger, Romain Schaller, Christina Furthmuller, Lorena Schrepfer, Dirk J. Schaefer, Alexandre Kaempfen
Summary: In this randomized controlled pilot trial, 3D-printed made-to-measure splints were compared to conventional custom-made thermoplastic splints in hand surgical patients. The study found that patient satisfaction ratings were similar for both types of splints, but the production process of 3D splints needs improvement and further materials testing is necessary.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Rehabilitation
Sara Kate Frye, Paula Richley Geigle
Summary: The study compared the effectiveness of custom and prefabricated resting hand splints, finding no significant difference in outcomes or user preference. Most participants adhered well to the splinting program without any adverse effects. Participant comments highlighted the helpfulness of splints in recovery, as well as challenges in directing caregivers and managing the splints.
CLINICAL REHABILITATION
(2021)
Editorial Material
Rheumatology
Giovanni Adami
Summary: The environment plays a crucial role in the development of various diseases, including rheumatic musculoskeletal diseases. Chronic exposure to air pollution has detrimental effects on the immune system, including direct activation of autoimmunity and production of autoantibodies. Rheumatoid arthritis is an example of how environmental stimuli can trigger autoimmunity. Evidence has shown that hard rock mining and chronic exposure to fine particulate matter in the air are associated with an increased risk of developing rheumatoid arthritis.
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Rheumatology
Nadia M. T. Roodenrijs, Attila Hamar, Melinda Kedves, Gyorgy Nagy, Jacob M. van Laar, Desiree van der Heijde, Paco M. J. Welsing
Summary: This systematic literature review highlights the lack of high-quality evidence on the treatment of patients with difficult-to-treat rheumatoid arthritis. The effectiveness of biologic/targeted synthetic DMARDs decreased in patients who had failed multiple previous treatments, but non-pharmacological interventions showed potential for improving non-inflammatory complaints and self-management.
Article
Engineering, Biomedical
Ruqi Huang, Caiyi Zhang, Yeyang Bu, Zheng Li, Xin Zheng, Shang Qiu, Jeremiah Ong'achwa Machuki, Lijie Zhang, Yun Yang, Kaijin Guo, Fenglei Gao
Summary: The study designed a metal/semiconductor composite for combination therapy of rheumatoid arthritis, aiming to remove hyperplasia of the synovium using photothermal therapy, photodynamic therapy, and chemotherapy. The findings showed that this composite nanomaterial may provide a potential treatment option for rheumatoid arthritis.
Review
Rheumatology
Deeba Minhas, Patricia Cagnoli, Carole Dodge
Summary: This review discusses the role of occupational therapists in inflammatory arthritis, recent updates on joint protection and assistive devices, as well as adjunctive treatment options for rheumatologists to help patients manage their symptoms.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Dario Cerasola, Christiano Argano, Valeria Chiovaro, Tatjana Trivic, Tijana Scepanovic, Patrik Drid, Salvatore Corrao
Summary: This study investigates the impact of a 30-day joint economy intervention on the quality of life of patients with rheumatoid arthritis (RA). The results show that combining physical exercise and occupational therapy can improve disease activity, overall health status, and mental health in RA patients.
Review
Rehabilitation
Christina Merete Tvede Madsen, Sara Kjaer Bisgaard, Jette Primdahl, Jeanette Reffstrup Christensen, Cecilie von Bulow
Summary: The study aimed to assess the effect of job loss prevention interventions on persons with inflammatory arthritis. Six randomized controlled trials were included, showing significant improvements in work ability, absenteeism reduction, and job loss prevention among individuals with IA. Despite some inconsistent results, further high-quality studies on this topic are recommended.
JOURNAL OF OCCUPATIONAL REHABILITATION
(2021)
Article
Immunology
Kai Du, Chen-Yu Zhang, Ao Li, Jia-Ze Hu, Ren Guo, Shu-Ming Li
Summary: This study found no direct causal relationship between specific occupational exposures and RA or AS through Mendelian randomization analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Mathematics, Interdisciplinary Applications
Zijian Wang, Jian Liu, Zongyun Gu, Chuanfu Li
Summary: In this study, we developed an efficient model powered by deep convolutional neural networks to automate the scoring of hand X-rays for rheumatoid arthritis patients. The experimental results showed that the model achieved high efficiency and accuracy, with no statistical difference compared to ratings from experienced radiologists.
