Journal
ONCOTARGET
Volume 6, Issue 33, Pages 34423-34436Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5406
Keywords
miR-129-5p; Twist1; Snail; EMT; breast cancer progression
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Funding
- National Natural Science Foundation of China [81372843, 81472472]
- National Science and Technology Support Program [2015BAI12B15]
- Tianjin Municipal Natural Science Foundation [13JCYBJC21800]
- Tianjin Higher Education Science and Technology Development Foundation [20130120]
- Natural Science Foundation of Tianjin Medical University [2014KYM05]
- Research Fund for the Doctoral Program of Tianjin Medical Uzniversity Cancer Institute and Hospital [B1402]
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The epithelial to mesenchymal transition (EMT) plays a pivotal role in breast cancer progression. We found that overexpression of miR-129-5p reversed EMT, whereas depletion of miR-129-5p induced EMT in breast cancer cells. We demonstrated that Twist1 is a direct target of miR-129-5p. Both Twist1 and Snail transcriptionally suppressed miR-129-5p expression. Levels of miR-129-5p were low in breast cancer tissues. miR-129-5p down-regulation correlated with advanced clinical stage and poor prognosis in patients with breast cancer. miR-129-5p expression negatively correlated with Twist1 and Snail expression. Thus, miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop.
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