Article
Pharmacology & Pharmacy
Jing Wang, Bomiao Ju, Li Zhu, Hanchao Li, Jing Luo, Jing Zhang, Nan Hu, Lingfei Mo, Yanhua Wang, Ying Pan, Jing Huang, Xiaohong Lv, Dan Pu, Zhiming Hao, Lan He, Yuanyuan Li
Summary: The study aimed to examine the kinetics of B cell subsets and activation markers in the early stage of belimumab treatment and their correction with treatment response. Flow cytometry was used to test the B cell subsets and activation markers of 27 systemic lupus erythematosus (SLE) patients receiving 6 months belimumab treatment. The results showed that B cell hyperactivity was rapidly inhibited in the early stage of belimumab treatment and the ratio of p-SYK/p-AKT may predict SLEDAI-2K decline.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Medicine, General & Internal
Carla Sans-Pola, Immaculada Danes, Josep Angel Bosch, Patricia Marrero-Alvarez, Josefina Cortes, Antonia Agusti
Summary: This study describes the outcomes and tolerability of off-label rituximab treatment in adult patients with non-renal SLE. Most patients achieved partial remission after treatment cycles, with significant improvement in platelet counts. However, patients with a predominant joint involvement had a lower response rate.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Jasvinder A. Singh, Nipam P. Shah, Amy S. Mudano
Summary: Belimumab at the FDA-approved dose of 10 mg/kg may be associated with a clinically meaningful efficacy benefit compared to placebo in participants with SLE. More data are needed for the longer-term efficacy of Belimumab.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Rheumatology
Fengchun Zhang, Jie Zheng, Yang Li, Guochun Wang, Mingjun Wang, Yin Su, Jieruo Gu, Xingfu Li, Damon Bass, Myron Chu, Paula Curtis, Kathleen DeRose, Regina Kurrasch, Jenny Lowe, Paige Meizlik, David A. Roth
Summary: The study evaluated the long-term safety and efficacy of belimumab in Chinese patients with SLE. The results showed favorable safety profile and disease control for up to 6 years, consistent with previous studies on belimumab.
Review
Immunology
Feng Chen, Ying Zheng, Xinying Chen, Zhanfa Wen, Youjia Xu, Jinghua Yang, Kaisi Xu
Summary: Belimumab is an important medication for the treatment of cSLE. However, there is a lack of sufficient research on its efficacy and safety, and further studies are needed to validate its clinical value.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Liping Xu, Xinwei Song, Qiaoding Dai, Tianrong Guan, Yan Zhang, Na Lin, Ji-an Wang
Summary: This case report highlights the efficacy of Belimumab in treating refractory Lupus Cystitis, with significant improvements in symptoms, urinary markers, and protein levels observed in the patient. No relapse of lupus cystitis or SLE activity occurred during the 10-month follow-up period, demonstrating positive outcomes with Belimumab treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Yoshiya Tanaka, Sang-Cheol Bae, Damon Bass, Paula Curtis, Myron Chu, Kathleen DeRose, Beulah Ji, Regina Kurrasch, Jenny Lowe, Paige Meizlik, David A. Roth
Summary: The study showed that belimumab had a favorable safety profile and treatment responses in patients with systemic lupus erythematosus from Japan and South Korea for up to 7 years.
Article
Immunology
Hao Cheng, Xiao-ying Zhang, Hui-dan Yang, Zhen Yu, Cheng-lan Yan, Chong Gao, Hong-yan Wen
Summary: This study showed that Belimumab in combination with low-dose intravenous CYC significantly reduced disease activity scores and maintained the B/T cell balance for SLE patients at 24 weeks. The Belimumab treatment group had lower adverse events and higher efficacy compared to conventional treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andreas Mackensen, Fabian Mueller, Dimitrios Mougiakakos, Sebastian Boeltz, Artur Wilhelm, Michael Aigner, Simon Voelkl, David Simon, Arnd Kleyer, Luis Munoz, Sascha Kretschmann, Soraya Kharboutli, Regina Gary, Hannah Reimann, Wolf Roesler, Stefan Uderhardt, Holger Bang, Martin Herrmann, Arif Buelent Ekici, Christian Buettner, Katharina Maria Habenicht, Thomas H. Winkler, Gerhard Kroenke, Georg Schett
Summary: A study of five patients with refractory systemic lupus erythematosus treated with anti-CD19 CAR T cell therapy showed remission of SLE disease in all patients after 3 months, and long-term drug-free remission was maintained during follow-up.
Article
Immunology
Qian Chen, Mengmeng Xiang, Zhanyan Gao, Fan Lvu, Zhan Sun, Yilun Wang, Xiangguang Shi, Jinhua Xu, Jie Wang, Jun Liang
Summary: This study demonstrates the occurrence of B-cell ferroptosis in both SLE patients and mice, and shows that treatment with liproxstatin-1, a potent ferroptosis inhibitor, can improve SLE symptoms and reduce autoantibody production. The results also suggest that ferroptosis may regulate B cell differentiation and plasma cell formation in SLE pathogenesis.
CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Ju-Yang Jung, Ji-Won Kim, Chang-Hee Suh, Hyoun-Ah Kim
Summary: This study describes a 16-year-old girl with SLE and immune thrombocytopenia who was diagnosed with TTP. She was successfully treated with plasmapheresis and rituximab therapy, and her relapse after 18 months was controlled using the same management.
Review
Biochemical Research Methods
Kavina Shah, Mark Cragg, Maria Leandro, Venkat Reddy
Summary: Systemic Lupus Erythematosus (SLE) is a complex autoimmune inflammatory condition that commonly affects young women and certain ethnicities, with a wide spectrum of disease manifestations. While conventional therapies have improved outcomes, there remains a great unmet need, leading to exploration of biological therapies.
Article
Biotechnology & Applied Microbiology
Roberto Depascale, Mariele Gatto, Margherita Zen, Francesca Saccon, Maddalena Larosa, Elisabetta Zanatta, Sara Bindoli, Andrea Doria, Luca Iaccarino
Summary: Belimumab, a fully humanized monoclonal antibody targeting B cells, has demonstrated efficacy and safety in clinical practice. Questions regarding the timing of its use, discontinuation, and potential combination with other biological drugs require further investigation.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Rheumatology
Yusuke Miyazaki, Shingo Nakayamada, Koshiro Sonomoto, Kawabe Akio, Yoshino Inoue, Naoaki Okubo, Shigeru Iwata, Kentaro Hanami, Yoshiya Tanaka
Summary: This study investigated the efficacy and safety of belimumab (BEL) in patients with systemic lupus erythematosus (SLE) during maintenance therapy. The results showed that BEL combined with standard-of-care therapy was effective in reducing glucocorticoid (GC) dosage and relapse rate in SLE patients. The study also identified factors associated with successful tapering of GC dosage.
Article
Immunology
D. Oleksyn, J. Zhao, A. Vosoughi, J. C. Zhao, R. Misra, A. P. Pentland, D. Ryan, J. Anolik, C. Ritchlin, J. Looney, A. P. Anandarajah, G. Schwartz, L. M. Calvi, M. Georger, C. Mohan, I. Sanz, L. Chen
IMMUNOLOGY LETTERS
(2017)
Article
Immunology
Anna K. Bird, Martin Chang, Jennifer Barnard, Bruce I. Goldman, Nida Meednu, Javier Rangel-Moreno, Jennifer H. Anolik
JOURNAL OF IMMUNOLOGY
(2017)
Article
Rheumatology
Lin Gao, Anna K. Bird, Nida Meednu, Kristin Dauenhauer, Jane Liesveld, Jennifer Anolik, R. John Looney
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Immunology
Scott A. Jenks, Kevin S. Cashman, Esther Zumaquero, Urko M. Marigorta, Aakash V. Patel, Xiaoqian Wang, Deepak Tomar, Matthew C. Woodruff, Zoe Simon, Regina Bugrovsky, Emily L. Blalock, Christopher D. Scharer, Christopher M. Tipton, Chungwen Wei, S. Sam Lim, Michelle Petri, Timothy B. Niewold, Jennifer H. Anolik, Greg Gibson, F. Eun-Hyung Lee, Jeremy M. Boss, Frances E. Lund, Ignacio Sanz
Article
Multidisciplinary Sciences
Wen Sun, Nida Meednu, Alexander Rosenberg, Javier Rangel-Moreno, Victor Wang, Jason Glanzman, Teresa Owen, Xichao Zhou, Hengwei Zhang, Brendan F. Boyce, Jennifer H. Anolik, Lianping Xing
NATURE COMMUNICATIONS
(2018)
Article
Rheumatology
Lin Gao, Maria Slack, Andrew McDavid, Jennifer Anolik, R. John Looney
CURRENT RHEUMATOLOGY REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Lin Gao, Mary OConnell, Maria Allen, Jane Liesveld, Andrew McDavid, Jennifer H. Anolik, Richard J. Looney
Article
Immunology
Yannick Dieudonne, Vincent Gies, Aurelien Guffroy, Celine Keime, Anna K. Bird, Jane Liesveld, Jennifer L. Barnas, Vincent Poindron, Nawal Douiri, Pauline Soulas-Sprauel, Thierry Martin, Eric Meffre, Jennifer H. Anolik, Anne-Sophie Korganow
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Immunology