Article
Rheumatology
Ho So, Isaac T. Cheng, Sze-Lok Lau, Evelyn Chow, Tommy Lam, Vivian W. Hung, Edmund K. Li, James F. Griffith, Vivian W. Lee, Lin Shi, Junbin Huang, Kitty Yan Kwok, Cheuk-Wan Yim, Tena K. Li, Vincent Lo, Jolie Lee, Jack Jock-Wai Lee, Ling Qin, Lai-Shan Tam
Summary: Denosumab showed greater efficacy than placebo in erosion repair in patients with rheumatoid arthritis after 24 months, as seen on HR-pQCT scans. A significant proportion of patients in the denosumab group experienced erosion healing, while no differences in erosion parameters were observed at 12 months.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Scott Scarneo, Philip Hughes, Robert Freeze, Kelly Yang, Juliane Totzke, Timothy Haystead
Summary: Selective targeting of TNF has provided therapeutic benefit in inflammatory diseases like rheumatoid arthritis, but the development of antidrug antibodies limits long-term efficacy, necessitating the development of alternative treatments. Targeting the protein kinase TAKI has shown promise in providing an effective alternative to frontline biologic-based RA therapeutics.
ACS CHEMICAL BIOLOGY
(2022)
Article
Rheumatology
Kathryn Hassel, Meike Pinnig
Summary: Patient care involving assistive devices and orthoses is crucial in the management of rheumatic diseases. The goals of hand therapy and assistive devices are to alleviate pain, stabilize and safeguard already damaged joints. It is essential to determine the need for assistive devices and educate patients on the practical application of joint protection. Close collaboration between occupational therapy and orthopedic/internal rheumatology is of utmost importance.
AKTUELLE RHEUMATOLOGIE
(2023)
Review
Chemistry, Multidisciplinary
Junkai Zhao, Xuan Chen, Kwun-Hei Ho, Chao Cai, Cheuk-Wing Li, Mo Yang, Changqing Yi
Summary: Rheumatoid arthritis is a chronic autoimmune disease that damages patients' bones and cartilage, making diagnosis and treatment crucial. The emergence of nanotechnology provides new insights, and integrating diagnosis and therapy is an ideal solution for disease management.
CHINESE CHEMICAL LETTERS
(2021)
Review
Rheumatology
James P. Gavin, Laura Rossiter, Vicky Fenerty, Jenny Leese, Alison Hammond, Eileen Davidson, Catherine L. Backman
Summary: This protocol reports a review on the role of occupational therapy in the self-management of rheumatoid arthritis. The review synthesizes current evidence and best practices to inform future research and strategies for promoting quality of life in individuals with rheumatoid arthritis.
MUSCULOSKELETAL CARE
(2023)
Article
Endocrinology & Metabolism
Micheal O. Breasail, Camille Pearse, Ayse Zengin, Landing Jarjou, Cyrus Cooper, Peter R. Ebeling, Ann Prentice, Kate A. Ward
Summary: This study aimed to describe musculoskeletal aging in Gambian adults. The results showed bone loss in all sites and a faster rate of loss in women in some indicators. Therefore, musculoskeletal health is an important challenge for resource-limited countries.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Eugene McCloskey, Nicholas C. Harvey, Cyrus Cooper, Rene Rizzoli, Bess Dawson-Hughes, Stefania Maggi, Jean-Yves Reginster
Summary: This position paper discusses the rationale for separate diagnostic and intervention thresholds in osteoporosis, and concludes that the current BMD-based diagnostic criteria should be retained.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Ayse Zengin, Micheal O. Breasail, Camille M. Parsons, Landing M. Jarjou, Ramatoulie E. Janha, Modou Jobe, Ann Prentice, Cyrus Cooper, Peter R. Ebeling, Kate A. Ward
Summary: This study investigated the sex differences in associations between cardiac workload, arterial stiffness, peripheral vascular calcification (PVC) and physical function in Gambian adults. The results revealed significant differences between men and women in these associations, with the differences partly mediated by fat mass index.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Nutrition & Dietetics
Faidra Laskou, Gregorio Bevilacqua, Leo D. Westbury, Ilse Bloom, Pritti Aggarwal, Cyrus Cooper, Harnish P. Patel, Elaine Dennison
Summary: This study investigated the changes in diet among older UK community-dwelling adults during the COVID-19 pandemic and found that individuals at higher nutritional risk were more likely to experience a deterioration in diet quality. Further research is needed to understand the factors leading to these changes and whether they can be reversed, which is important for future pandemic management.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Shengyu Lu, Nicholas R. Fuggle, Leo D. Westbury, Micheal O. Breasail, Gregorio Bevilacqua, Kate A. Ward, Elaine M. Dennison, Sasan Mahmoodi, Mahesan Niranjan, Cyrus Cooper
Summary: By combining computer vision and machine learning techniques with clinical risk factors and bone density measurements, researchers found that the accuracy of fracture risk assessment can be improved. This approach has the potential to make the information offered by HR-pQCT more accessible and applicable to healthcare professionals.
Article
Endocrinology & Metabolism
Farirayi Kowo-Nyakoko, Celia L. Gregson, Tafadzwa Madanhire, Lynda Stranix-Chibanda, Ruramayi Rukuni, Amaka C. Offiah, Lisa K. Micklesfield, Cyrus Cooper, Rashida A. Ferrand, Andrea M. Rehman, Kate A. Ward
Summary: This study aimed to compare and validate the Greulich and Pyle (GP) and Tanner and Whitehouse 3 (TW3) methods for evaluating bone age in sub-Saharan Africa (SSA). The results showed that there was a difference between bone age and chronological age in boys using both GP and TW3 methods, while there was no significant difference in girls. Furthermore, the agreement between GP method and chronological age improved as children got older.
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Stefania D'Angelo, Christopher R. Holroyd, Sarah R. Crozier, Keith M. Godfrey, Justin H. Davies, Cyrus Cooper, Nicholas C. Harvey
Summary: This study examines differential mother-offspring and father-offspring associations in body composition in early childhood. The results show a strong association between maternal fat mass and the fat mass of their daughters but not their sons, while there were weaker associations between the body composition of fathers and their children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Chun-Feng Huang, Jung-Fu Chen, Ian R. Reid, Wing P. Chan, Peter Robert Ebeling, Bente Langdahl, Shih-Te Tu, Toshio Matsumoto, Ding-Cheng Chan, Yoon-Sok Chung, Fang-Ping Chen, E. Michael Lewiecki, Keh-Sung Tsai, Rong-Sen Yang, Seng Bin Ang, Ko-En Huang, Yin-Fan Chang, Chung-Hwan Chen, Joon-Kiong Lee, Hsin-I Ma, Weibo Xia, Ambrish Mithal, David L. Kendler, Cyrus Cooper, Jawl-Shan Hwang, Chih-Hsing Wu
Summary: Postmenopausal women are at a high risk of osteoporotic fractures due to rapid bone loss. To prevent this, experts in the Asia-Pacific region have developed a set of statements for the prevention of fractures in postmenopausal women. They advocate for reimbursement of pharmaceutical therapy for women with a high risk of fractures and emphasize the need for more clinical experience and data to improve intervention strategies.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Cell Biology
Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. Macisaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Summary: Insulin resistance in muscle in older individuals is associated with differential DNA methylation, with muscle mass and body composition playing a significant role in these methylation changes.
Article
Public, Environmental & Occupational Health
Kathryn R. Hesketh, Janis Baird, Sarah R. Crozier, Keith M. Godfrey, Nicholas C. Harvey, Cyrus Cooper, Esther M. F. van Sluijs
Summary: This study aimed to explore the relationship between activity behaviors before/during pregnancy and later parenthood. The results showed that women who sat for long periods of time before/during pregnancy were more sedentary 4-7 years postpartum, and those who engaged in moderate-/strenuous exercise before/during pregnancy were more active in later parenthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Review
Geriatrics & Gerontology
Nicola Veronese, Germain Honvo, Olivier Bruyere, Rene Rizzoli, Mario Barbagallo, Stefania Maggi, Lee Smith, Shaun Sabico, Nasser Al-Daghri, Cyrus Cooper, Francesco Pegreffi, Jean-Yves Reginster
Summary: This umbrella review examined the association between knee osteoarthritis and adverse health outcomes. The results showed that knee osteoarthritis is significantly associated with cardiovascular mortality, falls, and conditions related to subclinical atherosclerosis. However, the certainty of this evidence is weak.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Rehabilitation
James Gavin, Laura Rossiter, Vicky Fenerty, Jenny Leese, Alison Hammond, Eileen Davidson, Catherine Backman, Jo Adams
BRITISH JOURNAL OF OCCUPATIONAL THERAPY
(2023)