Fan Zhang, Kevin Wei, Kamil Slowikowski, Chamith Y. Fonseka, Deepak A. Rao, Stephen Kelly, Susan M. Goodman, Darren Tabechian, Laura B. Hughes, Karen Salomon-Escoto, Gerald F. M. Watts, A. Helena Jonsson, Javier Rangel-Moreno, Nida Meednu, Cristina Rozo, William Apruzzese, Thomas M. Eisenhaure, David J. Lieb, David L. Boyle, Arthur M. Mandelin, Brendan F. Boyce, Edward DiCarlo, Ellen M. Gravallese, Peter K. Gregersen, Larry Moreland, Gary S. Firestein, Nir Hacohen, Chad Nusbaum, James A. Lederer, Harris Perlman, Costantino Pitzalis, Andrew Filer, V. Michael Holers, Vivian P. Bykerk, Laura T. Donlin, Jennifer H. Anolik, Michael B. Brenner, Soumya Raychaudhuri, Jennifer Albrecht, S. Louis Bridges, Christopher D. Buckley, Jane H. Buckner, James Dolan, Joel M. Guthridge, Maria Gutierrez-Arcelus, Lionel B. Ivashkiv, Eddie A. James, Judith A. James, Josh Keegan, Yvonne C. Lee, Mandy J. McGeachy, Michael A. McNamara, Joseph R. Mears, Fumitaka Mizoguchi, Jennifer P. Nguyen, Akiko Noma, Dana E. Orange, Mina Rohani-Pichavant, Christopher Ritchlin, William H. Robinson, Anupamaa Seshadri, Danielle Sutherby, Jennifer Seifert, Jason D. Turner, Paul J. Utz
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Immunology
Evan Der, Hemant Suryawanshi, Pavel Morozov, Manjunath Kustagi, Beatrice Goilav, Saritha Ranabathou, Peter Izmirly, Robert Clancy, H. Michael Belmont, Mordecai Koenigsberg, Michele Mokrzycki, Helen Rominieki, Jay A. Graham, Juan P. Rocca, Nicole Bornkamp, Nicole Jordan, Emma Schulte, Ming Wu, James Pullman, Kamil Slowikowski, Soumya Raychaudhuri, Joel Guthridge, Judith James, Jill Buyon, Thomas Tuschl, Chaim Putterman, Jennifer Anolik, William Apruzzese, Arnon Arazi, Celine Berthier, Michael Brenner, Sean Connery, Melissa Cunningham, Maria Dall'Era, Anne Davidson, Andrea Fava, Chamith Fonseka, Richard Furie, Dan Goldman, Rohit Gupta, Joel Guthridge, Nir Hacohen, David Hildeman, Paul Hoover, Raymond Hsu, Ruba Kado, Kenneth Kalunian, Diane Kamen, Mattias Kretzler, Holden Maecker, Elena Massarotti, William McCune, Maureen McMahon, Meyeon Park, Fernanda Payan-Schober, William Pendergraft, Michelle Petri, Mina Pichavant, Deepak Rao, Paul Utz, Dia Waguespack, David Wofsy, Fan Zhang
Correction
Rheumatology
Lin Gao, Maria Slack, Jennifer L. Barnas, Andrew McDavid, Jennifer Anolik, R. John Looney
CURRENT RHEUMATOLOGY REPORTS
(2019)
Article
Immunology
Arnon Arazi, Deepak A. Rao, Celine C. Berthier, Anne Davidson, Yanyan Liu, Paul J. Hoover, Adam Chicoine, Thomas M. Eisenhaure, A. Helena Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, Edward P. Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E. Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L. Kamen, Richard A. Furie, Fernanda Payan-Schober, William F. Pendergraft, Elizabeth A. McInnis, Jill P. Buyon, Michelle A. Petri, Chaim Putterman, Kenneth C. Kalunian, E. Steve Woodle, James A. Lederer, David A. Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H. Anolik, Michael B. Brenner, David Wofsy, Nir Hacohen, Betty Diamond, Dia Waguespack, Sean M. Connery, Maureen A. McMahon, William J. McCune, Ruba B. Kado, Raymond Hsu, Melissa A. Cunningham, Paul J. Utz, Mina Pichavant, Holden T. Maecker, Rohit Gupta, Judith A. James, Joel M. Guthridge, Chamith Fonseka, Evan der, Robert Clancy, Thomas Tuschl, Hemant Suryawanshi, Andrea Fava, Daniel H. Goldman
Correction
Immunology
Arnon Arazi, Deepak A. Rao, Celine C. Berthier, Anne Davidson, Yanyan Liu, Paul J. Hoover, Adam Chicoine, Thomas M. Eisenhaure, A. Helena Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, Edward P. Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E. Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L. Kamen, Richard A. Furie, Fernanda Payan-Schober, William F. Pendergraft, Elizabeth A. McInnis, Jill P. Buyon, Michelle A. Petri, Chaim Putterman, Kenneth C. Kalunian, E. Steve Woodle, James A. Lederer, David A. Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H. Anolik, Michael B. Brenner, David Wofsy, Nir Hacohen, Betty Diamond
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Rheumatology
Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik
ARTHRITIS RESEARCH & THERAPY
(2018)
Article
Medicine, Research & Experimental
Vincent Gies, Jean-Nicolas Schickel, Sophie Jung, Aurelie Joublin, Salome Glauzy, Anne-Marie Knapp, Anne Soley, Vincent Poindron, Aurelien Guffroy, Jin-Young Choi, Jacques-Eric Gottenberg, Jennifer H. Anolik, Thierry Martin, Pauline Soulas-Sprauel, Eric Meffre, Anne-Sophie Korganow